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Volume 11, Issue 9

1 May 2005

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Cover Image
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

The Biology Behind
Reviews
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Cancer Therapy: Preclinical
Cancer Prevention
Letters to the Editor

The Biology Behind

Transforming Growth Factor-β, Smads, and Cancer

William M. Grady

Extract

View articletitled, Transforming Growth Factor-β, Smads, and Cancer

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Reviews

Cell Death Independent of Caspases: A Review

Linda E. Bröker; Frank A.E. Kruyt; Giuseppe Giaccone

Abstract

View articletitled, Cell Death Independent of Caspases: A Review

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Mining the Tumor Phosphoproteome for Cancer Markers

Yoon Pin Lim

Abstract

View articletitled, Mining the Tumor Phosphoproteome for Cancer Markers

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Human Cancer Biology

Increased Estrogen Receptor βcx Expression during Mammary Carcinogenesis

Majida Esslimani-Sahla; Andrew Kramar; Joelle Simony-Lafontaine; Margaret Warner; Jan-Åke Gustafsson; Henri Rochefort

Abstract

View articletitled, Increased Estrogen Receptor βcx Expression during Mammary Carcinogenesis

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Ferritin Contributes to Melanoma Progression by Modulating Cell Growth and Sensitivity to Oxidative Stress

Alfonso Baldi; Daniela Lombardi; Patrizia Russo; Emanuele Palescandolo; Antonio De Luca; Daniele Santini; Feliciano Baldi; Luigi Rossiello; Maria Lucia Dell'Anna; Arianna Mastrofrancesco; Vittoria Maresca; Enrica Flori; Pier Giorgio Natali; Mauro Picardo; Marco G. Paggi

Abstract

View articletitled, Ferritin Contributes to Melanoma Progression by Modulating Cell Growth and Sensitivity to Oxidative Stress

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Down-Regulation and Growth Inhibitory Role of C/EBPα in Breast Cancer

Sigal Gery; Sakae Tanosaki; Shikha Bose; Namrata Bose; Jay Vadgama; H. Phillip Koeffler

Abstract

View articletitled, Down-Regulation and Growth Inhibitory Role of C/EBPα in Breast Cancer

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Differences in Smad4 Expression in Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Squamous Cell Carcinoma

Adriana Báez; Alan Cantor; Sharon Fonseca; Maria Marcos-Martinez; Linda A. Mathews; Carlos A. Muro-Cacho; Teresita Muñoz-Antonia

Abstract

View articletitled, Differences in Smad4 Expression in Human Papillomavirus Type 16–Positive and Human Papillomavirus Type 16–Negative Head and Neck Squamous Cell Carcinoma

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Imaging, Diagnosis, Prognosis

Int6 Expression Can Predict Survival in Early-Stage Non–Small Cell Lung Cancer Patients

Fiamma Buttitta; Carla Martella; Fabio Barassi; Lara Felicioni; Simona Salvatore; Sandra Rosini; Tommaso D'Antuono; Antonio Chella; Felice Mucilli; Rocco Sacco; Andrea Mezzetti; Franco Cuccurullo; Robert Callahan; Antonio Marchetti

Abstract

View articletitled, Int6 Expression Can Predict Survival in Early-Stage Non–Small Cell Lung Cancer Patients

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Serum Human Telomerase Reverse Transcriptase Messenger RNA as a Novel Tumor Marker for Hepatocellular Carcinoma

Norimasa Miura; Yoshiko Maeda; Takamasa Kanbe; Hiroaki Yazama; Yohei Takeda; Reina Sato; Tomoe Tsukamoto; Emi Sato; Akira Marumoto; Tomomi Harada; Akiko Sano; Yosuke Kishimoto; Yasuaki Hirooka; Yoshikazu Murawaki; Junichi Hasegawa; Goshi Shiota

Abstract

View articletitled, Serum Human Telomerase Reverse Transcriptase Messenger RNA as a Novel Tumor Marker for Hepatocellular Carcinoma

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Fluorodeoxyglucose Positron Emission Tomography as an Outcome Measure for Castrate Metastatic Prostate Cancer Treated with Antimicrotubule Chemotherapy

Michael J. Morris; Timothy Akhurst; Steven M. Larson; Marisa Ditullio; Elaina Chu; Karen Siedlecki; David Verbel; Glenn Heller; W. Kevin Kelly; Susan Slovin; Lawrence Schwartz; Howard I. Scher

Abstract

View articletitled, Fluorodeoxyglucose Positron Emission Tomography as an Outcome Measure for Castrate Metastatic Prostate Cancer Treated with Antimicrotubule Chemotherapy

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Activation of the RAS Pathway Is Predictive for a Chemosensitive Phenotype of Acute Myelogenous Leukemia Blasts

Thomas Illmer; Christian Thiede; Anke Fredersdorf; Sylvia Stadler; Andreas Neubauer; Gerhard Ehninger; Markus Schaich

Abstract

View articletitled, Activation of the RAS Pathway Is Predictive for a Chemosensitive Phenotype of Acute Myelogenous Leukemia Blasts

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Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas

Masatsugu Ueda; Yao-Ching Hung; Yoshito Terai; Koji Kanda; Masanori Kanemura; Hikari Futakuchi; Hiroyuki Yamaguchi; Daisuke Akise; Masayuki Yasuda; Minoru Ueki

Abstract

View articletitled, Vascular Endothelial Growth Factor-C Expression and Invasive Phenotype in Ovarian Carcinomas

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Increased Expression of Insulin-Like Growth Factor I and/or Its Receptor in Gastrinomas Is Associated with Low Curability, Increased Growth, and Development of Metastases

Masayuki Furukawa; Mark Raffeld; Carmen Mateo; Akio Sakamoto; Terry W. Moody; Tetsuhide Ito; David J. Venzon; Jose Serrano; Robert T. Jensen

Abstract

View articletitled, Increased Expression of Insulin-Like Growth Factor I and/or Its Receptor in Gastrinomas Is Associated with Low Curability, Increased Growth, and Development of Metastases

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Noninvasive Detection of Prostate Cancer by Quantitative Analysis of Telomerase Activity

Galina I. Botchkina; Roger H. Kim; Inna L. Botchkina; Alex Kirshenbaum; Zelik Frischer; Howard L. Adler

Abstract

View articletitled, Noninvasive Detection of Prostate Cancer by Quantitative Analysis of Telomerase Activity

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Cyclooxygenase-2 Expression Correlates with Local Chronic Inflammation and Tumor Neovascularization in Human Prostate Cancer

Wanzhong Wang; Anders Bergh; Jan-Erik Damber

Abstract

View articletitled, Cyclooxygenase-2 Expression Correlates with Local Chronic Inflammation and Tumor Neovascularization in Human Prostate Cancer

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Tissue Inhibitor of Matrix Metalloproteinase-1 Is Prognostic in Head and Neck Squamous Cell Carcinoma: Comparison of the Circulating and Tissue Immunoreactive Protein

Henni Ruokolainen; Paavo Pääkkö; Taina Turpeenniemi-Hujanen

Abstract

View articletitled, Tissue Inhibitor of Matrix Metalloproteinase-1 Is Prognostic in Head and Neck Squamous Cell Carcinoma: Comparison of the Circulating and Tissue Immunoreactive Protein

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Expression of Cell Cycle–Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications

Giuseppe Russo; Alessandra Zamparelli; Candace M. Howard; Corrado Minimo; Cristiana Bellan; Giovanna Carillo; Luigi Califano; Lorenzo Leoncini; Antonio Giordano; Pier Paolo Claudio

Abstract

View articletitled, Expression of Cell Cycle–Regulated Proteins pRB2/p130, p107, E2F4, p27, and pCNA in Salivary Gland Tumors: Prognostic and Diagnostic Implications

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14-3-3σ Expression Is an Independent Prognostic Parameter for Poor Survival in Colorectal Carcinoma Patients

Alexander Perathoner; Daniela Pirkebner; Gerald Brandacher; Gilbert Spizzo; Sylvia Stadlmann; Peter Obrist; Raimund Margreiter; Albert Amberger

Abstract

View articletitled, 14-3-3σ Expression Is an Independent Prognostic Parameter for Poor Survival in Colorectal Carcinoma Patients

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Shc Family Expression in Neuroblastoma: High Expression of shcC Is Associated with a Poor Prognosis in Advanced Neuroblastoma

Elena Terui; Tadashi Matsunaga; Hideo Yoshida; Katsunori Kouchi; Hiroaki Kuroda; Tomoro Hishiki; Takeshi Saito; Shin-ichi Yamada; Hiroshi Shirasawa; Naomi Ohnuma

Abstract

View articletitled, Shc Family Expression in Neuroblastoma: High Expression of shcC Is Associated with a Poor Prognosis in Advanced Neuroblastoma

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Metabotropic Glutamate Receptor 4 Expression in Colorectal Carcinoma and Its Prognostic Significance

Hee Jin Chang; Byong Chul Yoo; Seok-Byung Lim; Seung-Yong Jeong; Woo Ho Kim; Jae-Gahb Park

Abstract

View articletitled, Metabotropic Glutamate Receptor 4 Expression in Colorectal Carcinoma and Its Prognostic Significance

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Drg1 Expression in 131 Colorectal Liver Metastases: Correlation with Clinical Variables and Patient Outcomes

Manish A. Shah; Nancy Kemeny; Amanda Hummer; Marija Drobnjak; Monica Motwani; Carlos Cordon-Cardo; Mithat Gonen; Gary K. Schwartz

Abstract

View articletitled, Drg1 Expression in 131 Colorectal Liver Metastases: Correlation with Clinical Variables and Patient Outcomes

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P16 Loss and Mitotic Activity Predict Poor Survival in Patients with Peritoneal Malignant Mesothelioma

Alain C. Borczuk; Robert N. Taub; Mary Hesdorffer; Hanina Hibshoosh; John A. Chabot; Mary L. Keohan; Ritchie Alsberry; Diane Alexis; Charles A. Powell

Abstract

View articletitled, P16 Loss and Mitotic Activity Predict Poor Survival in Patients with Peritoneal Malignant Mesothelioma

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CD44 Expression Is Associated with Increased Survival in Node-Negative Invasive Breast Carcinoma

Leslie K. Diaz; Xiao Zhou; Edward T. Wright; Massimo Cristofanilli; Terry Smith; Ying Yang; Nour Sneige; Aysegul Sahin; Michael Z. Gilcrease

Abstract

View articletitled, CD44 Expression Is Associated with Increased Survival in Node-Negative Invasive Breast Carcinoma

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Prognostic Role of a Multigene Reverse Transcriptase-PCR Assay in Patients with Node-Negative Breast Cancer Not Receiving Adjuvant Systemic Therapy

Francisco J. Esteva; Aysegul A. Sahin; Massimo Cristofanilli; Kevin Coombes; Sang-Joon Lee; Joffre Baker; Maureen Cronin; Michael Walker; Drew Watson; Steven Shak; Gabriel N. Hortobagyi

Abstract

View articletitled, Prognostic Role of a Multigene Reverse Transcriptase-PCR Assay in Patients with Node-Negative Breast Cancer Not Receiving Adjuvant Systemic Therapy

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Human Kallikrein 6: A New Potential Serum Biomarker for Uterine Serous Papillary Cancer

Alessandro D. Santin; Eleftherios P. Diamandis; Stefania Bellone; Antoninus Soosaipillai; Stefania Cane; Michela Palmieri; Alexander Burnett; Juan J. Roman; Sergio Pecorelli

Abstract

View articletitled, Human Kallikrein 6: A New Potential Serum Biomarker for Uterine Serous Papillary Cancer

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YKL-40 Expression is Associated with Poorer Response to Radiation and Shorter Overall Survival in Glioblastoma

Christopher E. Pelloski; Anita Mahajan; Moshe Maor; Eric L. Chang; Shiao Woo; Mark Gilbert; Howard Colman; Helen Yang; Alicia Ledoux; Hilary Blair; Sandra Passe; Robert B. Jenkins; Kenneth D. Aldape

Abstract

View articletitled, YKL-40 Expression is Associated with Poorer Response to Radiation and Shorter Overall Survival in Glioblastoma

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Cancer Therapy: Clinical

Phase I Study of a Novel Taxane BMS-188797 in Adult Patients with Solid Malignancies

Christopher R. Garrett; Mayer N. Fishman; Randall R. Rago; Charles C. Williams; Anne M. Dellaportas; J. Joseph Mahany; Richard M. Lush; William S. Dalton; Ashwin Gollerkeri; Marvin B. Cohen; Daniel M. Sullivan

Abstract

View articletitled, Phase I Study of a Novel Taxane BMS-188797 in Adult Patients with Solid Malignancies

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A Phase I Clinical Trial of Thoracic Radiotherapy and Concurrent Celecoxib for Patients with Unfavorable Performance Status Inoperable/Unresectable Non–Small Cell Lung Cancer

Zhongxing Liao; Ritsuko Komaki; Luka Milas; Chen Yuan; Merrill Kies; Joe Y. Chang; Melenda Jeter; Thomas Guerrero; George Blumenschien; Cheryl M. Smith; Frank Fossella; Barry Brown; James D. Cox

Abstract

View articletitled, A Phase I Clinical Trial of Thoracic Radiotherapy and Concurrent Celecoxib for Patients with Unfavorable Performance Status Inoperable/Unresectable Non–Small Cell Lung Cancer

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High Relapse Rate in Patients with MALT Lymphoma Warrants Lifelong Follow-up

Markus Raderer; Berthold Streubel; Stefan Woehrer; Andreas Puespoek; Ulrich Jaeger; Michael Formanek; Andreas Chott

Abstract

View articletitled, High Relapse Rate in Patients with MALT Lymphoma Warrants Lifelong Follow-up

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Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

James L. Gulley; Philip M. Arlen; Anne Bastian; Steven Morin; Jennifer Marte; Patricia Beetham; Kwong-Yok Tsang; Junko Yokokawa; James W. Hodge; Cynthia Ménard; Kevin Camphausen; C. Norman Coleman; Francis Sullivan; Seth M. Steinberg; Jeffrey Schlom; William Dahut

Abstract

View articletitled, Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer

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Intratumoral COX-2 Gene Expression Is a Predictive Factor for Colorectal Cancer Response to Fluoropyrimidine-Based Chemotherapy

Kazumi Uchida; Sylke Schneider; Ji Min Yochim; Hidekazu Kuramochi; Kazuhiko Hayashi; Ken Takasaki; Dongyun Yang; Kathleen D. Danenberg; Peter V. Danenberg

Abstract

View articletitled, Intratumoral COX-2 Gene Expression Is a Predictive Factor for Colorectal Cancer Response to Fluoropyrimidine-Based Chemotherapy

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A Multicenter Phase II Trial of ZD6474, a Vascular Endothelial Growth Factor Receptor-2 and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients with Previously Treated Metastatic Breast Cancer

Kathy D. Miller; Jose Manuel Trigo; Catherine Wheeler; Alan Barge; Jacqui Rowbottom; George Sledge; Jose Baselga

Abstract

View articletitled, A Multicenter Phase II Trial of ZD6474, a Vascular Endothelial Growth Factor Receptor-2 and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor, in Patients with Previously Treated Metastatic Breast Cancer

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Generation of Potent Antitumor CTL from Patients with Multiple Myeloma Directed against HM1.24

Steven B. Rew; Karl Peggs; Irene Sanjuan; Arnold R. Pizzey; Yasuo Koishihara; Shigeto Kawai; Masaaki Kosaka; Shuji Ozaki; Benjamin Chain; Kwee L. Yong

Abstract

View articletitled, Generation of Potent Antitumor CTL from Patients with Multiple Myeloma Directed against HM1.24

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Phase I Pharmacokinetic-Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin (17AAG, NSC 330507), a Novel Inhibitor of Heat Shock Protein 90, in Patients with Refractory Advanced Cancers

Ramesh K. Ramanathan; Donald L. Trump; Julie L. Eiseman; Chandra P. Belani; Sanjiv S. Agarwala; Eleanor G. Zuhowski; Jing Lan; Douglas M. Potter; S. Percy Ivy; Sakkaraiappan Ramalingam; Adam M. Brufsky; Michael K.K. Wong; Susan Tutchko; Merrill J. Egorin

Abstract

View articletitled, Phase I Pharmacokinetic-Pharmacodynamic Study of 17-(Allylamino)-17-Demethoxygeldanamycin (17AAG, NSC 330507), a Novel Inhibitor of Heat Shock Protein 90, in Patients with Refractory Advanced Cancers

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Enhanced Pharmacodynamic and Antitumor Properties of a Histone Deacetylase Inhibitor Encapsulated in Liposomes or ErbB2-Targeted Immunoliposomes

Daryl C. Drummond; Corina Marx; Zexiong Guo; Gary Scott; Charles Noble; Donghui Wang; Maria Pallavicini; John W. Park; Dmitri B. Kirpotin; Christopher C. Benz

Abstract

View articletitled, Enhanced Pharmacodynamic and Antitumor Properties of a Histone Deacetylase Inhibitor Encapsulated in Liposomes or ErbB2-Targeted Immunoliposomes

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Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O⁶-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

E. Ruth Plummer; Mark R. Middleton; Christopher Jones; Anna Olsen; Ian Hickson; Peter McHugh; Geoffrey P. Margison; Gail McGown; Mary Thorncroft; Amanda J. Watson; Alan V. Boddy; A. Hilary Calvert; Adrian L. Harris; David R. Newell; Nicola J. Curtin

Abstract

View articletitled, Temozolomide Pharmacodynamics in Patients with Metastatic Melanoma: DNA Damage and Activity of Repair Enzymes O6-Alkylguanine Alkyltransferase and Poly(ADP-Ribose) Polymerase-1

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A Phase I and Pharmacologic Trial of Two Schedules of the Proteasome Inhibitor, PS-341 (Bortezomib, Velcade), in Patients with Advanced Cancer

Grace K. Dy; James P. Thomas; George Wilding; Laura Bruzek; Sumithra Mandrekar; Charles Erlichman; Dona Alberti; Kim Binger; Henry C. Pitot; Steven R. Alberts; Lorelei J. Hanson; Rebecca Marnocha; Kendra Tutsch; Scott H. Kaufmann; Alex A. Adjei

Abstract

View articletitled, A Phase I and Pharmacologic Trial of Two Schedules of the Proteasome Inhibitor, PS-341 (Bortezomib, Velcade), in Patients with Advanced Cancer

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Phase I Trial of the Matrix Metalloproteinase Inhibitor Marimastat Combined with Carboplatin and Paclitaxel in Patients with Advanced Non–Small Cell Lung Cancer

John R. Goffin; Ian C. Anderson; Jeffrey G. Supko; Joseph Paul Eder, Jr.; Geoffrey I. Shapiro; Thomas J. Lynch; Margaret Shipp; Bruce E. Johnson; Arthur T. Skarin

Abstract

View articletitled, Phase I Trial of the Matrix Metalloproteinase Inhibitor Marimastat Combined with Carboplatin and Paclitaxel in Patients with Advanced Non–Small Cell Lung Cancer

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Molecular Responses in Patients with Chronic Myelogenous Leukemia in Chronic Phase Treated with Imatinib Mesylate

Jorge Cortes; Moshe Talpaz; Susan O'Brien; Dan Jones; Rajyalakshmi Luthra; Jenny Shan; Francis Giles; Stefan Faderl; Srdan Verstovsek; Guillermo Garcia-Manero; Mary B. Rios; Hagop Kantarjian

Abstract

View articletitled, Molecular Responses in Patients with Chronic Myelogenous Leukemia in Chronic Phase Treated with Imatinib Mesylate

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Cancer Therapy: Preclinical

RNA Interference Demonstrates a Novel Role for Integrin-Linked Kinase as a Determinant of Pancreatic Adenocarcinoma Cell Gemcitabine Chemoresistance

Mark S. Duxbury; Hiromichi Ito; Eric Benoit; Talat Waseem; Stanley W. Ashley; Edward E. Whang

Abstract

View articletitled, RNA Interference Demonstrates a Novel Role for Integrin-Linked Kinase as a Determinant of Pancreatic Adenocarcinoma Cell Gemcitabine Chemoresistance

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Resistance to the Tubulin-Binding Agents in Renal Cell Carcinoma: No Mutations in the Class I β-Tubulin Gene but Changes in Tubulin Isotype Protein Expression

Roisean E. Ferguson; Claire Taylor; Anthea Stanley; Elizabeth Butler; Adrian Joyce; Patricia Harnden; Poulam M. Patel; Peter J. Selby; Rosamonde E. Banks

Abstract

View articletitled, Resistance to the Tubulin-Binding Agents in Renal Cell Carcinoma: No Mutations in the Class I β-Tubulin Gene but Changes in Tubulin Isotype Protein Expression

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Definition of an Immunogenic Region Within the Ovarian Tumor Antigen Stratum Corneum Chymotryptic Enzyme

Kristina L. Bondurant; Mark D. Crew; Alessandro D. Santin; Timothy J. O'Brien; Martin J. Cannon

Abstract

View articletitled, Definition of an Immunogenic Region Within the Ovarian Tumor Antigen Stratum Corneum Chymotryptic Enzyme

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Antimetastatic Effect of Salvicine on Human Breast Cancer MDA-MB-435 Orthotopic Xenograft Is Closely Related to Rho-Dependent Pathway

Jing-Yu Lang; Hua Chen; Jin Zhou; Yi-Xiang Zhang; Xiong-Wen Zhang; Mei-Hong Li; Li-Ping Lin; Jin-Sheng Zhang; Michael P. Waalkes; Jian Ding

Abstract

View articletitled, Antimetastatic Effect of Salvicine on Human Breast Cancer MDA-MB-435 Orthotopic Xenograft Is Closely Related to Rho-Dependent Pathway

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Systemic Delivery of Liposomal Short-Chain Ceramide Limits Solid Tumor Growth in Murine Models of Breast Adenocarcinoma

Thomas C. Stover; Arati Sharma; Gavin P. Robertson; Mark Kester

Abstract

View articletitled, Systemic Delivery of Liposomal Short-Chain Ceramide Limits Solid Tumor Growth in Murine Models of Breast Adenocarcinoma

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The Antitumor Effects of Angelica sinensis on Malignant Brain Tumors In vitro and In vivo

Nu-Man Tsai; Shinn-Zong Lin; Chau-Chin Lee; Shee-Ping Chen; Hsuan-Chi Su; Wen-Liang Chang; Horng-Jyh Harn

Abstract

View articletitled, The Antitumor Effects of Angelica sinensis on Malignant Brain Tumors In vitro and In vivo

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Sensitivity to Gemcitabine and Its Metabolizing Enzymes in Neuroblastoma

Masahiro Ogawa; Hiroki Hori; Takuya Ohta; Kaori Onozato; Masazumi Miyahara; Yoshihiro Komada

Abstract

View articletitled, Sensitivity to Gemcitabine and Its Metabolizing Enzymes in Neuroblastoma

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Blockade of Paracrine Supply of Insulin-Like Growth Factors Using Neutralizing Antibodies Suppresses the Liver Metastasis of Human Colorectal Cancers

Shin'ichi Miyamoto; Michio Nakamura; Kenya Shitara; Kazuyasu Nakamura; Yuji Ohki; Genichiro Ishii; Masato Goya; Keiji Kodama; Takafumi Sangai; Hiroyuki Maeda; Zhang Shi-chuang; Tsutomu Chiba; Atsushi Ochiai

Abstract

View articletitled, Blockade of Paracrine Supply of Insulin-Like Growth Factors Using Neutralizing Antibodies Suppresses the Liver Metastasis of Human Colorectal Cancers

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Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by ¹H-Decoupled-³¹P Magnetic Resonance Spectroscopy

Manickam Muruganandham; Alan A. Alfieri; Cornelia Matei; Yuchun Chen; George Sukenick; Isabel Schemainda; Max Hasmann; Leonard B. Saltz; Jason A. Koutcher

Abstract

View articletitled, Metabolic Signatures Associated with a NAD Synthesis Inhibitor–Induced Tumor Apoptosis Identified by 1H-Decoupled-31P Magnetic Resonance Spectroscopy

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Differential Effects of Vascular Endothelial Growth Factor Receptor-2 Inhibitor ZD6474 on Circulating Endothelial Progenitors and Mature Circulating Endothelial Cells: Implications for Use as a Surrogate Marker of Antiangiogenic Activity

Paul Beaudry; Jeremy Force; George N. Naumov; Andrew Wang; Cheryl H. Baker; Anderson Ryan; Shay Soker; Bruce E. Johnson; Judah Folkman; John V. Heymach

Abstract

View articletitled, Differential Effects of Vascular Endothelial Growth Factor Receptor-2 Inhibitor ZD6474 on Circulating Endothelial Progenitors and Mature Circulating Endothelial Cells: Implications for Use as a Surrogate Marker of Antiangiogenic Activity

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Flavopiridol Sensitivity of Cancer Cells Isolated from Ascites and Pleural Fluids

Christina Richard; Donald Matthews; Wilhelmina Duivenvoorden; Jonathan Yau; Paul S. Wright; John P.H. Th'ng

Abstract

View articletitled, Flavopiridol Sensitivity of Cancer Cells Isolated from Ascites and Pleural Fluids

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Antiangiogenic Properties of Gold Nanoparticles

Priyabrata Mukherjee; Resham Bhattacharya; Ping Wang; Ling Wang; Sujit Basu; Janice A. Nagy; Anthony Atala; Debabrata Mukhopadhyay; Shay Soker

Abstract

View articletitled, Antiangiogenic Properties of Gold Nanoparticles

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Epigenetic Modulation of Retinoic Acid Receptor β2 by the Histone Deacetylase Inhibitor MS-275 in Human Renal Cell Carcinoma

Xiao-fei Wang; David Z. Qian; Mingqiang Ren; Yukihiko Kato; Yongfeng Wei; Lu Zhang; Zoya Fansler; Doug Clark; Osamu Nakanishi; Roberto Pili

Abstract

View articletitled, Epigenetic Modulation of Retinoic Acid Receptor β2 by the Histone Deacetylase Inhibitor MS-275 in Human Renal Cell Carcinoma

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Noninvasive Monitoring of Murine Tumor Blood Flow During and After Photodynamic Therapy Provides Early Assessment of Therapeutic Efficacy

Guoqiang Yu; Turgut Durduran; Chao Zhou; Hsing-Wen Wang; Mary E. Putt; H. Mark Saunders; Chandra M. Sehgal; Eli Glatstein; Arjun G. Yodh; Theresa M. Busch

Abstract

View articletitled, Noninvasive Monitoring of Murine Tumor Blood Flow During and After Photodynamic Therapy Provides Early Assessment of Therapeutic Efficacy

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Reduction of Intracellular pH as a Strategy to Enhance the pH-Dependent Cytotoxic Effects of Melphalan for Human Breast Cancer Cells

Philip Wong; Carol Lee; Ian F. Tannock

Abstract

View articletitled, Reduction of Intracellular pH as a Strategy to Enhance the pH-Dependent Cytotoxic Effects of Melphalan for Human Breast Cancer Cells

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Retinoic Acid and the Histone Deacetylase Inhibitor Trichostatin A Inhibit the Proliferation of Human Renal Cell Carcinoma in a Xenograft Tumor Model

Sue Ellen Touma; Jonathan S. Goldberg; Paul Moench; Xiaojia Guo; Satish K. Tickoo; Lorraine J. Gudas; David M. Nanus

Abstract

View articletitled, Retinoic Acid and the Histone Deacetylase Inhibitor Trichostatin A Inhibit the Proliferation of Human Renal Cell Carcinoma in a Xenograft Tumor Model

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Anti-CD19-Targeted Liposomal Doxorubicin Improves the Therapeutic Efficacy in Murine B-Cell Lymphoma and Ameliorates the Toxicity of Liposomes with Varying Drug Release Rates

Theresa M. Allen; Davis R. Mumbengegwi; Gregory J.R. Charrois

Abstract

View articletitled, Anti-CD19-Targeted Liposomal Doxorubicin Improves the Therapeutic Efficacy in Murine B-Cell Lymphoma and Ameliorates the Toxicity of Liposomes with Varying Drug Release Rates

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Combined Liposome-Mediated Cytosine Deaminase Gene Therapy with Radiation in Killing Rectal Cancer Cells and Xenografts in Athymic Mice

Shiyong Li; Bo Yu; Ping An; Gang Chen; Wenping Lu; Huiyun Cai; Wenhua Guo; Fuyi Zuo

Abstract

View articletitled, Combined Liposome-Mediated Cytosine Deaminase Gene Therapy with Radiation in Killing Rectal Cancer Cells and Xenografts in Athymic Mice

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Autocrine Metabolism of Vitamin D in Normal and Malignant Breast Tissue

Kelly Townsend; Claire M. Banwell; Michelle Guy; Kay W. Colston; Janine L. Mansi; Paul M. Stewart; Moray J. Campbell; Martin Hewison

Abstract

View articletitled, Autocrine Metabolism of Vitamin D in Normal and Malignant Breast Tissue

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Cancer Prevention

Expression of HOXB2, a Retinoic Acid Signaling Target in Pancreatic Cancer and Pancreatic Intraepithelial Neoplasia

Davendra Segara; Andrew V. Biankin; James G. Kench; Catherine C. Langusch; Amanda C. Dawson; David A. Skalicky; David C. Gotley; Maxwell J. Coleman; Robert L. Sutherland; Susan M. Henshall

Abstract

View articletitled, Expression of HOXB2, a Retinoic Acid Signaling Target in Pancreatic Cancer and Pancreatic Intraepithelial Neoplasia

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Letters to the Editor

Growth and Molecular Interactions between Tamoxifen and Trastuzumab

Alejandro Vázquez-Martín; Ramon Colomer; Santiago Ropero; Javier Abel Menéndez

Extract

View articletitled, Growth and Molecular Interactions between Tamoxifen and Trastuzumab

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The Biology Behind

Reviews

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Cancer Prevention

Letters to the Editor

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