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Volume 11, Issue 12

15 June 2005

Cover Image

Cover Image
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
The Biology Behind
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Cancer Therapy: Preclinical
Cancer Prevention
Letters to the Editor
Correction

Editorial

Translating Research into Clinical Practice: Deliberations from the American Association for Cancer Research

William N. Hait

The Biology Behind

Getting at MYC through RAS

Pavan Bachireddy; Pavan K. Bendapudi; Dean W. Felsher

Human Cancer Biology

Regulation of Fibroblast Growth Factor-2 Activity by Human Ovarian Cancer Tumor Endothelium

Melissa K. Whitworth; Alison C. Backen; Andrew R. Clamp; Godfrey Wilson; Rhona McVey; Andreas Friedl; Alan C. Rapraeger; Guido David; Alan McGown; Richard J. Slade; John T. Gallagher; Gordon C. Jayson

Gefitinib-Sensitive Mutations of the Epidermal Growth Factor Receptor Tyrosine Kinase Domain in Chinese Patients with Non–Small Cell Lung Cancer

Xin Lin Mu; Long Yun Li; Xiao Tong Zhang; Men Zhao Wang; Rui E. Feng; Quan Cai Cui; Hai Sheng Zhou; Bing Qing Guo

Elevated Expression of Wnt Antagonists Is a Common Event in Hepatoblastomas

Arend Koch; Andreas Waha; Wolfgang Hartmann; Aksana Hrychyk; Ulrich Schüller; Anke Waha; Keith A. Wharton, Jr; Serge Y. Fuchs; Dietrich von Schweinitz; Torsten Pietsch

Up-Regulation of EphB4 in Mesothelioma and Its Biological Significance

Guangbin Xia; S. Ram Kumar; Rizwan Masood; Michael Koss; Claire Templeman; David Quinn; Sutao Zhu; Ramachandra Reddy; Valery Krasnoperov; Parkash S. Gill

Coxsackie and Adenovirus Receptor Promotes Adenocarcinoma Cell Survival and Is Expressionally Activated after Transition from Preneoplastic Precursor Lesions to Invasive Adenocarcinomas

Ansgar Brüning; Elmar Stickeler; Daniel Diederich; Lioba Walz; Hendrik Rohleder; Klaus Friese; Ingo B. Runnebaum

Disruption of Cooperation Between Ras and MycN in Human Neuroblastoma Cells Promotes Growth Arrest

Shira Yaari; Jasmine Jacob-Hirsch; Ninette Amariglio; Ronit Haklai; Gideon Rechavi; Yoel Kloog

Differential Expression of Full-length Telomerase Reverse Transcriptase mRNA and Telomerase Activity between Normal and Malignant Renal Tissues

Yidong Fan; Zhaoxu Liu; Xiaolei Fang; Zheng Ge; Nan Ge; Yong Jia; Peng Sun; Fenglan Lou; Magnus Björkholm; Astrid Gruber; Peter Ekman; Dawei Xu

Imaging, Diagnosis, Prognosis

Stability of Phosphoprotein as a Biological Marker of Tumor Signaling

Amanda F. Baker; Tomislav Dragovich; Nathan T. Ihle; Ryan Williams; Cecilia Fenoglio-Preiser; Garth Powis

2-[¹¹C]Thymidine Positron Emission Tomography Reproducibility in Humans

Paula Wells; Roger N. Gunn; Colin Steel; Alex S. Ranicar; Frank Brady; Safiye Osman; Terry Jones; Pat Price

Evaluation of the Combined Effect of p53 Codon 72 Polymorphism and Hotspot Mutations in Response to Anticancer Drugs

Faina Vikhanskaya; Mobin M. Siddique; Ming Kei Lee; Massimo Broggini; Kanaga Sabapathy

Aberrant Expression of Novel and Previously Described Cell Membrane Markers in Human Breast Cancer Cell Lines and Tumors

Huayi Huang; Jeff Groth; Khalid Sossey-Alaoui; Lesleyann Hawthorn; Stephanie Beall; Joseph Geradts

Steroid 5α-Reductase Isozymes I and II in Recurrent Prostate Cancer

Mark A. Titus; Christopher W. Gregory; O. Harris Ford, III; Michael J. Schell; Susan J. Maygarden; James L. Mohler

Down-Regulated Xanthine Oxidoreductase Is a Feature of Aggressive Breast Cancer

Nina Linder; Johan Lundin; Jorma Isola; Mikael Lundin; Kari O. Raivio; Heikki Joensuu

Effects of Chemotherapy on the Cytogenetic Constitution of Wilms' Tumor

Thorsten Schlomm; Bastian Gunawan; Hans-Jürgen Schulten; Björn Sander; Karthinathan Thangavelu; Norbert Graf; Ivo Leuschner; Rolf-Hermann Ringert; László Füzesi

Low-Molecular Weight Caldesmon as a Potential Serum Marker for Glioma

Ping-Pin Zheng; Wim C. Hop; Peter A.E. Sillevis Smitt; Martin J. van den Bent; Cees J.J. Avezaat; Theodorus M. Luider; Johan M. Kros

Polysomy 17 in HER-2/neu Status Elaboration in Breast Cancer: Effect on Daily Practice

Yan Ma; Laurence Lespagnard; Virginie Durbecq; Marianne Paesmans; Christine Desmedt; Maria Gomez-Galdon; Isabelle Veys; Fatima Cardoso; Christos Sotiriou; Angelo Di Leo; Martine J. Piccart; Denis Larsimont

Methylation Profiling of Archived Non–Small Cell Lung Cancer: A Promising Prognostic System

A. Mazin Safar; Horace Spencer, III; Xiaobo Su; Maureen Coffey; Craig A. Cooney; Luke D. Ratnasinghe; Laura F. Hutchins; Chun-Yang Fan

Validation of Genomics-Based Prognostic Tests in Malignant Pleural Mesothelioma

Gavin J. Gordon; Graham N. Rockwell; Paul A. Godfrey; Roderick V. Jensen; Jonathan N. Glickman; Beow Y. Yeap; William G. Richards; David J. Sugarbaker; Raphael Bueno

Supplementary data

Gene Expression Profiling of Progressive Papillary Noninvasive Carcinomas of the Urinary Bladder

Peter J. Wild; Alexander Herr; Christoph Wissmann; Robert Stoehr; Andre Rosenthal; Dirk Zaak; Ronald Simon; Ruth Knuechel; Christian Pilarsky; Arndt Hartmann

Supplementary data

Cancer Therapy: Clinical

Unexpected Association between Induction of Immunity to the Universal Tumor Antigen CYP1B1 and Response to Next Therapy

John G. Gribben; David P. Ryan; Richard Boyajian; Robert G. Urban; Mary L. Hedley; Kathleen Beach; Patrick Nealon; Ursula Matulonis; Susana Campos; Timothy D. Gilligan; Paul G. Richardson; Blossom Marshall; Donna Neuberg; Lee M. Nadler

Marimastat in the Treatment of Patients with Biochemically Relapsed Prostate Cancer: A Prospective Randomized, Double-Blind, Phase I/II Trial

Eli Rosenbaum; Marianna Zahurak; Victoria Sinibaldi; Michael A. Carducci; Roberto Pili; Menachem Laufer; Theodore L. DeWeese; Mario A. Eisenberger

The Cyclin-Dependent Kinase Inhibitor UCN-01 Plus Cisplatin in Advanced Solid Tumors: A California Cancer Consortium Phase I Pharmacokinetic and Molecular Correlative Trial

Primo N. Lara, Jr; Philip C. Mack; Timothy Synold; Paul Frankel; Jeff Longmate; Paul H. Gumerlock; James H. Doroshow; David R. Gandara

First Clinical Experience with α-Emitting Radium-223 in the Treatment of Skeletal Metastases

Sten Nilsson; Roy H. Larsen; Sophie D. Fosså; Lise Balteskard; Kari W. Borch; Jan-Erik Westlin; Gro Salberg; Øyvind S. Bruland

Combination of Imatinib Mesylate with Autologous Leukocyte-Derived Heat Shock Protein and Chronic Myelogenous Leukemia

Zihai Li; Yi Qiao; Bei Liu; Elizabeth J. Laska; Priyamvadha Chakravarthi; Judith M. Kulko; Robert D. Bona; Min Fang; Upendra Hegde; Victor Moyo; Susan H. Tannenbaum; Antoine Ménoret; Judy Gaffney; Laura Glynn; Carolyn D. Runowicz; Pramod K. Srivastava

Delayed Disease Progression after Allogeneic Cell Vaccination in Hormone-Resistant Prostate Cancer and Correlation with Immunologic Variables

Agnieska Michael; Graham Ball; Nadine Quatan; Fatima Wushishi; Nick Russell; Joe Whelan; Prabir Chakraborty; David Leader; Michael Whelan; Hardev Pandha

Cancer Therapy: Preclinical

Targeting the c-Met Pathway Potentiates Glioblastoma Responses to γ-Radiation

Bachchu Lal; Shuli Xia; Roger Abounader; John Laterra

In vivo RNA Interference–Mediated Ablation of MDR1 P-Glycoprotein

Andrea Pichler; Noam Zelcer; Julie L. Prior; Annemieke J. Kuil; David Piwnica-Worms

In vitro Induction of Myeloid Leukemia–Specific CD4 and CD8 T Cells by CD40 Ligand – Activated B Cells Gene Modified to Express Primary Granule Proteins

Hiroshi Fujiwara; J. Joseph Melenhorst; Frank El Ouriaghli; Sachiko Kajigaya; Matthias Grube; Giuseppe Sconocchia; Katayoun Rezvani; David A. Price; Nancy F. Hensel; Daniel C. Douek; A. John Barrett

Graft-versus-Leukemia Target Antigens in Chronic Myelogenous Leukemia Are Expressed on Myeloid Progenitor Cells

Catherine J. Wu; Melinda Biernacki; Jeffery L. Kutok; Shelby Rogers; Linyun Chen; Xiao-Feng Yang; Robert J. Soiffer; Jerome Ritz

Blockade of Transforming Growth Factor-β Signaling Suppresses Progression of Androgen-Independent Human Prostate Cancer in Nude Mice

Fahao Zhang; Juwon Lee; Shan Lu; Curtis A. Pettaway; Zhongyun Dong

The Antitumor and Antiangiogenic Activity of Vascular Endothelial Growth Factor Receptor Inhibition Is Potentiated by ErbB1 Blockade

Patrizia Sini; Lorenza Wyder; Christian Schnell; Terence O'Reilly; Amanda Littlewood; Ralph Brandt; Nancy E. Hynes; Jeanette Wood

The Requirement of Multimodal Therapy (Vaccine, Local Tumor Radiation, and Reduction of Suppressor Cells) to Eliminate Established Tumors

Chie Kudo-Saito; Jeffrey Schlom; Kevin Camphausen; C. Norman Coleman; James W. Hodge

Recognition of Six-Transmembrane Epithelial Antigen of the Prostate–Expressing Tumor Cells by Peptide Antigen–Induced Cytotoxic T Lymphocytes

David A. Rodeberg; Rebecca A. Nuss; Sherine F. Elsawa; Esteban Celis

Oncolytic Viral Therapy for Cervical and Ovarian Cancer Cells by Sindbis Virus AR339 Strain

Youichi Unno; Yuji Shino; Fukuo Kondo; Natsuhiko Igarashi; Gang Wang; Ryuhi Shimura; Taketo Yamaguchi; Takehide Asano; Hiromitsu Saisho; Souei Sekiya; Hiroshi Shirasawa

Low Levels of Her2/neu Expressed by Ewing's Family Tumor Cell Lines Can Redirect Cytokine-Induced Killer Cells

Michael R. Verneris; Arash Arshi; Matthias Edinger; Martin Kornacker; Yaso Natkunam; Mobin Karami; Yu-an Cao; Neyssa Marina; Christopher H. Contag; Robert S. Negrin

Enhancement of In vitro and In vivo Tumor Cell Radiosensitivity by the DNA Methylation Inhibitor Zebularine

Hideaki Dote; David Cerna; William E. Burgan; Donna J. Carter; Michael A. Cerra; Melinda G. Hollingshead; Kevin Camphausen; Philip J. Tofilon

Activation of p53-Dependent Apoptosis by Acute Ablation of Glycogen Synthase Kinase-3β in Colorectal Cancer Cells

Jagadish C. Ghosh; Dario C. Altieri

The Farnesyltransferase Inhibitor L744832 Potentiates UCN-01–Induced Apoptosis in Human Multiple Myeloma Cells

Xin-Yan Pei; Yun Dai; Mohamed Rahmani; Weiqun Li; Paul Dent; Steven Grant

Systemic Treatment with Tetra-O-Methyl Nordihydroguaiaretic Acid Suppresses the Growth of Human Xenograft Tumors

Richard Park; Chih-Chuan Chang; Yu-Chuan Liang; Yousun Chung; Ryan A. Henry; Elaine Lin; David E. Mold; Ru Chih C. Huang

Cancer Prevention

The Transforming Growth Factor-β Family Members Bone Morphogenetic Protein-2 and Macrophage Inhibitory Cytokine-1 as Mediators of the Antiangiogenic Activity of N-(4-Hydroxyphenyl)Retinamide

Nicoletta Ferrari; Ulrich Pfeffer; Raffaella Dell'Eva; Claudia Ambrosini; Douglas M. Noonan; Adriana Albini

Genetic Polymorphisms of Selected DNA Repair Genes, Estrogen and Progesterone Receptor Status, and Breast Cancer Risk

Kyoung-Mu Lee; Ji-Yeob Choi; Changwon Kang; Changsoo Paul Kang; Sue Kyung Park; Hyunmi Cho; Dae-Yeon Cho; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; Chung-Gyu Park; Qingyi Wei; Daehee Kang

Effects of Dosing Condition on the Oral Bioavailability of Green Tea Catechins after Single-Dose Administration of Polyphenon E in Healthy Individuals

H-H. Sherry Chow; Iman A. Hakim; Donna R. Vining; James A. Crowell; James Ranger-Moore; Wade M. Chew; Catherine A. Celaya; Steven R. Rodney; Yukihiko Hara; David S. Alberts

Letters to the Editor

Researchers Should Have Respect for the Originator of the Cell Lines

Yutaka Shimada

Correction

Correction: Article on Overexpression of Aurora-A and Malignant Development of Human Esophageal Squamous Cell Carcinoma

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