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Volume 10, Issue 4

15 February 2004

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Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

The Biology Behind
Cooperative Group Bulletin Board
Report from the FDA
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology

The Biology Behind

Targeting Cancer with Telomerase : Commentary re Q. Huang et al., A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells. Clin. Cancer Res., 10: 1439–1445, 2004.

William C. Hahn

Extract

View articletitled, Targeting Cancer with Telomerase : Commentary re Q. Huang et al., A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells. Clin. Cancer Res., 10: 1439–1445, 2004.

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Cooperative Group Bulletin Board

Evaluating Antiangiogenesis Agents in the Clinic: The Eastern Cooperative Oncology Group Portfolio of Clinical Trials

Joseph A. Sparano; Robert Gray; Bruce Giantonio; Peter O’Dwyer; Robert L. Comis

Abstract

View articletitled, Evaluating Antiangiogenesis Agents in the Clinic: The Eastern Cooperative Oncology Group Portfolio of Clinical Trials

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Report from the FDA

United States Food and Drug Administration Drug Approval Summary: Gefitinib (ZD1839; Iressa) Tablets

Martin H. Cohen; Grant A. Williams; Rajeshwari Sridhara; Gang Chen; W. David McGuinn, Jr.; David Morse; Sophia Abraham; Atiqur Rahman; Chenyi Liang; Richard Lostritto; Amy Baird; Richard Pazdur

Abstract

View articletitled, United States Food and Drug Administration Drug Approval Summary: Gefitinib (ZD1839; Iressa) Tablets

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Featured Articles

Clinical Trials

Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer

Celestia S. Higano; Nicholas J. Vogelzang; Jeffrey A. Sosman; Anyang Feng; Dania Caron; Eric J Small

Abstract

View articletitled, Safety and Biological Activity of Repeated Doses of Recombinant Human Flt3 Ligand in Patients with Bone Scan-Negative Hormone-Refractory Prostate Cancer

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Molecular Oncology, Markers, Clinical Correlates

Predicting Radiosensitivity Using DNA End-Binding Complex Analysis

Sheikh M. Ismail; Monica Puppi; Sheela Prithivirajsingh; Anupama Munshi; Uma Raju; Raymond E. Meyn; Thomas A. Buchholz; Michael D. Story; William A. Brock; Luka Milas; Howard D. Thames; Craig W. Stevens

Abstract

View articletitled, Predicting Radiosensitivity Using DNA End-Binding Complex Analysis

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Epithelial-Cadherin and β-Catenin Expression Changes in Pancreatic Intraepithelial Neoplasia

Maamoun M. Al-Aynati; Nikolina Radulovich; Robert H. Riddell; Ming-Sound Tsao

Abstract

View articletitled, Epithelial-Cadherin and β-Catenin Expression Changes in Pancreatic Intraepithelial Neoplasia

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High-Throughput Analysis of Genome-Wide Receptor Tyrosine Kinase Expression in Human Cancers Identifies Potential Novel Drug Targets

Carsten Müller-Tidow; Joachim Schwäble; Björn Steffen; Nicola Tidow; Burkhardt Brandt; Kerstin Becker; Eric Schulze-Bahr; Hartmut Halfter; Ulf Vogt; Ralf Metzger; Paul M. Schneider; Thomas Büchner; Christian Brandts; Wolfgang E. Berdel; Hubert Serve

Abstract

View articletitled, High-Throughput Analysis of Genome-Wide Receptor Tyrosine Kinase Expression in Human Cancers Identifies Potential Novel Drug Targets

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Pleomorphic Characteristics of a Germ-Line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia

Mark E. Robson; Emily Glogowski; Gunhild Sommer; Cristina R. Antonescu; Khedoudja Nafa; Robert G. Maki; Nathan Ellis; Peter Besmer; Murray Brennan; Kenneth Offit

Abstract

View articletitled, Pleomorphic Characteristics of a Germ-Line KIT Mutation in a Large Kindred with Gastrointestinal Stromal Tumors, Hyperpigmentation, and Dysphagia

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Experimental Therapeutics, Preclinical Pharmacology

Antiangiogenic Therapy by Local Intracerebral Microinfusion Improves Treatment Efficiency and Survival in an Orthotopic Human Glioblastoma Model

Nils Ole Schmidt; Mateo Ziu; Giorgio Carrabba; Carlo Giussani; Lorenzo Bello; Yanping Sun; Karl Schmidt; Mitchel Albert; Peter Mcl. Black; Rona S. Carroll

Abstract

View articletitled, Antiangiogenic Therapy by Local Intracerebral Microinfusion Improves Treatment Efficiency and Survival in an Orthotopic Human Glioblastoma Model

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Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models

Zhuo Zhang; Hui Wang; Gautam Prasad; Mao Li; Dong Yu; James A. Bonner; Sudhir Agrawal; Ruiwen Zhang

Abstract

View articletitled, Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models

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The Evaluation of Recombinant, Chimeric, Tetravalent Antihuman CD22 Antibodies

Ruiqi Meng; Joan E. Smallshaw; Laurentiu M. Pop; Michael Yen; Xiaoyun Liu; Lien Le; Maria-Ana Ghetie; Ellen S. Vitetta; Victor Ghetie

Abstract

View articletitled, The Evaluation of Recombinant, Chimeric, Tetravalent Antihuman CD22 Antibodies

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Regular Articles

Clinical Trials

Phase I and Pharmacokinetic Study of the Cytotoxic Ether Lipid Ilmofosine Administered by Weekly Two-Hour Infusion in Patients with Advanced Solid Tumors

Bruce J. Giantonio; Christine Derry; Cecilia McAleer; Joseph J. McPhillips; Peter J. O’Dwyer

Abstract

View articletitled, Phase I and Pharmacokinetic Study of the Cytotoxic Ether Lipid Ilmofosine Administered by Weekly Two-Hour Infusion in Patients with Advanced Solid Tumors

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Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors

Sridhar Mani; Hayley McDaid; Anne Hamilton; Howard Hochster; Marvin B. Cohen; Dineo Khabelle; Tom Griffin; David E. Lebwohl; Leonard Liebes; Franco Muggia; Susan Band Horwitz

Abstract

View articletitled, Phase I Clinical and Pharmacokinetic Study of BMS-247550, a Novel Derivative of Epothilone B, in Solid Tumors

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Clinical Efficacy, Tolerability, and Safety of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, in Patients with Relapsed or Refractory Non-Hodgkin’s Lymphoma: Results from a Phase II Multicenter Study

Miklos Pless; Karim Belhadj; Hans D. Menssen; Wolfgang Kern; Bertrand Coiffier; Jürgen Wolf; Richard Herrmann; Eckhard Thiel; Doug Bootle; Ivo Sklenar; Christian Müller; Les Choi; Carl Porter; Renaud Capdeville

Abstract

View articletitled, Clinical Efficacy, Tolerability, and Safety of SAM486A, a Novel Polyamine Biosynthesis Inhibitor, in Patients with Relapsed or Refractory Non-Hodgkin’s Lymphoma: Results from a Phase II Multicenter Study

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Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer

Tomasz M. Beer; Mark Garzotto; Bruce A. Lowe; William J. Ellis; Michelle A. Montalto; Paul H. Lange; Celestia S. Higano

Abstract

View articletitled, Phase I Study of Weekly Mitoxantrone and Docetaxel before Prostatectomy in Patients with High-Risk Localized Prostate Cancer

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Genetic and Plasma Markers of Venous Thromboembolism in Patients with High Grade Glioma

Francesca L. Sciacca; Emilio Ciusani; Antonio Silvani; Elena Corsini; Simona Frigerio; Simona Pogliani; Eugenio Parati; Danilo Croci; Amerigo Boiardi; Andrea Salmaggi

Abstract

View articletitled, Genetic and Plasma Markers of Venous Thromboembolism in Patients with High Grade Glioma

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Ribonucleotide Reductase Messenger RNA Expression and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients

Rafael Rosell; Kathleen D. Danenberg; Vincente Alberola; Gerold Bepler; Jose Javier Sanchez; Carlos Camps; Mariano Provencio; Dolores Isla; Miquel Taron; Pilar Diz; Angel Artal; on behalf of the Spanish Lung Cancer Group

Abstract

View articletitled, Ribonucleotide Reductase Messenger RNA Expression and Survival in Gemcitabine/Cisplatin-Treated Advanced Non-Small Cell Lung Cancer Patients

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Heterogeneous Patterns of FLT3 Asp⁸³⁵ Mutations in Relapsed de Novo Acute Myeloid Leukemia: A Comparative Analysis of 120 Paired Diagnostic and Relapse Bone Marrow Samples

Lee-Yung Shih; Chein-Fuang Huang; Jin-Hou Wu; Po-Nan Wang; Tung-Liang Lin; Po Dunn; Meng-Chu Chou; Ming-Chung Kuo; Chung-Chih Tang

Abstract

View articletitled, Heterogeneous Patterns of FLT3 Asp835 Mutations in Relapsed de Novo Acute Myeloid Leukemia: A Comparative Analysis of 120 Paired Diagnostic and Relapse Bone Marrow Samples

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PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma

Chong-Xian Pan; Michael S. Kinch; Peter A. Kiener; Solomon Langermann; Ginette Serrero; Le Sun; Joseph Corvera; Christopher J. Sweeney; Lang Li; Shaobo Zhang; Lee Ann Baldridge; Timothy D. Jones; Michael O. Koch; Thomas M. Ulbright; John N. Eble; Liang Cheng

Abstract

View articletitled, PC Cell-Derived Growth Factor Expression in Prostatic Intraepithelial Neoplasia and Prostatic Adenocarcinoma

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Down Regulation of High in Normal-1 (HIN-1) is a Frequent Event in Stage I Non-Small Cell Lung Cancer and Correlates with Poor Clinical Outcome

Antonio Marchetti; Fabio Barassi; Carla Martella; Antonio Chella; Simona Salvatore; Antonio Castrataro; Felice Mucilli; Rocco Sacco; Fiamma Buttitta

Abstract

View articletitled, Down Regulation of High in Normal-1 (HIN-1) is a Frequent Event in Stage I Non-Small Cell Lung Cancer and Correlates with Poor Clinical Outcome

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Vascular Endothelial Growth Factor Expression is Up-Regulated by EWS-ETS Oncoproteins and Sp1 and May Represent an Independent Predictor of Survival in Ewing’s Sarcoma

Bruno Fuchs; Carrie Y. Inwards; Ralf Janknecht

Abstract

View articletitled, Vascular Endothelial Growth Factor Expression is Up-Regulated by EWS-ETS Oncoproteins and Sp1 and May Represent an Independent Predictor of Survival in Ewing’s Sarcoma

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Phospho-Serine-118 Estrogen Receptor-α Detection in Human Breast Tumors in Vivo

Leigh Murphy; Tracy Cherlet; Adewale Adeyinka; Yulian Niu; Linda Snell; Peter Watson

Abstract

View articletitled, Phospho-Serine-118 Estrogen Receptor-α Detection in Human Breast Tumors in Vivo

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Altered Expression of FAS System Is Related to Adverse Clinical Outcome in Stage I-II Breast Cancer Patients Treated with Adjuvant Anthracycline-Based Chemotherapy

Claudio Botti; Simonetta Buglioni; Maria Benevolo; Diana Giannarelli; Paola Papaldo; Francesco Cognetti; Patrizia Vici; Franco Di Filippo; Franca Del Nonno; Franco Maria Venanzi; Pier Giorgio Natali; Marcella Mottolese

Abstract

View articletitled, Altered Expression of FAS System Is Related to Adverse Clinical Outcome in Stage I-II Breast Cancer Patients Treated with Adjuvant Anthracycline-Based Chemotherapy

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Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix: A Potential Predictor of Poor Survival

Gwi Eon Kim; Yong Bae Kim; Nam Hoon Cho; Hyun-Cheol Chung; Hong Ryull Pyo; Jong Doo Lee; Tchan Kyu Park; Woong Sub Koom; Mison Chun; Chang Ok Suh

Abstract

View articletitled, Synchronous Coexpression of Epidermal Growth Factor Receptor and Cyclooxygenase-2 in Carcinomas of the Uterine Cervix: A Potential Predictor of Poor Survival

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Plasminogen Activator Inhibitor-1 as a Potential Marker for the Malignancy of Esophageal Squamous Cell Carcinoma

Takumi Sakakibara; Kenji Hibi; Yasuhiro Kodera; Katsuki Ito; Seiji Akiyama; Akimasa Nakao

Abstract

View articletitled, Plasminogen Activator Inhibitor-1 as a Potential Marker for the Malignancy of Esophageal Squamous Cell Carcinoma

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Clinical Significance of the Loss of KiSS-1 and Orphan G-Protein–Coupled Receptor (hOT7T175) Gene Expression in Esophageal Squamous Cell Carcinoma

Masahide Ikeguchi; Ken-ichi Yamaguchi; Nobuaki Kaibara

Abstract

View articletitled, Clinical Significance of the Loss of KiSS-1 and Orphan G-Protein–Coupled Receptor (hOT7T175) Gene Expression in Esophageal Squamous Cell Carcinoma

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Functional Characterization of the Bladder Cancer Marker, BLCA-4

Thu-Suong Van Le; Julie Myers; Badrinath R. Konety; Timothy Barder; Robert H. Getzenberg

Abstract

View articletitled, Functional Characterization of the Bladder Cancer Marker, BLCA-4

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Clinical Significance of Immunocytochemical Detection of Tumor Cells Using Digital Microscopy in Peripheral Blood and Bone Marrow of Breast Cancer Patients

Jean-Yves Pierga; Charlyne Bonneton; Anne Vincent-Salomon; Patricia de Cremoux; Claude Nos; Nathalie Blin; Pierre Pouillart; Jean-Paul Thiery; Henri Magdelénat

Abstract

View articletitled, Clinical Significance of Immunocytochemical Detection of Tumor Cells Using Digital Microscopy in Peripheral Blood and Bone Marrow of Breast Cancer Patients

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Prognostic and Diagnostic Significance of β-Catenin Nuclear Immunostaining in Colorectal Cancer

Sze Chuen Cesar Wong; Elena Siu Fong Lo; King Chung Lee; John K. C. Chan; W. L. Wendy Hsiao

Abstract

View articletitled, Prognostic and Diagnostic Significance of β-Catenin Nuclear Immunostaining in Colorectal Cancer

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Experimental Therapeutics, Preclinical Pharmacology

Synergistic Interactions between Tamoxifen and Trastuzumab (Herceptin)

Athanassios Argiris; Chun-Xia Wang; Steve G. Whalen; Michael P. DiGiovanna

Abstract

View articletitled, Synergistic Interactions between Tamoxifen and Trastuzumab (Herceptin)

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Generation of Kidney Cancer-Specific Antitumor Immune Responses Using Peripheral Blood Monocytes Transduced With a Recombinant Adenovirus Encoding Carbonic Anhydrase 9

Hideki Mukouyama; Nicolette K. Janzen; Jose M. Hernandez; John S. Lam; Randy Caliliw; Allen Y. Wang; Robert A. Figlin; Arie S. Belldegrun; Gang Zeng

Abstract

View articletitled, Generation of Kidney Cancer-Specific Antitumor Immune Responses Using Peripheral Blood Monocytes Transduced With a Recombinant Adenovirus Encoding Carbonic Anhydrase 9

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An Angiogenesis Inhibitor E7820 Shows Broad-Spectrum Tumor Growth Inhibition in a Xenograft Model: Possible Value of Integrin α2 on Platelets as a Biological Marker

Taro Semba; Yasuhiro Funahashi; Naoto Ono; Yuji Yamamoto; Naoko Hata Sugi; Makoto Asada; Kentaro Yoshimatsu; Toshiaki Wakabayashi

Abstract

View articletitled, An Angiogenesis Inhibitor E7820 Shows Broad-Spectrum Tumor Growth Inhibition in a Xenograft Model: Possible Value of Integrin α2 on Platelets as a Biological Marker

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A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells

Qian Huang; Xiuwu Zhang; He Wang; Bin Yan; John Kirkpatrick; Mark W. Dewhrist; Chuan-Yuan Li

Abstract

View articletitled, A Novel Conditionally Replicative Adenovirus Vector Targeting Telomerase-Positive Tumor Cells

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Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate

Ian G. Kirwan; Paul M. Loadman; David J. Swaine; D. Alan Anthoney; George R. Pettit; John W. Lippert, III; Steve D. Shnyder; Patricia A. Cooper; Mike C. Bibby

Abstract

View articletitled, Comparative Preclinical Pharmacokinetic and Metabolic Studies of the Combretastatin Prodrugs Combretastatin A4 Phosphate and A1 Phosphate

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Adenovirus-Mediated Retinoblastoma 94 Gene Transfer Induces Human Pancreatic Tumor Regression in a Mouse Xenograft Model

Josep Maria Roig; Miguel Angel Molina; Anna Cascante; Joaquim Calbó; Neus Carbó; Uwe Wirtz; Sunil Sreedharan; Cristina Fillat; Adela Mazo

Abstract

View articletitled, Adenovirus-Mediated Retinoblastoma 94 Gene Transfer Induces Human Pancreatic Tumor Regression in a Mouse Xenograft Model

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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cooperates with Anticancer Drugs to Overcome Chemoresistance in Antiapoptotic Bcl-2 Family Members Expressing Jurkat Cells

Alberto Ballestrero; Alessio Nencioni; Davide Boy; Ilaria Rocco; Anna Garuti; Giuseppe Sandro Mela; Luk Van Parijs; Peter Brossart; Sebastian Wesselborg; Franco Patrone

Abstract

View articletitled, Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Cooperates with Anticancer Drugs to Overcome Chemoresistance in Antiapoptotic Bcl-2 Family Members Expressing Jurkat Cells

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The Metabolism of Pyrazoloacridine (NSC 366140) by Cytochromes P450 and Flavin Monooxygenase in Human Liver Microsomes

Joel M. Reid; Denise L. Walker; Jennifer K. Miller; Linda M. Benson; Andrew J. Tomlinson; Stephen Naylor; April L. Blajeski; Patricia M. LoRusso; Matthew M. Ames

Abstract

View articletitled, The Metabolism of Pyrazoloacridine (NSC 366140) by Cytochromes P450 and Flavin Monooxygenase in Human Liver Microsomes

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Imexon-Induced Apoptosis in Multiple Myeloma Tumor Cells Is Caspase-8 Dependent

Andrew M. Evens; Sheila Prachand; Bo Shi; Mary Paniaqua; Leo I. Gordon; Ronald B. Gartenhaus

Abstract

View articletitled, Imexon-Induced Apoptosis in Multiple Myeloma Tumor Cells Is Caspase-8 Dependent

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NADPH Alkenal/One Oxidoreductase Activity Determines Sensitivity of Cancer Cells to the Chemotherapeutic Alkylating Agent Irofulven

Ryan A. Dick; Xiang Yu; Thomas W. Kensler

Abstract

View articletitled, NADPH Alkenal/One Oxidoreductase Activity Determines Sensitivity of Cancer Cells to the Chemotherapeutic Alkylating Agent Irofulven

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Schedule-Dependent Cytotoxic Interaction between Epidoxorubicin and Gemcitabine in Human Bladder Cancer Cells in Vitro

Wainer Zoli; Luca Ricotti; Anna Tesei; Paola Ulivi; Anna Gasperi Campani; Francesco Fabbri; Roberta Gunelli; Giovanni Luca Frassineti; Dino Amadori

Abstract

View articletitled, Schedule-Dependent Cytotoxic Interaction between Epidoxorubicin and Gemcitabine in Human Bladder Cancer Cells in Vitro

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RWJ-241947 (MCC-555), A Unique Peroxisome Proliferator-Activated Receptor-γ Ligand with Antitumor Activity against Human Prostate Cancer in Vitro and in Beige/Nude/ X-Linked Immunodeficient Mice and Enhancement of Apoptosis in Myeloma Cells Induced by Arsenic Trioxide

Takashi Kumagai; Takayuki Ikezoe; Dorina Gui; James O’Kelly; Xiang-Jun Tong; Fredric J. Cohen; Jonathan W. Said; H. Phillip Koeffler

Abstract

View articletitled, RWJ-241947 (MCC-555), A Unique Peroxisome Proliferator-Activated Receptor-γ Ligand with Antitumor Activity against Human Prostate Cancer in Vitro and in Beige/Nude/ X-Linked Immunodeficient Mice and Enhancement of Apoptosis in Myeloma Cells Induced by Arsenic Trioxide

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Effect of a Selective Cyclooxygenase-2 Inhibitor, Nimesulide, on the Growth of Lung Tumors and Their Expression of Cyclooxygenase-2 and Peroxisome Proliferator- Activated Receptor-γ

Madhu Sudhan Shaik; Abhijit Chatterjee; Mandip Singh

Abstract

View articletitled, Effect of a Selective Cyclooxygenase-2 Inhibitor, Nimesulide, on the Growth of Lung Tumors and Their Expression of Cyclooxygenase-2 and Peroxisome Proliferator- Activated Receptor-γ

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Long-Term Exposure to Tamoxifen Induces Hypersensitivity to Estradiol

Lev M. Berstein; Ji-Ping Wang; Hong Zheng; Wei Yue; Mark Conaway; Richard J. Santen

Abstract

View articletitled, Long-Term Exposure to Tamoxifen Induces Hypersensitivity to Estradiol

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Combined 5-Fluorouracil/Systemic Interferon-β Gene Therapy Results in Long-Term Survival in Mice with Established Colorectal Liver Metastases

Eugene A. Choi; Hanqin Lei; David J. Maron; Rosemarie Mick; James Barsoum; Qian-chun Yu; Douglas L. Fraker; James M. Wilson; Francis R. Spitz

Abstract

View articletitled, Combined 5-Fluorouracil/Systemic Interferon-β Gene Therapy Results in Long-Term Survival in Mice with Established Colorectal Liver Metastases

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Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness

Douglas D. Boyd; Heng Wang; Hector Avila; Nila U. Parikh; Horst Kessler; Victor Magdolen; Gary E. Gallick

Abstract

View articletitled, Combination of an Src Kinase Inhibitor with a Novel Pharmacological Antagonist of the Urokinase Receptor Diminishes in Vitro Colon Cancer Invasiveness

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Issues

Cover Image

The Biology Behind

Cooperative Group Bulletin Board

Report from the FDA

Featured Articles

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Regular Articles

Clinical Trials

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

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