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Editorials

Moving Discovery into Clinical Practice

John Mendelsohn

Extract

View articletitled, Moving Discovery into Clinical Practice

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Toward Early Oral Cancer Detection using Gene Expression Profiling of Saliva: A Thoroughfare or Dead End?

William H. Westra; Joseph Califano

Extract

View articletitled, Toward Early Oral Cancer Detection using Gene Expression Profiling of Saliva: A Thoroughfare or Dead End?

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Review

Cell Cycle Genes in Ovarian Cancer: Steps Toward Earlier Diagnosis and Novel Therapies

Giuseppina D’Andrilli; Christine Kumar; Giovanni Scambia; Antonio Giordano

Abstract

View articletitled, Cell Cycle Genes in Ovarian Cancer: Steps Toward Earlier Diagnosis and Novel Therapies

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Perspective

Heat Shock Proteins and Their Use as Anticancer Vaccines

Giorgio Parmiani; Alessandro Testori; Michele Maio; Chiara Castelli; Licia Rivoltini; Lorenzo Pilla; Filiberto Belli; Vincenzo Mazzaferro; Jorgelina Coppa; Roberto Patuzzo; Mario R. Sertoli; Axel Hoos; Pramod K. Srivastava; Mario Santinami

Extract

View articletitled, Heat Shock Proteins and Their Use as Anticancer Vaccines

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Report from the FDA

Approval Summary: Docetaxel in Combination with Prednisone for the Treatment of Androgen-Independent Hormone-Refractory Prostate Cancer

Ramzi Dagher; Ning Li; Sophia Abraham; Atiqur Rahman; Raji Sridhara; Richard Pazdur

Abstract

View articletitled, Approval Summary: Docetaxel in Combination with Prednisone for the Treatment of Androgen-Independent Hormone-Refractory Prostate Cancer

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Featured Articles

Clinical Trials

Circulating Tumor Cells in Patients with Breast Cancer Dormancy

Abstract

View articletitled, Circulating Tumor Cells in Patients with Breast Cancer Dormancy

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Down-Regulation of Intratumoral Aromatase Messenger RNA Levels by Docetaxel in Human Breast Cancers

Yasuo Miyoshi; Seung Jin Kim; Kenji Akazawa; Shunji Kamigaki; Satsuki Ueda; Tetsu Yanagisawa; Tomoo Inoue; Tetsuya Taguchi; Yasuhiro Tamaki; Shinzaburo Noguchi

Abstract

View articletitled, Down-Regulation of Intratumoral Aromatase Messenger RNA Levels by Docetaxel in Human Breast Cancers

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Results of a Multicenter Randomized Phase II Trial of Thalidomide and Prednisone Maintenance Therapy for Multiple Myeloma after Autologous Stem Cell Transplant

A. Keith Stewart; Christine I. Chen; Kang Howson-Jan; Darrell White; Jean Roy; Michael J. Kovacs; Chaim Shustik; Anna Sadura; Lois Shepherd; Keyue Ding; Ralph M. Meyer; Andrew R. Belch

Abstract

View articletitled, Results of a Multicenter Randomized Phase II Trial of Thalidomide and Prednisone Maintenance Therapy for Multiple Myeloma after Autologous Stem Cell Transplant

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Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Sydney M. Evans; Kevin D. Judy; Isolde Dunphy; W. Timothy Jenkins; Wei-Ting Hwang; Peter T. Nelson; Robert A. Lustig; Kevin Jenkins; Deirdre P. Magarelli; Stephen M. Hahn; Ruth A. Collins; M. Sean Grady; Cameron J. Koch

Abstract

View articletitled, Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

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Trastuzumab Administration Can Effectively Target Chemotherapy-Resistant Cytokeratin-19 Messenger RNA–Positive Tumor Cells in the Peripheral Blood and Bone Marrow of Patients With Breast Cancer

Vassiliki Bozionellou; Dimitris Mavroudis; Maria Perraki; Savvas Papadopoulos; Stella Apostolaki; Efstathios Stathopoulos; Aliki Stathopoulou; Evi Lianidou; Vassilis Georgoulias

Abstract

View articletitled, Trastuzumab Administration Can Effectively Target Chemotherapy-Resistant Cytokeratin-19 Messenger RNA–Positive Tumor Cells in the Peripheral Blood and Bone Marrow of Patients With Breast Cancer

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Molecular Oncology, Markers, Clinical Correlates

High Frequency of Epidermal Growth Factor Receptor Mutations with Complex Patterns in Non–Small Cell Lung Cancers Related to Gefitinib Responsiveness in Taiwan

Shiu-Feng Huang; Hui-Ping Liu; Ling-Hui Li; Yuan-Chieh Ku; Yu-Ning Fu; Hsien-Yu Tsai; Ya-Ting Chen; Yung-Feng Lin; Wen-Cheng Chang; Han-Pin Kuo; Yi-Cheng Wu; Yi-Rong Chen; Shih-Feng Tsai

Abstract

View articletitled, High Frequency of Epidermal Growth Factor Receptor Mutations with Complex Patterns in Non–Small Cell Lung Cancers Related to Gefitinib Responsiveness in Taiwan

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Genetic and Expression Profiles of Squamous Cell Carcinoma of the Head and Neck Correlate with Cisplatin Sensitivity and Resistance in Cell Lines and Patients

Jan Akervall; Xiang Guo; Chao-Nan Qian; Jacqueline Schoumans; Brandon Leeser; Eric Kort; Andrew Cole; James Resau; Carol Bradford; Thomas Carey; Johan Wennerberg; Harald Anderson; Jan Tennvall; Bin T. Teh

Abstract

View articletitled, Genetic and Expression Profiles of Squamous Cell Carcinoma of the Head and Neck Correlate with Cisplatin Sensitivity and Resistance in Cell Lines and Patients

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Detection of Overexpressed and Phosphorylated Wild-Type Kit Receptor in Surgical Specimens of Small Cell Lung Cancer

Elena Tamborini; Lorena Bonadiman; Tiziana Negri; Angela Greco; Samantha Staurengo; Paolo Bidoli; Ugo Pastorino; Marco A. Pierotti; Silvana Pilotti

Abstract

View articletitled, Detection of Overexpressed and Phosphorylated Wild-Type Kit Receptor in Surgical Specimens of Small Cell Lung Cancer

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Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

Loukas G. Astrakas; David Zurakowski; A. Aria Tzika; Maria K. Zarifi; Douglas C. Anthony; Umberto De Girolami; Nancy J. Tarbell; Peter McLaren Black

Abstract

View articletitled, Noninvasive Magnetic Resonance Spectroscopic Imaging Biomarkers to Predict the Clinical Grade of Pediatric Brain Tumors

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Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Phenotype Identifies Poor Prognosis Colorectal Cancers

Stephanie Curran; Sinclair R. Dundas; Jenny Buxton; Matthew F. Leeman; Robin Ramsay; Graeme I. Murray

Abstract

View articletitled, Matrix Metalloproteinase/Tissue Inhibitors of Matrix Metalloproteinase Phenotype Identifies Poor Prognosis Colorectal Cancers

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Immunocytochemical Identification of VPAC₁, VPAC₂, and PAC₁ Receptors in Normal and Neoplastic Human Tissues with Subtype-Specific Antibodies

Solveig Schulz; Christoph Röcken; Christian Mawrin; Wolfgang Weise; Volker Höllt; Stefan Schulz

Abstract

View articletitled, Immunocytochemical Identification of VPAC1, VPAC2, and PAC1 Receptors in Normal and Neoplastic Human Tissues with Subtype-Specific Antibodies

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Experimental Therapeutics, Preclinical Pharmacology

Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer: An EGF Receptor Tyrosine Kinase Inhibitor Is Effective against MMP-7–Expressing Cancer Cells

Koshi Mimori; Keishi Yamashita; Mitsuhiko Ohta; Keiji Yoshinaga; Kenji Ishikawa; Hideshi Ishii; Tohru Utsunomiya; Graham F. Barnard; Hiroshi Inoue; Masaki Mori

Abstract

View articletitled, Coexpression of Matrix Metalloproteinase-7 (MMP-7) and Epidermal Growth Factor (EGF) Receptor in Colorectal Cancer: An EGF Receptor Tyrosine Kinase Inhibitor Is Effective against MMP-7–Expressing Cancer Cells

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Characterization of Gastrin-Induced Proangiogenic Effects In vivo in Orthotopic U373 Experimental Human Glioblastomas and In vitro in Human Umbilical Vein Endothelial Cells

Florence Lefranc; Tatjana Mijatovic; Véronique Mathieu; Sandrine Rorive; Christine Decaestecker; Olivier Debeir; Jacques Brotchi; Philippe Van Ham; Isabelle Salmon; Robert Kiss

Abstract

View articletitled, Characterization of Gastrin-Induced Proangiogenic Effects In vivo in Orthotopic U373 Experimental Human Glioblastomas and In vitro in Human Umbilical Vein Endothelial Cells

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Pseudolaric Acid B Inhibits Angiogenesis and Reduces Hypoxia-Inducible Factor 1α by Promoting Proteasome-Mediated Degradation

Mei-Hong Li; Ze-Hong Miao; Wen-Fu Tan; Jian-Min Yue; Chao Zhang; Li-Ping Lin; Xiong-Wen Zhang; Jian Ding

Abstract

View articletitled, Pseudolaric Acid B Inhibits Angiogenesis and Reduces Hypoxia-Inducible Factor 1α by Promoting Proteasome-Mediated Degradation

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Differential Effects of Delivery of Omega-3 Fatty Acids to Human Cancer Cells by Low-Density Lipoproteins versus Albumin

Iris J. Edwards; Isabelle M. Berquin; Haiguo Sun; Joseph T. O’Flaherty; Larry W. Daniel; Michael J. Thomas; Lawrence L. Rudel; Robert L. Wykle; Yong Q. Chen

Abstract

View articletitled, Differential Effects of Delivery of Omega-3 Fatty Acids to Human Cancer Cells by Low-Density Lipoproteins versus Albumin

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Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells

Frank A. Sinicrope; Robert C. Penington; Xi Ming Tang

Abstract

View articletitled, Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis Is Inhibited by Bcl-2 but Restored by the Small Molecule Bcl-2 Inhibitor, HA 14-1, in Human Colon Cancer Cells

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Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window

Hiroko Shibata; Yasuo Yoshioka; Shinji Ikemizu; Kyoko Kobayashi; Yoko Yamamoto; Yohei Mukai; Takayuki Okamoto; Madoka Taniai; Maki Kawamura; Yasuhiro Abe; Shinsaku Nakagawa; Takao Hayakawa; Satoshi Nagata; Yuriko Yamagata; Tadanori Mayumi; Haruhiko Kamada; Yasuo Tsutsumi

Abstract

View articletitled, Functionalization of Tumor Necrosis Factor-α Using Phage Display Technique and PEGylation Improves Its Antitumor Therapeutic Window

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Regular Articles

Clinical Trials

Phase I Clinical Trial of the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolate Mofetil (Cellcept) in Advanced Multiple Myeloma Patients

Naoko Takebe; Xiangfei Cheng; Suhlan Wu; Kenneth Bauer; Olga G. Goloubeva; Robert G. Fenton; Meyer Heyman; Aaron P. Rapoport; Ashraf Badros; John Shaughnessy; Douglas Ross; Barry Meisenberg; Guido Tricot

Abstract

View articletitled, Phase I Clinical Trial of the Inosine Monophosphate Dehydrogenase Inhibitor Mycophenolate Mofetil (Cellcept) in Advanced Multiple Myeloma Patients

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Human Autologous Tumor-Specific T-Cell Responses Induced by Liposomal Delivery of a Lymphoma Antigen

Sattva S. Neelapu; Sivasubramanian Baskar; Barry L. Gause; Carol B. Kobrin; Thelma M. Watson; Andrea Robin Frye; Robin Pennington; Linda Harvey; Elaine S. Jaffe; Richard J. Robb; Mircea C. Popescu; Larry W. Kwak

Abstract

View articletitled, Human Autologous Tumor-Specific T-Cell Responses Induced by Liposomal Delivery of a Lymphoma Antigen

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Phase I/II Randomized Trial Evaluating the Safety and Clinical Effects of Repifermin Administered to Reduce Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

Cesar O. Freytes; Voravit Ratanatharathorn; Charles Taylor; Camille Abboud; Nancy Chesser; Alejandro Restrepo; Jorge Arango; Daniel Odenheimer

Abstract

View articletitled, Phase I/II Randomized Trial Evaluating the Safety and Clinical Effects of Repifermin Administered to Reduce Mucositis in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

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Prospective Evaluation of Body Surface Area as a Determinant of Paclitaxel Pharmacokinetics and Pharmacodynamics in Women with Solid Tumors: Cancer and Leukemia Group B Study 9763

Antonius A. Miller; Gary L. Rosner; Merrill J. Egorin; Donna Hollis; Stuart M. Lichtman; Mark J. Ratain; for the Cancer and Leukemia Group B

Abstract

View articletitled, Prospective Evaluation of Body Surface Area as a Determinant of Paclitaxel Pharmacokinetics and Pharmacodynamics in Women with Solid Tumors: Cancer and Leukemia Group B Study 9763

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A Pilot Study to Establish a Clinical Model to Perform Phase II Studies of Breast Cancer Chemopreventive Agents in Women at High Risk with Biomarkers as Surrogate Endpoints for Activity

Vered Stearns; Ann Gallagher; Celina G. Kleer; Baljit Singh; Matthew Freedman; Bassem R. Haddad; Claudine Isaacs; Robert Warren; Martha Brown; Jennifer Cullen; Bruce Trock; Daniel F. Hayes

Abstract

View articletitled, A Pilot Study to Establish a Clinical Model to Perform Phase II Studies of Breast Cancer Chemopreventive Agents in Women at High Risk with Biomarkers as Surrogate Endpoints for Activity

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Factors Affecting Cytochrome P-450 3A Activity in Cancer Patients

Sharyn D. Baker; Ron H. N. van Schaik; Laurent P. Rivory; Albert J. ten Tije; Kimberly Dinh; Wilfried J. Graveland; Paul W. Schenk; Kellie A. Charles; Stephen J. Clarke; Michael A. Carducci; William P. McGuire; Fitzroy Dawkins; Hans Gelderblom; Jaap Verweij; Alex Sparreboom

Abstract

View articletitled, Factors Affecting Cytochrome P-450 3A Activity in Cancer Patients

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Cancer Biology, Immunology, Cytokines

Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion

Shailesh Singh; Udai P. Singh; Jonathan K. Stiles; William E. Grizzle; James W. Lillard, Jr.

Abstract

View articletitled, Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer

George V. Thomas; Steve Horvath; Bradley L. Smith; Katherine Crosby; Lori A. Lebel; Matthew Schrage; Jonathan Said; Jean De Kernion; Robert E. Reiter; Charles L. Sawyers

Abstract

View articletitled, Antibody-Based Profiling of the Phosphoinositide 3-Kinase Pathway in Clinical Prostate Cancer

Supplementary data

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Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial Adenomatous Polyposis

Irfan M. Hisamuddin; Mohammad A. Wehbi; Ann Chao; Hadley W. Wyre; Linda M. Hylind; Francis M. Giardiello; Vincent W. Yang

Abstract

View articletitled, Genetic Polymorphisms of Human Flavin Monooxygenase 3 in Sulindac-Mediated Primary Chemoprevention of Familial Adenomatous Polyposis

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ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer

Nobuhisa Ishikawa; Yataro Daigo; Wataru Yasui; Kouki Inai; Hitoshi Nishimura; Eiju Tsuchiya; Nobuoki Kohno; Yusuke Nakamura

Abstract

View articletitled, ADAM8 as a Novel Serological and Histochemical Marker for Lung Cancer

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Relative Bcl-2 Independence of Drug-Induced Cytotoxicity and Resistance in 518A2 Melanoma Cells

Luba Benimetskaya; Johnathan C. Lai; Anastasia Khvorova; Sijian Wu; Emily Hua; Paul Miller; Li-Ming Zhang; Cy A. Stein

Abstract

View articletitled, Relative Bcl-2 Independence of Drug-Induced Cytotoxicity and Resistance in 518A2 Melanoma Cells

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Artificial Neural Networks Analysis of Surface-Enhanced Laser Desorption/Ionization Mass Spectra of Serum Protein Pattern Distinguishes Colorectal Cancer from Healthy Population

Yi-ding Chen; Shu Zheng; Jie-kai Yu; Xun Hu

Abstract

View articletitled, Artificial Neural Networks Analysis of Surface-Enhanced Laser Desorption/Ionization Mass Spectra of Serum Protein Pattern Distinguishes Colorectal Cancer from Healthy Population

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Cancer-Associated Expression of Minichromosome Maintenance 3 Gene in Several Human Cancers and Its Involvement in Tumorigenesis

Seon-Ah Ha; Seung Min Shin; Hong Namkoong; Heejeong Lee; Goang Won Cho; Soo Young Hur; Tae Eung Kim; Jin Woo Kim

Abstract

View articletitled, Cancer-Associated Expression of Minichromosome Maintenance 3 Gene in Several Human Cancers and Its Involvement in Tumorigenesis

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Immunohistochemical and Molecular Analysis of Human Melanomas for Expression of the Human Cancer-Testis Antigens NY-ESO-1 and LAGE-1

Hilary A. Vaughan; Suzanne Svobodova; Duncan MacGregor; Sue Sturrock; Achim A. Jungbluth; Judy Browning; Ian D. Davis; Philip Parente; Yao-Tseng Chen; Elisabeth Stockert; Fiona St. Clair; Lloyd J. Old; Jonathan Cebon

Abstract

View articletitled, Immunohistochemical and Molecular Analysis of Human Melanomas for Expression of the Human Cancer-Testis Antigens NY-ESO-1 and LAGE-1

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Hypoxia-Inducible Factor 1α Expression as an Intrinsic Marker of Hypoxia: Correlation with Tumor Oxygen, Pimonidazole Measurements, and Outcome in Locally Advanced Carcinoma of the Cervix

Gillian J. Hutchison; Helen R. Valentine; Juliette A. Loncaster; Susan E. Davidson; Robert D. Hunter; Stephen A. Roberts; Adrian L. Harris; Ian J. Stratford; Patricia M. Price; Catharine M. L. West

Abstract

View articletitled, Hypoxia-Inducible Factor 1α Expression as an Intrinsic Marker of Hypoxia: Correlation with Tumor Oxygen, Pimonidazole Measurements, and Outcome in Locally Advanced Carcinoma of the Cervix

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Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer: Its Relationship to Lymph Node Metastasis

Hiroshi Kurahara; Sonshin Takao; Kousei Maemura; Hiroyuki Shinchi; Shoji Natsugoe; Takashi Aikou

Abstract

View articletitled, Impact of Vascular Endothelial Growth Factor-C and -D Expression in Human Pancreatic Cancer: Its Relationship to Lymph Node Metastasis

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mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms

Fikret Sahin; Rajesh Kannangai; Onikepe Adegbola; Jianzhou Wang; Gloria Su; Michael Torbenson

Abstract

View articletitled, mTOR and P70 S6 Kinase Expression in Primary Liver Neoplasms

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High Expression of Neuropeptide Y Receptors in Tumors of the Human Adrenal Gland and Extra-Adrenal Paraganglia

Meike Körner; Beatrice Waser; Jean Claude Reubi

Abstract

View articletitled, High Expression of Neuropeptide Y Receptors in Tumors of the Human Adrenal Gland and Extra-Adrenal Paraganglia

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Low Levels of Insulin-Like Growth Factor Type 1 Receptor Expression at Cancer Cell Membrane Predict Liver Metastasis in Dukes’ C Human Colorectal Cancers

Michio Nakamura; Shin’ichi Miyamoto; Hiroyuki Maeda; Shi-chuan Zhang; Takafumi Sangai; Genichiro Ishii; Takahiro Hasebe; Yasushi Endoh; Norio Saito; Masahiro Asaka; Atsushi Ochiai

Abstract

View articletitled, Low Levels of Insulin-Like Growth Factor Type 1 Receptor Expression at Cancer Cell Membrane Predict Liver Metastasis in Dukes’ C Human Colorectal Cancers

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Salivary Transcriptome Diagnostics for Oral Cancer Detection

Yang Li; Maie A. R. St. John; Xiaofeng Zhou; Yong Kim; Uttam Sinha; Richard C. K. Jordan; David Eisele; Elliot Abemayor; David Elashoff; No-Hee Park; David T. Wong

Abstract

View articletitled, Salivary Transcriptome Diagnostics for Oral Cancer Detection

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Correlation of Protease-Activated Receptor-1 With Differentiation Markers in Squamous Cell Carcinoma of the Head and Neck and Its Implication in Lymph Node Metastasis

Xin Zhang; Jennifer L. Hunt; Doug P. Landsittel; Susan Muller; Karen Adler-Storthz; Robert L. Ferris; Dong M. Shin; Zhuo (Georgia) Chen

Abstract

View articletitled, Correlation of Protease-Activated Receptor-1 With Differentiation Markers in Squamous Cell Carcinoma of the Head and Neck and Its Implication in Lymph Node Metastasis

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Nuclear Factor-κB Nuclear Localization Is Predictive of Biochemical Recurrence in Patients with Positive Margin Prostate Cancer

Vincent Fradet; Laurent Lessard; Louis R. Bégin; Pierre Karakiewicz; Anne-Marie Mes Masson; Fred Saad

Abstract

View articletitled, Nuclear Factor-κB Nuclear Localization Is Predictive of Biochemical Recurrence in Patients with Positive Margin Prostate Cancer

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Cyclooxygenase-2 Expression: A Significant Prognostic Indicator for Patients With Colorectal Cancer

Labile Togba Soumaoro; Hiroyuki Uetake; Tetsuro Higuchi; Yoko Takagi; Masayuki Enomoto; Kenichi Sugihara

Abstract

View articletitled, Cyclooxygenase-2 Expression: A Significant Prognostic Indicator for Patients With Colorectal Cancer

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A Quantitative Promoter Methylation Profile of Prostate Cancer

Carmen Jerónimo; Rui Henrique; Mohammad O. Hoque; Elizabeth Mambo; Franclim R. Ribeiro; Graça Varzim; Jorge Oliveira; Manuel R. Teixeira; Carlos Lopes; David Sidransky

Abstract

View articletitled, A Quantitative Promoter Methylation Profile of Prostate Cancer

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Loss of Heterozygosity and Immunohistochemistry of Adenocarcinomas of the Esophagus and Gastric Cardia

Willem A. Marsman; Rakesh S. Birjmohun; Bastiaan P. van Rees; Eric Caspers; G. Johan; A. Offerhaus; Piter J. Bosma; J. Jan; B. van Lanschot

Abstract

View articletitled, Loss of Heterozygosity and Immunohistochemistry of Adenocarcinomas of the Esophagus and Gastric Cardia

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Cyclin A as a Predictive Factor for Chemotherapy Response in Advanced Head and Neck Cancer

Maria Rodriguez-Pinilla; Jose L. Rodriguez-Peralto; Ricardo Hitt; Jose J. Sanchez; Claudio Ballestin; Ana Diez; Lydia Sanchez-Verde; Francesc Alameda; Montserrat Sanchez-Cespedes

Abstract

View articletitled, Cyclin A as a Predictive Factor for Chemotherapy Response in Advanced Head and Neck Cancer

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Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

Qiwei Yang; Peter Zage; David Kagan; Yufeng Tian; Roopa Seshadri; Helen R. Salwen; Shuqing Liu; Alexandre Chlenski; Susan L. Cohn

Abstract

View articletitled, Association of Epigenetic Inactivation of RASSF1A with Poor Outcome in Human Neuroblastoma

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Small Integrin Binding Ligand N-Linked Glycoprotein Gene Family Expression in Different Cancers

Larry W. Fisher; Alka Jain; Matt Tayback; Neal S. Fedarko

Abstract

View articletitled, Small Integrin Binding Ligand N-Linked Glycoprotein Gene Family Expression in Different Cancers

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Mitochondrial DNA Quantity Increases with Histopathologic Grade in Premalignant and Malignant Head and Neck Lesions

Michael M. Kim; John D. Clinger; Brett G. Masayesva; Patrick K. Ha; Marianna L. Zahurak; William H. Westra; Joseph A. Califano

Abstract

View articletitled, Mitochondrial DNA Quantity Increases with Histopathologic Grade in Premalignant and Malignant Head and Neck Lesions

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MAP2K4/MKK4 Expression in Pancreatic Cancer: Genetic Validation of Immunohistochemistry and Relationship to Disease Course

Wei Xin; Ki J. Yun; Francesca Ricci; Marianna Zahurak; Wanglong Qiu; Gloria H. Su; Charles J. Yeo; Ralph H. Hruban; Scott E. Kern; Christine A. Iacobuzio-Donahue

Abstract

View articletitled, MAP2K4/MKK4 Expression in Pancreatic Cancer: Genetic Validation of Immunohistochemistry and Relationship to Disease Course

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Transcription Factor AP-2γ Is a Developmentally Regulated Marker of Testicular Carcinoma In situ and Germ Cell Tumors

Christina E. Hoei-Hansen; John E. Nielsen; Kristian Almstrup; Si Brask Sonne; Niels Graem; Niels E. Skakkebaek; Henrik Leffers; Ewa Rajpert-De Meyts

Abstract

View articletitled, Transcription Factor AP-2γ Is a Developmentally Regulated Marker of Testicular Carcinoma In situ and Germ Cell Tumors

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Prognostic Relevance of Increased Angiogenesis in Osteosarcoma

Michael Kreuter; Ralf Bieker; Stefan S. Bielack; Tanja Auras; Horst Buerger; Georg Gosheger; Heribert Jurgens; Wolfgang E. Berdel; Rolf M. Mesters

Abstract

View articletitled, Prognostic Relevance of Increased Angiogenesis in Osteosarcoma

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Differences in Prognostic Molecular Markers between Women Over and Under 45 Years of Age with Advanced Ovarian Cancer

John K. Chan; Vera Loizzi; Alessandra Magistris; Fritz Lin; Joanne Rutgers; Kathryn Osann; Philip J. DiSaia; Michael L. Berman

Abstract

View articletitled, Differences in Prognostic Molecular Markers between Women Over and Under 45 Years of Age with Advanced Ovarian Cancer

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OCT4: A Sensitive and Specific Biomarker for Intratubular Germ Cell Neoplasia of the Testis

Timothy D. Jones; Thomas M. Ulbright; John N. Eble; Liang Cheng

Abstract

View articletitled, OCT4: A Sensitive and Specific Biomarker for Intratubular Germ Cell Neoplasia of the Testis

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Flt-4–Positive Endothelial Cell Density and Its Clinical Significance in Non–Small Cell Lung Cancer

Fengshi Chen; Kazumasa Takenaka; Eiji Ogawa; Kazuhiro Yanagihara; Yosuke Otake; Hiromi Wada; Fumihiro Tanaka

Abstract

View articletitled, Flt-4–Positive Endothelial Cell Density and Its Clinical Significance in Non–Small Cell Lung Cancer

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Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients: Correlation with Tumor Angiogenesis and Cyclooxygenase-2 Expression

Hiroshi Yoshimura; Dipok Kumar Dhar; Hitoshi Kohno; Hirofumi Kubota; Toshiyuki Fujii; Shuhei Ueda; Shoichi Kinugasa; Mitsuo Tachibana; Naofumi Nagasue

Abstract

View articletitled, Prognostic Impact of Hypoxia-Inducible Factors 1α and 2α in Colorectal Cancer Patients: Correlation with Tumor Angiogenesis and Cyclooxygenase-2 Expression

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Experimental Therapeutics, Preclinical Pharmacology

Efficacy and Safety Evaluation of Human Reovirus Type 3 in Immunocompetent Animals: Racine and Nonhuman Primates

Abstract

View articletitled, Efficacy and Safety Evaluation of Human Reovirus Type 3 in Immunocompetent Animals: Racine and Nonhuman Primates

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Ring Finger Protein 43 as a New Target for Cancer Immunotherapy

Naotaka Uchida; Takuya Tsunoda; Satoshi Wada; Yoichi Furukawa; Yusuke Nakamura; Hideaki Tahara

Abstract

View articletitled, Ring Finger Protein 43 as a New Target for Cancer Immunotherapy

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ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: Schedule-Dependent Enhancement of Antitumor Activity

Kaye J. Williams; Brian A. Telfer; Sandra Brave; Jane Kendrew; Lynsey Whittaker; Ian J. Stratford; Stephen R. Wedge

Abstract

View articletitled, ZD6474, a Potent Inhibitor of Vascular Endothelial Growth Factor Signaling, Combined With Radiotherapy: Schedule-Dependent Enhancement of Antitumor Activity

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Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer

Bradley A. Schiff; Andrea B. McMurphy; Samar A. Jasser; Maher N. Younes; Dao Doan; Orhan G. Yigitbasi; Seungwon Kim; Ge Zhou; Mahitosh Mandal; Benjamin N. Bekele; F. Christopher Holsinger; Steven I. Sherman; Sai-Ching Yeung; Adel K. El-Naggar; Jeffrey N. Myers

Abstract

View articletitled, Epidermal Growth Factor Receptor (EGFR) Is Overexpressed in Anaplastic Thyroid Cancer, and the EGFR Inhibitor Gefitinib Inhibits the Growth of Anaplastic Thyroid Cancer

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Cancer Therapy with a Replicating Oncolytic Adenovirus Targeting the Hypoxic Microenvironment of Tumors

Dawn E. Post; Narra Sarojini Devi; Zhenchao Li; Daniel J. Brat; Balveen Kaur; Ainsley Nicholson; Jeffrey J. Olson; Zhaobin Zhang; Erwin G. Van Meir

Abstract

View articletitled, Cancer Therapy with a Replicating Oncolytic Adenovirus Targeting the Hypoxic Microenvironment of Tumors

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Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Does Not Improve Paclitaxel Effect in an Orthotopic Mouse Model of Lung Cancer

Amir Onn; Takeshi Isobe; Wenjuan Wu; Satoshi Itasaka; Tomoaki Shintani; Keiko Shibuya; Yokoi Kenji; Michael S. O’Reilly; Isaiah J. Fidler; Roy S. Herbst

Abstract

View articletitled, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Does Not Improve Paclitaxel Effect in an Orthotopic Mouse Model of Lung Cancer

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Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma

John F. DiJoseph; Mary E. Goad; Maureen M. Dougher; Erwin R. Boghaert; Arthur Kunz; Philip R. Hamann; Nitin K. Damle

Abstract

View articletitled, Potent and Specific Antitumor Efficacy of CMC-544, a CD22-Targeted Immunoconjugate of Calicheamicin, against Systemically Disseminated B-Cell Lymphoma

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Mouse Homologue of a Novel Human Oncofetal Antigen, Glypican-3, Evokes T-Cell–Mediated Tumor Rejection without Autoimmune Reactions in Mice

Tetsuya Nakatsura; Hiroyuki Komori; Tatsuko Kubo; Yoshihiro Yoshitake; Satoru Senju; Toyomasa Katagiri; Yoichi Furukawa; Michio Ogawa; Yusuke Nakamura; Yasuharu Nishimura

Abstract

View articletitled, Mouse Homologue of a Novel Human Oncofetal Antigen, Glypican-3, Evokes T-Cell–Mediated Tumor Rejection without Autoimmune Reactions in Mice

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Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemocombination with Doxorubicin Targeting Nuclear Factor κB–Mediated Inducible Chemoresistance

Rana P. Singh; G. U. Mallikarjuna; Girish Sharma; Sivanandhan Dhanalakshmi; Anil K. Tyagi; Daniel C. F. Chan; Chapla Agarwal; Rajesh Agarwal

Abstract

View articletitled, Oral Silibinin Inhibits Lung Tumor Growth in Athymic Nude Mice and Forms a Novel Chemocombination with Doxorubicin Targeting Nuclear Factor κB–Mediated Inducible Chemoresistance

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3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor, Fluvastatin, as a Novel Agent for Prophylaxis of Renal Cancer Metastasis

Akio Horiguchi; Makoto Sumitomo; Junichi Asakuma; Takako Asano; Tomohiko Asano; Masamichi Hayakawa

Abstract

View articletitled, 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitor, Fluvastatin, as a Novel Agent for Prophylaxis of Renal Cancer Metastasis

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A Selective Retinoid X Receptor Agonist Bexarotene (Targretin) Prevents and Overcomes Acquired Paclitaxel (Taxol) Resistance in Human Non–Small Cell Lung Cancer

Wan-Ching Yen; Manny R. Corpuz; Rene Y. Prudente; Tracy A. Cooke; Reid P. Bissonnette; Andrés Negro-Vilar; William W. Lamph

Abstract

View articletitled, A Selective Retinoid X Receptor Agonist Bexarotene (Targretin) Prevents and Overcomes Acquired Paclitaxel (Taxol) Resistance in Human Non–Small Cell Lung Cancer

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2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

Justin L. Ricker; Zhong Chen; Xin Ping Yang; Victor S. Pribluda; Glenn M. Swartz; Carter Van Waes

Abstract

View articletitled, 2-Methoxyestradiol Inhibits Hypoxia-Inducible Factor 1α, Tumor Growth, and Angiogenesis and Augments Paclitaxel Efficacy in Head and Neck Squamous Cell Carcinoma

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Preparation and Biological Evaluation of Copper-64–Labeled Tyr³-Octreotate Using a Cross-Bridged Macrocyclic Chelator

Jennifer E. Sprague; Yijie Peng; Xiankai Sun; Gary R. Weisman; Edward H. Wong; Samuel Achilefu; Carolyn J. Anderson

Abstract

View articletitled, Preparation and Biological Evaluation of Copper-64–Labeled Tyr3-Octreotate Using a Cross-Bridged Macrocyclic Chelator

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Lactoferrin Down-Regulates G₁ Cyclin-Dependent Kinases during Growth Arrest of Head and Neck Cancer Cells

Yan Xiao; Constance L. Monitto; Khalid M. Minhas; David Sidransky

Abstract

View articletitled, Lactoferrin Down-Regulates G1 Cyclin-Dependent Kinases during Growth Arrest of Head and Neck Cancer Cells

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Selective Induction of Apoptosis with Proton Pump Inhibitor in Gastric Cancer Cells

Marie Yeo; Dong-Kyu Kim; Young-Bae Kim; Tae Young Oh; Jong-Eun Lee; Sung Won Cho; Hugh Chul Kim; Ki-Baik Hahm

Abstract

View articletitled, Selective Induction of Apoptosis with Proton Pump Inhibitor in Gastric Cancer Cells

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A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

Tyler O. Kirby; Angel Rivera; Daniel Rein; Minghui Wang; Ilya Ulasov; Martina Breidenbach; Manjula Kataram; Juan L. Contreras; Carlos Krumdieck; Masato Yamamoto; Marianne G. Rots; Hidde J. Haisma; Ronald D. Alvarez; Parameshwar J. Mahasreshti; David T. Curiel

Abstract

View articletitled, A Novel Ex vivo Model System for Evaluation of Conditionally Replicative Adenoviruses Therapeutic Efficacy and Toxicity

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Induction of Apoptosis by Flavopiridol in Human Neuroblastoma Cells Is Enhanced under Hypoxia and Associated With N-myc Proto-oncogene Down-Regulation

Maura Puppo; Sandra Pastorino; Giovanni Melillo; Annalisa Pezzolo; Luigi Varesio; Maria Carla Bosco

Abstract

View articletitled, Induction of Apoptosis by Flavopiridol in Human Neuroblastoma Cells Is Enhanced under Hypoxia and Associated With N-myc Proto-oncogene Down-Regulation

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Intermittent Hypoxia Induces Proteasome-Dependent Down-Regulation of Estrogen Receptor α in Human Breast Carcinoma

Charlton Cooper; Guang-Yu Liu; Yu-Lian Niu; Sylvia Santos; Leigh C. Murphy; Peter H. Watson

Abstract

View articletitled, Intermittent Hypoxia Induces Proteasome-Dependent Down-Regulation of Estrogen Receptor α in Human Breast Carcinoma

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Combination Antiangiogenic and Androgen Deprivation Therapy for Prostate Cancer: A Promising Therapeutic Approach

Brian Nicholson; Kathryn Gulding; Mark Conaway; Stephen R. Wedge; Dan Theodorescu

Abstract

View articletitled, Combination Antiangiogenic and Androgen Deprivation Therapy for Prostate Cancer: A Promising Therapeutic Approach

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Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier

Rongbao Zhao; Shrikanta Chattopadhyay; Marie Hanscom; I. David Goldman

Abstract

View articletitled, Antifolate Resistance in a HeLa Cell Line Associated With Impaired Transport Independent of the Reduced Folate Carrier

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Letters to the Editor

Mesothelin: A New Target for Immunotherapy

Denise R. Shaw; Zhanat E. Muminova; Theresa V. Strong

Extract

View articletitled, Mesothelin: A New Target for Immunotherapy

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Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cancer

Peter Krippl; Uwe Langsenlehner; Hellmut Samonigg; Wilfried Renner; Herwig Köppel

Extract

View articletitled, Vascular Endothelial Growth Factor in Predicting Outcome in Breast Cancer

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