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1 August 2006
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Three potential driver genes of the 20q13 amplification were studied: MYBL2, ZNF217, and STK6, using fluorescence in situ hybridization (FISH) of locus-specific BAC probes on sections of 466 breast tumors arrayed in tissue microarrays. The authors observed two types of amplification. In the first type, the ZNF217 locus was amplified, but amplification was not detected at the two other loci. In the second type, the amplified region seemed larger and involved two or three loci. The two types showed different gene expression profiles and were associated with different histoclinical features, including lymph node status and survival. For further details, please see Ginestier et al. on page 4533 in this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
The Biology Behind
Molecular Pathways
Reviews
Human Cancer Biology
Induction of Interleukin-6 by Hepatitis C Virus Core Protein in Hepatitis C–Associated Mixed Cryoglobulinemia and B-Cell Non–Hodgkin's Lymphoma
Georg Feldmann; Hans Dieter Nischalke; Jacob Nattermann; Brigitte Banas; Thomas Berg; Christian Teschendorf; Wolff Schmiegel; Ulrich Dührsen; Juliane Halangk; Agathe Iwan; Tilman Sauerbruch; Wolfgang H. Caselmann; Ulrich Spengler
Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α Are Expressed in Kaposi Sarcoma and Modulated by Insulin-like Growth Factor-I
Sergiu-Bogdan Catrina; Ileana Ruxandra Botusan; Anja Rantanen; Anca Irinel Catrina; Pawan Pyakurel; Octavian Savu; Magnus Axelson; Peter Biberfeld; Lorenz Poellinger; Kerstin Brismar
Imaging, Diagnosis, Prognosis
Prognosis and Gene Expression Profiling of 20q13-Amplified Breast Cancers
Christophe Ginestier; Nathalie Cervera; Pascal Finetti; Séverine Esteyries; Benjamin Esterni; José Adélaïde; Luc Xerri; Patrice Viens; Jocelyne Jacquemier; Emmanuelle Charafe-Jauffret; Max Chaffanet; Daniel Birnbaum; François Bertucci
A Validated Quantitative Assay to Detect Occult Micrometastases by Reverse Transcriptase-Polymerase Chain Reaction of Guanylyl Cyclase C in Patients with Colorectal Cancer
Stephanie Schulz; Terry Hyslop; Janis Haaf; Christine Bonaccorso; Karl Nielsen; Matthew E. Witek; Ruth Birbe; Juan Palazzo; David Weinberg; Scott A. Waldman
Expression of Late Cell Cycle Genes and an Increased Proliferative Capacity Characterize Very Early Relapse of Childhood Acute Lymphoblastic Leukemia
Renate Kirschner-Schwabe; Claudio Lottaz; Jörn Tödling; Peter Rhein; Leonid Karawajew; Cornelia Eckert; Arend von Stackelberg; Ute Ungethüm; Dennis Kostka; Andreas E. Kulozik; Wolf-Dieter Ludwig; Günter Henze; Rainer Spang; Christian Hagemeier; Karl Seeger
Hypoxia-Inducible Factor-1α Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer
Daniele Generali; Alfredo Berruti; Maria P. Brizzi; Leticia Campo; Simone Bonardi; Simon Wigfield; Alessandra Bersiga; Giovanni Allevi; Manuela Milani; Sergio Aguggini; Valeria Gandolfi; Luigi Dogliotti; Alberto Bottini; Adrian L. Harris; Stephen B. Fox
Endocan Expression and Relationship with Survival in Human Non–Small Cell Lung Cancer
Bogdan Dragos Grigoriu; Florence Depontieu; Arnaud Scherpereel; Delphine Gourcerol; Patrick Devos; Taoufik Ouatas; Jean-Jacques Lafitte; Marie-Christine Copin; Andre-Bernard Tonnel; Philippe Lassalle; The Thoracic Oncology Group
Early Detection of Chemoradioresponse in Esophageal Carcinoma by 3′-Deoxy-3′-3H-Fluorothymidine Using Preclinical Tumor Models
Smith Apisarnthanarax; Mian M. Alauddin; Firas Mourtada; Hisanori Ariga; Uma Raju; Osama Mawlawi; Dongmei Han; William G. Bornmann; Jaffer A. Ajani; Luka Milas; Juri G. Gelovani; K.S. Clifford Chao
Expression of Annexin A1 in Esophageal and Esophagogastric Junction Adenocarcinomas: Association with Poor Outcome
Kim L. Wang; Tsung-Teh Wu; Erika Resetkova; Huamin Wang; Arlene M. Correa; Wayne L. Hofstetter; Stephen G. Swisher; Jaffer A. Ajani; Asif Rashid; Stanley R. Hamilton; Constance T. Albarracin
Cancer Therapy: Clinical
Phase I Trial of Sequential Low-Dose 5-Aza-2′-Deoxycytidine Plus High-Dose Intravenous Bolus Interleukin-2 in Patients with Melanoma or Renal Cell Carcinoma
Jared A. Gollob; Catherine J. Sciambi; Bercedis L. Peterson; Tina Richmond; Monica Thoreson; Kelly Moran; Holly K. Dressman; Jaroslav Jelinek; Jean-Pierre J. Issa
A Phase I Study of Intravenous LBH589, a Novel Cinnamic Hydroxamic Acid Analogue Histone Deacetylase Inhibitor, in Patients with Refractory Hematologic Malignancies
Francis Giles; Thomas Fischer; Jorge Cortes; Guillermo Garcia-Manero; Joachim Beck; Farhad Ravandi; Eric Masson; Patricia Rae; Glen Laird; Sunil Sharma; Hagop Kantarjian; Margaret Dugan; Maher Albitar; Kapil Bhalla
Increased Bioavailability of Intravenous Versus Oral CI-1033, a Pan erbB Tyrosine Kinase Inhibitor: Results of a Phase I Pharmacokinetic Study
George R. Simon; Christopher R. Garrett; Stephen C. Olson; Michael Langevin; Irene A. Eiseman; John J. Mahany; Charles C. Williams; Richard Lush; Adil Daud; Pamela Munster; Alberto Chiappori; Mayer Fishman; Gerold Bepler; Peter F. Lenehan; Daniel M. Sullivan
Cancer Therapy: Preclinical
An In vivo Platform for Translational Drug Development in Pancreatic Cancer
Belen Rubio-Viqueira; Antonio Jimeno; George Cusatis; Xianfeng Zhang; Christine Iacobuzio-Donahue; Collins Karikari; Chanjusn Shi; Kathleen Danenberg; Peter V. Danenberg; Hidekazu Kuramochi; Koji Tanaka; Sharat Singh; Hossein Salimi-Moosavi; Nadia Bouraoud; Maria L. Amador; Soner Altiok; Piotr Kulesza; Charles Yeo; Wells Messersmith; James Eshleman; Ralph H. Hruban; Anirban Maitra; Manuel Hidalgo
Effect of Altering Dietary ω-6/ω-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E2
Naoko Kobayashi; R. James Barnard; Susanne M. Henning; David Elashoff; Srinivasa T. Reddy; Pinchas Cohen; Pak Leung; Jenny Hong-Gonzalez; Stephen J. Freedland; Jonathan Said; Dorina Gui; Navindra P. Seeram; Laura M. Popoviciu; Dilprit Bagga; David Heber; John A. Glaspy; William J. Aronson
Mutations Within the Kinase Domain and Truncations of the Epidermal Growth Factor Receptor Are Rare Events in Bladder Cancer: Implications for Therapy
Kelly N. Blehm; Philippe E. Spiess; Jolanta E. Bondaruk; Melanie E. Dujka; Gabriel J. Villares; Yi-jue Zhao; Oliver Bogler; Kenneth D. Aldape; H. Barton Grossman; Liana Adam; David J. McConkey; Bogdan A. Czerniak; Colin P. Dinney; Menashe Bar-Eli
Antisense to Cyclin D1 Inhibits Vascular Endothelial Growth Factor–Stimulated Growth of Vascular Endothelial Cells: Implication of Tumor Vascularization
Masayoshi Yasui; Hirofumi Yamamoto; Chew Yee Ngan; Bazarragchaa Damdinsuren; Yurika Sugita; Hiroki Fukunaga; Jinyu Gu; Makiko Maeda; Ichiro Takemasa; Masataka Ikeda; Yasushi Fujio; Mitsugu Sekimoto; Nariaki Matsuura; I. Bernard Weinstein; Morito Monden
The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261 Gliomas
Elizabeth W. Newcomb; Sandra Demaria; Yevgeniy Lukyanov; Yongzhao Shao; Tona Schnee; Noriko Kawashima; Li Lan; J. Keith Dewyngaert; David Zagzag; William H. McBride; Silvia C. Formenti
Growth-Inhibitory Effects of Human Anti-Insulin-Like Growth Factor-I Receptor Antibody (A12) in an Orthotopic Nude Mouse Model of Anaplastic Thyroid Carcinoma
Zhuoying Wang; Geetika Chakravarty; Seungwon Kim; Yasemin D. Yazici; Maher N. Younes; Samar A. Jasser; Alfredo A. Santillan; Corazon D. Bucana; Adel K. El-Naggar; Jeffrey N. Myers
Cancer Prevention
Letters to the Editor
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