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Volume 10, Issue 21

1 November 2004

Cover Image

Cover Image
Table of Contents

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

The Biology Behind
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology

The Biology Behind

Imaging Molecular Signatures in Oligodendroglioma: Commentary on Walker et al., pages 7182-7191

J. Gregory Cairncross

Featured Articles

Clinical Trials

Administration of CI-1033, an Irreversible Pan-erbB Tyrosine Kinase Inhibitor, Is Feasible on a 7-Day On, 7-Day Off Schedule: A Phase I Pharmacokinetic and Food Effect Study

Emiliano Calvo; Anthony W. Tolcher; Lisa A. Hammond; Amita Patnaik; Johan S. de Bono; Irene A. Eiseman; Stephen C. Olson; Peter F. Lenehan; Heather McCreery; Patricia LoRusso; Eric K. Rowinsky

The Influence of Androgen Deprivation Therapy on Dihydrotestosterone Levels in the Prostatic Tissue of Patients with Prostate Cancer

Tsutomu Nishiyama; Yutaka Hashimoto; Kota Takahashi

A Phase I Open Label Study of the Farnesyltransferase Inhibitor CP-609,754 in Patients with Advanced Malignant Tumors

Stacy L. Moulder; John J. Mahany; Richard Lush; Caio Rocha-Lima; Michael Langevin; Karen J. Ferrante; Lisa Michele Bartkowski; Shama M. Kajiji; Dennis A. Noe; Simone Paillet; Daniel M. Sullivan

Phase II Feasibility and Pharmacokinetic Study of Concurrent Administration of Trastuzumab and High-Dose Chemotherapy in Advanced HER2+ Breast Cancer

Yago Nieto; James J. Vredenburgh; Elizabeth J. Shpall; Scott I. Bearman; Peter A. McSweeney; Nelson Chao; David Rizzieri; Christina Gasparetto; Steve Matthes; Anna E. Barón; Roy B. Jones

Molecular Oncology, Markers, Clinical Correlates

High LYVE-1–Positive Lymphatic Vessel Numbers Are Associated with Poor Outcome in Breast Cancer

Petri Bono; Veli-Matti Wasenius; Päivi Heikkilä; Johan Lundin; David G. Jackson; Heikki Joensuu

Genetic Analysis of the RNASEL Gene in Hereditary, Familial, and Sporadic Prostate Cancer

Fredrik Wiklund; Björn-Anders Jonsson; Anthony J. Brookes; Linda Strömqvist; Jan Adolfsson; Monica Emanuelsson; Hans-Olov Adami; Katarina Augustsson-Bälter; Henrik Grönberg

Increased Serum Interleukin-8 in Patients with Early and Metastatic Breast Cancer Correlates with Early Dissemination and Survival

Ina H. Benoy; Roberto Salgado; Peter Van Dam; Katrien Geboers; Eric Van Marck; Simon Scharpé; Peter B. Vermeulen; Luc Y. Dirix

Delineation of Brain Tumor Extent with [¹¹C]l-Methionine Positron Emission Tomography: Local Comparison with Stereotactic Histopathology

Lutz W. Kracht; Hrvoje Miletic; Susanne Busch; Andreas H. Jacobs; Jurgen Voges; Moritz Hoevels; Johannes C. Klein; Karl Herholz; Wolf-D. Heiss

Angiogenic Profile of Breast Carcinoma Determines Leukocyte Infiltration

Jessica C. A. Bouma-ter Steege; Coen I. M. Baeten; Victor L. J. L. Thijssen; Sietske A. Satijn; Inge C. L. Verhoeven; Harry F. P. Hillen; John Wagstaff; Arjan W. Griffioen

Monoclonal Immunoglobulin Production Is a Frequent Event in Patients with Mucosa-Associated Lymphoid Tissue Lymphoma

Stefan Wöhrer; Berthold Streubel; Rupert Bartsch; Andreas Chott; Markus Raderer

Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component

Carol Walker; Daniel G. du Plessis; Diane Fildes; Brian Haylock; David Husband; Michael D. Jenkinson; Kathy A. Joyce; John Broome; Klaus Kopitski; Joanne Prosser; Trevor Smith; Sobhan Vinjamuri; Peter C. Warnke

Experimental Therapeutics, Preclinical Pharmacology

7-Hydroxystaurosporine (UCN-01) Inhibition of Akt Thr³⁰⁸ but not Ser⁴⁷³ Phosphorylation: A Basis for Decreased Insulin-Stimulated Glucose Transport

Sudhir B. Kondapaka; MaryJane Zarnowski; Dena R. Yver; Edward A. Sausville; Samuel W. Cushman

Impact of Human Neutralizing Antibodies on Antitumor Efficacy of an Oncolytic Adenovirus in a Murine Model

Van Tsai; Duane E. Johnson; Amena Rahman; Shu Fen Wen; Drake LaFace; Jennifer Philopena; Jonathan Nery; Monica Zepeda; Daniel C. Maneval; G. William Demers; Robert Ralston

In vitro Stimulation with WT1 Peptide-Loaded Epstein-Barr Virus-Positive B Cells Elicits High Frequencies of WT1 Peptide-Specific T Cells with In vitro and In vivo Tumoricidal Activity

Ekaterina S. Doubrovina; Mikhail M. Doubrovin; Sangyull Lee; Jae-Hung Shieh; Glen Heller; Eric Pamer; Richard J. O’Reilly

Regular Articles

Clinical Trials

Phase I Study of Docetaxel in Combination with the P-Glycoprotein Inhibitor, Zosuquidar, in Resistant Malignancies

Paula M. Fracasso; Lori J. Goldstein; Dinesh P. de Alwis; Janet S. Rader; Matthew A. Arquette; Sherry A. Goodner; Lisa P. Wright; Carole L. Fears; Robert J. Gazak; Valerie A. M. Andre; Michael F. Burgess; Christopher A. Slapak; Jan H. M. Schellens

A Phase I and Pharmacokinetic Study of Exisulind and Docetaxel in Patients with Advanced Solid Tumors

Samir E. Witta; Daniel L. Gustafson; A. Scott Pierson; Alexander Menter; Scott N. Holden; Michele Basche; Martha Persky; Cindy L. O’Bryant; Chan Zeng; Anna Baron; Michael E. Long; Amy Gibbs; Karen Kelly; Paul A. Bunn, Jr.; Daniel C. Chan; Patrick Pallansch; S. Gail Eckhardt

Plasma Coagulation Markers in Patients with Solid Tumors and Venous Thromboembolic Disease Receiving Oral Anticoagulation Therapy

Sabah Sallah; Aisha Husain; Vaia Sigounas; Jim Wan; Francesco Turturro; George Sigounas; Nam P. Nguyen

Delivery of a Liposomal c-raf-1 Antisense Oligonucleotide by Weekly Bolus Dosing in Patients with Advanced Solid Tumors: A Phase I Study

Charles M. Rudin; John L. Marshall; Chao Hui Huang; Hedy L. Kindler; Chuanbo Zhang; Deepak Kumar; Prafulla C. Gokhale; Joyce Steinberg; Steve Wanaski; Usha N. Kasid; Mark J. Ratain

Cancer Biology, Immunology, Cytokines

Type I Collagen Promotes the Malignant Phenotype of Pancreatic Ductal Adenocarcinoma

Thomas Armstrong; Graham Packham; Lindsay B. Murphy; Adrian C. Bateman; John A. Conti; David R. Fine; Colin D. Johnson; R. Christopher Benyon; John P. Iredale

Research Articles

Molecular Oncology, Markers, Clinical Correlates

X-Tile: A New Bio-Informatics Tool for Biomarker Assessment and Outcome-Based Cut-Point Optimization

Robert L. Camp; Marisa Dolled-Filhart; David L. Rimm

Increased Levels of Interleukin-10 in Serum from Patients with Hepatocellular Carcinoma Correlate with Profound Numerical Deficiencies and Immature Phenotype of Circulating Dendritic Cell Subsets

Susanne Beckebaum; Xia Zhang; Xiao Chen; Zhengya Yu; Andrea Frilling; Grzegorz Dworacki; Hans Grosse-Wilde; Christoph Erich Broelsch; Guido Gerken; Vito R. Cicinnati

Autoantibody Profiles and Neurological Correlations of Thymoma

Steven Vernino; Vanda A. Lennon

Molecular Profiling and Classification of Sporadic Renal Cell Carcinoma by Quantitative Methylation Analysis

Mark L. Gonzalgo; Srinivasan Yegnasubramanian; Gai Yan; Craig G. Rogers; Theresa L. Nicol; William G. Nelson; Christian P. Pavlovich

Mouse Mammary Tumor Virus-like RNA Transcripts and DNA Are Found in Affected Cells of Human Breast Cancer

Caroline E. Ford; Margaret Faedo; William D. Rawlinson

Loss of Methylthioadenosine Phosphorylase and Elevated Ornithine Decarboxylase Is Common in Pancreatic Cancer

Ahmad L. Subhi; Baiqing Tang; Binaifer R. Balsara; Deborah A. Altomare; Joseph R. Testa; Harry S. Cooper; John P. Hoffman; Neal J. Meropol; Warren D. Kruger

Prognostic Value of ERM Gene Expression in Human Primary Breast Cancers

Anne Chotteau-Lelièvre; Françoise Révillion; Valérie Lhotellier; Louis Hornez; Xavier Desbiens; Véronique Cabaret; Yvan de Launoit; Jean-Philippe Peyrat

Overexpression of Aurora-A Contributes to Malignant Development of Human Esophageal Squamous Cell Carcinoma

Tong Tong; Yali Zhong; Jianping Kong; Lijia Dong; Yongmei Song; Ming Fu; Zhihua Liu; Mingrong Wang; Liping Guo; Shixin Lu; Ming Wu; Qimin Zhan

Dominant Papillary Subtype Is a Significant Predictor of the Response to Gefitinib in Adenocarcinoma of the Lung

Young Hak Kim; Genichiro Ishii; Koichi Goto; Kanji Nagai; Koji Tsuta; Satoshi Shiono; Junichi Nitadori; Testuro Kodama; Yutaka Nishiwaki; Atsushi Ochiai

High Expression of PRL-3 Promotes Cancer Cell Motility and Liver Metastasis in Human Colorectal Cancer: A Predictive Molecular Marker of Metachronous Liver and Lung Metastases

Hirotaka Kato; Shuho Semba; Upik A. Miskad; Yasushi Seo; Masato Kasuga; Hiroshi Yokozaki

Absence of a Correlation between the Presence of a Single Nucleotide Polymorphism in the Matrix Metalloproteinase 1 Promoter and Outcome in Patients of Chondrosarcoma

Yi-Chin Fong; Charyl M. Dutton; Stephen S. Cha; Nandor Garamszegi; Franklin H. Sim; Sean P. Scully

Altered Expression of Metastasis-Associated and Regulatory Molecules in Effusions from Breast Cancer Patients: A Novel Model for Tumor Progression

Ben Davidson; Sophya Konstantinovsky; Søren Nielsen; Hiep Phuc Dong; Aasmund Berner; Mogens Vyberg; Reuven Reich

Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma

Makoto Tsuneoka; Hiromasa Fujita; Nobuyuki Arima; Kwesi Teye; Torahiko Okamura; Hiroki Inutsuka; Yoshiro Koda; Kazuo Shirouzu; Hiroshi Kimura

Experimental Therapeutics, Preclinical Pharmacology

Efficacy of the Novel Camptothecin Gimatecan against Orthotopic and Metastatic Human Tumor Xenograft Models

Michelandrea De Cesare; Graziella Pratesi; Silvia Veneroni; Raffaella Bergottini; Franco Zunino

Potent Antitumor Activity of Novel Iron Chelators Derived from Di-2-Pyridylketone Isonicotinoyl Hydrazone Involves Fenton-Derived Free Radical Generation

Timothy B. Chaston; Ralph N. Watts; Jun Yuan; Des R. Richardson

Effects of Exemestane and Tamoxifen in a Postmenopausal Breast Cancer Model

Danijela Jelovac; Luciana Macedo; Venkatesh Handratta; Brian J. Long; Olga G. Goloubeva; James N. Ingle; Angela M. H. Brodie

Antitumor Activity of Hydrophilic Paclitaxel Copolymer Prodrug Using Locoregional Delivery in Human Orthotopic Non–Small Cell Lung Cancer Xenograft Models

Yiyu Zou; Hao Fu; Sukhen Ghosh; David Farquhar; Jim Klostergaard

Androgen Receptor Is Targeted to Distinct Subcellular Compartments in Response to Different Therapeutic Antiandrogens

Hayley C. Whitaker; Sarah Hanrahan; Nick Totty; Simon C. Gamble; Jonathan Waxman; Andrew C. B. Cato; Helen C. Hurst; Charlotte L. Bevan

Myeloma Cells Are Highly Sensitive to the Granule Exocytosis Pathway Mediated by WT1-Specific Cytotoxic T Lymphocytes

Taichi Azuma; Takemi Otsuki; Kiyotaka Kuzushima; Christopher J. Froelich; Shigeru Fujita; Masaki Yasukawa

Therapeutic Synergy of Oral Taxane BMS-275183 and Cetuximab versus Human Tumor Xenografts

William C. Rose; Robert Wild

Antiproliferative Effects of Interferon-αCon1 on Ovarian Clear Cell Adenocarcinoma In vitro and In vivo

Yumi Takemoto; Hirohisa Yano; Seiya Momosaki; Sachiko Ogasawara; Naoyo Nishida; Sakiko Kojiro; Toshiharu Kamura; Masamichi Kojiro

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