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1 June 2006
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Immunohistochemistry for detecting FoxP3 (red nuclear labeling) was used to detect and quantify regulatory T cells (Treg) in anal carcinoma. Unexpectedly, the number of Treg cells did not affect the prognosis. By contrast, a strong negative effect of cytotoxic T cells on survival rates of patients with no evidence of disease was observed. For further details, please see Grabenbauer et al. on page 3355 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
Editorial
The Biology Behind
Molecular Pathways
Perspectives
Human Cancer Biology
Nuclear Factor-κB Signature of Inflammatory Breast Cancer by cDNA Microarray Validated by Quantitative Real-time Reverse Transcription-PCR, Immunohistochemistry, and Nuclear Factor-κB DNA-Binding
Steven J. Van Laere; Ilse Van der Auwera; Gert G. Van den Eynden; Hilde J. Elst; Joost Weyler; Adrian L. Harris; Peter van Dam; Eric A. Van Marck; Peter B. Vermeulen; Luc Y. Dirix
Identification of ROBO1 as a Novel Hepatocellular Carcinoma Antigen and a Potential Therapeutic and Diagnostic Target
Hirotaka Ito; Shin-ichi Funahashi; Naoko Yamauchi; Junji Shibahara; Yutaka Midorikawa; Shigeto Kawai; Yasuko Kinoshita; Akira Watanabe; Yoshitaka Hippo; Toshihiko Ohtomo; Hiroko Iwanari; Atsushi Nakajima; Masatoshi Makuuchi; Masashi Fukayama; Yuichi Hirata; Takao Hamakubo; Tatsuhiko Kodama; Masayuki Tsuchiya; Hiroyuki Aburatani
FAS Death Domain Deletions and Cellular FADD-like Interleukin 1β Converting Enzyme Inhibitory Protein (Long) Overexpression: Alternative Mechanisms for Deregulating the Extrinsic Apoptotic Pathway in Diffuse Large B-Cell Lymphoma Subtypes
Hidenobu Takahashi; Friedrich Feuerhake; Jeffery L. Kutok; Stefano Monti; Paola Dal Cin; Donna Neuberg; Jon C. Aster; Margaret A. Shipp
The Coincidence of Chromosome 15 Aberrations and β2-Microglobulin Gene Mutations Is Causative for the Total Loss of Human Leukocyte Antigen Class I Expression in Melanoma
Annette Paschen; Norbert Arens; Antje Sucker; Karin M. Greulich-Bode; Ester Fonsatti; Annunziata Gloghini; Sandra Striegel; Nicole Schwinn; Antonino Carbone; Ralf Hildenbrand; Adelheid Cerwenka; Michele Maio; Dirk Schadendorf
Imaging, Diagnosis, Prognosis
Which Cyclin E Prevails as Prognostic Marker for Breast Cancer? Results from a Retrospective Study Involving 635 Lymph Node–Negative Breast Cancer Patients
Anieta M. Sieuwerts; Maxime P. Look; Marion E. Meijer-van Gelder; Mieke Timmermans; Anita M.A.C. Trapman; Roberto Rodriguez Garcia; Miranda Arnold; Anneke J.W. Goedheer; Vanja de Weerd; Henk Portengen; Jan G.M. Klijn; John A. Foekens
Cancer Therapy: Clinical
A Phase I Trial to Determine the Optimal Biological Dose of Celecoxib when Combined with Erlotinib in Advanced Non–Small Cell Lung Cancer
Karen L. Reckamp; Kostyantyn Krysan; Jason D. Morrow; Ginger L. Milne; Robert A. Newman; Christopher Tucker; Robert M. Elashoff; Steven M. Dubinett; Robert A. Figlin
Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study
Jae-Gahb Park; Duck-Woo Kim; Chang Won Hong; Byung-Ho Nam; Young-Kyoung Shin; Sung-Hye Hong; Il-Jin Kim; Seok-Byung Lim; Melyssa Aronson; Marie Luise Bisgaard; Gregor J. Brown; John Burn; Elizabeth Chow; Peggy Conrad; Fiona Douglas; Malcolm Dunlop; James Ford; Marc S. Greenblatt; Jarvinen Heikki; Karl Heinimann; Elly L. Lynch; Finlay Macrae; Wendy C. McKinnon; Gabriela Möeslein; Benedito Mauro Rossi; Paul Rozen; Lyn Schofield; Carlos Vaccaro; Hans Vasen; Mary Velthuizen; Alessandra Viel; Juul Wijnen
Phase I/II Trial of an Allogeneic Cellular Immunotherapy in Hormone-Naïve Prostate Cancer
Jonathan W. Simons; Michael A. Carducci; Bahar Mikhak; Michael Lim; Barbara Biedrzycki; Flavia Borellini; Shirley M. Clift; Kristen M. Hege; Dale G. Ando; Steven Piantadosi; Richard Mulligan; William G. Nelson
Development and Validation of a Drug Activity Biomarker that Shows Target Inhibition in Cancer Patients Receiving Enzastaurin, a Novel Protein Kinase C-β Inhibitor
Lisa J. Green; Philip Marder; Chad Ray; Carolyn A. Cook; Susan Jaken; Luna C. Musib; Roy S. Herbst; Michael Carducci; Carolyn D. Britten; Michele Basche; S. Gail Eckhardt; Donald Thornton
Vaccination of Colorectal Cancer Patients with Modified Vaccinia Ankara Delivering the Tumor Antigen 5T4 (TroVax) Induces Immune Responses which Correlate with Disease Control: A Phase I/II Trial
Richard Harrop; Noel Connolly; Irina Redchenko; Juan Valle; Mark Saunders; Matthew G. Ryan; Kevin A. Myers; Noel Drury; Susan M. Kingsman; Robert E. Hawkins; Miles W. Carroll
Cancer Therapy: Preclinical
CIITA-Induced MHC Class II Expression in Mammary Adenocarcinoma Leads to a Th1 Polarization of the Tumor Microenvironment, Tumor Rejection, and Specific Antitumor Memory
Lorenzo Mortara; Patrizia Castellani; Raffaella Meazza; Giovanna Tosi; Andrea De Lerma Barbaro; Francesco A. Procopio; Alberto Comes; Luciano Zardi; Silvano Ferrini; Roberto S. Accolla
Effects of 12-O-Tetradecanoylphorbol-13-acetate (TPA) in Combination with Paclitaxel (Taxol) on Prostate Cancer LNCaP Cells Cultured In vitro or Grown as Xenograft Tumors in Immunodeficient Mice
Xi Zheng; Richard L. Chang; Xiao-Xing Cui; Gina E. Avila; Vidya Hebbar; Mark Garzotto; Weichung Joe Shih; Yong Lin; Shou-En Lu; Arnold B. Rabson; Ah Ng Tony Kong; Allan H. Conney
ABCB1 Modulation Does Not Circumvent Drug Extrusion from Primitive Leukemic Progenitor Cells and May Preferentially Target Residual Normal Cells in Acute Myelogenous Leukemia
Marc H.G.P. Raaijmakers; Elke P.L.M. de Grouw; Bert A. van der Reijden; Theo J.M. de Witte; Joop H. Jansen; Reinier A.P. Raymakers
Anti-CD26 Monoclonal Antibody–Mediated G1-S Arrest of Human Renal Clear Cell Carcinoma Caki-2 Is Associated with Retinoblastoma Substrate Dephosphorylation, Cyclin-Dependent Kinase 2 Reduction, p27kip1 Enhancement, and Disruption of Binding to the Extracellular Matrix
Teruo Inamoto; Tadanori Yamochi; Kei Ohnuma; Satoshi Iwata; Shinichiro Kina; Sakiko Inamoto; Masaaki Tachibana; Yoji Katsuoka; Nam H. Dang; Chikao Morimoto
Insulin-Like Growth Factor I Receptor Pathway Inhibition by ADW742, Alone or in Combination with Imatinib, Doxorubicin, or Vincristine, Is a Novel Therapeutic Approach in Ewing Tumor
Ana S. Martins; Carlos Mackintosh; David Herrero Martín; Maria Campos; Teresa Hernández; Jose-Luis Ordóñez; Enrique de Alava
Letters to the Editor
Corrections
CALGB 50th: Tomorrow’s Cancer Treatments Today
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