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Volume 10, Issue 7

1 April 2004

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Cover Image

Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorials
Reviews
The Biology Behind
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Letter to the Editor
Correction

Editorials

Positron Emission Tomography-Based Molecular Imaging in Human Cancer: Exploring the Link between Hypoxia and Accelerated Glucose Metabolism

Steven M. Larson

Extract

View articletitled, Positron Emission Tomography-Based Molecular Imaging in Human Cancer: Exploring the Link between Hypoxia and Accelerated Glucose Metabolism

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Kinase Inhibitors and Cytotoxic Drug Resistance

Steven Grant; Paul Dent

Extract

View articletitled, Kinase Inhibitors and Cytotoxic Drug Resistance

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Reviews

Androgen Receptor Coregulators in Prostate Cancer: Mechanisms and Clinical Implications

Mujib Rahman; Hiroshi Miyamoto; Chawnshang Chang

Extract

View articletitled, Androgen Receptor Coregulators in Prostate Cancer: Mechanisms and Clinical Implications

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The Biology Behind

Cancer Chemoprevention by Targeting Proteasomal Degradation : Commentary re KA Dragnev et al, Specific Chemopreventive Agents Trigger Proteasomal Degradation of G₁ Cyclins: Implications for Combination Therapy. Clin Cancer Res, 2004;10:2570–7

Chung S. Yang; Khew-Voon Chin; Joshua D. Lambert

Extract

View articletitled, Cancer Chemoprevention by Targeting Proteasomal Degradation : Commentary re KA Dragnev et al, Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy. Clin Cancer Res, 2004;10:2570–7

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Featured Articles

Clinical Trials

Phase I Clinical Trial of the Farnesyltransferase Inhibitor BMS-214662 Given as a 1-Hour Intravenous Infusion in Patients with Advanced Solid Tumors

David P. Ryan; Joseph P. Eder, Jr.; Thomas Puchlaski; Michael V. Seiden; Thomas J. Lynch; Charles S. Fuchs; Philip C. Amrein; Darrell Sonnichsen; Jeffrey G. Supko; Jeffrey W. Clark

Abstract

View articletitled, Phase I Clinical Trial of the Farnesyltransferase Inhibitor BMS-214662 Given as a 1-Hour Intravenous Infusion in Patients with Advanced Solid Tumors

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Second Round Results of the Finnish Population-Based Prostate Cancer Screening Trial

Tuukka Mäkinen; Teuvo L. J. Tammela; Ulf-Håkan Stenman; Liisa Määttänen; Jussi Aro; Harri Juusela; Paula Martikainen; Matti Hakama; Anssi Auvinen

Abstract

View articletitled, Second Round Results of the Finnish Population-Based Prostate Cancer Screening Trial

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Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer

Milly E. de Jonge; H. J. G. Desirée van den Bongard; Alwin D. R. Huitema; Ron A. A. Mathôt; Hilde Rosing; Paul Baas; Nico van Zandwijk; Jos H. Beijnen; Jan H. M. Schellens

Abstract

View articletitled, Bayesian Pharmacokinetically Guided Dosing of Paclitaxel in Patients with Non-Small Cell Lung Cancer

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Hypoxia and Glucose Metabolism in Malignant Tumors: Evaluation by [¹⁸F]Fluoromisonidazole and [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography Imaging

Joseph G. Rajendran; David A. Mankoff; Finbarr O’Sullivan; Lanell M. Peterson; David L. Schwartz; Ernest U. Conrad; Alexander M. Spence; Mark Muzi; D. Greg Farwell; Kenneth A. Krohn

Abstract

View articletitled, Hypoxia and Glucose Metabolism in Malignant Tumors: Evaluation by [18F]Fluoromisonidazole and [18F]Fluorodeoxyglucose Positron Emission Tomography Imaging

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Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin’s Lymphoma: IL-2 Mediated Natural Killer Cell Expansion Correlations with Clinical Response

William Larry Gluck; Deborah Hurst; Alan Yuen; Alexandra M. Levine; Mark A. Dayton; Jon P. Gockerman; Jennifer Lucas; Kimberly Denis-Mize; Barbara Tong; Dawn Navis; Anita Difrancesco; Sandra Milan; Susan E. Wilson; Maurice Wolin

Abstract

View articletitled, Phase I Studies of Interleukin (IL)-2 and Rituximab in B-Cell Non-Hodgkin’s Lymphoma: IL-2 Mediated Natural Killer Cell Expansion Correlations with Clinical Response

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Molecular Oncology, Markers, Clinical Correlates

Correlation of Major Cytogenetic Response with a Pharmacogenetic Marker in Chronic Myeloid Leukemia Patients Treated with Imatinib (STI571)

Marlene A. Dressman; Rachel Malinowski; Lee Anne McLean; Insa Gathmann; Renaud Capdeville; Martee Hensley; IRIS (International Randomized Study of Interferon-α versus STI571) Study Group; Mihael H. Polymeropoulos

Abstract

View articletitled, Correlation of Major Cytogenetic Response with a Pharmacogenetic Marker in Chronic Myeloid Leukemia Patients Treated with Imatinib (STI571)

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Classification of Human Breast Cancer Using Gene Expression Profiling as a Component of the Survival Predictor Algorithm

Gennadi V. Glinsky; Takuya Higashiyama; Anna B. Glinskii

Abstract

View articletitled, Classification of Human Breast Cancer Using Gene Expression Profiling as a Component of the Survival Predictor Algorithm

Supplementary data

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Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer

Ozlem Topaloglu; Mohammad Obaidul Hoque; Yutaka Tokumaru; Juna Lee; Edward Ratovitski; David Sidransky; Chul-so Moon

Abstract

View articletitled, Detection of Promoter Hypermethylation of Multiple Genes in the Tumor and Bronchoalveolar Lavage of Patients with Lung Cancer

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Tumor Tissue Levels of Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Marker in Primary Breast Cancer

Anne-Sofie Schrohl; Mads N. Holten-Andersen; Harry A. Peters; Maxine P. Look; Marion E. Meijer-van Gelder; Jan G. M. Klijn; Nils Brünner; John A. Foekens

Abstract

View articletitled, Tumor Tissue Levels of Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Marker in Primary Breast Cancer

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Experimental Therapeutics, Preclinical Pharmacology

Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine

Kenji Yokoi; Isaiah J. Fidler

Abstract

View articletitled, Hypoxia Increases Resistance of Human Pancreatic Cancer Cells to Apoptosis Induced by Gemcitabine

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Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells

Mark S. Duxbury; Hiromichi Ito; Michael J. Zinner; Stanley W. Ashley; Edward E. Whang

Abstract

View articletitled, Inhibition of Src Tyrosine Kinase Impairs Inherent and Acquired Gemcitabine Resistance in Human Pancreatic Adenocarcinoma Cells

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Regular Articles

Clinical Trials

Clinical Evaluation of the Delivery and Safety of Aerosolized Liposomal 9-Nitro-20(S)-Camptothecin in Patients with Advanced Pulmonary Malignancies

Claire F. Verschraegen; Brian E. Gilbert; Evelyne Loyer; Armando Huaringa; Garrett Walsh; Robert A. Newman; Vernon Knight

Abstract

View articletitled, Clinical Evaluation of the Delivery and Safety of Aerosolized Liposomal 9-Nitro-20(S)-Camptothecin in Patients with Advanced Pulmonary Malignancies

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Single Ascending Dose Tolerability, Pharmacokinetic–Pharmacodynamic Study of Dihydropyrimidine Dehydrogenase Inhibitor Ro 09-4889

S. Eralp Bellibas; Indra Patel; Emmanuel Chamorey; Bettyna Brivet; Ernest D. Bush; Catherine Kircher; Stephane Nave; Ludger Banken; Nicole Renée; Gérard Milano

Abstract

View articletitled, Single Ascending Dose Tolerability, Pharmacokinetic–Pharmacodynamic Study of Dihydropyrimidine Dehydrogenase Inhibitor Ro 09-4889

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Tamoxifen and Metabolite Concentrations in Serum and Breast Cancer Tissue during Three Dose Regimens in a Randomized Preoperative Trial

Elton R. Kisanga; Jennifer Gjerde; Aliana Guerrieri-Gonzaga; Francesca Pigatto; Adriana Pesci-Feltri; Chris Robertson; Davide Serrano; Giuseppe Pelosi; Andrea Decensi; Ernst A. Lien

Abstract

View articletitled, Tamoxifen and Metabolite Concentrations in Serum and Breast Cancer Tissue during Three Dose Regimens in a Randomized Preoperative Trial

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Prognostic Impact of ANX7-GTPase in Metastatic and HER2-Negative Breast Cancer Patients

Meera Srivastava; Lukas Bubendorf; Mark Raffeld; Christoph Bucher; Jochen Torhorst; Guido Sauter; Cara Olsen; Olli P. Kallioniemi; Ofer Eidelman; Harvey B. Pollard

Abstract

View articletitled, Prognostic Impact of ANX7-GTPase in Metastatic and HER2-Negative Breast Cancer Patients

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CCL21 Chemokine Regulates Chemokine Receptor CCR7 Bearing Malignant Melanoma Cells

Hiroya Takeuchi; Akihide Fujimoto; Maki Tanaka; Tomoki Yamano; Eddy Hsueh; Dave S. B. Hoon

Abstract

View articletitled, CCL21 Chemokine Regulates Chemokine Receptor CCR7 Bearing Malignant Melanoma Cells

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Defective Expression of Transforming Growth Factor β Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer

Hong-Tao Zhang; Xiao-Feng Chen; Ming-Hua Wang; Jiu-Cun Wang; Qing-Yuan Qi; Rong-Mei Zhang; Wei-Qing Xu; Qing-Yan Fei; Fei Wang; Qi-Qun Cheng; Feng Chen; Cheng-Song Zhu; Shi-Heng Tao; Zewei Luo

Abstract

View articletitled, Defective Expression of Transforming Growth Factor β Receptor Type II Is Associated with CpG Methylated Promoter in Primary Non-Small Cell Lung Cancer

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Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis

Jun Sugimura; Richard S. Foster; Oscar W. Cummings; Eric J. Kort; Masayuki Takahashi; Todd T. Lavery; Kyle A. Furge; Lawrence H. Einhorn; Bin Tean Teh

Abstract

View articletitled, Gene Expression Profiling of Early- and Late-Relapse Nonseminomatous Germ Cell Tumor and Primitive Neuroectodermal Tumor of the Testis

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Real-Time Gap Ligase Chain Reaction: A Rapid Semiquantitative Assay for Detecting p53 Mutation at Low Levels in Surgical Margins and Lymph Nodes from Resected Lung and Head and Neck Tumors

Susan V. Harden; David C. Thomas; Nicole Benoit; Khalid Minhas; William H. Westra; Joseph A. Califano; Wayne Koch; David Sidransky

Abstract

View articletitled, Real-Time Gap Ligase Chain Reaction: A Rapid Semiquantitative Assay for Detecting p53 Mutation at Low Levels in Surgical Margins and Lymph Nodes from Resected Lung and Head and Neck Tumors

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Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

Jens Koopmann; Phillip Buckhaults; David A. Brown; Marianna L. Zahurak; Norihiro Sato; Noriyoshi Fukushima; Lori J. Sokoll; Daniel W. Chan; Charles J. Yeo; Ralph H. Hruban; Samuel N. Breit; Kenneth W. Kinzler; Bert Vogelstein; Michael Goggins

Abstract

View articletitled, Serum Macrophage Inhibitory Cytokine 1 as a Marker of Pancreatic and Other Periampullary Cancers

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Endothelin-1-, Endothelin-A-, and Endothelin-B-Receptor Expression Is Correlated with Vascular Endothelial Growth Factor Expression and Angiogenesis in Breast Cancer

Pia Wülfing; Christian Kersting; Joke Tio; Rudolph-Josef Fischer; Christian Wülfing; Christopher Poremba; Raihanatou Diallo; Werner Böcker; Ludwig Kiesel

Abstract

View articletitled, Endothelin-1-, Endothelin-A-, and Endothelin-B-Receptor Expression Is Correlated with Vascular Endothelial Growth Factor Expression and Angiogenesis in Breast Cancer

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Quantitative Plasma Hypermethylated DNA Markers of Undifferentiated Nasopharyngeal Carcinoma

Thian-Sze Wong; Dora Lai-Wan Kwong; Jonathan Shun-Tong Sham; William Ignace Wei; Yok-Lam Kwong; Anthony Po-Wing Yuen

Abstract

View articletitled, Quantitative Plasma Hypermethylated DNA Markers of Undifferentiated Nasopharyngeal Carcinoma

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Predictive Significance of the Alterations of p16INK4A, p14ARF, p53, and Proliferating Cell Nuclear Antigen Expression in the Progression of Cervical Cancer

Jian-Liu Wang; Bi-Ying Zheng; Xi-Dan Li; Tord Ångström; Mikael S. Lindström; Keng-Ling Wallin

Abstract

View articletitled, Predictive Significance of the Alterations of p16INK4A, p14ARF, p53, and Proliferating Cell Nuclear Antigen Expression in the Progression of Cervical Cancer

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Cell-Free 59 kDa Immunoreactive Integrin-Linked Kinase: A Novel Marker for Ovarian Carcinoma

Nuzhat Ahmed; Karen Oliva; Greg E Rice; Michael A Quinn

Abstract

View articletitled, Cell-Free 59 kDa Immunoreactive Integrin-Linked Kinase: A Novel Marker for Ovarian Carcinoma

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The Expression of ERβcx in Human Breast Cancer and the Relationship to Endocrine Therapy and Survival

Carlo Palmieri; Eric W.-F. Lam; Janine Mansi; Claire MacDonald; Sami Shousha; Peter Madden; Yoko Omoto; Andrew Sunters; Margaret Warner; Jan-Åke Gustafsson; R. Charles Coombes

Abstract

View articletitled, The Expression of ERβcx in Human Breast Cancer and the Relationship to Endocrine Therapy and Survival

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Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma

Sarah Porter; Stuart D. Scott; Elaine M. Sassoon; Mark R. Williams; J. Louise Jones; Anne C. Girling; Richard Y. Ball; Dylan R. Edwards

Abstract

View articletitled, Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma

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UDP-Glucuronosyltransferase 1A7 Genetic Polymorphisms Are Associated with Hepatocellular Carcinoma in Japanese Patients with Hepatitis C Virus Infection

Yue Wang; Naoya Kato; Yujin Hoshida; Motoyuki Otsuka; Hiroyoshi Taniguchi; Masaru Moriyama; Shuichiro Shiina; Takao Kawabe; Yoichi M. Ito; Masao Omata

Abstract

View articletitled, UDP-Glucuronosyltransferase 1A7 Genetic Polymorphisms Are Associated with Hepatocellular Carcinoma in Japanese Patients with Hepatitis C Virus Infection

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Demethylation of the Synuclein γ Gene CpG Island in Primary Gastric Cancers and Gastric Cancer Cell Lines

Naoki Yanagawa; Gen Tamura; Teiichiro Honda; Makoto Endoh; Satoshi Nishizuka; Teiichi Motoyama

Abstract

View articletitled, Demethylation of the Synuclein γ Gene CpG Island in Primary Gastric Cancers and Gastric Cancer Cell Lines

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Evidence for Prostate Cancer-Associated Diagnostic Marker-1: Immunohistochemistry and in Situ Hybridization Studies

Akira Ohkia; Youji Hu; Min Wang; Fernando U. Garcia; Mark E. Stearns

Abstract

View articletitled, Evidence for Prostate Cancer-Associated Diagnostic Marker-1: Immunohistochemistry and in Situ Hybridization Studies

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The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis

Tamotsu Kuroki; Sai Yendamuri; Francesco Trapasso; Ayumi Matsuyama; Rami I. Aqeilan; Hansjuerg Alder; Shashi Rattan; Rossano Cesari; Maria L. Nolli; Noel N. Williams; Masaki Mori; Takashi Kanematsu; Carlo M. Croce

Abstract

View articletitled, The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis

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Expression of Nuclear Factor-κB and IκBα Proteins in Prostatic Adenocarcinomas: Correlation of Nuclear Factor-κB Immunoreactivity with Disease Recurrence

Jeffrey S. Ross; Bhaskar V. S. Kallakury; Christine E. Sheehan; Hugh A. G. Fisher; Ronald P. Kaufman, Jr.; Prabhjot Kaur; Karen Gray; Bradley Stringer

Abstract

View articletitled, Expression of Nuclear Factor-κB and IκBα Proteins in Prostatic Adenocarcinomas: Correlation of Nuclear Factor-κB Immunoreactivity with Disease Recurrence

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Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers

Sunil R. Lakhani; Sanjiv Manek; Frederique Penault-Llorca; Adrienne Flanagan; Laurent Arnout; Samantha Merrett; Lesley McGuffog; Dawn Steele; Peter Devilee; Jan G. M. Klijn; Hanne Meijers-Heijboer; Paolo Radice; Silvana Pilotti; Heli Nevanlinna; Ralf Butzow; Hagay Sobol; Jocylyne Jacquemier; Dominique Stoppa Lyonet; Susan L. Neuhausen; Barbara Weber; Teresa Wagner; Robert Winqvist; Yves-Jean Bignon; Franco Monti; Fernando Schmitt; Gilbert Lenoir; Susanne Seitz; Ute Hamman; Paul Pharoah; Geoff Lane; Bruce Ponder; D. Timothy Bishop; Douglas F. Easton

Abstract

View articletitled, Pathology of Ovarian Cancers in BRCA1 and BRCA2 Carriers

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Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma

Nozomi Niitsu; Hirokazu Nakamine; Masataka Okamoto; Hiroko Akamatsu; Masaaki Higashihara; Yoshio Honma; Junko Okabe-Kado; Masami Hirano

Abstract

View articletitled, Clinical Significance of Intracytoplasmic nm23-H1 Expression in Diffuse Large B-Cell Lymphoma

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Expression of Extracellular Matrix Components Versican, Chondroitin Sulfate, Tenascin, and Hyaluronan, and Their Association with Disease Outcome in Node-Negative Breast Cancer

Supaporn Suwiwat; Carmela Ricciardelli; Raija Tammi; Markku Tammi; Paivi Auvinen; Veli-Matti Kosma; Richard G. LeBaron; Wendy A. Raymond; Wayne D. Tilley; David J. Horsfall

Abstract

View articletitled, Expression of Extracellular Matrix Components Versican, Chondroitin Sulfate, Tenascin, and Hyaluronan, and Their Association with Disease Outcome in Node-Negative Breast Cancer

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Experimental Therapeutics, Preclinical Pharmacology

HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice

David Finkle; Zhi Ricky Quan; Vida Asghari; Jessica Kloss; Nazli Ghaboosi; Elaine Mai; Wai Lee Wong; Philip Hollingshead; Ralph Schwall; Hartmut Koeppen; Sharon Erickson

Abstract

View articletitled, HER2-Targeted Therapy Reduces Incidence and Progression of Midlife Mammary Tumors in Female Murine Mammary Tumor Virus huHER2-Transgenic Mice

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Treatment of HER-2/neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction

Corinna Warburton; Wieslawa H. Dragowska; Karen Gelmon; Stephen Chia; Hong Yan; Dana Masin; Tetyana Denyssevych; Anne E. Wallis; Marcel B. Bally

Abstract

View articletitled, Treatment of HER-2/neu Overexpressing Breast Cancer Xenograft Models with Trastuzumab (Herceptin) and Gefitinib (ZD1839): Drug Combination Effects on Tumor Growth, HER-2/neu and Epidermal Growth Factor Receptor Expression, and Viable Hypoxic Cell Fraction

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Plasma and Cerebrospinal Fluid Pharmacokinetics of Imatinib after Administration to Nonhuman Primates

Kathleen Neville; Robert A. Parise; Patrick Thompson; Alexander Aleksic; Merrill J. Egorin; Frank M. Balis; Leticia McGuffey; Cynthia McCully; Stacey L. Berg; Susan M. Blaney

Abstract

View articletitled, Plasma and Cerebrospinal Fluid Pharmacokinetics of Imatinib after Administration to Nonhuman Primates

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Improved Outcome When B-Cell Lymphoma Is Treated with Combinations of Immunoliposomal Anticancer Drugs Targeted to Both the CD19 and CD20 Epitopes

Puja Sapra; Theresa M. Allen

Abstract

View articletitled, Improved Outcome When B-Cell Lymphoma Is Treated with Combinations of Immunoliposomal Anticancer Drugs Targeted to Both the CD19 and CD20 Epitopes

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Trastuzumab (Herceptin) Enhances Class I-Restricted Antigen Presentation Recognized by HER-2/neu-Specific T Cytotoxic Lymphocytes

Koji Kono; Eiji Sato; Hirofumi Naganuma; Akihiro Takahashi; Kousaku Mimura; Hideaki Nukui; Hideki Fujii

Abstract

View articletitled, Trastuzumab (Herceptin) Enhances Class I-Restricted Antigen Presentation Recognized by HER-2/neu-Specific T Cytotoxic Lymphocytes

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Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy

Haruhiko Kamada; Yasuo Tsutsumi; Yasuo Yoshioka; Yoko Yamamoto; Hiroshi Kodaira; Shin-ichi Tsunoda; Takayuki Okamoto; Yohei Mukai; Hiroko Shibata; Shinsaku Nakagawa; Tadanori Mayumi

Abstract

View articletitled, Design of a pH-Sensitive Polymeric Carrier for Drug Release and Its Application in Cancer Therapy

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Introduction of Human Telomerase Reverse Transcriptase to Normal Human Fibroblasts Enhances DNA Repair Capacity

Ki-Hyuk Shin; Mo K. Kang; Erica Dicterow; Ayako Kameta; Marcel A. Baluda; No-Hee Park

Abstract

View articletitled, Introduction of Human Telomerase Reverse Transcriptase to Normal Human Fibroblasts Enhances DNA Repair Capacity

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Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts

Shousong Cao; Farukh A. Durrani; Youcef M. Rustum

Abstract

View articletitled, Selective Modulation of the Therapeutic Efficacy of Anticancer Drugs by Selenium Containing Compounds against Human Tumor Xenografts

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Specific Chemopreventive Agents Trigger Proteasomal Degradation of G₁ Cyclins: Implications for Combination Therapy

Konstantin H. Dragnev; Ian Pitha-Rowe; Yan Ma; W. Jeffrey Petty; David Sekula; Bryan Murphy; Mara Rendi; Nanjoo Suh; Neil B. Desai; Michael B. Sporn; Sarah J. Freemantle; Ethan Dmitrovsky

Abstract

View articletitled, Specific Chemopreventive Agents Trigger Proteasomal Degradation of G1 Cyclins: Implications for Combination Therapy

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Letter to the Editor

Epidermal Growth Factor Receptor Status in Operable Invasive Breast Cancer: Is It of Any Prognostic Value?

Raj S. Rampaul; Sarah E. Pinder; Pete M. Wencyk; Rob I. Nicholson; Roger W. Blamey; John F. Robertson; Ian O. Ellis

Extract

View articletitled, Epidermal Growth Factor Receptor Status in Operable Invasive Breast Cancer: Is It of Any Prognostic Value?

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Correction

Extract

View articletitled, Correction

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Email alerts

Online First Alert

eTOC Alert

Breaking

FDA Approves Drugs for MCL, Colorectal and Breast Cancers

NCI, NIH Directors Stepping Down

Pancreatic Cancer Survival Rate Stalls

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Issues

Cover Image

Editorials

Reviews

The Biology Behind

Featured Articles

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Regular Articles

Clinical Trials

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Letter to the Editor

Correction

Email alerts

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