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Volume 10, Issue 14

15 July 2004

Cover Image

Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Reviews
Perspective
Bulletin Board
Meeting Report
Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology
Correction

Reviews

The Clinical Application of Targeting Cancer through Histone Acetylation and Hypomethylation

Jill Gilbert; Steve D. Gore; James G. Herman; Michael A. Carducci

DNA Array-Based Gene Profiling in Tumor Immunology

Simone Mocellin; Ena Wang; Monica Panelli; Pierluigi Pilati; Francesco M. Marincola

Perspective

Development of the Novel Biologically Targeted Anticancer Agent Gefitinib: Determining the Optimum Dose for Clinical Efficacy

Michael Wolf; Helen Swaisland; Steven Averbuch

Bulletin Board

The Cooperative Prostate Cancer Tissue Resource: A Specimen and Data Resource for Cancer Researchers

Jonathan Melamed; Milton W. Datta; Michael J. Becich; Jan M. Orenstein; Rajiv Dhir; Sylvia Silver; Marie Fidélia-Lambert; André Kadjacsy-Balla; Virgilia Macias; Ashokkumar Patel; Paul D. Walden; Maarten C. Bosland; Jules J. Berman; the Cooperative Prostate Cancer Tissue Resource.

Meeting Report

State of the Translational Science: Summary of Baltimore Workshop on Gene Re-expression As a Therapeutic Target in Cancer January 2003

Arthur Zelent; Samuel Waxman; Michael Carducci; John Wright; James Zweibel; Steven D. Gore

Featured Articles

Clinical Trials

Hypoxia and Photofrin Uptake in the Intraperitoneal Carcinomatosis and Sarcomatosis of Photodynamic Therapy Patients

Theresa M. Busch; Stephen M. Hahn; E. Paul Wileyto; Cameron J. Koch; Douglas L. Fraker; Paul Zhang; Mary Putt; Kristen Gleason; Daniel B. Shin; Michael J. Emanuele; Kevin Jenkins; Eli Glatstein; Sydney M. Evans

Her2/neu Expression Predicts the Response to Antiaromatase Neoadjuvant Therapy in Primary Breast Cancer: Subgroup Analysis from Celecoxib Antiaromatase Neoadjuvant Trial

Li Zhu; Louis W. C. Chow; Wings T. Y. Loo; Xin-Yuan Guan; Mazakazu Toi

Molecular Oncology, Markers, Clinical Correlates

Patient Characteristics Compete with Dose as Predictors of Acute Treatment Toxicity in Early Phase Clinical Trials

André Rogatko; James S. Babb; Hao Wang; Michael J. Slifker; Gary R. Hudes

Alternative Splicing of the Multidrug Resistance Protein 1/ATP Binding Cassette Transporter Subfamily Gene in Ovarian Cancer Creates Functional Splice Variants and Is Associated with Increased Expression of the Splicing Factors PTB and SRp20

Xiaolong He; P. L. Rachel Ee; John S. Coon; William T. Beck

Experimental Therapeutics, Preclinical Pharmacology

Increased Expression of the Copper Efflux Transporter ATP7A Mediates Resistance to Cisplatin, Carboplatin, and Oxaliplatin in Ovarian Cancer Cells

Goli Samimi; Roohangiz Safaei; Kuniyuki Katano; Alison K. Holzer; Myriam Rochdi; Mika Tomioka; Murray Goodman; Stephen B. Howell

Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells

Francesca Spinella; Laura Rosanò; Valeriana Di Castro; Maria Rita Nicotra; Pier Giorgio Natali; Anna Bagnato

Regular Articles

Clinical Trials

A Phase II Clinical and Pharmacodynamic Study of E7070 in Patients with Metastatic, Recurrent, or Refractory Squamous Cell Carcinoma of the Head and Neck: Modulation of Retinoblastoma Protein Phosphorylation by a Novel Chloroindolyl Sulfonamide Cell Cycle Inhibitor

Robert I. Haddad; Lisa J. Weinstein; Tad J. Wieczorek; Nandita Bhattacharya; Harry Raftopoulos; Martin W. Oster; Xinxin Zhang; Vaughan M. Latham, Jr.; Rosemary Costello; Jarrod Faucher; Carolyn DeRosa; Murray Yule; Linda P. Miller; Massimo Loda; Marshall R. Posner; Geoffrey I. Shapiro

Immunization of Patients with the hTERT:540-548 Peptide Induces Peptide-Reactive T Lymphocytes That Do Not Recognize Tumors Endogenously Expressing Telomerase

Maria R. Parkhurst; John P. Riley; Takehito Igarashi; Yong Li; Paul F. Robbins; Steven A. Rosenberg

Fusion Cell Vaccination of Patients with Metastatic Breast and Renal Cancer Induces Immunological and Clinical Responses

David Avigan; Baldev Vasir; Jianlin Gong; Virginia Borges; Zekui Wu; Lynne Uhl; Michael Atkins; James Mier; David McDermott; Therese Smith; Nancy Giallambardo; Carolyn Stone; Kim Schadt; Jennifer Dolgoff; Jean-Claude Tetreault; Marisa Villarroel; Donald Kufe

Relationship between Non-Small Cell Lung Cancer Fluorodeoxyglucose Uptake at Positron Emission Tomography and Surgical Stage with Relevance to Patient Prognosis

Hubert Vesselle; Eric Turcotte; Linda Wiens; Rodney Schmidt; Julie E. Takasugi; Tasneem Lalani; Eric Vallières; Douglas E. Wood

Sequential Immunization of Melanoma Patients with GD3 Ganglioside Vaccine and Anti-Idiotypic Monoclonal Antibody That Mimics GD3 Ganglioside

Paul B. Chapman; Dianna Wu; Govind Ragupathi; Sharon Lu; Linda Williams; Wen-Jen Hwu; Diantha Johnson; Philip O. Livingston

A Phase I/II Study of Infusional Vinblastine with the P-Glycoprotein Antagonist Valspodar (PSC 833) in Renal Cell Carcinoma

Susan E. Bates; Susan Bakke; Min Kang; Robert W. Robey; Suoping Zhai; Paul Thambi; Clara C. Chen; Sheela Patil; Tom Smith; Seth M. Steinberg; Maria Merino; Barry Goldspiel; Beverly Meadows; Wilfred D. Stein; Peter Choyke; Frank Balis; William D. Figg; Tito Fojo

Research Articles

Molecular Oncology, Markers, Clinical Correlates

CpG Island Methylation Is Responsible for p14ARF Inactivation and Inversely Correlates with p53 Overexpression in Resected Non–Small Cell Lung Cancer

Han-Shui Hsu; Yu-Chien Wang; Ruo-Chia Tseng; Jer-Wei Chang; Jung-Ta Chen; Chuen-Ming Shih; Chih-Yi Chen; Yi-Ching Wang

Her-2/neu Expression in Prostate Cancer: A Dynamic Process?

Joan Carles; Josep Lloreta; Marta Salido; Albert Font; Marta Suarez; Veronica Baena; Miquel Nogue; Montserrat Domenech; Xavier Fabregat

Expression of Matrix Metalloproteinases and Their Inhibitors in Medulloblastomas and Their Prognostic Relevance

Özlem Özen; Bjarne Krebs; Bernhard Hemmerlein; Arnulf Pekrun; Hans Kretzschmar; Jochen Herms

On the Role of Melanoma-Specific CD8⁺ T-Cell Immunity in Disease Progression of Advanced-Stage Melanoma Patients

Monique van Oijen; Adriaan Bins; Sjoerd Elias; Johan Sein; Pauline Weder; Gijsbert de Gast; Henk Mallo; Maarten Gallee; Harm van Tinteren; Ton Schumacher; John Haanen

Expression of Trypsinogen-1, Trypsinogen-2, and Tumor-Associated Trypsin Inhibitor in Ovarian Cancer: Prognostic Study on Tissue and Serum

Annukka Paju; Juhani Vartiainen; Caj Haglund; Outi Itkonen; Kristina von Boguslawski; Arto Leminen; Torsten Wahlström; Ulf-Håkan Stenman

Meta-Analysis Suggests Association of L-myc EcoRI Polymorphism with Cancer Prognosis

Monica Spinola; Paola Pedotti; Tommaso A. Dragani; Emanuela Taioli

Overexpressed Decorin in Pancreatic Cancer: Potential Tumor Growth Inhibition and Attenuation of Chemotherapeutic Action

Jörg Köninger; Nathalia A. Giese; Fabio Francesco di Mola; Pascal Berberat; Thomas Giese; Irene Esposito; Max G. Bachem; Markus W. Büchler; Helmut Friess

Gastrin-Induced Cyclooxygenase-2 Expression in Barrett’s Carcinogenesis

Salem I. Abdalla; Pierre Lao-Sirieix; Marco R. Novelli; Laurence B. Lovat; Ian R. Sanderson; Rebecca C. Fitzgerald

Interlaboratory Comparison of HER-2 Oncogene Amplification as Detected by Chromogenic and Fluorescence in situ Hybridization

Jorma Isola; Minna Tanner; Amanda Forsyth; Timothy G. Cooke; Amanda D. Watters; John M. S. Bartlett

Overexpression of RhoA, Rac1, and Cdc42 GTPases Is Associated with Progression in Testicular Cancer

Takao Kamai; Tomonori Yamanishi; Hiromichi Shirataki; Kentaro Takagi; Hidekazu Asami; Yuji Ito; Ken-Ichiro Yoshida

The Use of Plasma Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Proteomic Patterns for Detection of Head and Neck Squamous Cell Cancers

Scott G. Soltys; Quynh-Thu Le; Gongyi Shi; Robert Tibshirani; A. J. Giaccia; Albert C. Koong

Experimental Therapeutics, Preclinical Pharmacology

Antiangiogenic Properties of 17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin: An Orally Bioavailable Heat Shock Protein 90 Modulator

Gurmeet Kaur; Dorina Belotti; Angelika M. Burger; Kirsten Fisher-Nielson; Patrizia Borsotti; Elena Riccardi; Jagada Thillainathan; Melinda Hollingshead; Edward A. Sausville; Raffaella Giavazzi

Inhibition of Hepatocellular Carcinomas in vitro and Hepatic Metastases in vivo in Mice by the Histone Deacetylase Inhibitor HA-But

Danila Coradini; Sonia Zorzet; Raffaella Rossin; Ignazio Scarlata; Cinzia Pellizzaro; Claudia Turrin; Michele Bello; Silvia Cantoni; Annalisa Speranza; Gianni Sava; Ulderico Mazzi; Alberto Perbellini

Treatment of Intracerebral Neoplasia and Neoplastic Meningitis with Regional Delivery of Oncolytic Recombinant Poliovirus

Hidenobu Ochiai; Stephanie A. Moore; Gary E. Archer; Tatsunori Okamura; Tracy A. Chewning; Jeffrey R. Marks; John H. Sampson; Matthias Gromeier

Enhanced Activity of Hu14.18-IL2 Immunocytokine against Murine NXS2 Neuroblastoma when Combined with Interleukin 2 Therapy

Zane C. Neal; Jeannie C. Yang; Alexander L. Rakhmilevich; Ilia N. Buhtoiarov; Hillary E. Lum; Michael Imboden; Jacquelyn A. Hank; Holger N. Lode; Ralph A. Reisfeld; Stephen D. Gillies; Paul M. Sondel

Cell Cycle–Dependent Antagonistic Interactions between Paclitaxel and γ-Radiation in Combination Therapy

Meihua Sui; Jennifer M. Dziadyk; Xueming Zhu; Weimin Fan

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

Roberto Bianco; Roberta Caputo; Rosa Caputo; Vincenzo Damiano; Sabino De Placido; Corrado Ficorella; Sudhir Agrawal; A. Raffaele Bianco; Fortunato Ciardiello; Giampaolo Tortora

Mechanisms of Inhibition of Tumor Angiogenesis and Vascular Tumor Growth by Epigallocatechin-3-Gallate

Gianfranco Fassina; Roberta Venè; Monica Morini; Simona Minghelli; Roberto Benelli; Douglas M. Noonan; Adriana Albini

Evaluation of the Therapeutic Potential of the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Preclinical Models of Bladder Cancer

Jose L. Dominguez-Escrig; John D. Kelly; David E. Neal; Sonya M. King; Barry R. Davies

ICAM-2 Gene Therapy for Peritoneal Dissemination of Scirrhous Gastric Carcinoma

Hiroaki Tanaka; Masakazu Yashiro; Takeshi Sunami; Yoji Sakate; Kinshi Kosaka; Kosei Hirakawa

Correction

Correction: Article on Treatment of B-Cell Lymphoma

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