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Volume 11, Issue 17
1 September 2005
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

Editorial

Combined Targeting of the Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways
Scott M. Lippman; Neil Gibson; Kotha Subbaramaiah; Andrew J. Dannenberg
View articletitled, Combined Targeting of the Epidermal Growth Factor Receptor and Cyclooxygenase-2 Pathways
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The Biology Behind

ERCC1 and Clinical Resistance to Platinum-Based Therapy
Eddie Reed
View articletitled, ERCC1 and Clinical Resistance to Platinum-Based Therapy
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Perspective

Translational Crossroads for Biomarkers
Robert C. Bast, Jr.; Hans Lilja; Nicole Urban; David L. Rimm; Herbert Fritsche; Joe Gray; Robert Veltri; George Klee; Andrew Allen; Nam Kim; Steven Gutman; Mark A. Rubin; Andrew Hruszkewycz
View articletitled, Translational Crossroads for Biomarkers
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Human Cancer Biology

Malignant B-Lymphoid Cells with Bone Lesions Express Receptor Activator of Nuclear Factor-κB Ligand and Vascular Endothelial Growth Factor to Enhance Osteoclastogenesis
Hironobu Shibata; Masahiro Abe; Kenji Hiura; Javier Wilde; Keiji Moriyama; Toshiaki Sano; Ken-ichi Kitazoe; Toshihiro Hashimoto; Shuji Ozaki; Shingo Wakatsuki; Shinsuke Kido; Daisuke Inoue; Toshio Matsumoto
View articletitled, Malignant B-Lymphoid Cells with Bone Lesions Express Receptor Activator of Nuclear Factor-κB Ligand and Vascular Endothelial Growth Factor to Enhance Osteoclastogenesis
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Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
Rebecca T. Marquez; Keith A. Baggerly; Andrea P. Patterson; Jinsong Liu; Russell Broaddus; Michael Frumovitz; Edward N. Atkinson; David I. Smith; Lynn Hartmann; David Fishman; Andrew Berchuck; Regina Whitaker; David M. Gershenson; Gordon B. Mills; Robert C. Bast, Jr.; Karen H. Lu
View articletitled, Patterns of Gene Expression in Different Histotypes of Epithelial Ovarian Cancer Correlate with Those in Normal Fallopian Tube, Endometrium, and Colon
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Enhanced Production of Interleukin 6 in Peripheral Blood Monocytes Stimulated with Mucins Secreted into the Bloodstream
Norio Yokoigawa; Noriko Takeuchi; Munetoyo Toda; Mizue Inoue; Masaki Kaibori; Hidesuke Yanagida; Hironori Tanaka; Tokuhiro Ogura; Hideho Takada; Tadayoshi Okumura; A-H Kwon; Yasuo Kamiyama; Hiroshi Nakada
View articletitled, Enhanced Production of Interleukin 6 in Peripheral Blood Monocytes Stimulated with Mucins Secreted into the Bloodstream
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BRAF Mutation in Endometrial Carcinoma and Hyperplasia: Correlation with KRAS and p53 Mutations and Mismatch Repair Protein Expression
Yu-Zhen Feng; Tanri Shiozawa; Tsutomu Miyamoto; Hiroyasu Kashima; Miyuki Kurai; Akihisa Suzuki; Ikuo Konishi
View articletitled, <em>BRAF</em> Mutation in Endometrial Carcinoma and Hyperplasia: Correlation with <em>KRAS</em> and <em>p53</em> Mutations and Mismatch Repair Protein Expression
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Estrogen Receptor α Binds to Peroxisome Proliferator–Activated Receptor Response Element and Negatively Interferes with Peroxisome Proliferator–Activated Receptor γ Signaling in Breast Cancer Cells
Daniela Bonofiglio; Sabrina Gabriele; Saveria Aquila; Stefania Catalano; Mariaelena Gentile; Emilia Middea; Francesca Giordano; Sebastiano Andò
View articletitled, Estrogen Receptor α Binds to Peroxisome Proliferator–Activated Receptor Response Element and Negatively Interferes with Peroxisome Proliferator–Activated Receptor γ Signaling in Breast Cancer Cells
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Estrogen-Responsive Finger Protein as a New Potential Biomarker for Breast Cancer
Takashi Suzuki; Tomohiko Urano; Tohru Tsukui; Kuniko Horie-Inoue; Takuya Moriya; Takanori Ishida; Masami Muramatsu; Yasuyoshi Ouchi; Hironobu Sasano; Satoshi Inoue
View articletitled, Estrogen-Responsive Finger Protein as a New Potential Biomarker for Breast Cancer
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Epidermal Growth Factor–Induced Cyclooxygenase-2 Expression Is Mediated through Phosphatidylinositol-3 Kinase, Not Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase, in Recurrent Respiratory Papillomas
Rong Wu; Allan L. Abramson; Mark J. Shikowitz; Andrew J. Dannenberg; Bettie M. Steinberg
View articletitled, Epidermal Growth Factor–Induced Cyclooxygenase-2 Expression Is Mediated through Phosphatidylinositol-3 Kinase, Not Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase, in Recurrent Respiratory Papillomas
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Imaging, Diagnosis, Prognosis

Expression of Cdx2 and Hepatocyte Antigen in Gastric Carcinoma: Correlation with Histologic Type and Implications for Prognosis
Zhaoqing Fan; Jiyou Li; Bin Dong; Xinfu Huang
View articletitled, Expression of Cdx2 and Hepatocyte Antigen in Gastric Carcinoma: Correlation with Histologic Type and Implications for Prognosis
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Effect of Angiosonography to Monitor Response During Imatinib Treatment in Patients with Metastatic Gastrointestinal Stromal Tumors
Ugo De Giorgi; Camillo Aliberti; Giorgio Benea; Matteo Conti; Maurizio Marangolo
View articletitled, Effect of Angiosonography to Monitor Response During Imatinib Treatment in Patients with Metastatic Gastrointestinal Stromal Tumors
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Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features
Tatsuhiro Shibata; Satomi Uryu; Akiko Kokubu; Fumie Hosoda; Misao Ohki; Tokuki Sakiyama; Yoshihiro Matsuno; Ryosuke Tsuchiya; Yae Kanai; Tadashi Kondo; Issei Imoto; Johji Inazawa; Setsuo Hirohashi
View articletitled, Genetic Classification of Lung Adenocarcinoma Based on Array-Based Comparative Genomic Hybridization Analysis: Its Association with Clinicopathologic Features
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Detection and Staging of Preinvasive Lesions and Occult Lung Cancer in the Central Airways with 18F-Fluorodeoxyglucose Positron Emission Tomography: A Pilot Study
Arifa Pasic; Hes A. Brokx; Emile F. Comans; Gerarda J. Herder; Elle K. Risse; Otto S. Hoekstra; Pieter E. Postmus; Tom G. Sutedja
View articletitled, Detection and Staging of Preinvasive Lesions and Occult Lung Cancer in the Central Airways with <sup>18</sup>F-Fluorodeoxyglucose Positron Emission Tomography: A Pilot Study
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Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors Expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas
Yi Ren; Brian Cao; Simon Law; Yi Xie; Ping Yin Lee; Leo Cheung; Yongxong Chen; Xin Huang; Hiu Man Chan; Ping Zhao; John Luk; George Vande Woude; John Wong
View articletitled, Hepatocyte Growth Factor Promotes Cancer Cell Migration and Angiogenic Factors Expression: A Prognostic Marker of Human Esophageal Squamous Cell Carcinomas
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Prognostic Impact of Immunohistochemical Expression of Ezrin in Highly Malignant Soft Tissue Sarcomas
Wen-Hui Weng; Jan Åhlén; Kristina Åström; Weng-Onn Lui; Catharina Larsson
View articletitled, Prognostic Impact of Immunohistochemical Expression of Ezrin in Highly Malignant Soft Tissue Sarcomas
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APE1 and XRCC1 Protein Expression Levels Predict Cancer-Specific Survival Following Radical Radiotherapy in Bladder Cancer
Sei C. Sak; Patricia Harnden; Colin F. Johnston; Alan B. Paul; Anne E. Kiltie
View articletitled, APE1 and XRCC1 Protein Expression Levels Predict Cancer-Specific Survival Following Radical Radiotherapy in Bladder Cancer
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Cancer Therapy: Clinical

ERCC1 Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer
Jérôme Viguier; Valérie Boige; Catherine Miquel; Marc Pocard; Bruno Giraudeau; Jean-Christophe Sabourin; Michel Ducreux; Alain Sarasin; Françoise Praz
View articletitled, <em>ERCC1</em> Codon 118 Polymorphism Is a Predictive Factor for the Tumor Response to Oxaliplatin/5-Fluorouracil Combination Chemotherapy in Patients with Advanced Colorectal Cancer
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In vivo Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna
Gerald A. Soff; Hao Wang; Deborah L. Cundiff; Keyi Jiang; Brenda Martone; Alfred W. Rademaker; Jennifer A. Doll; Timothy M. Kuzel
View articletitled, <em>In vivo</em> Generation of Angiostatin Isoforms by Administration of a Plasminogen Activator and a Free Sulfhydryl Donor: A Phase I Study of an Angiostatic Cocktail of Tissue Plasminogen Activator and Mesna
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Gene Expression Patterns and Profile Changes Pre- and Post-Erlotinib Treatment in Patients with Metastatic Breast Cancer
Sherry X. Yang; Richard M. Simon; Antoinette R. Tan; Diana Nguyen; Sandra M. Swain
View articletitled, Gene Expression Patterns and Profile Changes Pre- and Post-Erlotinib Treatment in Patients with Metastatic Breast Cancer
Supplementary data
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Phase I Clinical Trial of BMS-247550, A Derivative of Epothilone B, Using Accelerated Titration 2B Design
Shirish M. Gadgeel; Antoinette Wozniak; Ramesh R. Boinpally; Richard Wiegand; Lance K. Heilbrun; Vikas Jain; Ralph Parchment; Dimitrios Colevas; Marvin B. Cohen; Patricia M. LoRusso
View articletitled, Phase I Clinical Trial of BMS-247550, A Derivative of Epothilone B, Using Accelerated Titration 2B Design
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Dose-Finding Study of the Multitargeted Tyrosine Kinase Inhibitor SU6668 in Patients with Advanced Malignancies
Bart C. Kuenen; Giuseppe Giaccone; Rita Ruijter; Astrid Kok; Casper Schalkwijk; Klaas Hoekman; Herbert M. Pinedo
View articletitled, Dose-Finding Study of the Multitargeted Tyrosine Kinase Inhibitor SU6668 in Patients with Advanced Malignancies
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Phase I Evaluation of a 40-kDa Branched-Chain Long-Acting Pegylated IFN-α-2a With and Without Cytarabine in Patients with Chronic Myelogenous Leukemia
Moshe Talpaz; Ashok Rakhit; Karen Rittweger; Susan O'Brien; Jorge Cortes; Scott Fettner; Leon Hooftman; Hagop Kantarjian
View articletitled, Phase I Evaluation of a 40-kDa Branched-Chain Long-Acting Pegylated IFN-α-2a With and Without Cytarabine in Patients with Chronic Myelogenous Leukemia
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Phase I Combining a P-Glycoprotein Inhibitor, MS209, in Combination with Docetaxel in Patients with Advanced Malignancies
Véronique Diéras; Jacques Bonneterre; Valérie Laurence; Marian Degardin; Jean-Yves Pierga; Marie-Edith Bonneterre; Sandrine Marreaud; Denis Lacombe; Pierre Fumoleau
View articletitled, Phase I Combining a P-Glycoprotein Inhibitor, MS209, in Combination with Docetaxel in Patients with Advanced Malignancies
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Cancer Therapy: Preclinical

Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model
Xin Zhang; Zhuo (Georgia) Chen; Mi Sun Choe; Yan Lin; Shi-Yong Sun; H. Samuel Wieand; Hyung Ju C. Shin; Amy Chen; Fadlo R. Khuri; Dong M. Shin
View articletitled, Tumor Growth Inhibition by Simultaneously Blocking Epidermal Growth Factor Receptor and Cyclooxygenase-2 in a Xenograft Model
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Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
Amir Abdollahi; David W. Griggs; Heike Zieher; Alexandra Roth; Kenneth E. Lipson; Rainer Saffrich; Hermann-Josef Gröne; Dennis E. Hallahan; Ralph A. Reisfeld; Juergen Debus; Andreas G. Niethammer; Peter E. Huber
View articletitled, Inhibition of α<sub>v</sub>β<sub>3</sub> Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
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Targeting the Extracellular Domain of Fibroblast Growth Factor Receptor 3 with Human Single-Chain Fv Antibodies Inhibits Bladder Carcinoma Cell Line Proliferation
Jorge Martínez-Torrecuadrada; Gabriela Cifuentes; Paula López-Serra; Pilar Saenz; Antonio Martínez; J. Ignacio Casal
View articletitled, Targeting the Extracellular Domain of Fibroblast Growth Factor Receptor 3 with Human Single-Chain Fv Antibodies Inhibits Bladder Carcinoma Cell Line Proliferation
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Antiapoptotic Role of Growth Factors in the Myelodysplastic Syndromes: Concordance Between In vitro and In vivo Observations
Ramin Tehranchi; Bengt Fadeel; Jan Schmidt-Mende; Ann-Mari Forsblom; Emma Emanuelsson; Martin Jadersten; Birger Christensson; Robert Hast; Robert B. Howe; Jan Samuelsson; Boris Zhivotovsky; Eva Hellström-Lindberg
View articletitled, Antiapoptotic Role of Growth Factors in the Myelodysplastic Syndromes: Concordance Between <em>In vitro</em> and <em>In vivo</em> Observations
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Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers
Amir A. Jazaeri; Christopher S. Awtrey; Gadisetti V.R. Chandramouli; Yao Eric Chuang; Javed Khan; Christos Sotiriou; Olga Aprelikova; Cindy J. Yee; Kristin K. Zorn; Michael J. Birrer; J. Carl Barrett; Jeff Boyd
View articletitled, Gene Expression Profiles Associated with Response to Chemotherapy in Epithelial Ovarian Cancers
Supplementary data
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SMAD4 Levels and Response to 5-Fluorouracil in Colorectal Cancer
Pia Alhopuro; Hafid Alazzouzi; Heli Sammalkorpi; Verónica Dávalos; Reijo Salovaara; Akseli Hemminki; Heikki Järvinen; Jukka-Pekka Mecklin; Simo Schwartz, Jr.; Lauri A. Aaltonen; Diego Arango
View articletitled, SMAD4 Levels and Response to 5-Fluorouracil in Colorectal Cancer
Supplementary data
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Inhibition of Tumor Growth by RGD Peptide–Directed Delivery of Truncated Tissue Factor to the Tumor Vasculature
Torsten Kessler; Ralf Bieker; Teresa Padró; Christian Schwöppe; Thorsten Persigehl; Christoph Bremer; Michael Kreuter; Wolfgang E. Berdel; Rolf M. Mesters
View articletitled, Inhibition of Tumor Growth by RGD Peptide–Directed Delivery of Truncated Tissue Factor to the Tumor Vasculature
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Glucocorticoids Inhibit Cell Death in Ovarian Cancer and Up-regulate Caspase Inhibitor cIAP2
Ingo B. Runnebaum; Ansgar Brüning
View articletitled, Glucocorticoids Inhibit Cell Death in Ovarian Cancer and Up-regulate Caspase Inhibitor cIAP2
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Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor In vivo
Lifang Gao; Ling Zhang; Jiadi Hu; Feng Li; Yueting Shao; Dan Zhao; Dhananjaya V. Kalvakolanu; Dennis J. Kopecko; Xuejian Zhao; De-Qi Xu
View articletitled, Down-Regulation of Signal Transducer and Activator of Transcription 3 Expression Using Vector-Based Small Interfering RNAs Suppresses Growth of Human Prostate Tumor <em>In vivo</em>
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Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin
Junko Yokokawa; Claudia Palena; Philip Arlen; Raffit Hassan; Mitchell Ho; Ira Pastan; Jeffrey Schlom; Kwong Y. Tsang
View articletitled, Identification of Novel Human CTL Epitopes and Their Agonist Epitopes of Mesothelin
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Chromosomal Radiosensitivity in Two Cell Lineages Derived from Clinically Radiosensitive Cancer Patients
Carl N. Sprung; Michael Chao; Trevor Leong; Michael J. McKay
View articletitled, Chromosomal Radiosensitivity in Two Cell Lineages Derived from Clinically Radiosensitive Cancer Patients
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Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents
Sridhar Mani; Haiyan Huang; Sumathy Sundarababu; Wenjing Liu; Ganjam Kalpana; Amos B. Smith; Susan B. Horwitz
View articletitled, Activation of the Steroid and Xenobiotic Receptor (Human Pregnane X Receptor) by Nontaxane Microtubule-Stabilizing Agents
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Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation
Curtis Hose; Gurmeet Kaur; Edward A. Sausville; Anne Monks
View articletitled, Transcriptional Profiling Identifies Altered Intracellular Labile Iron Homeostasis as a Contributing Factor to the Toxicity of Adaphostin: Decreased Vascular Endothelial Growth Factor Secretion Is Independent of Hypoxia-Inducible Factor-1 Regulation
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Activity of Suberoylanilide Hydroxamic Acid Against Human Breast Cancer Cells with Amplification of Her-2
Purva Bali; Michael Pranpat; Ramona Swaby; Warren Fiskus; Hirohito Yamaguchi; Maria Balasis; Kathy Rocha; Hong-Gang Wang; Victoria Richon; Kapil Bhalla
View articletitled, Activity of Suberoylanilide Hydroxamic Acid Against Human Breast Cancer Cells with Amplification of Her-2
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Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor–Specific Antibody Generates Enhanced Antitumor Activity
Rushika M. Perera; Yoshitaka Narita; Frank B. Furnari; Hui K. Gan; Carmel Murone; Marika Ahlkvist; Rodney B. Luwor; Antony W. Burgess; Elisabeth Stockert; Achim A. Jungbluth; Lloyd J. Old; Webster K. Cavenee; Andrew M. Scott; Terrance G. Johns
View articletitled, Treatment of Human Tumor Xenografts with Monoclonal Antibody 806 in Combination with a Prototypical Epidermal Growth Factor Receptor–Specific Antibody Generates Enhanced Antitumor Activity
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Expression of the Apoptosis Inhibitor Protease Inhibitor 9 Predicts Clinical Outcome in Vaccinated Patients with Stage III and IV Melanoma
Inge S. van Houdt; Joost J. Oudejans; Alfonsus J.M. van den Eertwegh; Arnold Baars; Wim Vos; Bellinda A. Bladergroen; Donata Rimoldi; Jettie J.F. Muris; Erik Hooijberg; Chad M. Gundy; Chris J.L.M. Meijer; Jean A. Kummer
View articletitled, Expression of the Apoptosis Inhibitor Protease Inhibitor 9 Predicts Clinical Outcome in Vaccinated Patients with Stage III and IV Melanoma
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Correction

Correction: Article on Up-Regulation of the Peripheral Benzodiazepine Receptor during Human Colorectal Carcinogenesis and Tumor Spread
View articletitled, Correction: Article on Up-Regulation of the Peripheral Benzodiazepine Receptor during Human Colorectal Carcinogenesis and Tumor Spread
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