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1 July 2006
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Cover Image
Cover Image
About the Cover
The αvβ3 integrin is a key player in angiogenesis and tumor metastasis. The cover image shows an immunohistochemical stain of αvβ3 expression on the endothelium of a microvessel in a pigmented villonodular synovitis. In the same lesion, αvβ3 expression could also be demonstrated noninvasively by positron emission tomography (PET) using the αvβ3 selective tracer [18F]Galacto-RGD. The authors demonstrate that [18F]Galacto-RGD PET successfully identifies the level of αvβ3 expression in man noninvasively. For further details, please see Beer et al. on page 3942. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorials
The Biology Behind
Molecular Pathways
Review
Human Cancer Biology
Accurate Prediction of BRCA1 and BRCA2 Heterozygous Genotype Using Expression Profiling after Induced DNA Damage
Zsofia Kote-Jarai; Lucy Matthews; Ana Osorio; Susan Shanley; Ian Giddings; Francois Moreews; Imogen Locke; D. Gareth Evans; Diana Eccles; The Carrier Clinic Collaborators; Richard D. Williams; Mark Girolami; Colin Campbell; Ros Eeles
Imaging, Diagnosis, Prognosis
Exon 19 Deletion Mutations of Epidermal Growth Factor Receptor Are Associated with Prolonged Survival in Non–Small Cell Lung Cancer Patients Treated with Gefitinib or Erlotinib
David M. Jackman; Beow Y. Yeap; Lecia V. Sequist; Neal Lindeman; Alison J. Holmes; Victoria A. Joshi; Daphne W. Bell; Mark S. Huberman; Balazs Halmos; Michael S. Rabin; Daniel A. Haber; Thomas J. Lynch; Matthew Meyerson; Bruce E. Johnson; Pasi A. Jänne
Prognostic Associations of Activated Mitogen-Activated Protein Kinase and Akt Pathways in Glioblastoma
Christopher E. Pelloski; E Lin; Li Zhang; W.K. Alfred Yung; Howard Colman; Juinn-Lin Liu; Shaio Y. Woo; Amy B. Heimberger; Dima Suki; Michael Prados; Susan Chang; Fredrick G. Barker, III; Gregory N. Fuller; Kenneth D. Aldape
Positron Emission Tomography Using [18F]Galacto-RGD Identifies the Level of Integrin αvβ3 Expression in Man
Ambros J. Beer; Roland Haubner; Mario Sarbia; Michael Goebel; Stephan Luderschmidt; Anca Ligia Grosu; Oliver Schnell; Markus Niemeyer; Horst Kessler; Hans-Jürgen Wester; Wolfgang A. Weber; Markus Schwaiger
Molecular Profiling of Laser-Microdissected Matched Tumor and Normal Breast Tissue Identifies Karyopherin α2 as a Potential Novel Prognostic Marker in Breast Cancer
Edgar Dahl; Glen Kristiansen; Kathrin Gottlob; Irina Klaman; Elke Ebner; Bernd Hinzmann; Klaus Hermann; Christian Pilarsky; Matthias Dürst; Monika Klinkhammer-Schalke; Hagen Blaszyk; Ruth Knuechel; Arndt Hartmann; André Rosenthal; Peter J. Wild
Cancer Therapy: Clinical
Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer
Allan J. Pantuck; John T. Leppert; Nazy Zomorodian; William Aronson; Jenny Hong; R. James Barnard; Navindra Seeram; Harley Liker; Hejing Wang; Robert Elashoff; David Heber; Michael Aviram; Louis Ignarro; Arie Belldegrun
Cancer Therapy: Preclinical
Establishment in Severe Combined Immunodeficiency Mice of Subrenal Capsule Xenografts and Transplantable Tumor Lines from a Variety of Primary Human Lung Cancers: Potential Models for Studying Tumor Progression–Related Changes
Jean-Claude Cutz; Jun Guan; Jane Bayani; Maisa Yoshimoto; Hui Xue; Margaret Sutcliffe; John English; Julia Flint; Jean LeRiche; John Yee; Jeremy A. Squire; Peter W. Gout; Stephen Lam; Yu-Zhuo Wang
PHA-680632, a Novel Aurora Kinase Inhibitor with Potent Antitumoral Activity
Chiara Soncini; Patrizia Carpinelli; Laura Gianellini; Daniele Fancelli; Paola Vianello; Luisa Rusconi; Paola Storici; Paola Zugnoni; Enrico Pesenti; Valter Croci; Roberta Ceruti; Maria Laura Giorgini; Paolo Cappella; Dario Ballinari; Francesco Sola; Mario Varasi; Rodrigo Bravo; Jürgen Moll
Signaling via ErbB2 and ErbB3 Associates with Resistance and Epidermal Growth Factor Receptor (EGFR) Amplification with Sensitivity to EGFR Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cells
Kaisa Erjala; Maria Sundvall; Teemu T. Junttila; Na Zhang; Mika Savisalo; Pekka Mali; Jarmo Kulmala; Jaakko Pulkkinen; Reidar Grenman; Klaus Elenius
Blockage of Epidermal Growth Factor Receptor-Phosphatidylinositol 3-Kinase-AKT Signaling Increases Radiosensitivity of K-RAS Mutated Human Tumor Cells In vitro by Affecting DNA Repair
Mahmoud Toulany; Ulla Kasten-Pisula; Ingo Brammer; Shaomeng Wang; Jianyong Chen; Klaus Dittmann; Michael Baumann; Ekkehard Dikomey; H. Peter Rodemann
Letters to the Editor
Correction
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