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Molecular Oncology, Markers, Clinical Correlates
Loss of Heterozygosity at the Thymidylate Synthase (TS) Locus on Chromosome 18 Affects Tumor Response and Survival in Individuals Heterozygous for a 28-bp Polymorphism in the TS Gene
Kazumi Uchida; Kazuhiko Hayashi; Kazuyuki Kawakami; Sylke Schneider; Ji Min Yochim; Hidekazu Kuramochi; Ken Takasaki; Kathleen D. Danenberg; Peter V. Danenberg
Experimental Therapeutics, Preclinical Pharmacology
Regulating the Tumor Suppressor Gene Maspin in Breast Cancer Cells: A Potential Mechanism for the Anticancer Properties of Tamoxifen
Zhila Khalkhali-Ellis; Abby L. Christian; Dawn A. Kirschmann; Elijah M. Edwards; Maryam Rezaie-Thompson; Mohammad A. Vasef; Lynn M. Gruman; Richard E. B. Seftor; Laura E. Norwood; Mary J. C. Hendrix
Regular Articles
Clinical Trials
A Phase I Dose-Escalation and Pharmacokinetic Study of Brostallicin (PNU-166196A), a Novel DNA Minor Groove Binder, in Adult Patients with Advanced Solid Tumors
A. Craig Lockhart; Martin Howard; Kenneth R. Hande; Bruce J. Roth; Jordan D. Berlin; Franzanne Vreeland; Angela Campbell; Erminia Fontana; Francesca Fiorentini; Camilla Fowst; Victoria A. Paty; Odessa Lankford; Mace L. Rothenberg
Research Articles
Molecular Oncology, Markers, Clinical Correlates
Increased Risk for Hereditary Nonpolyposis Colorectal Cancer-Associated Synchronous and Metachronous Malignancies in Patients with Microsatellite Instability-Positive Endometrial Carcinoma Lacking MLH1 Promoter Methylation
Barbara M. Buttin; Matthew A. Powell; David G. Mutch; Janet S. Rader; Thomas J. Herzog; Randall K. Gibb; Phyllis Huettner; Tina Bocker Edmonston; Paul J. Goodfellow
Elevated Cyclooxygenase-2 Expression Is Associated with Altered Expression of p53 and SMAD4, Amplification of HER-2/neu, and Poor Outcome in Serous Ovarian Carcinoma
Tiina-Liisa Erkinheimo; Heini Lassus; Patrik Finne; Bastiaan P. van Rees; Arto Leminen; Olavi Ylikorkala; Caj Haglund; Ralf Butzow; Ari Ristimäki
Microsatellite Instability Predicts Poor Short-Term Survival in Patients with Advanced Breast Cancer after High-Dose Chemotherapy and Autologous Stem-Cell Transplantation
Peter J. Wild; Albrecht Reichle; Reinhard Andreesen; Georg Röckelein; Wolfgang Dietmaier; Josef Rüschoff; Hagen Blaszyk; Ferdinand Hofstädter; Arndt Hartmann
Membranous Expression of Secreted Frizzled-Related Protein 4 Predicts for Good Prognosis in Localized Prostate Cancer and Inhibits PC3 Cellular Proliferation in Vitro
Lisa G. Horvath; Susan M. Henshall; James G. Kench; Darren N. Saunders; C.-Soon Lee; David Golovsky; Phillip C. Brenner; Gordon F. O’Neill; Raji Kooner; Phillip D. Stricker; John J. Grygiel; Robert L. Sutherland
Experimental Therapeutics, Preclinical Pharmacology
The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD1839 (Iressa) Suppresses c-Src and Pak1 Pathways and Invasiveness of Human Cancer Cells
Zhibo Yang; Rozita Bagheri-Yarmand; Rui-An Wang; Liana Adam; Vali Vassiliki Papadimitrakopoulou; Gary L. Clayman; Adel El-Naggar; Reuben Lotan; Christopher J. Barnes; Waun Ki Hong; Rakesh Kumar
gp100209–2M Peptide Immunization of Human Lymphocyte Antigen-A2+ Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD8+ T Cells
Edwin B. Walker; Daniel Haley; William Miller; Kevin Floyd; Ketura P. Wisner; Nelson Sanjuan; Holden Maecker; Pedro Romero; Hong-Ming Hu; W. Gregory Alvord; John W. Smith, II; Bernard A. Fox; Walter J. Urba
In Vivo Assessment of Antiangiogenic Activity of SU6668 in an Experimental Colon Carcinoma Model
Pasquina Marzola; Anna Degrassi; Laura Calderan; Paolo Farace; Caterina Crescimanno; Elena Nicolato; Anna Giusti; Enrico Pesenti; Andrea Terron; Andrea Sbarbati; Tinya Abrams; Lesley Murray; Francesco Osculati
Imatinib Inhibits Proliferation of Ewing Tumor Cells Mediated by the Stem Cell Factor/KIT Receptor Pathway, and Sensitizes Cells to Vincristine and Doxorubicin-Induced Apoptosis
Iranzu González; Enrique J. Andreu; Angel Panizo; Susana Inogés; Ana Fontalba; José Luis Fernández-Luna; Mirella Gaboli; Luis Sierrasesúmaga; Salvador Martín-Algarra; Javier Pardo; Felipe Prósper; Enrique de Alava
Antitumor Activity of ZD6474, a Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitor, in Human Cancer Cells with Acquired Resistance to Antiepidermal Growth Factor Receptor Therapy
Fortunato Ciardiello; Roberto Bianco; Roberta Caputo; Rosa Caputo; Vincenzo Damiano; Teresa Troiani; Davide Melisi; Ferdinando De Vita; Sabino De Placido; A. Raffaele Bianco; Giampaolo Tortora
Letter to the Editor
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