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Issues

Volume 10, Issue 22
15 November 2004
Issue Cover
All Issues
ISSN 1078-0432
EISSN 1557-3265

Perspective

Recurrent Ovarian Cancer: How Important Is It to Treat to Disease Progression?
Thomas J. Herzog
View articletitled, Recurrent Ovarian Cancer<span class="subtitle-colon">: </span><span class="subtitle">How Important Is It to Treat to Disease Progression?</span>
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Featured Articles

Clinical Trials
A Phase I Trial of Perifosine (NSC 639966) on a Loading Dose/Maintenance Dose Schedule in Patients with Advanced Cancer
Lynn Van Ummersen; Kim Binger; Jennifer Volkman; Rebecca Marnocha; Kendra Tutsch; Jill Kolesar; Rhoda Arzoomanian; Dona Alberti; George Wilding
View articletitled, A Phase I Trial of Perifosine (NSC 639966) on a Loading Dose/Maintenance Dose Schedule in Patients with Advanced Cancer
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Molecular Oncology, Markers, Clinical Correlates
Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients
Martin G. Friedrich; Daniel J. Weisenberger; Jonathan C. Cheng; Shahin Chandrasoma; Kimberly D. Siegmund; Mark L. Gonzalgo; Marieta I. Toma; Hartwig Huland; Christine Yoo; Yvonne C. Tsai; Peter W. Nichols; Bernard H. Bochner; Peter A. Jones; Gangning Liang
View articletitled, Detection of Methylated Apoptosis-Associated Genes in Urine Sediments of Bladder Cancer Patients
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Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer
Isabelle Treilleux; Jean-Yves Blay; Nathalie Bendriss-Vermare; Isabelle Ray-Coquard; Thomas Bachelot; Jean-Paul Guastalla; Alain Bremond; Sophie Goddard; Jean-Jacques Pin; Clarisse Barthelemy-Dubois; Serge Lebecque
View articletitled, Dendritic Cell Infiltration and Prognosis of Early Stage Breast Cancer
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Epigenetic Inactivation of ID4 in Colorectal Carcinomas Correlates with Poor Differentiation and Unfavorable Prognosis
Naoyuki Umetani; Hiroya Takeuchi; Akihide Fujimoto; Masaru Shinozaki; Anton J. Bilchik; Dave S. B. Hoon
View articletitled, Epigenetic Inactivation of <strong><em>ID4</em></strong> in Colorectal Carcinomas Correlates with Poor Differentiation and Unfavorable Prognosis
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p16INK4A Hypermethylation Is Associated with Hepatitis Virus Infection, Age, and Gender in Hepatocellular Carcinoma
Xin Li; Ai-Min Hui; Lin Sun; Kiyoshi Hasegawa; Guido Torzilli; Masami Minagawa; Tadatoshi Takayama; Masatoshi Makuuchi
View articletitled, p16<sup>INK4A</sup> Hypermethylation Is Associated with Hepatitis Virus Infection, Age, and Gender in Hepatocellular Carcinoma
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Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer
Torsten A. Hopp; Heidi L. Weiss; Irma S. Parra; Yukun Cui; C. Kent Osborne; Suzanne A. W. Fuqua
View articletitled, Low Levels of Estrogen Receptor β Protein Predict Resistance to Tamoxifen Therapy in Breast Cancer
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Proteomic Analysis to Identify Breast Cancer Biomarkers in Nipple Aspirate Fluid
Hannah Alexander; Andrew L. Stegner; Colette Wagner-Mann; Garrett C. Du Bois; Stephen Alexander; Edward R. Sauter
View articletitled, Proteomic Analysis to Identify Breast Cancer Biomarkers in Nipple Aspirate Fluid
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The Use of Real-Time Reverse Transcription-PCR for Prostate-Specific Antigen mRNA to Discriminate between Blood Samples from Healthy Volunteers and from Patients with Metastatic Prostate Cancer
Kinnari Patel; Peter J. Whelan; Stephen Prescott; Samantha C. Brownhill; Colin F. Johnston; Peter J. Selby; Susan A. Burchill
View articletitled, The Use of Real-Time Reverse Transcription-PCR for Prostate-Specific Antigen mRNA to Discriminate between Blood Samples from Healthy Volunteers and from Patients with Metastatic Prostate Cancer
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Experimental Therapeutics, Preclinical Pharmacology
Differential Radiosensitization in DNA Mismatch Repair-Proficient and -Deficient Human Colon Cancer Xenografts with 5-Iodo-2-pyrimidinone-2′-deoxyribose
Yuji Seo; Tao Yan; Jane E. Schupp; Valdir Colussi; Kerri L. Taylor; Timothy J. Kinsella
View articletitled, Differential Radiosensitization in DNA Mismatch Repair-Proficient and -Deficient Human Colon Cancer Xenografts with 5-Iodo-2-pyrimidinone-2′-deoxyribose
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The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma
Takashi Ishida; Shinsuke Iida; Yoshiki Akatsuka; Toshihiko Ishii; Mikinori Miyazaki; Hirokazu Komatsu; Hiroshi Inagaki; Noriko Okada; Teizo Fujita; Kenya Shitara; Shiro Akinaga; Toshitada Takahashi; Atae Utsunomiya; Ryuzo Ueda
View articletitled, The CC Chemokine Receptor 4 as a Novel Specific Molecular Target for Immunotherapy in Adult T-Cell Leukemia/Lymphoma
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Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment
Toshiaki Hayashi; Teru Hideshima; Aaron N. Nguyen; Olivier Munoz; Klaus Podar; Makoto Hamasaki; Kenji Ishitsuka; Hiroshi Yasui; Paul Richardson; Sarvajit Chakravarty; Alison Murphy; Dharminder Chauhan; Linda S. Higgins; Kenneth C. Anderson
View articletitled, Transforming Growth Factor β Receptor I Kinase Inhibitor Down-Regulates Cytokine Secretion and Multiple Myeloma Cell Growth in the Bone Marrow Microenvironment
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Regular Articles

Clinical Trials
Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Represses Cyclin D1 in Aerodigestive Tract Cancers
W. Jeffrey Petty; Konstantin H. Dragnev; Vincent A. Memoli; Yan Ma; Neil B. Desai; Adrian Biddle; Thomas H. Davis; William C. Nugent; Natalie Memoli; Marta Hamilton; Kenneth K. Iwata; James R. Rigas; Ethan Dmitrovsky
View articletitled, Epidermal Growth Factor Receptor Tyrosine Kinase Inhibition Represses Cyclin D1 in Aerodigestive Tract Cancers
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ING-1, a Monoclonal Antibody Targeting Ep-CAM in Patients with Advanced Adenocarcinomas
Johann S. de Bono; Anthony W. Tolcher; Andre Forero; Gertrude F. A. Vanhove; Chris Takimoto; Robert J. Bauer; Lisa A. Hammond; Amita Patnaik; Mark L. White; Sui Shen; Muhammad B. Khazaeli; Eric K. Rowinsky; Albert F. LoBuglio
View articletitled, ING-1, a Monoclonal Antibody Targeting Ep-CAM in Patients with Advanced Adenocarcinomas
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Characterization and Multiparameter Analysis of Visual Adverse Events in Irofulven Single-Agent Phase I and II Trials
Eric Raymond; Carmen Kahatt; Marie Hélène Rigolet; William Sutherland; François Lokiec; Jérôme Alexandre; Bertrand Tombal; Michael Elman; Michael S. Lee; John R. MacDonald; Michael Cullen; Jean-Louis Misset; Esteban Cvitkovic
View articletitled, Characterization and Multiparameter Analysis of Visual Adverse Events in Irofulven Single-Agent Phase I and II Trials
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Associations between Serum Testosterone Fall and Cognitive Function in Prostate Cancer Patients
Eeva K. Salminen; Raija I. Portin; Aki Koskinen; Hans Helenius; Martti Nurmi
View articletitled, Associations between Serum Testosterone Fall and Cognitive Function in Prostate Cancer Patients
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A Pilot Surrogate End Point Biomarker Trial of Perillyl Alcohol in Breast Neoplasia
Vered Stearns; Andrew Coop; Baljit Singh; Ann Gallagher; Hideko Yamauchi; Ronald Lieberman; Marie Pennanen; Bruce Trock; Daniel F. Hayes; Matthew J. Ellis
View articletitled, A Pilot Surrogate End Point Biomarker Trial of Perillyl Alcohol in Breast Neoplasia
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Cancer Biology, Immunology, Cytokines
Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis
Soichi Tsutsumi; Takashi Yanagawa; Tatsuo Shimura; Hiroyuki Kuwano; Avraham Raz
View articletitled, Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis
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Research Articles

Molecular Oncology, Markers, Clinical Correlates
Methylenetetrahydrofolate Reductase Genotype Affects Risk of Relapse after Hematopoietic Cell Transplantation for Chronic Myelogenous Leukemia
Kim Robien; Cornelia M. Ulrich; Jeannette Bigler; Yutaka Yasui; Ted Gooley; Barbara Bruemmer; John D. Potter; Jerald P. Radich
View articletitled, Methylenetetrahydrofolate Reductase Genotype Affects Risk of Relapse after Hematopoietic Cell Transplantation for Chronic Myelogenous Leukemia
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CD34+ Cells from Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Normal Bone Marrow Display Different Apoptosis and Drug Resistance–Associated Phenotypes
Lilia Suárez; María-Belén Vidriales; José García-Laraña; Guillermo Sanz; María-José Moreno; Antonio López; Susana Barrena; Rafael Martínez; Mar Tormo; Luis Palomera; Esperanza Lavilla; Ma Consuelo López-Berges; María de Santiago; M. Encarnación Pérez de Equiza; Jesús F. San Miguel; Alberto Orfao; for the PETHEMA Cooperative Group
View articletitled, CD34<sup>+</sup> Cells from Acute Myeloid Leukemia, Myelodysplastic Syndromes, and Normal Bone Marrow Display Different Apoptosis and Drug Resistance–Associated Phenotypes
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Inactivation of the FHIT Gene Favors Bladder Cancer Development
Andrea Vecchione; Cinzia Sevignani; Enrico Giarnieri; Nicola Zanesi; Hideshi Ishii; Rossano Cesari; Louise Y. Y. Fong; Leonard G. Gomella; Carlo M. Croce; Raffaele Baffa
View articletitled, Inactivation of the <strong><em>FHIT</em></strong> Gene Favors Bladder Cancer Development
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A Clinicobiological Model Predicting Survival in Medulloblastoma
Amit Ray; Michael Ho; Jing Ma; Robert K. Parkes; Todd G. Mainprize; Shigeo Ueda; John McLaughlin; Eric Bouffet; James T. Rutka; Cynthia E. Hawkins
View articletitled, A Clinicobiological Model Predicting Survival in Medulloblastoma
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Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis
Johanna M. Pellikainen; Kirsi M. Ropponen; Vesa V. Kataja; Jari K. Kellokoski; Matti J. Eskelinen; Veli-Matti Kosma
View articletitled, Expression of Matrix Metalloproteinase (MMP)-2 and MMP-9 in Breast Cancer with a Special Reference to Activator Protein-2, HER2, and Prognosis
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Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma
Siu Tim Cheung; San Yu Wong; Ka Ling Leung; Xin Chen; Samuel So; Irene O. Ng; Sheung Tat Fan
View articletitled, Granulin–Epithelin Precursor Overexpression Promotes Growth and Invasion of Hepatocellular Carcinoma
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HMGA1 Protein Overexpression in Human Breast Carcinomas: Correlation with ErbB2 Expression
Gennaro Chiappetta; Gerardo Botti; Mario Monaco; Rosa Pasquinelli; Francesca Pentimalli; Maurizio Di Bonito; Giuseppe D’Aiuto; Monica Fedele; Rodolfo Iuliano; Emiliano A. Palmieri; Giovanna Maria Pierantoni; Vincenzo Giancotti; Alfredo Fusco
View articletitled, HMGA1 Protein Overexpression in Human Breast Carcinomas<span class="subtitle-colon">: </span><span class="subtitle">Correlation with ErbB2 Expression</span>
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Experimental Therapeutics, Preclinical Pharmacology
Inhibition of Inhibitor of Nuclear Factor-κB Phosphorylation Increases the Efficacy of Paclitaxel in in Vitro and in Vivo Ovarian Cancer Models
Seiji Mabuchi; Masahide Ohmichi; Yukihiro Nishio; Tadashi Hayasaka; Akiko Kimura; Tsuyoshi Ohta; Jun Kawagoe; Kazuhiro Takahashi; Namiko Yada-Hashimoto; Hozumi Seino-Noda; Masahiro Sakata; Teiichi Motoyama; Hirohisa Kurachi; Joseph R. Testa; Keiichi Tasaka; Yuji Murata
View articletitled, Inhibition of Inhibitor of Nuclear Factor-κB Phosphorylation Increases the Efficacy of Paclitaxel in <strong><em>in Vitro</em></strong> and <strong><em>in Vivo</em></strong> Ovarian Cancer Models
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The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma
Linda Nici; Barbara Monfils; Paul Calabresi
View articletitled, The Effects of Taurolidine, a Novel Antineoplastic Agent, on Human Malignant Mesothelioma
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Antitumor Efficacy of Oblimersen Bcl-2 Antisense Oligonucleotide Alone and in Combination with Vinorelbine in Xenograft Models of Human Non–Small Cell Lung Cancer
YanPing Hu; Gwyn Bebb; Sophia Tan; Rebecca Ng; Hong Yan; Jason R. Sartor; Lawrence D. Mayer; Marcel B. Bally
View articletitled, Antitumor Efficacy of Oblimersen Bcl-2 Antisense Oligonucleotide Alone and in Combination with Vinorelbine in Xenograft Models of Human Non–Small Cell Lung Cancer
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Sensitization of Tumor-Associated Endothelial Cell Apoptosis by the Novel Vascular-Targeting Agent ZD6126 in Combination with Cisplatin
Hisatsugu Goto; Seiji Yano; Yuka Matsumori; Hirohisa Ogawa; David C. Blakey; Saburo Sone
View articletitled, Sensitization of Tumor-Associated Endothelial Cell Apoptosis by the Novel Vascular-Targeting Agent ZD6126 in Combination with Cisplatin
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Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy
Ze Lu; Teng-Kuang Yeh; Max Tsai; Jessie L.-S. Au; M. Guill Wientjes
View articletitled, Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy
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Inhibition of Metastatic Tumor Growth in Mouse Lung by Repeated Administration of Polyethylene Glycol-Conjugated Catalase: Quantitative Analysis with Firefly Luciferase-Expressing Melanoma Cells
Kenji Hyoudou; Makiya Nishikawa; Yukari Umeyama; Yuki Kobayashi; Fumiyoshi Yamashita; Mitsuru Hashida
View articletitled, Inhibition of Metastatic Tumor Growth in Mouse Lung by Repeated Administration of Polyethylene Glycol-Conjugated Catalase<span class="subtitle-colon">: </span><span class="subtitle">Quantitative Analysis with Firefly Luciferase-Expressing Melanoma Cells</span>
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Species Differences in Troxacitabine Pharmacokinetics and Pharmacodynamics: Implications for Clinical Development
Henriette Gourdeau; Lorraine Leblond; Bettina Hamelin; Kelly Dong; France Ouellet; Chantal Boudreau; Dominique Custeau; Annie Richard; Marie-Josée Gilbert; Jacques Jolivet
View articletitled, Species Differences in Troxacitabine Pharmacokinetics and Pharmacodynamics<span class="subtitle-colon">: </span><span class="subtitle">Implications for Clinical Development</span>
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Dietary Flaxseed Enhances the Inhibitory Effect of Tamoxifen on the Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) in Nude Mice
Jianmin Chen; Evon Hui; Terence Ip; Lilian U. Thompson
View articletitled, Dietary Flaxseed Enhances the Inhibitory Effect of Tamoxifen on the Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) in Nude Mice
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Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation
Hisataka Kobayashi; Koen Reijnders; Sean English; Alexander T. Yordanov; Diane E. Milenic; Anastasia L. Sowers; Deborah Citrin; Murali C. Krishna; Thomas A. Waldmann; James B. Mitchell; Martin W. Brechbiel
View articletitled, Application of a Macromolecular Contrast Agent for Detection of Alterations of Tumor Vessel Permeability Induced by Radiation
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Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer
Junichi Yano; Kazuko Hirabayashi; Shin-ichiro Nakagawa; Tohru Yamaguchi; Masaki Nogawa; Isao Kashimori; Haruna Naito; Hidetoshi Kitagawa; Kouichi Ishiyama; Tadaaki Ohgi; Tatsuro Irimura
View articletitled, Antitumor Activity of Small Interfering RNA/Cationic Liposome Complex in Mouse Models of Cancer
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Regression of Mouse Prostatic Intraepithelial Neoplasia by Nonsteroidal Anti-inflammatory Drugs in the Transgenic Adenocarcinoma Mouse Prostate Model
Bhagavathi A. Narayanan; Narayanan K. Narayanan; Brian Pittman; Bandaru S. Reddy
View articletitled, Regression of Mouse Prostatic Intraepithelial Neoplasia by Nonsteroidal Anti-inflammatory Drugs in the Transgenic Adenocarcinoma Mouse Prostate Model
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Vector Targeting Makes 5-Fluorouracil Chemotherapy Less Toxic and More Effective in Animal Models of Epithelial Neoplasms
Hakan Akbulut; Yucheng Tang; Jonathan Maynard; Lixin Zhang; Giuseppe Pizzorno; Albert Deisseroth
View articletitled, Vector Targeting Makes 5-Fluorouracil Chemotherapy Less Toxic and More Effective in Animal Models of Epithelial Neoplasms
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Trastuzumab Down-Regulates Bcl-2 Expression and Potentiates Apoptosis Induction by Bcl-2/Bcl-XL Bispecific Antisense Oligonucleotides in HER-2Gene–Amplified Breast Cancer Cells
Michele Milella; Daniela Trisciuoglio; Tiziana Bruno; Ludovica Ciuffreda; Marcella Mottolese; Anna Cianciulli; Francesco Cognetti; Uwe Zangemeister-Wittke; Donatella Del Bufalo; Gabriella Zupi
View articletitled, Trastuzumab Down-Regulates Bcl-2 Expression and Potentiates Apoptosis Induction by Bcl-2/Bcl-X<sub>L</sub> Bispecific Antisense Oligonucleotides in <strong><em>HER-2</em></strong>Gene–Amplified Breast Cancer Cells
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In vitro Effects of the BH3 Mimetic, (−)-Gossypol, on Head and Neck Squamous Cell Carcinoma Cells
Christopher L. Oliver; Joshua A. Bauer; Keith G. Wolter; Mathew L. Ubell; Ajita Narayan; Kathleen M. O’Connell; Susan G. Fisher; Shaomeng Wang; Xihan Wu; Min Ji; Thomas E. Carey; Carol R. Bradford
View articletitled, <strong><em>In vitro</em></strong> Effects of the BH3 Mimetic, (−)-Gossypol, on Head and Neck Squamous Cell Carcinoma Cells
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Deregulated Cyclin D1 Expression Is Associated with Decreased Efficacy of the Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cell Lines
Larry H. Kalish; Rhonda A. Kwong; Ian E. Cole; Richard M. Gallagher; Robert L. Sutherland; Elizabeth A. Musgrove
View articletitled, Deregulated Cyclin D1 Expression Is Associated with Decreased Efficacy of the Selective Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Head and Neck Squamous Cell Carcinoma Cell Lines
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Letters to the Editor

MIB-1 and p27Kip1 Expression in Nephroblastoma
Chris Jones; Kathy Pritchard-Jones
View articletitled, MIB-1 and p27<sup>Kip1</sup> Expression in Nephroblastoma
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Correction

Correction: Article on The Na+/I-Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Downregulated in the Thyroid
View articletitled, Correction: Article on The Na+/I-Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Downregulated in the Thyroid
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Correction: Article on Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias
View articletitled, Correction: Article on Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias
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