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Volume 11, Issue 16

15 August 2005

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Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorials
The Biology Behind
Report from the FDA
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Cancer Therapy: Preclinical
Cancer Prevention
Letters to the Editor

Editorials

Phase II Oncology Trials: Let's Be Positive

Mark J. Ratain

Extract

View articletitled, Phase II Oncology Trials: Let's Be Positive

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Personalized, Multivalent, and More Affordable: The Globalization of Vaccines

Waldemar Debinski

Extract

View articletitled, Personalized, Multivalent, and More Affordable: The Globalization of Vaccines

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The Biology Behind

Cyclin D1 and Pancreatic Carcinoma: A Proliferative Agonist and Chemotherapeutic Antagonist

J. Alan Diehl; Sharon Benzeno

Extract

View articletitled, Cyclin D1 and Pancreatic Carcinoma: A Proliferative Agonist and Chemotherapeutic Antagonist

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Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer: Predicting Clinical Response to Kinase Inhibitors

Lecia V. Sequist; Daniel A. Haber; Thomas J. Lynch

Extract

View articletitled, Epidermal Growth Factor Receptor Mutations in Non–Small Cell Lung Cancer: Predicting Clinical Response to Kinase Inhibitors

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Report from the FDA

Letrozole in the Extended Adjuvant Treatment of Postmenopausal Women with History of Early-Stage Breast Cancer Who Have Completed 5 Years of Adjuvant Tamoxifen

Bhupinder S. Mann; John R. Johnson; Roswitha Kelly; Rajeshwari Sridhara; Grant Williams; Richard Pazdur

Abstract

View articletitled, Letrozole in the Extended Adjuvant Treatment of Postmenopausal Women with History of Early-Stage Breast Cancer Who Have Completed 5 Years of Adjuvant Tamoxifen

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Human Cancer Biology

Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Roman Rouzier; Charles M. Perou; W. Fraser Symmans; Nuhad Ibrahim; Massimo Cristofanilli; Keith Anderson; Kenneth R. Hess; James Stec; Mark Ayers; Peter Wagner; Paolo Morandi; Chang Fan; Islam Rabiul; Jeffrey S. Ross; Gabriel N. Hortobagyi; Lajos Pusztai

Abstract

View articletitled, Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy

Supplementary data

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CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T₁ Breast Cancer

Neslihan Cabioglu; M. Sertac Yazici; Banu Arun; Kristine R. Broglio; Gabriel N. Hortobagyi; Janet E. Price; Aysegul Sahin

Abstract

View articletitled, CCR7 and CXCR4 as Novel Biomarkers Predicting Axillary Lymph Node Metastasis in T1 Breast Cancer

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Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma

Shahnaz Begum; Dengfeng Cao; Maura Gillison; Marianna Zahurak; William H. Westra

Abstract

View articletitled, Tissue Distribution of Human Papillomavirus 16 DNA Integration in Patients with Tonsillar Carcinoma

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A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma

Quynh-Thu Le; Carol D. Jones; Tsz-Kok Yau; Haider A. Shirazi; Priscilla H. Wong; Ella N. Thomas; Bruce K. Patterson; Anne W.M. Lee; James L. Zehnder

Abstract

View articletitled, A Comparison Study of Different PCR Assays in Measuring Circulating Plasma Epstein-Barr Virus DNA Levels in Patients with Nasopharyngeal Carcinoma

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Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De novo Acute Myeloid Leukemia

Hideto Tamura; Kazuo Dan; Koji Tamada; Kyoko Nakamura; Yumiko Shioi; Hideya Hyodo; Sheng-Dian Wang; Haidong Dong; Lieping Chen; Kiyoyuki Ogata

Abstract

View articletitled, Expression of Functional B7-H2 and B7.2 Costimulatory Molecules and Their Prognostic Implications in De novo Acute Myeloid Leukemia

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Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women

Lukas A. Hefler; Christoph Grimm; Tilmann Lantzsch; Dieter Lampe; Sepp Leodolter; Heinz Koelbl; Georg Heinze; Alexander Reinthaller; Dan Tong-Cacsire; Clemens Tempfer; Robert Zeillinger

Abstract

View articletitled, Interleukin-1 and Interleukin-6 Gene Polymorphisms and the Risk of Breast Cancer in Caucasian Women

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Identification of Two Molecular Groups of Seminomas by Using Expression and Tissue Microarrays

Matthias D. Hofer; Tara J. Browne; Le He; Rolf I. Skotheim; Ragnhild A. Lothe; Mark A. Rubin

Abstract

View articletitled, Identification of Two Molecular Groups of Seminomas by Using Expression and Tissue Microarrays

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Gene Signatures of Progression and Metastasis in Renal Cell Cancer

Jon Jones; Hasan Otu; Dimitrios Spentzos; Shakirahmed Kolia; Mehmet Inan; Wolf D. Beecken; Christian Fellbaum; Xuesong Gu; Marie Joseph; Allan J. Pantuck; Dietger Jonas; Towia A. Libermann

Abstract

View articletitled, Gene Signatures of Progression and Metastasis in Renal Cell Cancer

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Comprehensive Analysis of CDKN2A Status in Microdissected Urothelial Cell Carcinoma Reveals Potential Haploinsufficiency, a High Frequency of Homozygous Co-deletion and Associations with Clinical Phenotype

Emma J. Chapman; Patricia Harnden; Philip Chambers; Colin Johnston; Margaret A. Knowles

Abstract

View articletitled, Comprehensive Analysis of CDKN2A Status in Microdissected Urothelial Cell Carcinoma Reveals Potential Haploinsufficiency, a High Frequency of Homozygous Co-deletion and Associations with Clinical Phenotype

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Decreased T-Cell Receptor Excision Circles in Cutaneous T-Cell Lymphoma

Kei-ichi Yamanaka; Nikhil Yawalkar; David A. Jones; Daniel Hurwitz; Katalin Ferenczi; Sara Eapen; Thomas S. Kupper

Abstract

View articletitled, Decreased T-Cell Receptor Excision Circles in Cutaneous T-Cell Lymphoma

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The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer

Christine H. Holschneider; Rae Lynn Baldwin; Kiran Tumber; Chisa Aoyama; Beth Y. Karlan

Abstract

View articletitled, The Fragile Histidine Triad Gene: A Molecular Link Between Cigarette Smoking and Cervical Cancer

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The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates

Evangelos Ntougkos; Robert Rush; Diane Scott; Tobias Frankenberg; Hani Gabra; John F. Smyth; Grant C. Sellar

Abstract

View articletitled, The IgLON Family in Epithelial Ovarian Cancer: Expression Profiles and Clinicopathologic Correlates

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WOX1 Is Essential for UVB Irradiation–Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo

Feng-Jie Lai; Ching-Li Cheng; Shur-Tzu Chen; Chin-Han Wu; Li-Jin Hsu; J. Yu-Yun Lee; Sheau-Chiou Chao; Maw-Chang Sheen; Ching-Liang Shen; Nan-Shan Chang; Hamm-Ming Sheu

Abstract

View articletitled, WOX1 Is Essential for UVB Irradiation–Induced Apoptosis and Down-Regulated via Translational Blockade in UVB-Induced Cutaneous Squamous Cell Carcinoma In vivo

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Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

Weida Gong; Yixing Jiang; Liwei Wang; Daoyan Wei; James Yao; Suyun Huang; Shengyun Fang; Keping Xie

Abstract

View articletitled, Expression of Autocrine Motility Factor Correlates with the Angiogenic Phenotype of and Poor Prognosis for Human Gastric Cancer

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Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer

Hidenori Bando; Toshiya Atsumi; Taro Nishio; Hirokatsu Niwa; Shinya Mishima; Chikara Shimizu; Narihito Yoshioka; Richard Bucala; Takao Koike

Abstract

View articletitled, Phosphorylation of the 6-Phosphofructo-2-Kinase/Fructose 2,6-Bisphosphatase/PFKFB3 Family of Glycolytic Regulators in Human Cancer

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Cytochrome P450 1B1 Is Overexpressed and Regulated by Hypomethylation in Prostate Cancer

Takashi Tokizane; Hiroaki Shiina; Mikio Igawa; Hideki Enokida; Shinji Urakami; Toshifumi Kawakami; Tatsuya Ogishima; Steven T. Okino; Long-Cheng Li; Yuichiro Tanaka; Norio Nonomura; Akihiko Okuyama; Rajvir Dahiya

Abstract

View articletitled, Cytochrome P450 1B1 Is Overexpressed and Regulated by Hypomethylation in Prostate Cancer

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Role of Mononuclear Cells and Inflammatory Cytokines in Pancreatic Cancer-Related Cachexia

Marc E. Martignoni; Phillipp Kunze; Wulf Hildebrandt; Beat Künzli; Pascal Berberat; Thomas Giese; Oliver Klöters; Jürgen Hammer; Markus W. Büchler; Nathalia A. Giese; Helmut Friess

Abstract

View articletitled, Role of Mononuclear Cells and Inflammatory Cytokines in Pancreatic Cancer-Related Cachexia

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Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 Signaling Pathway

Ming-Tsai Lin; Chung-Yaou Zuon; Cheng-Chi Chang; Szu-Ta Chen; Chih-Ping Chen; Been-Ren Lin; Ming-Yang Wang; Yung-Ming Jeng; King-Jen Chang; Po-Huang Lee; Wei-Jao Chen; Min-Liang Kuo

Abstract

View articletitled, Cyr61 Induces Gastric Cancer Cell Motility/Invasion via Activation of the Integrin/Nuclear Factor-κB/Cyclooxygenase-2 Signaling Pathway

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Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

Akihiro Tamori; Yoshihiro Yamanishi; Shuichi Kawashima; Minoru Kanehisa; Masaru Enomoto; Hiromu Tanaka; Shoji Kubo; Susumu Shiomi; Shuhei Nishiguchi

Abstract

View articletitled, Alteration of Gene Expression in Human Hepatocellular Carcinoma with Integrated Hepatitis B Virus DNA

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Imaging, Diagnosis, Prognosis

Early Antiangiogenic Activity of SU11248 Evaluated In vivo by Dynamic Contrast-Enhanced Magnetic Resonance Imaging in an Experimental Model of Colon Carcinoma

Pasquina Marzola; Anna Degrassi; Laura Calderan; Paolo Farace; Elena Nicolato; Caterina Crescimanno; Marco Sandri; Anna Giusti; Enrico Pesenti; Andrea Terron; Andrea Sbarbati; Francesco Osculati

Abstract

View articletitled, Early Antiangiogenic Activity of SU11248 Evaluated In vivo by Dynamic Contrast-Enhanced Magnetic Resonance Imaging in an Experimental Model of Colon Carcinoma

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Characterization of a New Antibody Raised against the NH₂ Terminus of P-Glycoprotein

Prema S. Rao; Rajgopal Govindarajan; Kavita B. Mallya; William West; U. Subrahmanyeswara Rao

Abstract

View articletitled, Characterization of a New Antibody Raised against the NH2 Terminus of P-Glycoprotein

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New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA

Masanori Onda; Mark Willingham; Satoshi Nagata; Tapan K. Bera; Richard Beers; Mitchell Ho; Raffit Hassan; Robert J. Kreitman; Ira Pastan

Abstract

View articletitled, New Monoclonal Antibodies to Mesothelin Useful for Immunohistochemistry, Fluorescence-Activated Cell Sorting, Western Blotting, and ELISA

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Proteomic Analysis of Apoptotic Pathways Reveals Prognostic Factors in Follicular Lymphoma

Christian Gulmann; Virginia Espina; Emanuel Petricoin, III; Dan L. Longo; Mariarita Santi; Turid Knutsen; Mark Raffeld; Elaine S. Jaffe; Lance A. Liotta; Andrew L. Feldman

Abstract

View articletitled, Proteomic Analysis of Apoptotic Pathways Reveals Prognostic Factors in Follicular Lymphoma

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Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis

Amanda Psyrri; Ziwei Yu; Paul M. Weinberger; Clarence Sasaki; Bruce Haffty; Robert Camp; David Rimm; Barbara Ann Burtness

Abstract

View articletitled, Quantitative Determination of Nuclear and Cytoplasmic Epidermal Growth Factor Receptor Expression in Oropharyngeal Squamous Cell Cancer by Using Automated Quantitative Analysis

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Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence

Hongzhen Li; Ying Zhang; Andrew Glass; Tobias Zellweger; Edmund Gehan; Lukas Bubendorf; Edward P. Gelmann; Marja T. Nevalainen

Abstract

View articletitled, Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence

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P-Cadherin Overexpression Is an Indicator of Clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation

Joana Paredes; André Albergaria; João T. Oliveira; Carmen Jerónimo; Fernanda Milanezi; Fernando C. Schmitt

Abstract

View articletitled, P-Cadherin Overexpression Is an Indicator of Clinical Outcome in Invasive Breast Carcinomas and Is Associated with CDH3 Promoter Hypomethylation

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Activating Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Are Associated with Improved Survival in Gefitinib-Treated Chemorefractory Lung Adenocarcinomas

Miguel Taron; Yukito Ichinose; Rafael Rosell; Tony Mok; Bartomeu Massuti; Lurdes Zamora; Jose Luis Mate; Christian Manegold; Mayumi Ono; Cristina Queralt; Thierry Jahan; Jose Javier Sanchez; Maria Sanchez-Ronco; Victor Hsue; David Jablons; Jose Miguel Sanchez; Teresa Moran

Abstract

View articletitled, Activating Mutations in the Tyrosine Kinase Domain of the Epidermal Growth Factor Receptor Are Associated with Improved Survival in Gefitinib-Treated Chemorefractory Lung Adenocarcinomas

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Cancer Therapy: Clinical

Analysis of the DPYD Gene Implicated in 5-Fluorouracil Catabolism in a Cohort of Caucasian Individuals

Katharina Seck; Silvia Riemer; Ronald Kates; Tobias Ullrich; Verena Lutz; Nadia Harbeck; Manfred Schmitt; Marion Kiechle; Robert Diasio; Eva Gross

Abstract

View articletitled, Analysis of the DPYD Gene Implicated in 5-Fluorouracil Catabolism in a Cohort of Caucasian Individuals

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Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study

Gareth J. Veal; Michael Cole; Julie Errington; Annie Parry; Juliet Hale; Andrew D.J. Pearson; Karen Howe; Julia C. Chisholm; Carol Beane; Bernadette Brennan; Fiona Waters; Adam Glaser; Sue Hemsworth; Heather McDowell; Yvonne Wright; Kathy Pritchard-Jones; Ross Pinkerton; Gail Jenner; James Nicholson; Ann M. Elsworth; Alan V. Boddy; UKCCSG Pharmacology Working Group

Abstract

View articletitled, Pharmacokinetics of Dactinomycin in a Pediatric Patient Population: a United Kingdom Children's Cancer Study Group Study

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Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma

Naoki Yajima; Ryuya Yamanaka; Takashi Mine; Naoto Tsuchiya; Jumpei Homma; Masakazu Sano; Terukazu Kuramoto; Yayoi Obata; Nobukazu Komatsu; Yoshimi Arima; Akira Yamada; Minoru Shigemori; Kyogo Itoh; Ryuichi Tanaka

Abstract

View articletitled, Immunologic Evaluation of Personalized Peptide Vaccination for Patients with Advanced Malignant Glioma

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Phase I Study of Combined Pegylated Liposomal Doxorubicin with Protracted Daily Topotecan for Ovarian Cancer

Deepu Mirchandani; Howard Hochster; Anne Hamilton; Leonard Liebes; Herman Yee; John P. Curtin; Sang Lee; Joan Sorich; Cornelia Dellenbaugh; Franco M. Muggia

Abstract

View articletitled, Phase I Study of Combined Pegylated Liposomal Doxorubicin with Protracted Daily Topotecan for Ovarian Cancer

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High-Dose Radioimmunotherapy Combined with Fixed, Low-Dose Paclitaxel in Metastatic Prostate and Breast Cancer by Using a MUC-1 Monoclonal Antibody, m170, Linked to Indium-111/Yttrium-90 via a Cathepsin Cleavable Linker with Cyclosporine to Prevent Human Anti-mouse Antibody

Carol M. Richman; Sally J. DeNardo; Robert T. O'Donnell; Aina Yuan; Sui Shen; Desiree S. Goldstein; Joseph M. Tuscano; Ted Wun; Helen K. Chew; Primo N. Lara; David L. Kukis; Arutselvan Natarajan; Claude F. Meares; Kathleen R. Lamborn; Gerald L. DeNardo

Abstract

View articletitled, High-Dose Radioimmunotherapy Combined with Fixed, Low-Dose Paclitaxel in Metastatic Prostate and Breast Cancer by Using a MUC-1 Monoclonal Antibody, m170, Linked to Indium-111/Yttrium-90 via a Cathepsin Cleavable Linker with Cyclosporine to Prevent Human Anti-mouse Antibody

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Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval

John Goffin; Stefan Baral; Dongsheng Tu; Dora Nomikos; Lesley Seymour

Abstract

View articletitled, Objective Responses in Patients with Malignant Melanoma or Renal Cell Cancer in Early Clinical Studies Do Not Predict Regulatory Approval

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Phase 1 Trial of Flavopiridol Combined with Cisplatin or Carboplatin in Patients with Advanced Malignancies with the Assessment of Pharmacokinetic and Pharmacodynamic End Points

Keith C. Bible; Janet L. Lensing; Sacha A. Nelson; Yean K. Lee; Joel M. Reid; Matthew M. Ames; Crescent R. Isham; Jill Piens; Stacie L. Rubin; Joseph Rubin; Scott H. Kaufmann; Pamela J. Atherton; Jeffrey A. Sloan; Michelle K. Daiss; Alex A. Adjei; Charles Erlichman

Abstract

View articletitled, Phase 1 Trial of Flavopiridol Combined with Cisplatin or Carboplatin in Patients with Advanced Malignancies with the Assessment of Pharmacokinetic and Pharmacodynamic End Points

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Phase I and Pharmacokinetic Study of Weekly Docetaxel, Cisplatin, and Daily Capecitabine in Patients with Advanced Solid Tumors

Marwan G. Fakih; Patrick J. Creaven; Nithya Ramnath; Donald Trump; Milind Javle; Sandra Strychor; Trisha V.W. Repinski; Beth A. Zamboni; James K. Schwarz; Renee A. French; William C. Zamboni

Abstract

View articletitled, Phase I and Pharmacokinetic Study of Weekly Docetaxel, Cisplatin, and Daily Capecitabine in Patients with Advanced Solid Tumors

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Cancer Therapy: Preclinical

CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy

Maria V. Nesterova; Natalie R. Johnson; Trina Stewart; Scott Abrams; Yoon S. Cho-Chung

Abstract

View articletitled, CpG Immunomer DNA Enhances Antisense Protein Kinase A RIα Inhibition of Multidrug-Resistant Colon Carcinoma Growth in Nude Mice: Molecular Basis for Combinatorial Therapy

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Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene

Jurre Hageman; Bart J. Eggen; Tom Rozema; Kevin Damman; Harm H. Kampinga; Robert P. Coppes

Abstract

View articletitled, Radiation and Transforming Growth Factor-β Cooperate in Transcriptional Activation of the Profibrotic Plasminogen Activator Inhibitor-1 Gene

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PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

Seung-Ki Kim; Theresa G. Cargioli; Marcelle Machluf; Wendy Yang; Yanping Sun; Ruqayyah Al-Hashem; Seung U. Kim; Peter M. Black; Rona S. Carroll

Abstract

View articletitled, PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

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Generation of Rituximab Polymer May Cause Hyper-Cross-linking–Induced Apoptosis in Non-Hodgkin's Lymphomas

Nan Zhang; Leslie A. Khawli; Peisheng Hu; Alan L. Epstein

Abstract

View articletitled, Generation of Rituximab Polymer May Cause Hyper-Cross-linking–Induced Apoptosis in Non-Hodgkin's Lymphomas

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Plasma and Cerebrospinal Fluid Pharmacokinetics of Clofarabine in Nonhuman Primates

Stacey L. Berg; Peter L. Bonate; Jed G. Nuchtern; Robert Dauser; Leticia McGuffey; Bruce Bernacky; Susan M. Blaney

Abstract

View articletitled, Plasma and Cerebrospinal Fluid Pharmacokinetics of Clofarabine in Nonhuman Primates

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Immunomodulatory Drug CC-5013 or CC-4047 and Rituximab Enhance Antitumor Activity in a Severe Combined Immunodeficient Mouse Lymphoma Model

Francisco J. Hernandez-Ilizaliturri; Nishitha Reddy; Beata Holkova; Edris Ottman; Myron S. Czuczman

Abstract

View articletitled, Immunomodulatory Drug CC-5013 or CC-4047 and Rituximab Enhance Antitumor Activity in a Severe Combined Immunodeficient Mouse Lymphoma Model

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Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen–Derived HLA-A2–Restricted CAP-1 Peptide and Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Primary Metastatic Colorectal Cancer

Martin R. Weihrauch; Sascha Ansén; Elke Jurkiewicz; Caroline Geisen; Zhinan Xia; Karen S. Anderson; Edith Gracien; Manuel Schmidt; Burghardt Wittig; Volker Diehl; Juergen Wolf; Heribert Bohlen; Lee M. Nadler

Abstract

View articletitled, Phase I/II Combined Chemoimmunotherapy with Carcinoembryonic Antigen–Derived HLA-A2–Restricted CAP-1 Peptide and Irinotecan, 5-Fluorouracil, and Leucovorin in Patients with Primary Metastatic Colorectal Cancer

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Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo

Vincent K.W. Wong; Pauline Chiu; Stephen S.M. Chung; Larry M.C. Chow; Yun-Zhe Zhao; Burton B. Yang; Ben C.B. Ko

Abstract

View articletitled, Pseudolaric Acid B, a Novel Microtubule-Destabilizing Agent That Circumvents Multidrug Resistance Phenotype and Exhibits Antitumor Activity In vivo

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Targeting Matrilysin and Its Impact on Tumor Growth In vivo: The Potential Implications in Breast Cancer Therapy

Wen G. Jiang; Gaynor Davies; Tracey A. Martin; Christian Parr; Gareth Watkins; Malcolm D. Mason; Kefah Mokbel; Robert E. Mansel

Abstract

View articletitled, Targeting Matrilysin and Its Impact on Tumor Growth In vivo: The Potential Implications in Breast Cancer Therapy

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Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-β Combined with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models

Christian J. Streck; Paxton V. Dickson; Catherine Y.C. Ng; Junfang Zhou; John T. Gray; Amit C. Nathwani; Andrew M. Davidoff

Abstract

View articletitled, Adeno-Associated Virus Vector-Mediated Systemic Delivery of IFN-β Combined with Low-Dose Cyclophosphamide Affects Tumor Regression in Murine Neuroblastoma Models

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Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

Aikou Okamoto; Takashi Nikaido; Kazunori Ochiai; Satoshi Takakura; Misato Saito; Yuko Aoki; Nobuya Ishii; Nozomu Yanaihara; Kyosuke Yamada; Osamu Takikawa; Rie Kawaguchi; Seiji Isonishi; Tadao Tanaka; Mitsuyoshi Urashima

Abstract

View articletitled, Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

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Green Tea Component, Catechin, Induces Apoptosis of Human Malignant B Cells via Production of Reactive Oxygen Species

Tomonori Nakazato; Keisuke Ito; Yasuo Ikeda; Masahiro Kizaki

Abstract

View articletitled, Green Tea Component, Catechin, Induces Apoptosis of Human Malignant B Cells via Production of Reactive Oxygen Species

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Genetic Variations in the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia

Wim J.E. Tissing; Jules P.P. Meijerink; Monique L. den Boer; Bas Brinkhof; Elisabeth F.C. van Rossum; Elisabeth R. van Wering; Jan W. Koper; Pieter Sonneveld; Rob Pieters

Abstract

View articletitled, Genetic Variations in the Glucocorticoid Receptor Gene Are Not Related to Glucocorticoid Resistance in Childhood Acute Lymphoblastic Leukemia

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Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341

Robert Buzzeo; Steven Enkemann; Rama Nimmanapalli; Melissa Alsina; Mathias G. Lichtenheld; William S. Dalton; Darrin M. Beaupre

Abstract

View articletitled, Characterization of a R115777-Resistant Human Multiple Myeloma Cell Line with Cross-Resistance to PS-341

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Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH₂-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer

Ho-Young Lee; Seung-Hyun Oh; Young-Ah Suh; Jin Hyen Baek; Vali Papadimitrakopoulou; Suyun Huang; Waun Ki Hong

Abstract

View articletitled, Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH2-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer

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Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene–Expressing Pancreatic Tumor Cell Line

Hector Biliran, Jr.; Yong Wang; Sanjeev Banerjee; Haiming Xu; Henry Heng; Archana Thakur; Aliccia Bollig; Fazlul H. Sarkar; Joshua D. Liao

Abstract

View articletitled, Overexpression of Cyclin D1 Promotes Tumor Cell Growth and Confers Resistance to Cisplatin-Mediated Apoptosis in an Elastase-myc Transgene–Expressing Pancreatic Tumor Cell Line

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Cancer Prevention

Levels of Prostaglandin E Metabolite, the Major Urinary Metabolite of Prostaglandin E₂, Are Increased in Smokers

Neil D. Gross; Jay O. Boyle; Jason D. Morrow; Myles K. Williams; Chaya S. Moskowitz; Kotha Subbaramaiah; Andrew J. Dannenberg; Anna J. Duffield-Lillico

Abstract

View articletitled, Levels of Prostaglandin E Metabolite, the Major Urinary Metabolite of Prostaglandin E2, Are Increased in Smokers

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Letters to the Editor

The Potential and Suitability of 2-Methoxyestradiol in Cancer Therapy

Carolyn Sidor; Robert D'Amato; Kathy D. Miller

Extract

View articletitled, The Potential and Suitability of 2-Methoxyestradiol in Cancer Therapy

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Editorials

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Report from the FDA

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Cancer Prevention

Letters to the Editor

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