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Issues

Volume 10, Issue 9
1 May 2004
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

The Biology Behind

E1A as a Tumor Suppressor Gene : Commentary re S. Madhusudan et al. A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene. Clin Cancer Res 2004;10:2905–2907.
Steven M. Frisch
View articletitled, E1A as a Tumor Suppressor Gene <span class="subtitle-colon">: </span><span class="subtitle">Commentary re S. Madhusudan et al. A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/<strong><em>neu</em></strong> Oncogene. Clin Cancer Res 2004;10:2905–2907.</span>
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Featured Articles

Clinical Trials
A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia
Francis Giles; Deborah Thomas; Guillermo Garcia-Manero; Stefan Faderl; Jorge Cortes; Srdan Verstovsek; Alessandra Ferrajoli; Sima Jeha; Miloslav Beran; Charles Koller; Michael Andreeff; Ann Cahill; Caroline Clairmont; Mario Sznol; Hagop Kantarjian
View articletitled, A Phase I and Pharmacokinetic Study of VNP40101M, a Novel Sulfonylhydrazine Alkylating Agent, in Patients with Refractory Leukemia
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Molecular Oncology, Markers, Clinical Correlates
BRCA Mutations and Risk of Prostate Cancer in Ashkenazi Jews
Tomas Kirchhoff; Noah D. Kauff; Nandita Mitra; Kedoudja Nafa; Helen Huang; Crystal Palmer; Tony Gulati; Eve Wadsworth; Sheri Donat; Mark E. Robson; Nathan A. Ellis; Kenneth Offit
View articletitled, <strong><em>BRCA</em></strong> Mutations and Risk of Prostate Cancer in Ashkenazi Jews
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A Cross-Study Comparison of Gene Expression Studies for the Molecular Classification of Lung Cancer
Giovanni Parmigiani; Elizabeth S. Garrett-Mayer; Ramaswamy Anbazhagan; Edward Gabrielson
View articletitled, A Cross-Study Comparison of Gene Expression Studies for the Molecular Classification of Lung Cancer
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DNA Methylation Profiles of Lymphoid and Hematopoietic Malignancies
Takao Takahashi; Narayan Shivapurkar; Jyotsna Reddy; Hisayuki Shigematsu; Kuniharu Miyajima; Makoto Suzuki; Shinichi Toyooka; Sabine Zöchbauer-Müller; Johannes Drach; Gunjan Parikh; Yingye Zheng; Ziding Feng; Steven H. Kroft; Charles Timmons; Robert W. McKenna; Adi F. Gazdar
View articletitled, DNA Methylation Profiles of Lymphoid and Hematopoietic Malignancies
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Experimental Therapeutics, Preclinical Pharmacology
Synergistic Cytotoxicity and Pharmacogenetics of Gemcitabine and Pemetrexed Combination in Pancreatic Cancer Cell Lines
Elisa Giovannetti; Valentina Mey; Romano Danesi; Irene Mosca; Mario Del Tacca
View articletitled, Synergistic Cytotoxicity and Pharmacogenetics of Gemcitabine and Pemetrexed Combination in Pancreatic Cancer Cell Lines
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Regular Articles

Clinical Trials
Dendritic Cell Vaccination in Medullary Thyroid Carcinoma
Anton Stift; Monika Sachet; Rubina Yagubian; Clemens Bittermann; Peter Dubsky; Christine Brostjan; Roswitha Pfragner; Bruno Niederle; Raimund Jakesz; Michael Gnant; Josef Friedl
View articletitled, Dendritic Cell Vaccination in Medullary Thyroid Carcinoma
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Immunological Responses in Women with Human Papillomavirus Type 16 (HPV-16)-Associated Anogenital Intraepithelial Neoplasia Induced by Heterologous Prime-Boost HPV-16 Oncogene Vaccination
Lucy J. C. Smyth; Mariëtte I. E. van Poelgeest; Emma J. Davidson; Kitty M. C. Kwappenberg; Debbie Burt; Peter Sehr; Michael Pawlita; Stephen Man; Julian K. Hickling; Alison N. Fiander; Amanda Tristram; Henry C. Kitchener; Rienk Offringa; Peter L. Stern; Sjoerd H. van der Burg
View articletitled, Immunological Responses in Women with Human Papillomavirus Type 16 (HPV-16)-Associated Anogenital Intraepithelial Neoplasia Induced by Heterologous Prime-Boost HPV-16 Oncogene Vaccination
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Intraperitoneal Cisplatin with Intraperitoneal Gemcitabine in Patients with Epithelial Ovarian Cancer: Results of a Phase I/II Trial
Paul Sabbatini; Carol Aghajanian; Mario Leitao; Ennapadam Venkatraman; Sybil Anderson; Jakob Dupont; Don Dizon; Catherine O’Flaherty; Jeffrey Bloss; Dennis Chi; David Spriggs
View articletitled, Intraperitoneal Cisplatin with Intraperitoneal Gemcitabine in Patients with Epithelial Ovarian Cancer<span class="subtitle-colon">: </span><span class="subtitle">Results of a Phase I/II Trial</span>
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Phase I Study of the Farnesyltransferase Inhibitor Lonafarnib with Paclitaxel in Solid Tumors
Fadlo R. Khuri; Bonnie S. Glisson; Edward S. Kim; Paul Statkevich; Peter F. Thall; Michael L. Meyers; Roy S. Herbst; Reginald F. Munden; Craig Tendler; Yali Zhu; Sandra Bangert; Elizabeth Thompson; Charles Lu; Xue-Mei Wang; Dong M. Shin; Merrill S. Kies; Vali Papadimitrakopoulou; Frank V. Fossella; Paul Kirschmeier; W. Robert Bishop; Waun Ki Hong
View articletitled, Phase I Study of the Farnesyltransferase Inhibitor Lonafarnib with Paclitaxel in Solid Tumors
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Plasma Etoposide Catechol Increases in Pediatric Patients Undergoing Multiple-Day Chemotherapy with Etoposide
Naiyu Zheng; Carolyn A. Felix; Shaokun Pang; Ray Boston; Peter Moate; Jennifer Scavuzzo; Ian A. Blair
View articletitled, Plasma Etoposide Catechol Increases in Pediatric Patients Undergoing Multiple-Day Chemotherapy with Etoposide
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A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene
Srinivasan Madhusudan; Ayala Tamir; Nicholas Bates; Elizabeth Flanagan; Martin E. Gore; Desmond P. J. Barton; Peter Harper; Michael Seckl; Hilary Thomas; Nicholas R. Lemoine; Mark Charnock; Nagy A. Habib; Robert Lechler; Joanna Nicholls; Massimo Pignatelli; Trivadi S. Ganesan
View articletitled, A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/<strong><em>neu</em></strong> Oncogene
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Somatostatin Receptor Subtype 2 Is Expressed by Supratentorial Primitive Neuroectodermal Tumors of Childhood and Can Be Targeted for Somatostatin Receptor Imaging
Michael C. Frühwald; Christian H. Rickert; M. Sue O’Dorisio; Mark Madsen; Monika Warmuth-Metz; Geetika Khanna; Werner Paulus; Joachim Kühl; Heribert Jürgens; Peter Schneider; Hermann L. Müller
View articletitled, Somatostatin Receptor Subtype 2 Is Expressed by Supratentorial Primitive Neuroectodermal Tumors of Childhood and Can Be Targeted for Somatostatin Receptor Imaging
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Research Articles

Molecular Oncology, Markers, Clinical Correlates
Elevated Expression of Valosin-Containing Protein (p97) Is Associated with Poor Prognosis of Prostate Cancer
Yuichi Tsujimoto; Yasuhiko Tomita; Yoshihiko Hoshida; Takuro Kono; Toshitsugu Oka; Shinji Yamamoto; Norio Nonomura; Akihiko Okuyama; Katsuyuki Aozasa
View articletitled, Elevated Expression of Valosin-Containing Protein (p97) Is Associated with Poor Prognosis of Prostate Cancer
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Comparative Study between DNA Copy Number Aberrations Determined by Quantitative Microsatellite Analysis and Clinical Outcome in Patients with Stomach Cancer
Seiji Suzuki; Kaku Egami; Koji Sasajima; Mohammad Ghazizadeh; Hajime Shimizu; Hidehiro Watanabe; Hirokazu Hasegawa; Shinya Iida; Takeshi Matsuda; Yuji Okihama; Masaru Hosone; Kazuo Shimizu; Oichi Kawanami; Takashi Tajiri
View articletitled, Comparative Study between DNA Copy Number Aberrations Determined by Quantitative Microsatellite Analysis and Clinical Outcome in Patients with Stomach Cancer
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Reliable and Sensitive Identification of Occult Tumor Cells Using the Improved Rare Event Imaging System
Stine-Kathrein Kraeft; Andras Ladanyi; Kevin Galiger; Anna Herlitz; Andrew C. Sher; Danielle E. Bergsrud; Gaelle Even; Stephanie Brunelle; Lyndsay Harris; Ravi Salgia; Tom Dahl; John Kesterson; Lan Bo Chen
View articletitled, Reliable and Sensitive Identification of Occult Tumor Cells Using the Improved Rare Event Imaging System
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High Level of Glutathione-S-Transferase π Expression in Mantle Cell Lymphomas
Annelise Bennaceur-Griscelli; Jacques Bosq; Serge Koscielny; François Lefrère; Ali Turhan; Nicole Brousse; Olivier Hermine; Vincent Ribrag
View articletitled, High Level of Glutathione-<strong><em>S</em></strong>-Transferase π Expression in Mantle Cell Lymphomas
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Demethylation of Urokinase Promoter as a Prognostic Marker in Patients with Breast Carcinoma
Pouya Pakneshan; Bernard Têtu; Shafaat A. Rabbani
View articletitled, Demethylation of Urokinase Promoter as a Prognostic Marker in Patients with Breast Carcinoma
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Intracellular Patterns of Her-2/neu, ras, and Ploidy Abnormalities in Primary Human Breast Cancers Predict Postoperative Clinical Disease-Free Survival
Stanley E. Shackney; Charles A. Smith; Agnese Pollice; Kathryn Brown; Roger Day; Thomas Julian; Jan F. Silverman
View articletitled, Intracellular Patterns of Her-2/neu, ras, and Ploidy Abnormalities in Primary Human Breast Cancers Predict Postoperative Clinical Disease-Free Survival
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Loss of WWOX Expression in Gastric Carcinoma
Rami I. Aqeilan; Tamotsu Kuroki; Yuri Pekarsky; Omar Albagha; Francesco Trapasso; Raffaele Baffa; Kay Huebner; Pamela Edmonds; Carlo M. Croce
View articletitled, Loss of <strong><em>WWOX</em></strong> Expression in Gastric Carcinoma
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DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri
Peter Melsheimer; Svetlana Vinokurova; Nicolas Wentzensen; Gunther Bastert; Magnus von Knebel Doeberitz
View articletitled, DNA Aneuploidy and Integration of Human Papillomavirus Type 16 E6/E7 Oncogenes in Intraepithelial Neoplasia and Invasive Squamous Cell Carcinoma of the Cervix Uteri
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Loss of 14-3-3σ in Prostate Cancer and Its Precursors
Liang Cheng; Chong-Xian Pan; Jian-Ting Zhang; Shaobo Zhang; Michael S. Kinch; Lang Li; Lee Ann Baldridge; Christopher Wade; Zhiqiang Hu; Michael O. Koch; Thomas M. Ulbright; John N. Eble
View articletitled, Loss of 14-3-3σ in Prostate Cancer and Its Precursors
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Epidermal Growth Factor Receptor, c-MET, β-Catenin, and p53 Expression as Prognostic Indicators in Stage II Colon Cancer: A Tissue Microarray Study
Murray B. Resnick; Justin Routhier; Tamako Konkin; Edmond Sabo; Victor E. Pricolo
View articletitled, Epidermal Growth Factor Receptor, c-MET, β-Catenin, and p53 Expression as Prognostic Indicators in Stage II Colon Cancer<span class="subtitle-colon">: </span><span class="subtitle">A Tissue Microarray Study</span>
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Prognostic Significance of c-kit Mutation in Localized Gastrointestinal Stromal Tumors
Tae Won Kim; Hyoungnam Lee; Yoon-Koo Kang; Mi Sun Choe; Min-Hee Ryu; Heung Moon Chang; Jung Sun Kim; Jeong Hwan Yook; Byung Sik Kim; Jung Shin Lee
View articletitled, Prognostic Significance of <strong><em>c-kit</em></strong> Mutation in Localized Gastrointestinal Stromal Tumors
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Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas
Kazuo Konishi; Toshiko Yamochi; Reiko Makino; Kazuhiro Kaneko; Taikan Yamamoto; Hisako Nozawa; Atsushi Katagiri; Hiroaki Ito; Kentarou Nakayama; Hidekazu Ota; Keiji Mitamura; Michio Imawari
View articletitled, Molecular Differences between Sporadic Serrated and Conventional Colorectal Adenomas
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The Prognostic Value of Isolated Tumor Cells in Bone Marrow in Breast Cancer Patients: Evaluation of Morphological Categories and the Number of Clinically Significant Cells
Bjørn Naume; Gro Wiedswang; Elin Borgen; Gunnar Kvalheim; Rolf Kåresen; Hanne Qvist; Jan Janbu; Torstein Harbitz; Jahn M. Nesland
View articletitled, The Prognostic Value of Isolated Tumor Cells in Bone Marrow in Breast Cancer Patients<span class="subtitle-colon">: </span><span class="subtitle">Evaluation of Morphological Categories and the Number of Clinically Significant Cells</span>
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Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma
Giuseppina D’Andrilli; Valeria Masciullo; Luigi Bagella; Tiziana Tonini; Corrado Minimo; Gian Franco Zannoni; Robert L. Giuntoli, II; John A. Carlson, Jr.; Dianne Robert Soprano; Kenneth J. Soprano; Giovanni Scambia; Antonio Giordano
View articletitled, Frequent Loss of pRb2/p130 in Human Ovarian Carcinoma
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Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung
Jyoti Mehrotra; Mustafa Vali; Megan McVeigh; Scott L. Kominsky; Mary Jo Fackler; Jaana Lahti-Domenici; Kornelia Polyak; Nicoletta Sacchi; Elizabeth Garrett-Mayer; Pedram Argani; Saraswati Sukumar
View articletitled, Very High Frequency of Hypermethylated Genes in Breast Cancer Metastasis to the Bone, Brain, and Lung
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Expression of Matrix Metalloproteinase-9 in Head and Neck Squamous Cell Carcinoma: A Potential Marker for Prognosis
Henni Ruokolainen; Paavo Pääkkö; Taina Turpeenniemi-Hujanen
View articletitled, Expression of Matrix Metalloproteinase-9 in Head and Neck Squamous Cell Carcinoma<span class="subtitle-colon">: </span><span class="subtitle">A Potential Marker for Prognosis</span>
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Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer
Gabriella Ferrandina; Franco Oreste Ranelletti; Francesco Legge; Marco Gessi; Vanda Salutari; Maria Grazia Distefano; Libero Lauriola; Gian Franco Zannoni; Enrica Martinelli; Giovanni Scambia
View articletitled, Prognostic Role of the Ratio between Cyclooxygenase-2 in Tumor and Stroma Compartments in Cervical Cancer
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Death-Associated Protein Kinase Loss of Expression Is a New Marker for Breast Cancer Prognosis
Delphine Lévy; Geneviève Plu-Bureau; Yves Decroix; Danielle Hugol; William Rostène; Adi Kimchi; Anne Gompel
View articletitled, Death-Associated Protein Kinase Loss of Expression Is a New Marker for Breast Cancer Prognosis
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Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival
Meri Varga; Peter Obrist; Stephan Schneeberger; Gilbert Mühlmann; Christina Felgel-Farnholz; Dominic Fong; Mathias Zitt; Thomas Brunhuber; Georg Schäfer; Guenther Gastl; Gilbert Spizzo
View articletitled, Overexpression of Epithelial Cell Adhesion Molecule Antigen in Gallbladder Carcinoma Is an Independent Marker for Poor Survival
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Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors
Bei Zheng; Georgios V. Georgakis; Yang Li; Alok Bharti; David McConkey; Bharat B. Aggarwal; Anas Younes
View articletitled, Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors
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Experimental Therapeutics, Preclinical Pharmacology
Pretargeted α Emitting Radioimmunotherapy Using 213Bi 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid-Biotin
Zhengsheng Yao; Meili Zhang; Kayhan Garmestani; Donald B. Axworthy; Robert W. Mallett; Alan R. Fritzberg; Lou J. Theodore; Paul S. Plascjak; William C. Eckelman; Thomas A. Waldmann; Ira Pastan; Chang H. Paik; Martin W. Brechbiel; Jorge A. Carrasquillo
View articletitled, Pretargeted α Emitting Radioimmunotherapy Using <sup>213</sup>Bi 1,4,7,10-Tetraazacyclododecane-<strong><em>N</em></strong>,<strong><em>N</em></strong>′,<strong><em>N</em></strong>″,<strong><em>N</em></strong>‴-Tetraacetic Acid-Biotin
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Development of a New Isogenic Cell-Xenograft System for Evaluation of NAD(P)H:Quinone Oxidoreductase-Directed Antitumor Quinones: Evaluation of the Activity of RH1
Donna L. Dehn; Shannon L. Winski; David Ross
View articletitled, Development of a New Isogenic Cell-Xenograft System for Evaluation of NAD(P)H:Quinone Oxidoreductase-Directed Antitumor Quinones<span class="subtitle-colon">: </span><span class="subtitle">Evaluation of the Activity of RH1</span>
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Decreased Nucleotide Excision Repair Activity and Alterations of Topoisomerase IIα Are Associated with the in Vivo Resistance of a P388 Leukemia Subline to F11782, a Novel Catalytic Inhibitor of Topoisomerases I and II
Anna Kruczynski; Jean-Marc Barret; Benoît van Hille; Nathalie Chansard; Jackie Astruc; Yoann Menon; Carole Duchier; Laurent Créancier; Bridget T. Hill
View articletitled, Decreased Nucleotide Excision Repair Activity and Alterations of Topoisomerase IIα Are Associated with the <strong><em>in Vivo</em></strong> Resistance of a P388 Leukemia Subline to F11782, a Novel Catalytic Inhibitor of Topoisomerases I and II
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Suppression of Constitutive and Tumor Necrosis Factor α-Induced Nuclear Factor (NF)-κB Activation and Induction of Apoptosis by Apigenin in Human Prostate Carcinoma PC-3 Cells: Correlation with Down-Regulation of NF-κB-Responsive Genes
Sanjeev Shukla; Sanjay Gupta
View articletitled, Suppression of Constitutive and Tumor Necrosis Factor α-Induced Nuclear Factor (NF)-κB Activation and Induction of Apoptosis by Apigenin in Human Prostate Carcinoma PC-3 Cells: Correlation with Down-Regulation of NF-κB-Responsive Genes
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Arsenic Trioxide-Induced Death of Neuroblastoma Cells Involves Activation of Bax and Does Not Require p53
Jenny Karlsson; Ingrid Øra; Isabella Pörn-Ares; Sven Påhlman
View articletitled, Arsenic Trioxide-Induced Death of Neuroblastoma Cells Involves Activation of Bax and Does Not Require p53
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Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor
Meredith A. Preuss; John T. Lam; Minghui Wang; Charles A. Leath, III; Manjula Kataram; Parameshwar J. Mahasreshti; Ronald D. Alvarez; David T. Curiel
View articletitled, Transcriptional Blocks Limit Adenoviral Replication in Primary Ovarian Tumor
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Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen)
Anthony Raffo; Johnathan C. Lai; C. A. Stein; Paul Miller; Steven Scaringe; Anastasia Khvorova; Luba Benimetskaya
View articletitled, Antisense RNA Down-Regulation of bcl-2 Expression in DU145 Prostate Cancer Cells Does Not Diminish the Cytostatic Effects of G3139 (Oblimersen)
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Resistance to Tyrosine Kinase Inhibition by Mutant Epidermal Growth Factor Receptor Variant III Contributes to the Neoplastic Phenotype of Glioblastoma Multiforme
Chris A. Learn; Tristan L. Hartzell; Carol J. Wikstrand; Gary E. Archer; Jeremy N. Rich; Allan H. Friedman; Henry S. Friedman; Darell D. Bigner; John H. Sampson
View articletitled, Resistance to Tyrosine Kinase Inhibition by Mutant Epidermal Growth Factor Receptor Variant III Contributes to the Neoplastic Phenotype of Glioblastoma Multiforme
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Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells: A Potential Target to Increase Anticancer Activity
Stephen F. Stanziale; Henrik Petrowsky; Prasad S. Adusumilli; Leah Ben-Porat; Mithat Gonen; Yuman Fong
View articletitled, Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells<span class="subtitle-colon">: </span><span class="subtitle">A Potential Target to Increase Anticancer Activity</span>
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Correction

Correction
View articletitled, Correction
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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