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Volume 11, Issue 10

15 May 2005

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Cover Image
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

The Biology Behind
Report from the FDA
Human Cancer Biology
Imaging, Diagnosis, Prognosis
Cancer Therapy: Clinical
Cancer Therapy: Preclinical
Letters to the Editor
Corrections

The Biology Behind

The Pathway to Biomarker Discovery: Carbonic Anhydrase IX and the Prediction of Immune Responsiveness

Monica C. Panelli; Ena Wang; Francesco M. Marincola

Extract

View articletitled, The Pathway to Biomarker Discovery: Carbonic Anhydrase IX and the Prediction of Immune Responsiveness

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Report from the FDA

Approval Summary: Azacitidine for Treatment of Myelodysplastic Syndrome Subtypes

Edvardas Kaminskas; Ann Farrell; Sophia Abraham; Amy Baird; Li-Shan Hsieh; Shwu-Luan Lee; John K. Leighton; Hasmukh Patel; Atiqur Rahman; Rajeshwara Sridhara; Yong-Cheng Wang; Richard Pazdur

Abstract

View articletitled, Approval Summary: Azacitidine for Treatment of Myelodysplastic Syndrome Subtypes

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Human Cancer Biology

DDEF1 Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma

Justis P. Ehlers; Lori Worley; Michael D. Onken; J. William Harbour

Abstract

View articletitled, DDEF1 Is Located in an Amplified Region of Chromosome 8q and Is Overexpressed in Uveal Melanoma

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A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLA^low Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing

Tianyu Yang; Philip E. Lapinski; Haotian Zhao; Qunmin Zhou; Huiming Zhang; Malini Raghavan; Yang Liu; Pan Zheng

Abstract

View articletitled, A Rare Transporter Associated with Antigen Processing Polymorphism Overpresented in HLAlow Colon Cancer Reveals the Functional Significance of the Signature Domain in Antigen Processing

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Proteins and Protein Pattern Differences between Glioma Cell Lines and Glioblastoma Multiforme

Timothy W. Vogel; Zhengping Zhuang; Jie Li; Hiroaki Okamoto; Makoto Furuta; Youn-Soo Lee; Weifen Zeng; Edward H. Oldfield; Alexander O. Vortmeyer; Robert J. Weil

Abstract

View articletitled, Proteins and Protein Pattern Differences between Glioma Cell Lines and Glioblastoma Multiforme

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In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models

Sang Hoon Lee; Daniel Lopes de Menezes; Jayesh Vora; Alex Harris; Helen Ye; Lara Nordahl; Evelyn Garrett; Emil Samara; Sharon Lea Aukerman; Arnold B. Gelb; Carla Heise

Abstract

View articletitled, In vivo Target Modulation and Biological Activity of CHIR-258, a Multitargeted Growth Factor Receptor Kinase Inhibitor, in Colon Cancer Models

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Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance

Sayaka Otake; Hiroaki Takeda; Yasukuni Suzuki; Tadahisa Fukui; Shinichiro Watanabe; Katsuyoshi Ishihama; Takafumi Saito; Hitoshi Togashi; Tadashi Nakamura; Yuji Matsuzawa; Sumio Kawata

Abstract

View articletitled, Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance

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Vascular Endothelial Growth Factor Polymorphisms in Relation to Breast Cancer Development and Prognosis

Qianren Jin; Kari Hemminki; Kerstin Enquist; Per Lenner; Ewa Grzybowska; Rüdiger Klaes; Roger Henriksson; Bowang Chen; Jolanta Pamula; Wioletta Pekala; Helena Zientek; Jadwiga Rogozinska-Szczepka; Beata Utracka-Hutka; Göran Hallmans; Asta Försti

Abstract

View articletitled, Vascular Endothelial Growth Factor Polymorphisms in Relation to Breast Cancer Development and Prognosis

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Distinct Methylation Patterns of Benign and Malignant Liver Tumors Revealed by Quantitative Methylation Profiling

Ulrich Lehmann; Ina Berg-Ribbe; Luzie U. Wingen; Kai Brakensiek; Thomas Becker; Jürgen Klempnauer; Brigitte Schlegelberger; Hans Kreipe; Peer Flemming

Abstract

View articletitled, Distinct Methylation Patterns of Benign and Malignant Liver Tumors Revealed by Quantitative Methylation Profiling

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Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

Gema Mateo; Mariana Castellanos; Ana Rasillo; Norma C. Gutiérrez; Ma. Angeles Montalbán; Ma. Luisa Martín; Jesús Ma. Hernández; Ma. Consuelo López-Berges; Laura Montejano; Joan Bladé; Ma. Victoria Mateos; Anna Sureda; Javier de la Rubia; Joaquín Díaz-Mediavilla; Atanasio Pandiella; Juan José Lahuerta; Alberto Orfao; Jesús F. San Miguel

Abstract

View articletitled, Genetic Abnormalities and Patterns of Antigenic Expression in Multiple Myeloma

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Imaging, Diagnosis, Prognosis

Analysis of KIT Mutations in Sporadic and Familial Gastrointestinal Stromal Tumors: Therapeutic Implications through Protein Modeling

Chi Tarn; Erin Merkel; Adrian A. Canutescu; Wei Shen; Yuliya Skorobogatko; Martin J. Heslin; Burton Eisenberg; Ruth Birbe; Arthur Patchefsky; Roland Dunbrack; J. Pablo Arnoletti; Margaret von Mehren; Andrew K. Godwin

Abstract

View articletitled, Analysis of KIT Mutations in Sporadic and Familial Gastrointestinal Stromal Tumors: Therapeutic Implications through Protein Modeling

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Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity

Volkmar Müller; Nicole Stahmann; Sabine Riethdorf; Thomas Rau; Tanja Zabel; Alexander Goetz; Fritz Jänicke; Klaus Pantel

Abstract

View articletitled, Circulating Tumor Cells in Breast Cancer: Correlation to Bone Marrow Micrometastases, Heterogeneous Response to Systemic Therapy and Low Proliferative Activity

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Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers

Andrew Berchuck; Edwin S. Iversen; Johnathan M. Lancaster; Jennifer Pittman; Jingqin Luo; Paula Lee; Susan Murphy; Holly K. Dressman; Phillip G. Febbo; Mike West; Joseph R. Nevins; Jeffrey R. Marks

Abstract

View articletitled, Patterns of Gene Expression That Characterize Long-term Survival in Advanced Stage Serous Ovarian Cancers

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An Innovative Microarray Strategy Identities Informative Molecular Markers for the Detection of Micrometastatic Breast Cancer

Kaidi Mikhitarian; William E. Gillanders; Jonas S. Almeida; Renee Hebert Martin; Juan C. Varela; John S. Metcalf; David J. Cole; Michael Mitas

Abstract

View articletitled, An Innovative Microarray Strategy Identities Informative Molecular Markers for the Detection of Micrometastatic Breast Cancer

Supplementary data

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Tumor Dose Response to the Vascular Disrupting Agent, 5,6-Dimethylxanthenone-4-Acetic Acid, Using In vivo Magnetic Resonance Spectroscopy

Lesley D. McPhail; Yuen-Li Chung; Basetti Madhu; Simon Clark; John R. Griffiths; Lloyd R. Kelland; Simon P. Robinson

Abstract

View articletitled, Tumor Dose Response to the Vascular Disrupting Agent, 5,6-Dimethylxanthenone-4-Acetic Acid, Using In vivo Magnetic Resonance Spectroscopy

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Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer

Michael Atkins; Meredith Regan; David McDermott; James Mier; Eric Stanbridge; Amanda Youmans; Philip Febbo; Melissa Upton; Mirna Lechpammer; Sabina Signoretti

Abstract

View articletitled, Carbonic Anhydrase IX Expression Predicts Outcome of Interleukin 2 Therapy for Renal Cancer

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Evaluation of a Panel of Tumor Markers for Molecular Detection of Circulating Cancer Cells in Women with Suspected Breast Cancer

Monica M. Reinholz; Andrea Nibbe; Leslie M. Jonart; Kathleen Kitzmann; Vera J. Suman; James N. Ingle; Raymond Houghton; Barbara Zehentner; Patrick C. Roche; Wilma L. Lingle

Abstract

View articletitled, Evaluation of a Panel of Tumor Markers for Molecular Detection of Circulating Cancer Cells in Women with Suspected Breast Cancer

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The Relationship of Molecular Markers of p53 Function and Angiogenesis to Prognosis of Stage I Epithelial Ovarian Cancer

Michael J. Goodheart; Justine M. Ritchie; Stephen L. Rose; John P. Fruehauf; Barry R. De Young; Richard E. Buller

Abstract

View articletitled, The Relationship of Molecular Markers of p53 Function and Angiogenesis to Prognosis of Stage I Epithelial Ovarian Cancer

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Functionality of Androgen Receptor–Based Gene Expression Imaging in Hormone Refractory Prostate Cancer

Makoto Sato; Mai Johnson; Liqun Zhang; Sanjiv S. Gambhir; Michael Carey; Lily Wu

Abstract

View articletitled, Functionality of Androgen Receptor–Based Gene Expression Imaging in Hormone Refractory Prostate Cancer

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Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer

Teh-Ying Chou; Chao-Hua Chiu; Ling-Hui Li; Chun-Yen Hsiao; Chin-Yuan Tzen; Kuo-Ting Chang; Yuh-Min Chen; Reury-Perng Perng; Shih-Feng Tsai; Chun-Ming Tsai

Abstract

View articletitled, Mutation in the Tyrosine Kinase Domain of Epidermal Growth Factor Receptor Is a Predictive and Prognostic Factor for Gefitinib Treatment in Patients with Non–Small Cell Lung Cancer

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Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis

Meera Kumarakulasingham; Patrick H. Rooney; Sinclair R. Dundas; Colin Telfer; William T. Melvin; Stephanie Curran; Graeme I. Murray

Abstract

View articletitled, Cytochrome P450 Profile of Colorectal Cancer: Identification of Markers of Prognosis

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Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm

Jayne L. Dennis; Torgeir R. Hvidsten; Ernst C. Wit; Jan Komorowski; Alexandra K. Bell; Ian Downie; Jacqueline Mooney; Caroline Verbeke; Christopher Bellamy; W. Nicol Keith; Karin A. Oien

Abstract

View articletitled, Markers of Adenocarcinoma Characteristic of the Site of Origin: Development of a Diagnostic Algorithm

Supplementary data

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Detection of Micrometastases in Pelvic Lymph Nodes in Patients Undergoing Radical Cystectomy for Focally Invasive Bladder Cancer by Real-time Reverse Transcriptase-PCR for Cytokeratin 19 and Uroplakin II

Toshifumi Kurahashi; Isao Hara; Nobutoshi Oka; Sadao Kamidono; Hiroshi Eto; Hideaki Miyake

Abstract

View articletitled, Detection of Micrometastases in Pelvic Lymph Nodes in Patients Undergoing Radical Cystectomy for Focally Invasive Bladder Cancer by Real-time Reverse Transcriptase-PCR for Cytokeratin 19 and Uroplakin II

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Prognostic Role of Thymidylate Synthase Polymorphisms in Gastric Cancer Patients Treated with Surgery and Adjuvant Chemotherapy

Kazuyuki Kawakami; Francesco Graziano; Go Watanabe; Annamaria Ruzzo; Daniele Santini; Vincenzo Catalano; Renato Bisonni; Federica Arduini; Italo Bearzi; Stefano Cascinu; Pietro Muretto; Giuseppe Perrone; Carla Rabitti; Lucio Giustini; Giuseppe Tonini; Francesca Pizzagalli; Mauro Magnani

Abstract

View articletitled, Prognostic Role of Thymidylate Synthase Polymorphisms in Gastric Cancer Patients Treated with Surgery and Adjuvant Chemotherapy

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Cyclooxygenase-2 Overexpression Is Associated with a Poor Outcome in Resected Ampullary Cancer Patients

Daniele Santini; Bruno Vincenzi; Giuseppe Tonini; Susanna Scarpa; Fortunata Vasaturo; Carolina Malacrino; Fabio Vecchio; Domenico Borzomati; Sergio Valeri; Roberto Coppola; Paolo Magistrelli; Gennaro Nuzzo; Aurelio Picciocchi

Abstract

View articletitled, Cyclooxygenase-2 Overexpression Is Associated with a Poor Outcome in Resected Ampullary Cancer Patients

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Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment

Pascal O. Berberat; Zilvinas Dambrauskas; Antanas Gulbinas; Thomas Giese; Nathalia Giese; Beat Künzli; Frank Autschbach; Stefen Meuer; Markus W. Büchler; Helmut Friess

Abstract

View articletitled, Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment

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Cancer Therapy: Clinical

Proton Beam Therapy for Hepatocellular Carcinoma: A Retrospective Review of 162 Patients

Toshiya Chiba; Koichi Tokuuye; Yasushi Matsuzaki; Shinji Sugahara; Yoshimichi Chuganji; Kenji Kagei; Junichi Shoda; Masaharu Hata; Masato Abei; Hiroshi Igaki; Naomi Tanaka; Yasuyuki Akine

Abstract

View articletitled, Proton Beam Therapy for Hepatocellular Carcinoma: A Retrospective Review of 162 Patients

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Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given on Days 1 and 8 of a 3-Week Cycle in Patients with Advanced Solid Tumors

Maja J.A. de Jonge; Ate van der Gaast; André S.T. Planting; Leny van Doorn; Aletta Lems; Inge Boot; Jantien Wanders; Masahiko Satomi; Jaap Verweij

Abstract

View articletitled, Phase I and Pharmacokinetic Study of the Dolastatin 10 Analogue TZT-1027, Given on Days 1 and 8 of a 3-Week Cycle in Patients with Advanced Solid Tumors

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Humoral Immune Response to Mesothelin in Mesothelioma and Ovarian Cancer Patients

Mitchell Ho; Raffit Hassan; Jingli Zhang; Qing-cheng Wang; Masanori Onda; Tapan Bera; Ira Pastan

Abstract

View articletitled, Humoral Immune Response to Mesothelin in Mesothelioma and Ovarian Cancer Patients

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Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient Interleukin-2 Gene Transfer in Vaccinated Rats

Yasuo Iwadate; Makoto Inoue; Takashi Saegusa; Yumiko Tokusumi; Hiroaki Kinoh; Mamoru Hasegawa; Masatoshi Tagawa; Akira Yamaura; Hideaki Shimada

Abstract

View articletitled, Recombinant Sendai Virus Vector Induces Complete Remission of Established Brain Tumors through Efficient Interleukin-2 Gene Transfer in Vaccinated Rats

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Dietary Flaxseed Alters Tumor Biological Markers in Postmenopausal Breast Cancer

Lilian U. Thompson; Jian Min Chen; Tong Li; Kathrin Strasser-Weippl; Paul E. Goss

Abstract

View articletitled, Dietary Flaxseed Alters Tumor Biological Markers in Postmenopausal Breast Cancer

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A Phase I Clinical Trial of the Sequential Combination of Irinotecan Followed by Flavopiridol

Manish A. Shah; Jeremy Kortmansky; Monica Motwani; Marija Drobnjak; Mithat Gonen; Sandy Yi; Amanda Weyerbacher; Carlos Cordon-Cardo; Robert Lefkowitz; Baruch Brenner; Eileen O'Reilly; Leonard Saltz; William Tong; David P. Kelsen; Gary K. Schwartz

Abstract

View articletitled, A Phase I Clinical Trial of the Sequential Combination of Irinotecan Followed by Flavopiridol

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Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer

John Nemunaitis; Irene Eiseman; Casey Cunningham; Neil Senzer; Adrienne Williams; Peter F. Lenehan; Stephen C. Olson; Paul Bycott; Michael Schlicht; Rebecca Zentgraff; Dong M. Shin; Ralph G. Zinner

Abstract

View articletitled, Phase 1 Clinical and Pharmacokinetics Evaluation of Oral CI-1033 in Patients with Refractory Cancer

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A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer

Anthony W. Tolcher; Kim Chi; John Kuhn; Martin Gleave; Amita Patnaik; Chris Takimoto; Garry Schwartz; Ian Thompson; Kristin Berg; Susan D'Aloisio; Nevin Murray; Stanley R. Frankel; Elzbieta Izbicka; Eric Rowinsky

Abstract

View articletitled, A Phase II, Pharmacokinetic, and Biological Correlative Study of Oblimersen Sodium and Docetaxel in Patients with Hormone-Refractory Prostate Cancer

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Cancer Therapy: Preclinical

Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

Julianne L. Holleran; Robert A. Parise; Erin Joseph; Julie L. Eiseman; Joseph M. Covey; Elizabeth R. Glaze; Alexander V. Lyubimov; Ya-Fei Chen; David Z. D'Argenio; Merrill J. Egorin

Abstract

View articletitled, Plasma Pharmacokinetics, Oral Bioavailability, and Interspecies Scaling of the DNA Methyltransferase Inhibitor, Zebularine

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Recognition of Prostate and Breast Tumor Cells by Helper T Lymphocytes Specific for a Prostate and Breast Tumor-Associated Antigen, TARP

Hiroya Kobayashi; Toshihiro Nagato; Kensuke Oikawa; Keisuke Sato; Shoji Kimura; Naoko Aoki; Ryusuke Omiya; Masatoshi Tateno; Esteban Celis

Abstract

View articletitled, Recognition of Prostate and Breast Tumor Cells by Helper T Lymphocytes Specific for a Prostate and Breast Tumor-Associated Antigen, TARP

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A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

Daniel A. Vallera; Deborah A. Todhunter; David W. Kuroki; Yanqun Shu; Andy Sicheneder; Hua Chen

Abstract

View articletitled, A Bispecific Recombinant Immunotoxin, DT2219, Targeting Human CD19 and CD22 Receptors in a Mouse Xenograft Model of B-Cell Leukemia/Lymphoma

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Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo

Xiaoying Yin; Hong Zhang; Francis Burrows; Lin Zhang; Carol G. Shores

Abstract

View articletitled, Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo

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A Neutralizing Anti–Fibroblast Growth Factor 8 Monoclonal Antibody Shows Potent Antitumor Activity against Androgen-Dependent Mouse Mammary Tumors In vivo

Naoki Shimada; Toshihiko Ishii; Teruyoshi Imada; Katsumi Takaba; Yuka Sasaki; Kumiko Maruyama-Takahashi; Yoshimi Maekawa-Tokuda; Hideaki Kusaka; Shiro Akinaga; Akira Tanaka; Kenya Shitara

Abstract

View articletitled, A Neutralizing Anti–Fibroblast Growth Factor 8 Monoclonal Antibody Shows Potent Antitumor Activity against Androgen-Dependent Mouse Mammary Tumors In vivo

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Characterization of Chemical Constituents in Scutellaria baicalensis with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma

Michael Bonham; Jeff Posakony; Ilsa Coleman; Bruce Montgomery; Julian Simon; Peter S. Nelson

Abstract

View articletitled, Characterization of Chemical Constituents in Scutellaria baicalensis with Antiandrogenic and Growth-Inhibitory Activities toward Prostate Carcinoma

Supplementary data

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Dexrazoxane Protects against Myelosuppression from the DNA Cleavage–Enhancing Drugs Etoposide and Daunorubicin but not Doxorubicin

Kenneth Francis Hofland; Annemette Vinding Thougaard; Maxwell Sehested; Peter Buhl Jensen

Abstract

View articletitled, Dexrazoxane Protects against Myelosuppression from the DNA Cleavage–Enhancing Drugs Etoposide and Daunorubicin but not Doxorubicin

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Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in Experimental Metastasis and Angiogenesis

Reuven Reich; Yiffat Katz; Rivka Hadar; Eli Breuer

Abstract

View articletitled, Carbamoylphosphonate Matrix Metalloproteinase Inhibitors 3: In vivo Evaluation of Cyclopentylcarbamoylphosphonic Acid in Experimental Metastasis and Angiogenesis

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In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors

Gayathri R. Devi; Tomasz M. Beer; Christopher L. Corless; Vikram Arora; Doreen L. Weller; Patrick L. Iversen

Abstract

View articletitled, In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors

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p12^CDK2-AP1 Gene Therapy Strategy Inhibits Tumor Growth in an In vivo Mouse Model of Head and Neck Cancer

Marxa L. Figueiredo; Yong Kim; Maie A.R. St. John; David T.W. Wong

Abstract

View articletitled, p12CDK2-AP1 Gene Therapy Strategy Inhibits Tumor Growth in an In vivo Mouse Model of Head and Neck Cancer

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Frequent Immune Responses to a Cancer/Testis Antigen, CAGE, in Patients with Microsatellite instability–Positive Endometrial Cancer

Takashi Iwata; Tomonobu Fujita; Nobumaru Hirao; Yuriko Matsuzaki; Tsutomu Okada; Hiroshi Mochimaru; Nobuyuki Susumu; Eri Matsumoto; Kokichi Sugano; Naohide Yamashita; Shiro Nozawa; Yutaka Kawakami

Abstract

View articletitled, Frequent Immune Responses to a Cancer/Testis Antigen, CAGE, in Patients with Microsatellite instability–Positive Endometrial Cancer

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Novel Histone Deacetylase Inhibitors in the Treatment of Thyroid Cancer

Constantine S. Mitsiades; Vassiliki Poulaki; Ciaran McMullan; Joseph Negri; Galinos Fanourakis; Athina Goudopoulou; Victoria M. Richon; Paul A. Marks; Nicholas Mitsiades

Abstract

View articletitled, Novel Histone Deacetylase Inhibitors in the Treatment of Thyroid Cancer

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Letters to the Editor

Significance of Hypoxia in Malignant Glioma. Re: Evans et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 2004;10:8177–84

Dirk Vordermark

Extract

View articletitled, Significance of Hypoxia in Malignant Glioma. Re: Evans et al. Hypoxia is important in the biology and aggression of human glial brain tumors. Clin Cancer Res 2004;10:8177–84

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Corrections

Article on Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates

Extract

View articletitled, Article on Efficient Elimination of B-Lineage Lymphomas by Anti-CD20–Auristatin Conjugates

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Email alerts

Online First Alert

eTOC Alert

Breaking

AbbVie Inks Deal for T-Cell Engager

GSK Buys Gastrointestinal-Focused Biopharma

Eli Lilly Snaps Up PI3Kα Inhibitor

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Issues

Cover Image

The Biology Behind

Report from the FDA

Human Cancer Biology

Imaging, Diagnosis, Prognosis

Cancer Therapy: Clinical

Cancer Therapy: Preclinical

Letters to the Editor

Corrections

Email alerts

AACR Journals

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