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Volume 10, Issue 13

1 July 2004

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Cover Image

ISSN 1078-0432

EISSN 1557-3265

Issue Sections

Featured Articles
Regular Articles
- Clinical Trials
Research Articles
- Molecular Oncology, Markers, Clinical Correlates
- Experimental Therapeutics, Preclinical Pharmacology

Featured Articles

Clinical Trials

Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

Ellen L. Jones; Leonard R. Prosnitz; Mark W. Dewhirst; P. Kelly Marcom; Patricia H. Hardenbergh; Lawrence B. Marks; David M. Brizel; Zeljko Vujaskovic

Abstract

View articletitled, Thermochemoradiotherapy Improves Oxygenation in Locally Advanced Breast Cancer

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The Na⁺/I⁻ Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Down-Regulated in the Thyroid

Irene L. Wapnir; Michael Goris; Anthony Yudd; Orsolya Dohan; Donna Adelman; Kent Nowels; Nancy Carrasco

Abstract

View articletitled, The Na+/I− Symporter Mediates Iodide Uptake in Breast Cancer Metastases and Can Be Selectively Down-Regulated in the Thyroid

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Molecular Oncology, Markers, Clinical Correlates

Imaging Correlates of Molecular Signatures in Oligodendrogliomas

Joseph F. Megyesi; Edward Kachur; Donald H. Lee; Magdalena C. Zlatescu; Rebecca A. Betensky; Peter A. Forsyth; Yoshifumi Okada; Hikaru Sasaki; Masahiro Mizoguchi; David N. Louis; J. Gregory Cairncross

Abstract

View articletitled, Imaging Correlates of Molecular Signatures in Oligodendrogliomas

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The Tumor-Associated Antigen PRAME Is Universally Expressed in High-Stage Neuroblastoma and Associated with Poor Outcome

André Oberthuer; Barbara Hero; Rüdiger Spitz; Frank Berthold; Matthias Fischer

Abstract

View articletitled, The Tumor-Associated Antigen PRAME Is Universally Expressed in High-Stage Neuroblastoma and Associated with Poor Outcome

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Chromatin Remodeling Factors and BRM/BRG1 Expression as Prognostic Indicators in Non-Small Cell Lung Cancer

Junya Fukuoka; Takeshi Fujii; Joanna H. Shih; Tatiana Dracheva; Daoud Meerzaman; Audrey Player; Kyeong Hong; Sharon Settnek; Ajay Gupta; Kenneth Buetow; Stephen Hewitt; William D. Travis; Jin Jen

Abstract

View articletitled, Chromatin Remodeling Factors and BRM/BRG1 Expression as Prognostic Indicators in Non-Small Cell Lung Cancer

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Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer

Makoto Ishikawa; Joji Kitayama; Hirokazu Nagawa

Abstract

View articletitled, Enhanced Expression of Leptin and Leptin Receptor (OB-R) in Human Breast Cancer

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Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma

Firouzeh Korangy; Lars A. Ormandy; Jörg S. Bleck; Jürgen Klempnauer; Ludwig Wilkens; Michael P. Manns; Tim F. Greten

Abstract

View articletitled, Spontaneous Tumor-Specific Humoral and Cellular Immune Responses to NY-ESO-1 in Hepatocellular Carcinoma

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Experimental Therapeutics, Preclinical Pharmacology

A Cox-2 Promoter-Based Replication-Selective Adenoviral Vector to Target the Cox-2-Expressing Human Bladder Cancer Cells

Toshiro Shirakawa; Katsuyuki Hamada; Zhujun Zhang; Hiroshi Okada; Masatoshi Tagawa; Sadao Kamidono; Masato Kawabata; Akinobu Gotoh

Abstract

View articletitled, A Cox-2 Promoter-Based Replication-Selective Adenoviral Vector to Target the Cox-2-Expressing Human Bladder Cancer Cells

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Depleted Dopamine in Gastric Cancer Tissues: Dopamine Treatment Retards Growth of Gastric Cancer by Inhibiting Angiogenesis

Debanjan Chakroborty; Chandrani Sarkar; Rita Basu Mitra; Samir Banerjee; Partha Sarathi Dasgupta; Sujit Basu

Abstract

View articletitled, Depleted Dopamine in Gastric Cancer Tissues: Dopamine Treatment Retards Growth of Gastric Cancer by Inhibiting Angiogenesis

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Regular Articles

Clinical Trials

The dl1520 Virus Is Found Preferentially in Tumor Tissue after Direct Intratumoral Injection in Oral Carcinoma

Stephen Morley; Gordon MacDonald; David Kirn; Stan Kaye; Robert Brown; David Soutar

Abstract

View articletitled, The dl1520 Virus Is Found Preferentially in Tumor Tissue after Direct Intratumoral Injection in Oral Carcinoma

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A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors

Paul R. Helft; Richard L. Schilsky; Frank J. Hoke; Daphne Williams; Hedy L. Kindler; Evie Sprague; Mark DeWitte; Helen K. Martino; John Erickson; Lini Pandite; Mark Russo; John M. Lambert; Maria Howard; Mark J. Ratain

Abstract

View articletitled, A Phase I Study of Cantuzumab Mertansine Administered as a Single Intravenous Infusion Once Weekly in Patients with Advanced Solid Tumors

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Uracil/Tegafur Plus Cisplatin with Concurrent Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer: A Multi-institutional Phase II Trial

Yukito Ichinose; Yushi Nakai; Shoji Kudoh; Hiroshi Semba; Susumu Yoshida; Toshihiro Nukiwa; Hidehiko Yamamoto; Yoshio Yamane; Hisanobu Niitani; UP-RT Study Group

Abstract

View articletitled, Uracil/Tegafur Plus Cisplatin with Concurrent Radiotherapy for Locally Advanced Non-Small-Cell Lung Cancer: A Multi-institutional Phase II Trial

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A Phase I Clinical and Pharmacokinetic Study of Ro 31-7453 Given as a 7- or 14-Day Oral Twice Daily Schedule Every 4 Weeks in Patients with Solid Tumors

Ramon Salazar; Donald Bissett; Chris Twelves; Lars Breimer; Mark DeMario; Sophia Campbell; Jay Zhi; Steve Ritland; Jim Cassidy

Abstract

View articletitled, A Phase I Clinical and Pharmacokinetic Study of Ro 31-7453 Given as a 7- or 14-Day Oral Twice Daily Schedule Every 4 Weeks in Patients with Solid Tumors

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Gefitinib (ZD1839) Monotherapy as a Salvage Regimen for Previously Treated Advanced Non-Small Cell Lung Cancer

Jinny Park; Byung Bae Park; Jee Youn Kim; Se-Hoon Lee; Soon Il Lee; Ho Young Kim; Jung Han Kim; Se Hoon Park; Kyung-Eun Lee; Joon Oh Park; Kihyun Kim; Chul Won Jung; Young Suk Park; Young-Hyuck Im; Won Ki Kang; Mark H. Lee; Keunchil Park

Abstract

View articletitled, Gefitinib (ZD1839) Monotherapy as a Salvage Regimen for Previously Treated Advanced Non-Small Cell Lung Cancer

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A Two-by-Two Factorial Trial Comparing Oral with Transdermal Estrogen Therapy and Fenretinide with Placebo on Breast Cancer Biomarkers

Andrea Decensi; Bernardo Bonanni; Laura Baglietto; Aliana Guerrieri-Gonzaga; Francesca Ramazzotto; Harriet Johansson; Chris Robertson; Irene Marinucci; Frederique Mariette; Maria Teresa Sandri; Cristina Daldoss; Vanda Bianco; Marco Buttarelli; Massimiliano Cazzaniga; Dorella Franchi; Enrico Cassano; Umberto Omodei

Abstract

View articletitled, A Two-by-Two Factorial Trial Comparing Oral with Transdermal Estrogen Therapy and Fenretinide with Placebo on Breast Cancer Biomarkers

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Combination of Somatostatin Analog, Dexamethasone, and Standard Androgen Ablation Therapy in Stage D3 Prostate Cancer Patients with Bone Metastases

Michael Koutsilieris; Constantine S. Mitsiades; John Bogdanos; Theodoros Dimopoulos; Dimitrios Karamanolakis; Constantine Milathianakis; Athanassios Tsintavis

Abstract

View articletitled, Combination of Somatostatin Analog, Dexamethasone, and Standard Androgen Ablation Therapy in Stage D3 Prostate Cancer Patients with Bone Metastases

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Dose-Ranging Study of the Safety and Pharmacokinetics of Atrasentan in Patients with Refractory Malignancies

Christopher W. Ryan; Nicholas J. Vogelzang; Everett E. Vokes; Hedy L. Kindler; Samir D. Undevia; Rod Humerickhouse; Amy K. André; Qiang Wang; Robert A. Carr; Mark J. Ratain

Abstract

View articletitled, Dose-Ranging Study of the Safety and Pharmacokinetics of Atrasentan in Patients with Refractory Malignancies

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Research Articles

Molecular Oncology, Markers, Clinical Correlates

Cytochrome P450 and Glutathione Transferase Expression in Squamous Cell Cancer

Shadan Ali; Basil F. El-Rayes; Lance K. Heilbrun; Fazlul H. Sarkar; John F. Ensley; Omar Kucuk; Philip A. Philip

Abstract

View articletitled, Cytochrome P450 and Glutathione Transferase Expression in Squamous Cell Cancer

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Mouse Mammary Tumor-Like Virus Is Associated with p53 Nuclear Accumulation and Progesterone Receptor Positivity but not Estrogen Positivity in Human Female Breast Cancer

Margaret Faedo; Caroline E. Ford; Reena Mehta; Katrina Blazek; William D. Rawlinson

Abstract

View articletitled, Mouse Mammary Tumor-Like Virus Is Associated with p53 Nuclear Accumulation and Progesterone Receptor Positivity but not Estrogen Positivity in Human Female Breast Cancer

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The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients

Gillian Gifford; Jim Paul; Paul A. Vasey; Stanley B. Kaye; Robert Brown; on behalf of the Scottish Gynaecological Clinical Trials Group

Abstract

View articletitled, The Acquisition of hMLH1 Methylation in Plasma DNA after Chemotherapy Predicts Poor Survival for Ovarian Cancer Patients

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Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer

Viola A. Heinzelmann-Schwarz; Margaret Gardiner-Garden; Susan M. Henshall; James Scurry; Richard A. Scolyer; Michael J. Davies; Matthias Heinzelmann; Larry H. Kalish; Anish Bali; James G. Kench; Lyndal S. Edwards; Patricia M. Vanden Bergh; Neville F. Hacker; Robert L. Sutherland; Philippa M. O’Brien

Abstract

View articletitled, Overexpression of the Cell Adhesion Molecules DDR1, Claudin 3, and Ep-CAM in Metaplastic Ovarian Epithelium and Ovarian Cancer

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M34 Actin Regulatory Protein Is a Sensitive Diagnostic Marker for Early- and Late-Stage Mammary Carcinomas

Zoraida Soriano; Joel D. Pardee

Abstract

View articletitled, M34 Actin Regulatory Protein Is a Sensitive Diagnostic Marker for Early- and Late-Stage Mammary Carcinomas

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Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy

Maria Pellisé; Antoni Castells; Àngels Ginès; Rubén Agrelo; Manel Solé; Sergi Castellví-Bel; Glòria Fernández-Esparrach; Josep Llach; Manel Esteller; Josep M. Bordas; Josep M. Piqué

Abstract

View articletitled, Detection of Lymph Node Micrometastases by Gene Promoter Hypermethylation in Samples Obtained by Endosonography- Guided Fine-Needle Aspiration Biopsy

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Intratumoral CD8⁺ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma

Svetlana Kondratiev; Edmond Sabo; Evgeny Yakirevich; Ofer Lavie; Murray B. Resnick

Abstract

View articletitled, Intratumoral CD8+ T Lymphocytes as a Prognostic Factor of Survival in Endometrial Carcinoma

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Predicting Early Failure after Adjuvant Chemotherapy in High-Risk Breast Cancer Patients with Extensive Lymph Node Involvement

Ian F. Faneyte; Johannes L. Peterse; Harm van Tinteren; Corina Pronk; Elisabeth G. E. de Vries; Sjoerd Rodenhuis; Marc J. van de Vijver

Abstract

View articletitled, Predicting Early Failure after Adjuvant Chemotherapy in High-Risk Breast Cancer Patients with Extensive Lymph Node Involvement

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Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma

Kårstein Måseide; Rita A. Kandel; Robert S. Bell; Charles N. Catton; Brian O’Sullivan; Jay S. Wunder; Melania Pintilie; David Hedley; Richard P. Hill

Abstract

View articletitled, Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma

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The A₃ Adenosine Receptor Is Highly Expressed in Tumor versus Normal Cells: Potential Target for Tumor Growth Inhibition

Lea Madi; Avivit Ochaion; Lea Rath-Wolfson; Sara Bar-Yehuda; Abigail Erlanger; Gil Ohana; Arie Harish; Ofer Merimski; Faina Barer; Pnina Fishman

Abstract

View articletitled, The A3 Adenosine Receptor Is Highly Expressed in Tumor versus Normal Cells: Potential Target for Tumor Growth Inhibition

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Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression

Ricardo López de Cicco; James C. Watson; Daniel E. Bassi; Samuel Litwin; Andrés J. Klein-Szanto

Abstract

View articletitled, Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression

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Experimental Therapeutics, Preclinical Pharmacology

Alpha-Particle Emitting Atomic Generator (Actinium-225)-Labeled Trastuzumab (Herceptin) Targeting of Breast Cancer Spheroids: Efficacy versus HER2/neu Expression

Åse M. Ballangrud; Wei-Hong Yang; Stig Palm; Richard Enmon; Paul E. Borchardt; Virginia A. Pellegrini; Michael R. McDevitt; David A. Scheinberg; George Sgouros

Abstract

View articletitled, Alpha-Particle Emitting Atomic Generator (Actinium-225)-Labeled Trastuzumab (Herceptin) Targeting of Breast Cancer Spheroids: Efficacy versus HER2/neu Expression

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Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

Ahmad Jalili; Marcin Makowski; Tomasz Świtaj; Dominika Nowis; Grzegorz M. Wilczyński; Ewa Wilczek; Magdalena Chorąży-Massalska; Anna Radzikowska; Włodzimierz Maśliński; Łukasz Biały; Jacek Sieńko; Aleksander Sieroń; Mariusz Adamek; Grzegorz Basak; Paweł Mróz; Ireneusz W. Krasnodębski; Marek Jakóbisiak; Jakub Gołąb

Abstract

View articletitled, Effective Photoimmunotherapy of Murine Colon Carcinoma Induced by the Combination of Photodynamic Therapy and Dendritic Cells

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Angiogenesis Inhibition by an Oncolytic Herpes Virus Expressing Interleukin 12

Richard J. Wong; Mei-Ki Chan; Zhenkun Yu; Ronald A. Ghossein; Ivan Ngai; Prasad S. Adusumilli; Brendon M. Stiles; Jatin P. Shah; Bhuvanesh Singh; Yuman Fong

Abstract

View articletitled, Angiogenesis Inhibition by an Oncolytic Herpes Virus Expressing Interleukin 12

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Gabexate Mesilate Inhibits Colon Cancer Growth, Invasion, and Metastasis by Reducing Matrix Metalloproteinases and Angiogenesis

Wan-Hee Yoon; Yeon-Joo Jung; Tae-Dong Kim; Ge Li; Byoung-Jeon Park; Ji-Yeon Kim; Young-Chul Lee; Jin-Man Kim; Jong-Il Park; Hae-Duck Park; Zae-Sung No; Kyu Lim; Byung-Doo Hwang; Young S. Kim

Abstract

View articletitled, Gabexate Mesilate Inhibits Colon Cancer Growth, Invasion, and Metastasis by Reducing Matrix Metalloproteinases and Angiogenesis

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Combinatorial Administration of Molecules That Simultaneously Inhibit Angiogenesis and Invasion Leads to Increased Therapeutic Efficacy in Mouse Models of Malignant Glioma

Lorenzo Bello; Valeria Lucini; Francesco Costa; Mauro Pluderi; Carlo Giussani; Francesco Acerbi; Giorgio Carrabba; Marilou Pannacci; Dario Caronzolo; Silvia Grosso; Svetlana Shinkaruk; Federica Colleoni; Xavier Canron; Giustino Tomei; Gerard Deleris; Andreas Bikfalvi

Abstract

View articletitled, Combinatorial Administration of Molecules That Simultaneously Inhibit Angiogenesis and Invasion Leads to Increased Therapeutic Efficacy in Mouse Models of Malignant Glioma

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Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193-N-Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewis^y and Eliminates Lewis^y-Positive Human Carcinoma Cells and Xenografts

Erwin R. Boghaert; Latha Sridharan; Douglas C. Armellino; Kiran M. Khandke; John F. DiJoseph; Arthur Kunz; Maureen M. Dougher; Fan Jiang; Lyka B. Kalyandrug; Philip R. Hamann; Philip Frost; Nitin K. Damle

Abstract

View articletitled, Antibody-Targeted Chemotherapy with the Calicheamicin Conjugate hu3S193-N-Acetyl γ Calicheamicin Dimethyl Hydrazide Targets Lewisy and Eliminates Lewisy-Positive Human Carcinoma Cells and Xenografts

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Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress

Anne Lewis; Matthew Ough; Ling Li; Marilyn M. Hinkhouse; Justine M. Ritchie; Douglas R. Spitz; Joseph J. Cullen

Abstract

View articletitled, Treatment of Pancreatic Cancer Cells with Dicumarol Induces Cytotoxicity and Oxidative Stress

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Zoledronic Acid Inhibits Visceral Metastases in the 4T1/luc Mouse Breast Cancer Model

Toru Hiraga; Paul J. Williams; Akimi Ueda; Daisuke Tamura; Toshiyuki Yoneda

Abstract

View articletitled, Zoledronic Acid Inhibits Visceral Metastases in the 4T1/luc Mouse Breast Cancer Model

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Antisense Protein Kinase A RIα Inhibits 7,12-Dimethylbenz(a)anthracene-Induction of Mammary Cancer: Blockade at the Initial Phase of Carcinogenesis

Maria V. Nesterova; Yoon S. Cho-Chung

Abstract

View articletitled, Antisense Protein Kinase A RIα Inhibits 7,12-Dimethylbenz(a)anthracene-Induction of Mammary Cancer: Blockade at the Initial Phase of Carcinogenesis

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Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

Kuniyuki Katano; Roohangiz Safaei; Goli Samimi; Alison Holzer; Mika Tomioka; Murray Goodman; Stephen B. Howell

Abstract

View articletitled, Confocal Microscopic Analysis of the Interaction between Cisplatin and the Copper Transporter ATP7B in Human Ovarian Carcinoma Cells

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Regorafenib plus Vincristine and Irinotecan in Pediatric Patients with Recurrent/Refractory Solid Tumors: An Innovative Therapy for Children with Cancer Study

Validation of the Clinical Use of GIScar, an Academic-developed Genomic Instability Score Predicting Sensitivity to Maintenance Olaparib for Ovarian Cancer

Upregulation of Indoleamine 2,3-dioxygenase 1 in tumor cells and tertiary lymphoid structures is a hallmark of inflamed non-small cell lung cancer

Time to Think About Human Leukocyte Antigen–Based Diagnostics in Lung Cancer?

Issues

Cover Image

Featured Articles

Clinical Trials

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Regular Articles

Clinical Trials

Research Articles

Molecular Oncology, Markers, Clinical Correlates

Experimental Therapeutics, Preclinical Pharmacology

Email alerts

AACR Journals

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