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Editorial

Chemokine Receptor 7, A New Player in Regulating Apoptosis of CD8⁺ T Cells in Cancer Patients

Giorgio Parmiani; Chiara Castelli; Licia Rivoltini

View articletitled, Chemokine Receptor 7, A New Player in Regulating Apoptosis of CD8+ T Cells in Cancer Patients

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The Biology Behind

A Dynamic De-Escalating Dosing Strategy to Determine the Optimal Biological Dose for Antiangiogenic Drugs

Urban Emmenegger; Robert S. Kerbel

Extract

View articletitled, A Dynamic De-Escalating Dosing Strategy to Determine the Optimal Biological Dose for Antiangiogenic Drugs

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Human Cancer Biology

Multidrug Resistance Proteins in Gastrointestinal Stromal Tumors: Site-Dependent Expression and Initial Response to Imatinib

Nathalie Théou; Sophie Gil; Anne Devocelle; Catherine Julié; Anne Lavergne-Slove; Alain Beauchet; Patrice Callard; Robert Farinotti; Axel Le Cesne; Antoinette Lemoine; Laurence Faivre-Bonhomme; Jean-François Emile

Abstract

View articletitled, Multidrug Resistance Proteins in Gastrointestinal Stromal Tumors: Site-Dependent Expression and Initial Response to Imatinib

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The Phenotypic Plasticity of Myeloma Plasma Cells as Expressed by Dedifferentiation into an Immature, Resilient, and Apoptosis-Resistant Phenotype

Shmuel Yaccoby

Abstract

View articletitled, The Phenotypic Plasticity of Myeloma Plasma Cells as Expressed by Dedifferentiation into an Immature, Resilient, and Apoptosis-Resistant Phenotype

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Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells

Seok J. Kwon; Jae J. Song; Yong J. Lee

Abstract

View articletitled, Signal Pathway of Hypoxia-Inducible Factor-1α Phosphorylation and its Interaction with von Hippel-Lindau Tumor Suppressor Protein During Ischemia in MiaPaCa-2 Pancreatic Cancer Cells

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Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

Stuart C. Winter; Ketan A. Shah; Leticia Campo; Helen Turley; Russell Leek; Rogan J. Corbridge; Graham J. Cox; Adrian L. Harris

Abstract

View articletitled, Relation of Erythropoietin and Erythropoietin Receptor Expression to Hypoxia and Anemia in Head and Neck Squamous Cell Carcinoma

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X-Linked Inhibitor of Apoptosis Protein Expression Level in Colorectal Cancer Is Regulated by Hepatocyte Growth Factor/C-Met Pathway via Akt Signaling

Hiroya Takeuchi; Joseph Kim; Akihide Fujimoto; Naoyuki Umetani; Takuji Mori; Anton Bilchik; Rod Turner; Andy Tran; Christine Kuo; Dave S.B. Hoon

Abstract

View articletitled, X-Linked Inhibitor of Apoptosis Protein Expression Level in Colorectal Cancer Is Regulated by Hepatocyte Growth Factor/C-Met Pathway via Akt Signaling

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Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment

Tsuyoshi Kuroda; Yasuhiko Kitadai; Shinji Tanaka; Xiaoqin Yang; Naofumi Mukaida; Masaharu Yoshihara; Kazuaki Chayama

Abstract

View articletitled, Monocyte Chemoattractant Protein-1 Transfection Induces Angiogenesis and Tumorigenesis of Gastric Carcinoma in Nude Mice via Macrophage Recruitment

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Tumor Lymphangiogenesis in Inflammatory Breast Carcinoma: A Histomorphometric Study

Ilse Van der Auwera; Gert G. Van den Eynden; Cecile G. Colpaert; Steven J. Van Laere; Peter van Dam; Eric A. Van Marck; Luc Y. Dirix; Peter B. Vermeulen

Abstract

View articletitled, Tumor Lymphangiogenesis in Inflammatory Breast Carcinoma: A Histomorphometric Study

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Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis

Eleanor B. Carson-Walter; Jessica Hampton; Eveline Shue; Daniel M. Geynisman; Pramod Kumar Pillai; Ramasri Sathanoori; Stephen L. Madden; Ronald L. Hamilton; Kevin A. Walter

Abstract

View articletitled, Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis

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Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Colleen M. Feltmate; Kenneth R. Lee; Michael Johnson; John O. Schorge; Kwong-kwok Wong; Ke Hao; William R. Welch; Debra A. Bell; Ross S. Berkowitz; Samuel C. Mok

Abstract

View articletitled, Whole-Genome Allelotyping Identified Distinct Loss-of-Heterozygosity Patterns in Mucinous Ovarian and Appendiceal Carcinomas

Supplementary data

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The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer

Jane L. Boddy; Stephen B. Fox; Cheng Han; Leticia Campo; Helen Turley; Suresh Kanga; Peter R. Malone; Adrian L. Harris

Abstract

View articletitled, The Androgen Receptor Is Significantly Associated with Vascular Endothelial Growth Factor and Hypoxia Sensing via Hypoxia-Inducible Factors HIF-1a, HIF-2a, and the Prolyl Hydroxylases in Human Prostate Cancer

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Plitidepsin Has a Cytostatic Effect in Human Undifferentiated (Anaplastic) Thyroid Carcinoma

Susana B. Bravo; María E.R. García-Rendueles; Rafael Seoane; Vanesa Dosil; José Cameselle-Teijeiro; Luis López-Lázaro; Juan Zalvide; Francisco Barreiro; Celia M. Pombo; Clara V. Álvarez

Abstract

View articletitled, Plitidepsin Has a Cytostatic Effect in Human Undifferentiated (Anaplastic) Thyroid Carcinoma

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Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer

Harnisha Dalwadi; Kostyantyn Krysan; Nathalie Heuze-Vourc'h; Mariam Dohadwala; David Elashoff; Sherven Sharma; Nicholas Cacalano; Alan Lichtenstein; Steven Dubinett

Abstract

View articletitled, Cyclooxygenase-2-Dependent Activation of Signal Transducer and Activator of Transcription 3 by Interleukin-6 in Non–Small Cell Lung Cancer

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Basic Fibroblast Growth Factor (FGF-2) Overexpression Is a Risk Factor for Esophageal Cancer Recurrence and Reduced Survival, which Is Ameliorated by Coexpression of the FGF-2 Antisense Gene

Christie Barclay; Audrey W. Li; Laurette Geldenhuys; Mark Baguma-Nibasheka; Geoffrey A. Porter; Paul J. Veugelers; Paul R. Murphy; Alan G. Casson

Abstract

View articletitled, Basic Fibroblast Growth Factor (FGF-2) Overexpression Is a Risk Factor for Esophageal Cancer Recurrence and Reduced Survival, which Is Ameliorated by Coexpression of the FGF-2 Antisense Gene

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Imaging, Diagnosis, Prognosis

Immunization Using Autologous Dendritic Cells Pulsed with the Melanoma-Associated Antigen gp100-Derived G280-9V Peptide Elicits CD8⁺ Immunity

Gerald P. Linette; Dongsheng Zhang; F. Stephen Hodi; Eric P. Jonasch; Simonne Longerich; Christopher P. Stowell; Iain J. Webb; Heather Daley; Robert J. Soiffer; Amy M. Cheung; Sara G. Eapen; Sharon V. Fee; Krista M. Rubin; Arthur J. Sober; Frank G. Haluska

Abstract

View articletitled, Immunization Using Autologous Dendritic Cells Pulsed with the Melanoma-Associated Antigen gp100-Derived G280-9V Peptide Elicits CD8+ Immunity

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The HCCR Oncoprotein as a Biomarker for Human Breast Cancer

Sang Seol Jung; Hyung Soon Park; Insong James Lee; Hong Namkoong; Seung Min Shin; Goang Won Cho; Seon-Ah Ha; Yong Gyu Park; Youn Soo Lee; Jesang Ko; Jin Woo Kim

Abstract

View articletitled, The HCCR Oncoprotein as a Biomarker for Human Breast Cancer

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Role of Activating Fibroblast Growth Factor Receptor 3 Mutations in the Development of Bladder Tumors

Karsten Zieger; Lars Dyrskjøt; Carsten Wiuf; Jens L. Jensen; Claus L. Andersen; Klaus Møller-Ernst Jensen; Torben Falck Ørntoft

Abstract

View articletitled, Role of Activating Fibroblast Growth Factor Receptor 3 Mutations in the Development of Bladder Tumors

Supplementary data

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Immunogenotype Changes Prevail in Relapses of Young Children with TEL-AML1-Positive Acute Lymphoblastic Leukemia and Derive Mainly from Clonal Selection

E. Renate Panzer-Grümayer; Giovanni Cazzaniga; Vincent H.J. van der Velden; Laura del Giudice; Martina Peham; Georg Mann; Conny Eckert; Andre Schrauder; Giuseppe Germano; Jochen Harbott; Giuseppe Basso; Andrea Biondi; Jacques J.M. van Dongen; Helmut Gadner; Oskar A. Haas

Abstract

View articletitled, Immunogenotype Changes Prevail in Relapses of Young Children with TEL-AML1-Positive Acute Lymphoblastic Leukemia and Derive Mainly from Clonal Selection

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Methylation Assay for the Diagnosis of Lung Cancer on Bronchial Aspirates: A Cohort Study

Viola Schmiemann; Alfred Böcking; Marietta Kazimirek; Alexandre Sherlley Casimiro Onofre; Helmut Erich Gabbert; Rainer Kappes; Claus Dieter Gerharz; Hans Juergen Grote

Abstract

View articletitled, Methylation Assay for the Diagnosis of Lung Cancer on Bronchial Aspirates: A Cohort Study

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Racial Differences in Prognostic Value of Adult Height for Biochemical Progression Following Radical Prostatectomy

Stephen J. Freedland; William J. Aronson; Bruce Trock; Pinchas Cohen; Christopher J. Kane; Christopher L. Amling; Joseph C. Presti, Jr.; Martha K. Terris; for the Shared Equal Access Regional Cancer Hospital Database Study Group

Abstract

View articletitled, Racial Differences in Prognostic Value of Adult Height for Biochemical Progression Following Radical Prostatectomy

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A Simple and Fast Method for the Simultaneous Detection of Nine Fibroblast Growth Factor Receptor 3 Mutations in Bladder Cancer and Voided Urine

Johanna M.M. van Oers; Irene Lurkin; Antonius J.A. van Exsel; Yvette Nijsen; Bas W.G. van Rhijn; Madelon N.M. van der Aa; Ellen C. Zwarthoff

Abstract

View articletitled, A Simple and Fast Method for the Simultaneous Detection of Nine Fibroblast Growth Factor Receptor 3 Mutations in Bladder Cancer and Voided Urine

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Mesenchymal Stem Cell Targeting of Microscopic Tumors and Tumor Stroma Development Monitored by Noninvasive In vivo Positron Emission Tomography Imaging

Shih-Chieh Hung; Win-Ping Deng; Wen K. Yang; Ren-Shyan Liu; Chien-Chih Lee; Tzu-Chi Su; Rue-Jen Lin; Den-Mei Yang; Chi-Wei Chang; Wei-Hong Chen; Hon-Jian Wei; Juri G. Gelovani

Abstract

View articletitled, Mesenchymal Stem Cell Targeting of Microscopic Tumors and Tumor Stroma Development Monitored by Noninvasive In vivo Positron Emission Tomography Imaging

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Allogeneic Transplant with Reduced Intensity Conditioning Regimens may Overcome the Poor Prognosis of B-Cell Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Variable Heavy-Chain Gene and Chromosomal Abnormalities (11q− and 17p−)

Dolores Caballero; Jose A. García-Marco; Rodrigo Martino; Victoria Mateos; José M. Ribera; José Sarrá; Angel León; Guillermo Sanz; Javier de la Serna; Rafael Cabrera; Marcos González; Jorge Sierra; Jesús San Miguel

Abstract

View articletitled, Allogeneic Transplant with Reduced Intensity Conditioning Regimens may Overcome the Poor Prognosis of B-Cell Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Variable Heavy-Chain Gene and Chromosomal Abnormalities (11q− and 17p−)

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MRP3, BCRP, and P-Glycoprotein Activities are Prognostic Factors in Adult Acute Myeloid Leukemia

Zineb Benderra; Anne Marie Faussat; Lydia Sayada; Jean-Yves Perrot; Ruoping Tang; Driss Chaoui; Hamid Morjani; Christophe Marzac; Jean-Pierre Marie; Ollivier Legrand

Abstract

View articletitled, MRP3, BCRP, and P-Glycoprotein Activities are Prognostic Factors in Adult Acute Myeloid Leukemia

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Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure

Stephane Ferretti; Peter R. Allegrini; Terence O'Reilly; Christian Schnell; Michael Stumm; Markus Wartmann; Jeanette Wood; Paul M.J. McSheehy

Abstract

View articletitled, Patupilone Induced Vascular Disruption in Orthotopic Rodent Tumor Models Detected by Magnetic Resonance Imaging and Interstitial Fluid Pressure

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The Role of S100A6 in Pancreatic Cancer Development and Its Clinical Implication as a Diagnostic Marker and Therapeutic Target

Kenoki Ohuchida; Kazuhiro Mizumoto; Nami Ishikawa; Kei Fujii; Hiroyuki Konomi; Eishi Nagai; Koji Yamaguchi; Masazumi Tsuneyoshi; Masao Tanaka

Abstract

View articletitled, The Role of S100A6 in Pancreatic Cancer Development and Its Clinical Implication as a Diagnostic Marker and Therapeutic Target

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Cancer Therapy: Clinical

Pharmacokinetics and Tolerability of a Single Dose of DN-101, a New Formulation of Calcitriol, in Patients with Cancer

Tomasz M. Beer; Milind Javle; Gilbert N. Lam; W. David Henner; Alvin Wong; Donald L. Trump

Abstract

View articletitled, Pharmacokinetics and Tolerability of a Single Dose of DN-101, a New Formulation of Calcitriol, in Patients with Cancer

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Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan

Nielka P.H. van Erp; Sharyn D. Baker; Ming Zhao; Michelle A. Rudek; Henk-Jan Guchelaar; Johan W.R. Nortier; Alex Sparreboom; Hans Gelderblom

Abstract

View articletitled, Effect of Milk Thistle (Silybum marianum) on the Pharmacokinetics of Irinotecan

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A Phase I Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously Daily for 5 Consecutive Days Every 3 Weeks in Patients with Advanced Solid Tumors

Scot Ebbinghaus; Eric Rubin; Evan Hersh; Lee D. Cranmer; Peter L. Bonate; Robert J. Fram; Antti Jekunen; Steve Weitman; Lisa A. Hammond

Abstract

View articletitled, A Phase I Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously Daily for 5 Consecutive Days Every 3 Weeks in Patients with Advanced Solid Tumors

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Phase I Study of Cloretazine (VNP40101M), a Novel Sulfonylhydrazine Alkylating Agent, Combined with Cytarabine in Patients with Refractory Leukemia

Francis Giles; Srdan Verstovsek; Deborah Thomas; Stanton Gerson; Jorge Cortes; Stefan Faderl; Alessandra Ferrajoli; Farhad Ravandi; Steven Kornblau; Guillermo Garcia-Manero; Elias Jabbour; Susan O'Brien; Verena Karsten; Ann Cahill; Karen Yee; Maher Albitar; Mario Sznol; Hagop Kantarjian

Abstract

View articletitled, Phase I Study of Cloretazine (VNP40101M), a Novel Sulfonylhydrazine Alkylating Agent, Combined with Cytarabine in Patients with Refractory Leukemia

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Phase I and Pharmacokinetic Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously on Days 1, 3, and 5 Every 3 Weeks in Patients with Advanced Solid Tumors

Casey Cunningham; Leonard J. Appleman; Miora Kirvan-Visovatti; David P. Ryan; Eileen Regan; Svetislava Vukelja; Peter L. Bonate; Francis Ruvuna; Robert J. Fram; Antti Jekunen; Steve Weitman; Lisa A. Hammond; Joseph P. Eder, Jr.

Abstract

View articletitled, Phase I and Pharmacokinetic Study of the Dolastatin-15 Analogue Tasidotin (ILX651) Administered Intravenously on Days 1, 3, and 5 Every 3 Weeks in Patients with Advanced Solid Tumors

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A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules

Alan V. Boddy; E. Ruth Plummer; Radha Todd; Julieann Sludden; Melanie Griffin; Lesley Robson; James Cassidy; Donald Bissett; Alberto Bernareggi; Mark W. Verrill; A. Hilary Calvert

Abstract

View articletitled, A Phase I and Pharmacokinetic Study of Paclitaxel Poliglumex (XYOTAX), Investigating Both 3-Weekly and 2-Weekly Schedules

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Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01

Abstract

View articletitled, Molecular Study of Malignant Gliomas Treated with Epidermal Growth Factor Receptor Inhibitors: Tissue Analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01

Supplementary data

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Phase I Trial of a Monoclonal Antibody Specific for α_vβ₃ Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion

Douglas G. McNeel; Jens Eickhoff; Fred T. Lee; David M. King; Dona Alberti; James P. Thomas; Andreas Friedl; Jill Kolesar; Rebecca Marnocha; Jennifer Volkman; Jianliang Zhang; Luz Hammershaimb; James A. Zwiebel; George Wilding

Abstract

View articletitled, Phase I Trial of a Monoclonal Antibody Specific for αvβ3 Integrin (MEDI-522) in Patients with Advanced Malignancies, Including an Assessment of Effect on Tumor Perfusion

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Phase II Trial of the O⁶-Alkylguanine DNA Alkyltransferase Inhibitor O⁶-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

Thomas F. Gajewski; Jeffrey Sosman; Stanton L. Gerson; Lili Liu; Eileen Dolan; Shang Lin; Everett E. Vokes

Abstract

View articletitled, Phase II Trial of the O6-Alkylguanine DNA Alkyltransferase Inhibitor O6-Benzylguanine and 1,3-Bis(2-Chloroethyl)-1-Nitrosourea in Advanced Melanoma

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Phase 1 Study of Weekly Polyethylene Glycol-Camptothecin in Patients with Advanced Solid Tumors and Lymphomas

James A. Posey, III; M. Wasif Saif; Ronda Carlisle; Andrew Goetz; Jinee Rizzo; Suzanne Stevenson; Marc S. Rudoltz; Joseph Kwiatek; Paul Simmons; Eric K. Rowinsky; Chris H. Takimoto; Anthony W. Tolcher

Abstract

View articletitled, Phase 1 Study of Weekly Polyethylene Glycol-Camptothecin in Patients with Advanced Solid Tumors and Lymphomas

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Adaptive Signature Design: An Adaptive Clinical Trial Design for Generating and Prospectively Testing A Gene Expression Signature for Sensitive Patients

Boris Freidlin; Richard Simon

Abstract

View articletitled, Adaptive Signature Design: An Adaptive Clinical Trial Design for Generating and Prospectively Testing A Gene Expression Signature for Sensitive Patients

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Cancer Therapy: Preclinical

Therapeutic Advantage of Pretargeted Radioimmunotherapy Using a Recombinant Bispecific Antibody in a Human Colon Cancer Xenograft

Habibe Karacay; Pierre-Yves Brard; Robert M. Sharkey; Chien-Hsing Chang; Edmund A. Rossi; William J. McBride; Dan R. Ragland; Ivan D. Horak; David M. Goldenberg

Abstract

View articletitled, Therapeutic Advantage of Pretargeted Radioimmunotherapy Using a Recombinant Bispecific Antibody in a Human Colon Cancer Xenograft

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Oncolytic Herpes Simplex Virus Vector G47Δ in Combination with Androgen Ablation for the Treatment of Human Prostate Adenocarcinoma

Hiroshi Fukuhara; Robert L. Martuza; Samuel D. Rabkin; Yoshikazu Ito; Tomoki Todo

Abstract

View articletitled, Oncolytic Herpes Simplex Virus Vector G47Δ in Combination with Androgen Ablation for the Treatment of Human Prostate Adenocarcinoma

Supplementary data

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Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells

Shigeo Koido; Eiichi Hara; Sadamu Homma; Akira Torii; Yoichi Toyama; Hidejiro Kawahara; Michiaki Watanabe; Katsuhiko Yanaga; Kiyotaka Fujise; Hisao Tajiri; Jianlin Gong; Gotaro Toda

Abstract

View articletitled, Dendritic Cells Fused with Allogeneic Colorectal Cancer Cell Line Present Multiple Colorectal Cancer–Specific Antigens and Induce Antitumor Immunity against Autologous Tumor Cells

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Chemokine C Receptor 7 Expression and Protection of Circulating CD8⁺ T Lymphocytes from Apoptosis

Jeong-Whun Kim; Robert L. Ferris; Theresa L. Whiteside

Abstract

View articletitled, Chemokine C Receptor 7 Expression and Protection of Circulating CD8+ T Lymphocytes from Apoptosis

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Establishment of a Serum Tumor Marker for Preclinical Trials of Mouse Prostate Cancer Models

Isaac Van Huizen; Guojun Wu; Madeleine Moussa; Joseph L. Chin; Aaron Fenster; James C. Lacefield; Hideki Sakai; Norman M. Greenberg; Jim W. Xuan

Abstract

View articletitled, Establishment of a Serum Tumor Marker for Preclinical Trials of Mouse Prostate Cancer Models

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Radioimmunotherapy of CD22-Expressing Daudi Tumors in Nude Mice with a ⁹⁰Y-Labeled Anti-CD22 Monoclonal Antibody

Daniel A. Vallera; Martin W. Brechbiel; Linda J. Burns; Angela Panoskaltsis-Mortari; Katie E. Dusenbery; Dennis R. Clohisy; Ellen S. Vitetta

Abstract

View articletitled, Radioimmunotherapy of CD22-Expressing Daudi Tumors in Nude Mice with a 90Y-Labeled Anti-CD22 Monoclonal Antibody

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[¹³¹I]meta-Iodobenzylguanidine and Topotecan Combination Treatment of Tumors Expressing the Noradrenaline Transporter

Anthony G. McCluskey; Marie Boyd; Susan C. Ross; Emilio Cosimo; Anne Marie Clark; Wilson J. Angerson; Mark N. Gaze; Robert J. Mairs

Abstract

View articletitled, [131I]meta-Iodobenzylguanidine and Topotecan Combination Treatment of Tumors Expressing the Noradrenaline Transporter

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Novel Phase I Dose De-escalation Design Trial to Determine the Biological Modulatory Dose of the Antiangiogenic Agent SU5416

Afshin Dowlati; Kelly Robertson; Tomas Radivoyevitch; John Waas; Nicholas P. Ziats; Paul Hartman; Fadi W. Abdul-Karim; Jay K. Wasman; Jack Jesberger; Jonathan Lewin; Keith McCrae; Percy Ivy; Scot C. Remick

Abstract

View articletitled, Novel Phase I Dose De-escalation Design Trial to Determine the Biological Modulatory Dose of the Antiangiogenic Agent SU5416

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Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells

Isamu Hoshino; Hisahiro Matsubara; Naoyuki Hanari; Mikito Mori; Takanori Nishimori; Yasuo Yoneyama; Yasunori Akutsu; Haruhito Sakata; Kazuyuki Matsushita; Naohiko Seki; Takenori Ochiai

Abstract

View articletitled, Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells

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Cancer Prevention

Prevention of Hepatocellular Carcinoma by Universal Vaccination against Hepatitis B Virus: The Effect and Problems

Mei-Hwei Chang; Tony Hsiu-Hsi Chen; Hsu-Mei Hsu; Tzee-Chung Wu; Man-Shan Kong; Der-Cherng Liang; Yen-Hsuan Ni; Chien-Jen Chen; Ding-Shinn Chen; for the Taiwan Childhood HCC Study Group

Abstract

View articletitled, Prevention of Hepatocellular Carcinoma by Universal Vaccination against Hepatitis B Virus: The Effect and Problems

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Letters to the Editor

Independent Test Set Performance in the Prediction of Early Relapse in Ovarian Cancer with Gene Expression Profiles

Frank De Smet; Nathalie L.M.M. Pochet; Bart L.R. De Moor; Toon Van Gorp; Dirk Timmerman; Ignace B. Vergote

Extract

View articletitled, Independent Test Set Performance in the Prediction of Early Relapse in Ovarian Cancer with Gene Expression Profiles

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Correction

Correction: Article on Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

Extract

View articletitled, Correction: Article on Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer

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Issues

Cover Image

Editorial

The Biology Behind

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Cancer Prevention

Letters to the Editor

Correction

Email alerts

AACR Journals

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