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15 May 2006
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Transabdominal perfusion PET scan after infusion of oxygen-15 radiolabeled water showing a well perfused spleen and normal liver with poorly perfused hepatic metastases (anteriorly and laterally). Blood flow modelling confirmed that perfusion to metastases improved after administration of carbogen and nicotinamide. For further details, please see Gupta et al. on page 3115 in this issue. - PDF Icon PDF LinkTable of Contents
ISSN 1078-0432
EISSN 1557-3265
The Biology Behind
Report from the FDA
CCR Drug Updates
Molecular Pathways
Human Cancer Biology
Mixed Lineage Leukemia–Rearranged Childhood Pro-B and CD10-Negative Pre-B Acute Lymphoblastic Leukemia Constitute a Distinct Clinical Entity
Andishe Attarbaschi; Georg Mann; Margit König; Manuel Steiner; Sabine Strehl; Anita Schreiberhuber; Björn Schneider; Claus Meyer; Rolf Marschalek; Arndt Borkhardt; Winfried F. Pickl; Thomas Lion; Helmut Gadner; Oskar A. Haas; Michael N. Dworzak; on behalf of the Austrian Berlin-Frankfurt-Münster Cooperative Study Group
CpG Island M`ethylation Status in Gastric Carcinoma with and without Infection of Epstein-Barr Virus
Moon-Sung Chang; Hiroshi Uozaki; Ja-Mun Chong; Tetsuo Ushiku; Kazuya Sakuma; Shunpei Ishikawa; Rumi Hino; Rita Rani Barua; Yoshiaki Iwasaki; Kuniyoshi Arai; Hideki Fujii; Hideo Nagai; Masashi Fukayama
17β-Estradiol Induces Down-Regulation of Cap43/NDRG1/Drg-1, a Putative Differentiation-Related and Metastasis Suppressor Gene, in Human Breast Cancer Cells
Abbas Fotovati; Teruhiko Fujii; Miki Yamaguchi; Masayoshi Kage; Kazuo Shirouzu; Shinji Oie; Yuji Basaki; Mayumi Ono; Hideaki Yamana; Michihiko Kuwano
Phosphatidylinositol 3′-Kinase/AKT Signaling Is Activated in Medulloblastoma Cell Proliferation and Is Associated with Reduced Expression of PTEN
Wolfgang Hartmann; Boris Digon-Söntgerath; Arend Koch; Anke Waha; Elmar Endl; Indra Dani; Dorota Denkhaus; Cynthia G. Goodyer; Niels Sörensen; Otmar D. Wiestler; Torsten Pietsch
Imaging, Diagnosis, Prognosis
Achieving a Major Molecular Response at the Time of a Complete Cytogenetic Response (CCgR) Predicts a Better Duration of CCgR in Imatinib-Treated Chronic Myeloid Leukemia Patients
Ilaria Iacobucci; Giuseppe Saglio; Gianantonio Rosti; Nicoletta Testoni; Fabrizio Pane; Marilina Amabile; Angela Poerio; Simona Soverini; Simona Bassi; Daniela Cilloni; Renato Bassan; Massimo Breccia; Francesco Lauria; Barbara Izzo; Serena Merante; Francesco Frassoni; Stefania Paolini; Enrico Montefusco; Michele Baccarani; Giovanni Martinelli; for the GIMEMA Working Party on Chronic Myeloid Leukemia
NOTCH1 Mutations in T-Cell Acute Lymphoblastic Leukemia: Prognostic Significance and Implication in Multifactorial Leukemogenesis
Yong-Mei Zhu; Wei-Li Zhao; Jian-Fei Fu; Jing-Yi Shi; Qin Pan; Jiong Hu; Xiao-Dong Gao; Bing Chen; Jun-Min Li; Shu-Min Xiong; Long-Jun Gu; Jing-Yi Tang; Hui Liang; Hui Jiang; Yong-Quan Xue; Zhi-Xiang Shen; Zhu Chen; Sai-Juan Chen
Cancer Therapy: Clinical
Epidermal Growth Factor Receptor Messenger RNA Expression, Gene Dosage, and Gefitinib Sensitivity in Non–Small Cell Lung Cancer
Rafal Dziadziuszko; Samir E. Witta; Federico Cappuzzo; Seongjin Park; Koji Tanaka; Peter V. Danenberg; Anna E. Barón; Lucio Crino; Wilbur A. Franklin; Paul A. Bunn, Jr.; Marileila Varella-Garcia; Kathleen D. Danenberg; Fred R. Hirsch
Fenretinide Activity in Retinoid-Resistant Oral Leukoplakia
Scott M. Lippman; J. Jack Lee; Jack W. Martin; Adel K. El-Naggar; Xiaochun Xu; Dong M. Shin; Margaret Thomas; Li Mao; Herbert A. Fritsche, Jr.; Xian Zhou; Vassiliki Papadimitrakopoulou; Fadlo R. Khuri; Hai Tran; Gary L. Clayman; Walter N. Hittelman; Waun Ki Hong; Reuben Lotan
Carbogen and Nicotinamide Increase Blood Flow and 5-Fluorouracil Delivery but not 5-Fluorouracil Retention in Colorectal Cancer Metastases in Patients
Nishi Gupta; Azeem Saleem; Barbara Kötz; Safiye Osman; Eric O. Aboagye; Robert Phillips; Clare Vernon; Harpreet Wasan; Terry Jones; Peter J. Hoskin; Patricia M. Price
Cancer Therapy: Preclinical
Detection and Functional Analysis of CD8+ T Cells Specific for PRAME: a Target for T-Cell Therapy
Marieke Griffioen; Jan H. Kessler; Martina Borghi; Ronald A. van Soest; Caroline E. van der Minne; Jan Nouta; Sjoerd H. van der Burg; Jan Paul Medema; Peter I. Schrier; J.H. Frederik Falkenburg; Susanne Osanto; Cornelis J.M. Melief
Infectivity-Enhanced Adenoviruses Deliver Efficacy in Clinical Samples and Orthotopic Models of Disseminated Gastric Cancer
Lotta Kangasniemi; Tuula Kiviluoto; Anna Kanerva; Mari Raki; Tuuli Ranki; Merja Sarkioja; Hongju Wu; Frank Marini; Krister Höckerstedt; Helena Isoniemi; Henrik Alfthan; Ulf-Håkan Stenman; David T. Curiel; Akseli Hemminki
Immunogenic HLA-B*0702-Restricted Epitopes Derived from Human Telomerase Reverse Transcriptase That Elicit Antitumor Cytotoxic T-Cell Responses
Olivier Adotévi; Karine Mollier; Christine Neuveut; Sylvain Cardinaud; Emmanuelle Boulanger; Blandine Mignen; Wolf-Hervé Fridman; Maurizio Zanetti; Pierre Charneau; Eric Tartour; François Lemonnier; Pierre Langlade-Demoyen
Cancer Prevention
Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome
Nicholas Hearle; Valérie Schumacher; Fred H. Menko; Sylviane Olschwang; Lisa A. Boardman; Johan J.P. Gille; Josbert J. Keller; Anne Marie Westerman; Rodney J. Scott; Wendy Lim; Jill D. Trimbath; Francis M. Giardiello; Stephen B. Gruber; G. Johan A. Offerhaus; Felix W.M. de Rooij; J.H. Paul Wilson; Anika Hansmann; Gabriela Möslein; Brigitte Royer-Pokora; Tilman Vogel; Robin K.S. Phillips; Allan D. Spigelman; Richard S. Houlston
Correction
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