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Volume 11, Issue 6
15 March 2005
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

Review

Caspase Regulation in Non–Small Cell Lung Cancer and its Potential for Therapeutic Exploitation
Dean A. Fennell
View articletitled, Caspase Regulation in Non–Small Cell Lung Cancer and its Potential for Therapeutic Exploitation
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Human Cancer Biology

Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer
Sei Hoon Yang; Leah E. Mechanic; Ping Yang; Maria Teresa Landi; Elise D. Bowman; Jason Wampfler; Daoud Meerzaman; Kyeong Man Hong; Felicia Mann; Tatiana Dracheva; Junya Fukuoka; William Travis; Neil E. Caporaso; Curtis C. Harris; Jin Jen
View articletitled, Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer
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Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer
Eddie Myers; Arnold D.K. Hill; Gabrielle Kelly; Enda W. McDermott; Niall J. O'Higgins; Yvonne Buggy; Leonie S. Young
View articletitled, Associations and Interactions between Ets-1 and Ets-2 and Coregulatory Proteins, SRC-1, AIB1, and NCoR in Breast Cancer
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Histologic Type, Organ of Origin, and Wnt Pathway Status: Effect on Gene Expression in Ovarian and Uterine Carcinomas
Kerby A. Shedden; Malti P. Kshirsagar; Donald R. Schwartz; Rong Wu; Hongfeng Yu; David E. Misek; Samir Hanash; Hidetaka Katabuchi; Lora Hedrick Ellenson; Eric R. Fearon; Kathleen R. Cho
View articletitled, Histologic Type, Organ of Origin, and Wnt Pathway Status: Effect on Gene Expression in Ovarian and Uterine Carcinomas
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Transfer of the sFLT-1 Gene in Morris Hepatoma Results in Decreased Growth and Perfusion and Induction of Genes Associated with Stress Response
Kerstin Schmidt; Johannes Hoffend; Annette Altmann; Ludwig G. Strauss; Antonia Dimitrakopoulou-Strauss; Britta Engelhardt; Dirk Koczan; Jörg Peter; Silke Vorwald; Helmut Eskerski; Michael Eisenhut; Jürgen Metz; Ralf Kinscherf; Uwe Haberkorn
View articletitled, Transfer of the <em>sFLT-1</em> Gene in Morris Hepatoma Results in Decreased Growth and Perfusion and Induction of Genes Associated with Stress Response
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Morphology of Tumor Cell Nuclei Is Significantly Related with Survival Time of Patients with Glioblastomas
Reinhold Nafe; Kea Franz; Wolfgang Schlote; Berthold Schneider
View articletitled, Morphology of Tumor Cell Nuclei Is Significantly Related with Survival Time of Patients with Glioblastomas
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Imaging, Diagnosis, Prognosis

Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy
Lynn C. Hartmann; Karen H. Lu; Gerald P. Linette; William A. Cliby; Kimberly R. Kalli; David Gershenson; Robert C. Bast; James Stec; Natalia Iartchouk; David I. Smith; Jeffrey S. Ross; Sebastian Hoersch; Viji Shridhar; James Lillie; Scott H. Kaufmann; Edwin A. Clark; Andrew I. Damokosh
View articletitled, Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy
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Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis
Masaru Shinozaki; Dave S.B. Hoon; Armando E. Giuliano; Nora M. Hansen; He-Jing Wang; Roderick Turner; Bret Taback
View articletitled, Distinct Hypermethylation Profile of Primary Breast Cancer Is Associated with Sentinel Lymph Node Metastasis
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Absence of HER4 Expression Predicts Recurrence of Ductal Carcinoma In situ of the Breast
Nicola L.P. Barnes; Sahar Khavari; Gary P. Boland; Angela Cramer; W. Fiona Knox; Nigel J. Bundred
View articletitled, Absence of HER4 Expression Predicts Recurrence of Ductal Carcinoma <em>In situ</em> of the Breast
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Association of NCOA3 Polymorphisms with Breast Cancer Risk
Barbara Burwinkel; Michael Wirtenberger; Rüdiger Klaes; Rita K. Schmutzler; Ewa Grzybowska; Asta Försti; Bernd Frank; Justo Lorenzo Bermejo; Peter Bugert; Barbara Wappenschmidt; Dorota Butkiewicz; Jolanta Pamula; Wioletta Pekala; Helena Zientek; Danuta Mielzynska; Ewa Siwinska; Claus R. Bartram; Kari Hemminki
View articletitled, Association of <em>NCOA3</em> Polymorphisms with Breast Cancer Risk
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Glutathione S-transferase P1 Genotype and Prognosis in Hodgkin's Lymphoma
Stefan Hohaus; Annalisa Di Ruscio; Annalaura Di Febo; Giuseppina Massini; Francesco D'Alo'; Francesco Guidi; Giovanna Mansueto; Maria Teresa Voso; Giuseppe Leone
View articletitled, Glutathione <em>S</em>-transferase P1 Genotype and Prognosis in Hodgkin's Lymphoma
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Microsatellite Instability Testing in Colorectal Carcinoma: Choice of Markers Affects Sensitivity of Detection of Mismatch Repair–Deficient Tumors
Stephanie B. Hatch; Harry M. Lightfoot, Jr.; Christopher P. Garwacki; Dominic T. Moore; Benjamin F. Calvo; John T. Woosley; Janiece Sciarrotta; William K. Funkhouser; Rosann A. Farber
View articletitled, Microsatellite Instability Testing in Colorectal Carcinoma: Choice of Markers Affects Sensitivity of Detection of Mismatch Repair–Deficient Tumors
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Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival
Tomoya Segawa; Makio Shozu; Kouich Murakami; Tadayuki Kasai; Kazunori Shinohara; Kazuhito Nomura; Satoshi Ohno; Masaki Inoue
View articletitled, Aromatase Expression in Stromal Cells of Endometrioid Endometrial Cancer Correlates with Poor Survival
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Generation of PRL-3- and PRL-1-Specific Monoclonal Antibodies as Potential Diagnostic Markers for Cancer Metastases
Jie Li; Ke Guo; Vicki Wei Chyi Koh; Jing Ping Tang; Bin Qi Gan; Hong Shi; Hui Xiang Li; Qi Zeng
View articletitled, Generation of PRL-3- and PRL-1-Specific Monoclonal Antibodies as Potential Diagnostic Markers for Cancer Metastases
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Accurate Discrimination of Barrett's Esophagus and Esophageal Adenocarcinoma Using a Quantitative Three-Tiered Algorithm and Multimarker Real-time Reverse Transcription-PCR
Michael Mitas; Jonas S. Almeida; Kaidi Mikhitarian; William E. Gillanders; David N. Lewin; Demetri D. Spyropoulos; Loretta Hoover; Amanda Graham; Tammy Glenn; Peter King; David J. Cole; Robert Hawes; Carolyn E. Reed; Brenda J. Hoffman
View articletitled, Accurate Discrimination of Barrett's Esophagus and Esophageal Adenocarcinoma Using a Quantitative Three-Tiered Algorithm and Multimarker Real-time Reverse Transcription-PCR
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High Gene Expression of TS1, GSTP1, and ERCC1 Are Risk Factors for Survival in Patients Treated with Trimodality Therapy for Esophageal Cancer
Mary-Beth Moore Joshi; Yoshinori Shirota; Kathleen D. Danenberg; Debbi H. Conlon; Dennis S. Salonga; James E. Herndon, II; Peter V. Danenberg; David H. Harpole, Jr.
View articletitled, High Gene Expression of <em>TS1</em>, <em>GSTP1</em>, and <em>ERCC1</em> Are Risk Factors for Survival in Patients Treated with Trimodality Therapy for Esophageal Cancer
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Prognostic Significance of Co-expression of RON and MET Receptors in Node-Negative Breast Cancer Patients
Wen-Ying Lee; Helen H.W. Chen; Nan-Haw Chow; Wu-Chou Su; Pin-Wen Lin; How-Ran Guo
View articletitled, Prognostic Significance of Co-expression of RON and MET Receptors in Node-Negative Breast Cancer Patients
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Signet-Ring Cell or Mucinous Histology after Preoperative Chemoradiation and Survival in Patients with Esophageal or Esophagogastric Junction Adenocarcinoma
Lucian R. Chirieac; Stephen G. Swisher; Arlene M. Correa; Jaffer A. Ajani; Ritsuko R. Komaki; Asif Rashid; Stanley R. Hamilton; Tsung-Teh Wu
View articletitled, Signet-Ring Cell or Mucinous Histology after Preoperative Chemoradiation and Survival in Patients with Esophageal or Esophagogastric Junction Adenocarcinoma
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Reg IV: A Promising Marker of Hormone Refractory Metastatic Prostate Cancer
Zhennan Gu; Mark A. Rubin; Yu Yang; Samuel E. Deprimo; Hongjuan Zhao; Steven Horvath; James D. Brooks; Massimo Loda; Robert E. Reiter
View articletitled, <em>Reg IV:</em> A Promising Marker of Hormone Refractory Metastatic Prostate Cancer
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Predictors of the Response to Gefitinib in Refractory Non–Small Cell Lung Cancer
Kyu-Sik Kim; Ju-Yeon Jeong; Young-Chul Kim; Kook-Joo Na; Yun-Hyeon Kim; Sung-Ja Ahn; Sun-Mi Baek; Chang-Soo Park; Chang-Min Park; Yu-Il Kim; Sung-Chul Lim; Kyung-Ok Park
View articletitled, Predictors of the Response to Gefitinib in Refractory Non–Small Cell Lung Cancer
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Stratification of Intermediate-Risk Endometrial Cancer Patients into Groups at High Risk or Low Risk for Recurrence Based on Tumor Gene Expression Profiles
Sarah E. Ferguson; Adam B. Olshen; Agnès Viale; Richard R. Barakat; Jeff Boyd
View articletitled, Stratification of Intermediate-Risk Endometrial Cancer Patients into Groups at High Risk or Low Risk for Recurrence Based on Tumor Gene Expression Profiles
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YKL-40 Is a Differential Diagnostic Marker for Histologic Subtypes of High-Grade Gliomas
Catherine L. Nutt; Rebecca A. Betensky; Melissa A. Brower; Tracy T. Batchelor; David N. Louis; Anat O. Stemmer-Rachamimov
View articletitled, YKL-40 Is a Differential Diagnostic Marker for Histologic Subtypes of High-Grade Gliomas
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Cytoplasmic Phospholipase A2 Levels Correlate with Apoptosis in Human Colon Tumorigenesis
Mei Dong; Michael Johnson; Anahita Rezaie; Jillian N.M. Ilsley; Masako Nakanishi; Melinda M. Sanders; Faripour Forouhar; Joel Levine; David C. Montrose; Charles Giardina; Daniel W. Rosenberg
View articletitled, Cytoplasmic Phospholipase A<sub>2</sub> Levels Correlate with Apoptosis in Human Colon Tumorigenesis
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Stromelysin 3, Ets-1, and Vascular Endothelial Growth Factor Expression in Oral Precancerous and Cancerous Lesions: Correlation with Microvessel Density, Progression, and Prognosis
Shilpi Arora; Jatinder Kaur; Chavvi Sharma; Meera Mathur; Sudhir Bahadur; Nootan K. Shukla; Suryanaryana V.S. Deo; Ranju Ralhan
View articletitled, Stromelysin 3, Ets-1, and Vascular Endothelial Growth Factor Expression in Oral Precancerous and Cancerous Lesions: Correlation with Microvessel Density, Progression, and Prognosis
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Quantitative Assessment of Telomerase Activity and Human Telomerase Reverse Transcriptase Messenger RNA Levels in Pancreatic Juice Samples for the Diagnosis of Pancreatic Cancer
Kenoki Ohuchida; Kazuhiro Mizumoto; Yasuhiro Ogura; Nami Ishikawa; Eishi Nagai; Koji Yamaguchi; Masao Tanaka
View articletitled, Quantitative Assessment of Telomerase Activity and Human Telomerase Reverse Transcriptase Messenger RNA Levels in Pancreatic Juice Samples for the Diagnosis of Pancreatic Cancer
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Legumain Expression in Relation to Clinicopathologic and Biological Variables in Colorectal Cancer
Raghavendra Vasudeva Murthy; Gunnar Arbman; Jingfang Gao; G. David Roodman; Xiao-Feng Sun
View articletitled, Legumain Expression in Relation to Clinicopathologic and Biological Variables in Colorectal Cancer
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Cancer Therapy: Clinical

Gefitinib in Patients with Malignant Mesothelioma: A Phase II Study by the Cancer and Leukemia Group B
Ramaswamy Govindan; Robert A. Kratzke; James E. Herndon, II; Gloria A. Niehans; Robin Vollmer; Dorothy Watson; Mark R. Green; Hedy L. Kindler; on behalf of the Cancer and Leukemia Group B (CALGB 30101)
View articletitled, Gefitinib in Patients with Malignant Mesothelioma: A Phase II Study by the Cancer and Leukemia Group B
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9-cis-Retinoic Acid Treatment Increases Serum Concentrations of α-Tocopherol in Former Smokers
Ji-Youn Han; Diane D. Liu; J. Jack Lee; Jonathan Kurie; Reuben Lotan; Waun K. Hong; Ho-Young Lee
View articletitled, 9-<em>cis</em>-Retinoic Acid Treatment Increases Serum Concentrations of α-Tocopherol in Former Smokers
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Cancer Therapy: Preclinical

A Selective Small Molecule c-MET Inhibitor, PHA665752, Cooperates with Rapamycin
Patrick C. Ma; Erik Schaefer; James G. Christensen; Ravi Salgia
View articletitled, A Selective Small Molecule c-MET Inhibitor, PHA665752, Cooperates with Rapamycin
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Cyclosporin A Is a Broad-Spectrum Multidrug Resistance Modulator
Misbah Qadir; Kieran L. O'Loughlin; Stacy M. Fricke; Nicole A. Williamson; William R. Greco; Hans Minderman; Maria R. Baer
View articletitled, Cyclosporin A Is a Broad-Spectrum Multidrug Resistance Modulator
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Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density
Rinpei Niwa; Mikiko Sakurada; Yukari Kobayashi; Aya Uehara; Kouji Matsushima; Ryuzo Ueda; Kazuyasu Nakamura; Kenya Shitara
View articletitled, Enhanced Natural Killer Cell Binding and Activation by Low-Fucose IgG1 Antibody Results in Potent Antibody-Dependent Cellular Cytotoxicity Induction at Lower Antigen Density
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Antiangiogenic Treatment with the Three Thrombospondin-1 Type 1 Repeats Recombinant Protein in an Orthotopic Human Pancreatic Cancer Model
Xuefeng Zhang; Eric Galardi; Mark Duquette; Marko Delic; Jack Lawler; Sareh Parangi
View articletitled, Antiangiogenic Treatment with the Three Thrombospondin-1 Type 1 Repeats Recombinant Protein in an Orthotopic Human Pancreatic Cancer Model
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4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells In vitro through Down-Regulation of c-Myc, Up-Regulation of p27Kip1, and Modulation of Bcl-2 Family Members
Juliette Gauduchon; Fabrice Gouilleux; Sébastien Maillard; Véronique Marsaud; Jack-Michel Renoir; Brigitte Sola
View articletitled, 4-Hydroxytamoxifen Inhibits Proliferation of Multiple Myeloma Cells <em>In vitro</em> through Down-Regulation of c-Myc, Up-Regulation of p27<sup>Kip1</sup>, and Modulation of Bcl-2 Family Members
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Casein Kinase 2 Regulates Both Apoptosis and the Cell Cycle Following DNA Damage Induced by 6-Thioguanine
Kazuhiko Yamane; Timothy J. Kinsella
View articletitled, Casein Kinase 2 Regulates Both Apoptosis and the Cell Cycle Following DNA Damage Induced by 6-Thioguanine
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Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family
Surita Dalal; Andrea M. Berry; Catherine J. Cullinane; D. Charles Mangham; Robert Grimer; Ian J. Lewis; Colin Johnston; Valerie Laurence; Susan A. Burchill
View articletitled, Vascular Endothelial Growth Factor: A Therapeutic Target for Tumors of the Ewing's Sarcoma Family
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Methylseleninic Acid Potentiates Apoptosis Induced by Chemotherapeutic Drugs in Androgen-Independent Prostate Cancer Cells
Hongbo Hu; Cheng Jiang; Clement Ip; Youcef M. Rustum; Junxuan Lü
View articletitled, Methylseleninic Acid Potentiates Apoptosis Induced by Chemotherapeutic Drugs in Androgen-Independent Prostate Cancer Cells
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Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma
Saminathan S. Nathan; Gene R. DiResta; Jorge E. Casas-Ganem; Bang H. Hoang; Rebecca Sowers; Rui Yang; Andrew G. Huvos; Richard Gorlick; John H. Healey
View articletitled, Elevated Physiologic Tumor Pressure Promotes Proliferation and Chemosensitivity in Human Osteosarcoma
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Targeting the Mevalonate Pathway Inhibits the Function of the Epidermal Growth Factor Receptor
Angela J. Mantha; Jennifer E.L. Hanson; Glenwood Goss; Alain E. Lagarde; Ian A. Lorimer; Jim Dimitroulakos
View articletitled, Targeting the Mevalonate Pathway Inhibits the Function of the Epidermal Growth Factor Receptor
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Effective Inhibition of Experimental Human Ovarian Cancers with a Targeted Cytotoxic Bombesin Analogue AN-215
Jörg B. Engel; Gunhild Keller; Andrew V. Schally; Gabor Halmos; Brian Hammann; Attila Nagy
View articletitled, Effective Inhibition of Experimental Human Ovarian Cancers with a Targeted Cytotoxic Bombesin Analogue AN-215
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Induction of an Antigen Cascade by Diversified Subcutaneous/Intratumoral Vaccination Is Associated with Antitumor Responses
Chie Kudo-Saito; Jeffrey Schlom; James W. Hodge
View articletitled, Induction of an Antigen Cascade by Diversified Subcutaneous/Intratumoral Vaccination Is Associated with Antitumor Responses
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Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4+ Adult T-Cell Leukemia Cells
Takatoshi Shimauchi; Satoshi Imai; Ryosuke Hino; Yoshiki Tokura
View articletitled, Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4<sup>+</sup> Adult T-Cell Leukemia Cells
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Breast Cancer Resistance Protein in Drug Resistance of Primitive CD34+38− Cells in Acute Myeloid Leukemia
Marc H.G.P. Raaijmakers; Elke P.L.M. de Grouw; Leonie H.H. Heuver; Bert A. van der Reijden; Joop H. Jansen; Rik J. Scheper; George L. Scheffer; Theo J.M. de Witte; Reinier A.P. Raymakers
View articletitled, Breast Cancer Resistance Protein in Drug Resistance of Primitive CD34+38− Cells in Acute Myeloid Leukemia
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Letters to the Editor

Coxsackievirus and Adenovirus Receptor Expression on Primary Osteosarcoma Specimens and Implications for Gene Therapy with Recombinant Adenoviruses
Harm C.A. Graat; Paul I.J.M. Wuisman; Victor W. van Beusechem; Jan E. Carette; Winald R. Gerritsen; Johannes Bras; Gerard R. Schaap; Gertjan J.L. Kaspers
View articletitled, Coxsackievirus and Adenovirus Receptor Expression on Primary Osteosarcoma Specimens and Implications for Gene Therapy with Recombinant Adenoviruses
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Corrections

Correction: Article on the Enforced Expression of Wild-Type p53 and the Transcription of the O6-Methylguanine-DNA Methyltransferase Gene
View articletitled, Correction: Article on the Enforced Expression of Wild-Type p53 and the Transcription of the <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase Gene
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Correction: Article on the Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors
View articletitled, Correction: Article on the Aberrant Promoter Methylation of Cancer-Related Genes in Sporadic Breast Tumors
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