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Volume 10, Issue 17

1 September 2004

Cover Image

Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Editorial
Review
The Biology Behind
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Letters to the Editor

Editorial

Detection Characteristics in Randomized Prostate Screening

Fritz H. Schröder; Monique J. Roobol

Review

Treatment of Relapsed Central Nervous System Lymphoma with High-Dose Methotrexate

Scott R. Plotkin; Rebecca A. Betensky; Fred H. Hochberg; Stuart A. Grossman; Glenn J. Lesser; L. Burt Nabors; Brian Chon; Tracy T. Batchelor

The Biology Behind

Mouse Mammary Tumor Virus-Like Viral Infection and Human Breast Cancer

James F. Holland; Beatriz G. T. Pogo

Featured Articles

Clinical Trials

Pilot Study of the Mechanism of Action of Preoperative Trastuzumab in Patients with Primary Operable Breast Tumors Overexpressing HER2

Roberto Gennari; Sylvie Menard; Francesco Fagnoni; Luisa Ponchio; Mario Scelsi; Elda Tagliabue; Fabio Castiglioni; Laura Villani; Cesare Magalotti; Nadia Gibelli; Barbara Oliviero; Bettina Ballardini; Gianantonio Da Prada; Alberto Zambelli; Alberto Costa

Molecular Oncology, Markers, Clinical Correlates

Clonal Isolation of Different Strains of Mouse Mammary Tumor Virus-Like DNA Sequences from Both the Breast Tumors and Non-Hodgkin’s Lymphomas of Individual Patients Diagnosed with Both Malignancies

Polly R. Etkind; Alexandre F. R. Stewart; Thambi Dorai; Daniel J. Purcell; Peter H. Wiernik

Nuclear Localization of Apoptosis Protease Activating Factor-1 Predicts Survival after Tumor Resection in Early-Stage Non–Small Cell Lung Cancer

Benjamin Besse; Céline Candé; Jean-Philippe Spano; Antoine Martin; David Khayat; Thierry Le Chevalier; Thomas Tursz; Laure Sabatier; Jean-Charles Soria; Guido Kroemer

HER-2 Amplification, HER-1 Expression, and Tamoxifen Response in Estrogen Receptor-Positive Metastatic Breast Cancer: A Southwest Oncology Group Study

Grazia Arpino; Stephanie J. Green; D. Craig Allred; Dannika Lew; Silvana Martino; C. Kent Osborne; Richard M. Elledge

Circulating Growth Factor Levels Are Associated with Tumorigenesis in Neurofibromatosis Type 1

George A. Mashour; Pablo Hernáiz Driever; Melanie Hartmann; Stephanie N. Drissel; Tingguo Zhang; Bianca Scharf; Ursula Felderhoff-Müser; Sadatoshi Sakuma; Reinhard E. Friedrich; Robert L. Martuza; Victor Felix Mautner; Andreas Kurtz

Prognostic Significance of p16 Protein Levels in Oropharyngeal Squamous Cell Cancer

Paul M. Weinberger; Z. Yu; B.G. Haffty; D. Kowalski; M. Harigopal; C. Sasaki; D. L. Rimm; A. Psyrri

A Global Expression-based Analysis of the Consequences of the t(4;14) Translocation in Myeloma

Ann M. Dring; Faith E. Davies; James A. L. Fenton; Philippa L. Roddam; Kathryn Scott; David Gonzalez; Sara Rollinson; Andrew C. Rawstron; Karen S. Rees-Unwin; Cheng Li; Nikhil C. Munshi; Kenneth C. Anderson; Gareth J. Morgan

N-Cadherin Is Regulated by Activin A and Associated with Tumor Aggressiveness in Esophageal Carcinoma

Keiji Yoshinaga; Hiroshi Inoue; Tohru Utsunomiya; Hideto Sonoda; Takaaki Masuda; Koshi Mimori; Yoichi Tanaka; Masaki Mori

Melanoma-Associated Antigens in Esophageal Adenocarcinoma: Identification of Novel MAGE-A10 Splice Variants

Jules Lin; Lin Lin; Dafydd G. Thomas; Joel K. Greenson; Thomas J. Giordano; Gregory S. Robinson; Ruteja A. Barve; Frank A. Weishaar; Jeremy M. G. Taylor; Mark B. Orringer; David G. Beer

Experimental Therapeutics, Preclinical Pharmacology

Effects of the Steroidal Aromatase Inhibitor Exemestane and the Nonsteroidal Aromatase Inhibitor Letrozole on Bone and Lipid Metabolism in Ovariectomized Rats

Paul E. Goss; Shangle Qi; Angela M. Cheung; Haiqing Hu; Maria Mendes; Kenneth P. H. Pritzker

Ionizing Radiation Causes a Dose-Dependent Release of Transforming Growth Factor α In vitro from Irradiated Xenografts and during Palliative Treatment of Hormone-Refractory Prostate Carcinoma

Michael Hagan; Adly Yacoub; Paul Dent

Regular Articles

Clinical Trials

Phase II Study of the Antiangiogenic Agent SU5416 in Patients with Advanced Soft Tissue Sarcomas

John V. Heymach; Jayesh Desai; Judith Manola; Darren W. Davis; David J. McConkey; David Harmon; David P. Ryan; Geraldine Goss; Travis Quigley; Annick D. Van den Abbeele; Stuart G. Silverman; Susan Connors; Judah Folkman; Christopher D. M. Fletcher; George D. Demetri

Carbon Ion Radiotherapy for Unresectable Sacral Chordomas

Reiko Imai; Tadashi Kamada; Hiroshi Tsuji; Takeshi Yanagi; Masayuki Baba; Tadaaki Miyamoto; Shingo Kato; Susumu Kandatsu; Jun-etsu Mizoe; Hirohiko Tsujii; Shin-ichiro Tatezaki; for the Working Group for Bone, Soft Tissue Sarcomas

A Phase I Trial of TNFerade Biologic in Patients with Soft Tissue Sarcoma in the Extremities

Arno J. Mundt; Srinivasan Vijayakumar; John Nemunaitis; Alan Sandler; Herbert Schwartz; Nader Hanna; Terrence Peabody; Neil Senzer; Karen Chu; Camilla S. Rasmussen; Paul D. Kessler; Henrik S. Rasmussen; Michael Warso; Donald W. Kufe; Tapas Das Gupta; Ralph R. Weichselbaum

Phase II Study of Feasibility of Dose-Dense FEC Followed by Alternating Weekly Taxanes in High-Risk, Four or More Node-Positive Breast Cancer

Chau T. Dang; Gabriella M. D’Andrea; Mary E. Moynahan; Maura N. Dickler; Andrew D. Seidman; Monica Fornier; Mark E. Robson; Maria Theodoulou; Diana Lake; Violante E. Currie; Arti Hurria; Katherine S. Panageas; Larry Norton; Clifford A. Hudis

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Human Telomerase Reverse Transcriptase Gene Expression and the Surgical Management of Suspicious Thyroid Tumors

Christopher B. Umbricht; George T. Conrad; Douglas P. Clark; William H. Westra; Dañelle C. Smith; Marianna Zahurak; Motoyasu Saji; Robert C. Smallridge; Steven Goodman; Martha A. Zeiger

Estrogen Receptor β (ERβ) Level but Not Its ERβcx Variant Helps to Predict Tamoxifen Resistance in Breast Cancer

Majida Esslimani-Sahla; Joelle Simony-Lafontaine; Andrew Kramar; Roselyne Lavaill; Caroline Mollevi; Margaret Warner; Jan-Åke Gustafsson; Henri Rochefort

Quantification of Colorectal Cancer Micrometastases in Lymph Nodes by Nested and Real-Time Reverse Transcriptase-PCR Analysis for Carcinoembryonic Antigen

Samuel B. Ho; Ann Hyslop; Richard Albrecht; Amanda Jacobson; Michael Spencer; David A. Rothenberger; Gloria A. Niehans; John D’Cunha; Robert A. Kratzke

Amplification of the BRCA2 Pathway Gene EMSY in Sporadic Breast Cancer Is Related to Negative Outcome

Carmen Rodriguez; Luke Hughes-Davies; Hélène Vallès; Béatrice Orsetti; Marguerite Cuny; Lisa Ursule; Tony Kouzarides; Charles Theillet

Casein Kinase II Alpha Subunit and C1-Inhibitor Are Independent Predictors of Outcome in Patients with Squamous Cell Carcinoma of the Lung

Pornchai O-charoenrat; Valerie Rusch; Simon G. Talbot; Inderpal Sarkaria; Agnes Viale; Nicholas Socci; Ivan Ngai; Pulivarthi Rao; Bhuvanesh Singh

Expression of Transforming Growth Factor β Isoforms and Their Receptors in Malignant Fibrous Histiocytoma of Soft Tissues

Tetsuji Yamamoto; Toshihiro Akisue; Takashi Marui; Ikuo Fujita; Keiji Matsumoto; Toshiaki Hitora; Teruya Kawamoto; Keiko Nagira; Tetsuya Nakatani; Masahiro Kurosaka

Prognostic Value of Combined “Triple”-Reverse Transcription-PCR Analysis for Prostate-Specific Antigen, Human Kallikrein 2, and Prostate-Specific Membrane Antigen mRNA in Peripheral Blood and Lymph Nodes of Prostate Cancer Patients

Ralf Kurek; German Nunez; Nikolaos Tselis; Lutz Konrad; Thomas Martin; Sandra Roeddiger; Gerd Aumüller; Nikolaos Zamboglou; Daniel W. Lin; Ulf W. Tunn; Heiner Renneberg

Tumor Neoangiogenesis by CD31 and CD105 Expression Evaluation in Breast Carcinoma Tissue Microarrays

Colette Charpin; Jean-Philippe Dales; Stéphane Garcia; Séverine Carpentier; Amina Djemli; Lucile Andrac; Marie-Noëlle Lavaut; Claude Allasia; Pascal Bonnier

Overexpressed eIF4E Is Functionally Active in Surgical Margins of Head and Neck Cancer Patients via Activation of the Akt/Mammalian Target of Rapamycin Pathway

Cherie-Ann O. Nathan; Nazanin Amirghahari; Fleurette Abreo; Xiaohua Rong; Gloria Caldito; M. Lamar Jones; Huijuan Zhou; Melanie Smith; Donnellan Kimberly; Jonathan Glass

Two Proliferation-Related Proteins, TYMS and PGK1, Could Be New Cytotoxic T Lymphocyte-Directed Tumor-Associated Antigens of HLA-A2⁺ Colon Cancer

Shigeki Shichijo; Kouichi Azuma; Nobukazu Komatsu; Masaaki Ito; Yoshiaki Maeda; Yuki Ishihara; Kyogo Itoh

Favorable Neuroblastoma Genes and Molecular Therapeutics of Neuroblastoma

Xao X. Tang; Marjorie E. Robinson; Justin S. Riceberg; David Y. Kim; Bing Kung; Tracy B. Titus; Satoshi Hayashi; Alan W. Flake; David Carpentieri; Naohiko Ikegaki

p53 Polymorphism and Age of Onset of Hereditary Nonpolyposis Colorectal Cancer in a Caucasian Population

J. Shawn Jones; Xuedong Chi; Xiangjun Gu; Patrick M. Lynch; Christopher I. Amos; Marsha L. Frazier

Steroid Sulfatase and Estrogen Sulfotransferase in Human Endometrial Carcinoma

Hiroki Utsunomiya; Kiyoshi Ito; Takashi Suzuki; Takako Kitamura; Chika Kaneko; Taisuke Nakata; Hitoshi Niikura; Kunihiro Okamura; Nobuo Yaegashi; Hironobu Sasano

SEL1L and Squamous Cell Carcinoma of the Esophagus

Paola Granelli; Monica Cattaneo; Stefano Ferrero; Luca Bottiglieri; Silvano Bosari; Giuseppe Fichera; Ida Biunno

Characterization of a Human Homologue of Proteolysis-Inducing Factor and Its Role in Cancer Cachexia

Constance L. Monitto; Seung-Myung Dong; Jin Jen; David Sidransky

Subepithelial Myofibroblasts Express Cyclooxygenase-2 in Colorectal Tubular Adenomas

Patrick A. Adegboyega; Omiyosoye Ololade; Jamal Saada; Randy Mifflin; John F. Di Mari; Don W. Powell

Thymidylate Synthase Gene Polymorphism Predicts Toxicity in Colorectal Cancer Patients Receiving 5-Fluorouracil-based Chemotherapy

Thierry Lecomte; Jean-Marc Ferraz; Franck Zinzindohoué; Marie-Anne Loriot; David-Alexandre Tregouet; Bruno Landi; Anne Berger; Paul-Henri Cugnenc; Raymond Jian; Philippe Beaune; Pierre Laurent-Puig

ABCG2 Pharmacogenetics: Ethnic Differences in Allele Frequency and Assessment of Influence on Irinotecan Disposition

Floris A. de Jong; Sharon Marsh; Ron H. J. Mathijssen; Cristi King; Jaap Verweij; Alex Sparreboom; Howard L. McLeod

Elevated Expression of A₃ Adenosine Receptors in Human Colorectal Cancer Is Reflected in Peripheral Blood Cells

Stefania Gessi; Elena Cattabriga; Arianna Avitabile; Roberta Gafa’; Giovanni Lanza; Luigi Cavazzini; Nicoletta Bianchi; Roberto Gambari; Carlo Feo; Alberto Liboni; Sergio Gullini; Edward Leung; Stephen Mac-Lennan; Pier Andrea Borea

Phospho-Serine-118 Estrogen Receptor-α Expression Is Associated with Better Disease Outcome in Women Treated with Tamoxifen

Leigh C. Murphy; Yulian Niu; Linda Snell; Peter Watson

Experimental Therapeutics, Preclinical Pharmacology

Soluble Type II Transforming Growth Factor-β Receptor Inhibits Established Murine Malignant Mesothelioma Tumor Growth by Augmenting Host Antitumor Immunity

Eiji Suzuki; Veena Kapoor; H.-Kam Cheung; Leona E. Ling; Peter A. DeLong; Larry R. Kaiser; Steven M. Albelda

The Role of Hyperthermia in Regional Alkylating Agent Chemotherapy

Omar I. Abdel-Wahab; Elizabeth Grubbs; Benjamin L. Viglianti; Tsung-Yen Cheng; Tomio Ueno; SaeHee Ko; Zahid Rabbani; Simon Curtis; Scott K. Pruitt; Mark W. Dewhirst; Doug S. Tyler

Simultaneously Targeting Epidermal Growth Factor Receptor Tyrosine Kinase and Cyclooxygenase-2, an Efficient Approach to Inhibition of Squamous Cell Carcinoma of the Head and Neck

Zhuo (Georgia) Chen; Xin Zhang; Mengfeng Li; Zhiqiang Wang; H. Samuel Wieand; Jennifer R. Grandis; Dong M. Shin

Antitumor Activity of Gefitinib in Malignant Rhabdoid Tumor Cells In vitro and In vivo

Yasumichi Kuwahara; Hajime Hosoi; Shinya Osone; Masakazu Kita; Tomoko Iehara; Hiroshi Kuroda; Tohru Sugimoto

Thalidomide Pharmacokinetics and Metabolite Formation in Mice, Rabbits, and Multiple Myeloma Patients

Francisco Chung; Jun Lu; Brian D. Palmer; Philip Kestell; Peter Browett; Bruce C. Baguley; Malcolm Tingle; Lai-Ming Ching

In vitro Toxicity of A-431 Carcinoma Cells with Antibodies to Epidermal Growth Factor Receptor and Epithelial Glycoprotein-1 Conjugated to Radionuclides Emitting Low-Energy Electrons

Rosana B. Michel; Mary Ellen Castillo; Philip M. Andrews; M. Jules Mattes

Letters to the Editor

Consideration of QT/QTc Interval Data in a Phase I Study in Patients with Advanced Cancer

Mary Varterasian; Howard Fingert; Marilyn Agin; Mark Meyer

Limitations of the Adenoma–Carcinoma Sequence in Colorectum

Jeremy R. Jass

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