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Issues

Volume 10, Issue 3
1 February 2004
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

Review

Epstein-Barr Virus and Cancer
Matthew P. Thompson; Razelle Kurzrock
View articletitled, Epstein-Barr Virus and Cancer
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Perspectives

Evaluating a New Marker’s Predictive Contribution
Michael W. Kattan
View articletitled, Evaluating a New Marker’s Predictive Contribution
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The Biology Behind

Blasting into the Microworld of Tissue Proteomics: A New Window on Cancer : Commentary re S. A. Schwartz et al., Protein Profiling in Brain Tumors Using Mass Spectrometry: Feasibility of a New Technique for the Analysis of Protein Expression. Clin. Cancer Res., 10: 981–987, 2004.
David H. Geho; Emanuel F. Petricoin; Lance A. Liotta
View articletitled, Blasting into the Microworld of Tissue Proteomics: A New Window on Cancer <span class="subtitle-colon">: </span><span class="subtitle">Commentary re S. A. Schwartz <em>et al.</em>, Protein Profiling in Brain Tumors Using Mass Spectrometry: Feasibility of a New Technique for the Analysis of Protein Expression. Clin. Cancer Res., <em>10:</em> 981–987, 2004.</span>
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Featured Articles

Clinical Trials
Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes
Robert H. Vonderheide; Susan M. Domchek; Joachim L. Schultze; Daniel J. George; Kara M. Hoar; Dih-Yih Chen; Katherine F. Stephans; Kenkichi Masutomi; Massimo Loda; Zhinan Xia; Karen S. Anderson; William C. Hahn; Lee M. Nadler
View articletitled, Vaccination of Cancer Patients Against Telomerase Induces Functional Antitumor CD8+ T Lymphocytes
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Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors
Lars M. Wagner; Kristine R. Crews; Lisa C. Iacono; Peter J. Houghton; Christine E. Fuller; M. Beth McCarville; Robert E. Goldsby; Karen Albritton; Clinton F. Stewart; Victor M. Santana
View articletitled, Phase I Trial of Temozolomide and Protracted Irinotecan in Pediatric Patients with Refractory Solid Tumors
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Gene Expression Profiles Predict Survival and Progression of Pleural Mesothelioma
Harvey I. Pass; Zhandong Liu; Anil Wali; Raphael Bueno; Susan Land; Daniel Lott; Fauzia Siddiq; Fulvio Lonardo; Michele Carbone; Sorin Draghici
View articletitled, Gene Expression Profiles Predict Survival and Progression of Pleural Mesothelioma
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Molecular Oncology, Markers, Clinical Correlates
Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization Mass Spectrometry
Jens Koopmann; Zhen Zhang; Nicole White; Jason Rosenzweig; Neal Fedarko; Sanjay Jagannath; Marcia I. Canto; Charles J. Yeo; Daniel W. Chan; Michael Goggins
View articletitled, Serum Diagnosis of Pancreatic Adenocarcinoma Using Surface-Enhanced Laser Desorption and Ionization Mass Spectrometry
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Meningiomas May Be a Component Tumor of Multiple Endocrine Neoplasia Type 1
Behnam Asgharian; Yuan-Jia Chen; Nicholas J. Patronas; Paolo L. Peghini; James C. Reynolds; Alexander Vortmeyer; Zhengping Zhuang; David J. Venzon; Fathia Gibril; Robert T. Jensen
View articletitled, Meningiomas May Be a Component Tumor of Multiple Endocrine Neoplasia Type 1
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Experimental Therapeutics, Preclinical Pharmacology
Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
Nicola J. Curtin; Lan-Zhen Wang; Anthie Yiakouvaki; Suzanne Kyle; Christine A. Arris; Stacie Canan-Koch; Stephen E. Webber; Barbara W. Durkacz; Hilary A. Calvert; Zdenek Hostomsky; David R. Newell
View articletitled, Novel Poly(ADP-ribose) Polymerase-1 Inhibitor, AG14361, Restores Sensitivity to Temozolomide in Mismatch Repair-Deficient Cells
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Identification of HLA-A24-Restricted CTL Epitope from Cancer-Testis Antigen, NY-ESO-1, and Induction of a Specific Antitumor Immune Response
Hiroshi Yamaguchi; Fumiaki Tanaka; Mitsuhiko Ohta; Hiroshi Inoue; Masaki Mori
View articletitled, Identification of HLA-A24-Restricted CTL Epitope from Cancer-Testis Antigen, NY-ESO-1, and Induction of a Specific Antitumor Immune Response
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Targeting the Platelet-Derived Growth Factor Receptor in Antivascular Therapy for Human Ovarian Carcinoma
Sachin M. Apte; Dominic Fan; Jerald J. Killion; Isaiah J. Fidler
View articletitled, Targeting the Platelet-Derived Growth Factor Receptor in Antivascular Therapy for Human Ovarian Carcinoma
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Regular Articles

Clinical Trials
Phase I and Pharmacokinetic Study of Prinomastat, a Matrix Metalloprotease Inhibitor
Kenneth R. Hande; Mary Collier; Linda Paradiso; Jill Stuart-Smith; Mary Dixon; Neil Clendeninn; Geoff Yeun; Donna Alberti; Kim Binger; George Wilding
View articletitled, Phase I and Pharmacokinetic Study of Prinomastat, a Matrix Metalloprotease Inhibitor
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Vaccination of Small Cell Lung Cancer Patients with Polysialic Acid or N-Propionylated Polysialic Acid Conjugated to Keyhole Limpet Hemocyanin
Lee M. Krug; Govind Ragupathi; Kenneth K. Ng; Chandra Hood; Harold J. Jennings; Zhongwu Guo; Mark G. Kris; Vincent Miller; Barbara Pizzo; Leslie Tyson; Valerie Baez; Philip O. Livingston
View articletitled, Vaccination of Small Cell Lung Cancer Patients with Polysialic Acid or <em>N</em>-Propionylated Polysialic Acid Conjugated to Keyhole Limpet Hemocyanin
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A Phase II Trial of Flavopiridol (NSC #649890) in Patients with Previously Untreated Metastatic Androgen-Independent Prostate Cancer
Glenn Liu; David R. Gandara; Primo N. Lara, Jr.; Derek Raghavan; James H. Doroshow; Przemyslaw Twardowski; Philip Kantoff; William Oh; KyungMann Kim; George Wilding
View articletitled, A Phase II Trial of Flavopiridol (NSC #649890) in Patients with Previously Untreated Metastatic Androgen-Independent Prostate Cancer
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Cancer Biology, Immunology, Cytokines
A Definitive Role of RhoC in Metastasis of Orthotopic Lung Cancer in Mice
Tetsuro Ikoma; Tomoyuki Takahashi; Satoshi Nagano; Yun-Mo Li; Yasushi Ohno; Kazuki Ando; Takako Fujiwara; Hisayoshi Fujiwara; Ken-ichiro Kosai
View articletitled, A Definitive Role of RhoC in Metastasis of Orthotopic Lung Cancer in Mice
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Research Articles

Molecular Oncology, Markers, Clinical Correlates
Humoral Responses to Peptides Correlate with Overall Survival in Advanced Cancer Patients Vaccinated with Peptides Based on Pre-existing, Peptide-Specific Cellular Responses
Takashi Mine; Yuji Sato; Masanori Noguchi; Teruo Sasatomi; Rumi Gouhara; Naotake Tsuda; Shoko Tanaka; Hiroki Shomura; Kazuko Katagiri; Touru Rikimaru; Shigeki Shichijo; Toshiharu Kamura; Takashi Hashimoto; Kazuo Shirouzu; Akira Yamada; Satoru Todo; Kyogo Itoh; Hideaki Yamana
View articletitled, Humoral Responses to Peptides Correlate with Overall Survival in Advanced Cancer Patients Vaccinated with Peptides Based on Pre-existing, Peptide-Specific Cellular Responses
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Expression of Ligand-Activated KIT and Platelet-Derived Growth Factor Receptor β Tyrosine Kinase Receptors in Synovial Sarcoma
Elena Tamborini; Lorena Bonadiman; Angela Greco; Alessandro Gronchi; Carla Riva; Rossella Bertulli; Paolo G. Casali; Marco A. Pierotti; Silvana Pilotti
View articletitled, Expression of Ligand-Activated KIT and Platelet-Derived Growth Factor Receptor β Tyrosine Kinase Receptors in Synovial Sarcoma
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HER2 Expression in Salivary Gland Carcinomas: Dependence on Histological Subtype
Bonnie Glisson; A. Dimitrios Colevas; Robert Haddad; Jeoffrey Krane; Adel El-Naggar; Merrill Kies; Rosemary Costello; Carmen Summey; Matthew Arquette; Corey Langer; Philip C. Amrein; Marshall Posner
View articletitled, HER2 Expression in Salivary Gland Carcinomas<span class="subtitle-colon">: </span><span class="subtitle">Dependence on Histological Subtype</span>
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Different Molecular Profiles Characterize Well-Differentiated Endocrine Tumors and Poorly Differentiated Endocrine Carcinomas of the Gastroenteropancreatic Tract
Daniela Furlan; Roberta Cerutti; Silvia Uccella; Stefano La Rosa; Elena Rigoli; Anna Genasetti; Carlo Capella
View articletitled, Different Molecular Profiles Characterize Well-Differentiated Endocrine Tumors and Poorly Differentiated Endocrine Carcinomas of the Gastroenteropancreatic Tract
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Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of BRCA1 Mutation Carrier Status
Zsofia Kote-Jarai; Richard D. Williams; Nicola Cattini; Maria Copeland; Ian Giddings; Richard Wooster; Robert H. tePoele; Paul Workman; Barry Gusterson; John Peacock; Gerald Gui; Colin Campbell; Ros Eeles
View articletitled, Gene Expression Profiling after Radiation-Induced DNA Damage Is Strongly Predictive of <em>BRCA1</em> Mutation Carrier Status
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CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells
Anna Corcione; Nicoletta Arduino; Elisa Ferretti; Lizzia Raffaghello; Silvio Roncella; Davide Rossi; Franco Fedeli; Luciano Ottonello; Livio Trentin; Franco Dallegri; Gianpietro Semenzato; Vito Pistoia
View articletitled, CCL19 and CXCL12 Trigger <strong><em>in Vitro</em></strong> Chemotaxis of Human Mantle Cell Lymphoma B Cells
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Microsatellite Instability, Immunohistochemistry, and Additional PMS2 Staining in Suspected Hereditary Nonpolyposis Colorectal Cancer
Andrea E. de Jong; Marjo van Puijenbroek; Yvonne Hendriks; Carli Tops; Juul Wijnen; Margreet G. E. M. Ausems; Hanne Meijers-Heijboer; Anja Wagner; Theo A. M. van Os; Annette H. J. T. Bröcker-Vriends; Hans F. A. Vasen; Hans Morreau
View articletitled, Microsatellite Instability, Immunohistochemistry, and Additional PMS2 Staining in Suspected Hereditary Nonpolyposis Colorectal Cancer
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Protein Profiling in Brain Tumors Using Mass Spectrometry: Feasibility of a New Technique for the Analysis of Protein Expression
Sarah A. Schwartz; Robert J. Weil; Mahlon D. Johnson; Steven A. Toms; Richard M. Caprioli
View articletitled, Protein Profiling in Brain Tumors Using Mass Spectrometry<span class="subtitle-colon">: </span><span class="subtitle">Feasibility of a New Technique for the Analysis of Protein Expression</span>
Supplementary data
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Molecular Serological Detection of DNA Alterations in Transitional Cell Carcinoma Is Highly Sensitive and Stage Independent
Rolf von Knobloch; Heidrun Brandt; Andres J. Schrader; Axel Heidenreich; Rainer Hofmann
View articletitled, Molecular Serological Detection of DNA Alterations in Transitional Cell Carcinoma Is Highly Sensitive and Stage Independent
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Ubiquitous Aberrant RASSF1A Promoter Methylation in Childhood Neoplasia1
Ivy H. N. Wong; Jacqueline Chan; Joyce Wong; Paul K. H. Tam
View articletitled, Ubiquitous Aberrant <em>RASSF1A</em> Promoter Methylation in Childhood Neoplasia<sup class="sup-zero"><a href="#AFF1" class="link-ref">1</a></sup>
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The Prognostic and Therapeutic Relevance of p27kip1 in Ewing’s Family Tumors
Tomoya Matsunobu; Kazuhiro Tanaka; Yoshihiro Matsumoto; Fumihiko Nakatani; Riku Sakimura; Masuo Hanada; Xu Li; Yoshinao Oda; Ichiro Naruse; Hideki Hoshino; Masazumi Tsuneyoshi; Hiromasa Miura; Yukihide Iwamoto
View articletitled, The Prognostic and Therapeutic Relevance of p27<sup>kip1</sup> in Ewing’s Family Tumors
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Determinants of Rapamycin Sensitivity in Breast Cancer Cells
Woo-Chul Noh; Wallace H. Mondesire; Junying Peng; Weiguo Jian; Haixia Zhang; JinJiang Dong; Gordon B. Mills; Mien-Chie Hung; Funda Meric-Bernstam
View articletitled, Determinants of Rapamycin Sensitivity in Breast Cancer Cells
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Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
Dragan Golijanin; Jian-You Tan; Agnieszka Kazior; Erik G. Cohen; Paul Russo; Guido Dalbagni; Karen J. Auborn; Kotha Subbaramaiah; Andrew J. Dannenberg
View articletitled, Cyclooxygenase-2 and Microsomal Prostaglandin E Synthase-1 Are Overexpressed in Squamous Cell Carcinoma of the Penis
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Expression of Androgen Receptor Coregulators in Prostate Cancer
Marika J. Linja; Kati P. Porkka; Zhikang Kang; Kimmo J. Savinainen; Olli A. Jänne; Teuvo L. J. Tammela; Robert L. Vessella; Jorma J. Palvimo; Tapio Visakorpi
View articletitled, Expression of Androgen Receptor Coregulators in Prostate Cancer
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Mitochondrial DNA Mutation at the D310 (Displacement Loop) Mononucleotide Sequence in the Pathogenesis of Gallbladder Carcinoma
Moying Tang; Sergio Baez; Martha Pruyas; Alfonso Diaz; Alfonso Calvo; Erick Riquelme; Ignacio I. Wistuba
View articletitled, Mitochondrial DNA Mutation at the D310 (Displacement Loop) Mononucleotide Sequence in the Pathogenesis of Gallbladder Carcinoma
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Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy Individuals and Patients with B-Cell Malignancies
Matthias Grube; Katayoun Rezvani; Adrian Wiestner; Hiroshi Fujiwara; Giuseppe Sconocchia; Jan J. Melenhorst; Nancy Hensel; Gerald E. Marti; Larry W. Kwak; Wyndham Wilson; John A. Barrett
View articletitled, Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy Individuals and Patients with B-Cell Malignancies
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A High Serum Matrix Metalloproteinase-2 Level Is Associated with an Adverse Prognosis in Node-Positive Breast Carcinoma
Sirpa Leppä; Tiina Saarto; Leena Vehmanen; Carl Blomqvist; Inkeri Elomaa
View articletitled, A High Serum Matrix Metalloproteinase-2 Level Is Associated with an Adverse Prognosis in Node-Positive Breast Carcinoma
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Genetic Pathways and New Progression Markers for Prostate Cancer Suggested by Microsatellite Allelotyping
Rolf von Knobloch; Lutz Konrad; Peter J. Barth; Heidrun Brandt; Sebastian Wille; Axel Heidenreich; Roland Moll; Rainer Hofmann
View articletitled, Genetic Pathways and New Progression Markers for Prostate Cancer Suggested by Microsatellite Allelotyping
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Experimental Therapeutics, Preclinical Pharmacology
Deguelin-Induced Inhibition of Cyclooxygenase-2 Expression in Human Bronchial Epithelial Cells
Ho-Young Lee; Young-Ah Suh; Jerome W. Kosmeder; John M. Pezzuto; Waun Ki Hong; Jonathan M. Kurie
View articletitled, Deguelin-Induced Inhibition of Cyclooxygenase-2 Expression in Human Bronchial Epithelial Cells
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The Role of α-Folate Receptor-Mediated Transport in the Antitumor Activity of Antifolate Drugs
Davinder S. Theti; Ann L. Jackman
View articletitled, The Role of α-Folate Receptor-Mediated Transport in the Antitumor Activity of Antifolate Drugs
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Intratumoral Vaccination and Diversified Subcutaneous/ Intratumoral Vaccination with Recombinant Poxviruses Encoding a Tumor Antigen and Multiple Costimulatory Molecules
Chie Kudo-Saito; Jeffrey Schlom; James W. Hodge
View articletitled, Intratumoral Vaccination and Diversified Subcutaneous/ Intratumoral Vaccination with Recombinant Poxviruses Encoding a Tumor Antigen and Multiple Costimulatory Molecules
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Improved Therapeutic Responses in a Xenograft Model of Human B Lymphoma (Namalwa) for Liposomal Vincristine versus Liposomal Doxorubicin Targeted via Anti-CD19 IgG2a or Fab′ Fragments
Puja Sapra; Elaine H. Moase; Jie Ma; Theresa M. Allen
View articletitled, Improved Therapeutic Responses in a Xenograft Model of Human B Lymphoma (Namalwa) for Liposomal Vincristine <strong><em>versus</em></strong> Liposomal Doxorubicin Targeted via Anti-CD19 IgG2a or Fab′ Fragments
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Identification of Peptide Vaccine Candidates Sharing among HLA-A3+, -A11+, -A31+, and -A33+ Cancer Patients
Hiroko Takedatsu; Shigeki Shichijo; Kazuko Katagiri; Hiromi Sawamizu; Michio Sata; Kyogo Itoh
View articletitled, Identification of Peptide Vaccine Candidates Sharing among HLA-A3<sup>+</sup>, -A11<sup>+</sup>, -A31<sup>+</sup>, and -A33<sup>+</sup> Cancer Patients
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Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
Rami G. Azrak; Shousong Cao; Harry K. Slocum; Károly Tóth; Farukh A. Durrani; Ming-biao Yin; Lakshmi Pendyala; Wanghai Zhang; Howard L. McLeod; Youcef M. Rustum
View articletitled, Therapeutic Synergy Between Irinotecan and 5-Fluorouracil against Human Tumor Xenografts
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Effects of Acyclic Retinoid on Growth, Cell Cycle Control, Epidermal Growth Factor Receptor Signaling, and Gene Expression in Human Squamous Cell Carcinoma Cells
Masahito Shimizu; Masumi Suzui; Atsuko Deguchi; Jin T. E. Lim; I. Bernard Weinstein
View articletitled, Effects of Acyclic Retinoid on Growth, Cell Cycle Control, Epidermal Growth Factor Receptor Signaling, and Gene Expression in Human Squamous Cell Carcinoma Cells
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Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells
Noriyuki Takai; Julian C. Desmond; Takashi Kumagai; Dorina Gui; Jonathan W. Said; Sadie Whittaker; Isao Miyakawa; H. Phillip Koeffler
View articletitled, Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells
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Phenylbutyrate and Phenylacetate Induce Differentiation and Inhibit Proliferation of Human Medulloblastoma Cells
Xiao-Nan Li; Suhag Parikh; Qin Shu; Hye-Lim Jung; Chi-Wan Chow; Laszlo Perlaky; Hon-Chiu Eastwood Leung; Jack Su; Susan Blaney; Ching C. Lau
View articletitled, Phenylbutyrate and Phenylacetate Induce Differentiation and Inhibit Proliferation of Human Medulloblastoma Cells
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Synergistic Cytotoxicity of Pyrazoloacridine with Doxorubicin, Etoposide, and Topotecan in Drug-Resistant Tumor Cells
YanPing Hu; Awtar Krishan; WeiJia Nie; Kasi S. Sridhar; Lawrence D. Mayer; Marcel Bally
View articletitled, Synergistic Cytotoxicity of Pyrazoloacridine with Doxorubicin, Etoposide, and Topotecan in Drug-Resistant Tumor Cells
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Multiple Myeloma Regression Mediated by Bruceantin
Muriel Cuendet; Konstantin Christov; Daniel D. Lantvit; Yunfan Deng; Samad Hedayat; Lawrence Helson; James D. McChesney; John M. Pezzuto
View articletitled, Multiple Myeloma Regression Mediated by Bruceantin
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Reduced Growth, Increased Vascular Area, and Reduced Response to Cisplatin in CD13-Overexpressing Human Ovarian Cancer Xenografts
Yvette van Hensbergen; Henk J. Broxterman; Sareena Rana; Paul J. van Diest; Monique C. A. Duyndam; Klaas Hoekman; Herbert M. Pinedo; Epie Boven
View articletitled, Reduced Growth, Increased Vascular Area, and Reduced Response to Cisplatin in CD13-Overexpressing Human Ovarian Cancer Xenografts
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Correction

Correction
View articletitled, Correction
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  • Online ISSN 1557-3265
  • Print ISSN 1078-0432

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