Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer

Wong, Jeffrey Y. C.; Somlo, George; Odom-Maryon, Tamara; Williams, Lawrence E.; Liu, An; Yamauchi, Dave; Wu, Anna M.; Yazaki, Paul; Wilczynski, Sharon; Shively, John E.; Forman, Stephen; Doroshow, James H.; Raubitschek, Andrew A.

Article navigation

Session VI: Clinical Radioimmunotherapy: Solid Tumors| October 01 1999

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer^¹

Jeffrey Y. C. Wong;

Jeffrey Y. C. Wong ²

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

²To whom requests for reprints should be addressed, at the Division of Radiation Oncology and Radiation Research; City of Hope National Medical Center; 1500 East Duarte Road, Duarte, CA 91010. Phone: 626-301-8247; Fax: 626-930-5334.

Search for other works by this author on:

This Site

PubMed

Google Scholar

George Somlo;

George Somlo

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Tamara Odom-Maryon;

Tamara Odom-Maryon

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Lawrence E. Williams;

Lawrence E. Williams

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

An Liu;

An Liu

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Dave Yamauchi;

Dave Yamauchi

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Anna M. Wu;

Anna M. Wu

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Paul Yazaki;

Paul Yazaki

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Sharon Wilczynski;

Sharon Wilczynski

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

John E. Shively;

John E. Shively

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Stephen Forman;

Stephen Forman

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

James H. Doroshow;

James H. Doroshow

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Andrew A. Raubitschek

Divisions of Radiation Oncology and Radiation Research [JYCW, AL, AAR], Radioimmunotherapy [J. Y. C. W., A. L., A. A. R.], Medical Oncology and Experimental Therapeutics [G. S., S. F., J. H. D.], Biostatistics [T. O-M.], Diagnostic Radiology [L. E. W., D. Y.], Biology [A. M. W., P. Y.], Pathology [S. W.], Immunology [J. E. S.], and Hematology and Bone Marrow Transplantation [G. S., S. F., J. H. D.], City of Hope National Medical Center and Beckman Research Institute, Duarte, California 91010

Search for other works by this author on:

This Site

PubMed

Google Scholar

Author & Article Information

²To whom requests for reprints should be addressed, at the Division of Radiation Oncology and Radiation Research; City of Hope National Medical Center; 1500 East Duarte Road, Duarte, CA 91010. Phone: 626-301-8247; Fax: 626-930-5334.

Online ISSN: 1557-3265

Print ISSN: 1078-0432

1999

Clin Cancer Res (1999) 5 (10): 3224s–3231s.

Abstract

cT84.66 is a human/murine IgG₁ with high affinity and specificity for carcinoembryonic antigen (CEA). An earlier Phase I trial defined the maximum tolerated dose for ⁹⁰Y-diethylenetriaminepentaacetic acid (DTPA)-cT84.66 at 22 mCi/m². Dose-limiting toxicities were reversible leukopenia and thrombocytopenia. The purpose of this Phase I trial was to evaluate the feasibility and toxicities of administering higher activities of ⁹⁰Y-DTPA-cT84.66 with stem cell support in patients with CEA-producing breast cancer. Patients with CEA-producing breast cancer refractory to standard therapies underwent peripheral stem cell collection followed by infusion of ¹¹¹indium-DTPA-cT84.66. Those patients demonstrating tumor targeting received a single therapy dose of ⁹⁰Y-DTPA-cT84.66, followed by Ca-DTPA infusion for 72 h posttherapy. Stem cells were reinfused following a divided schedule. To date, seven patients have been accrued to this trial. Each patient received an imaging dose of ¹¹¹In-cT84.66. Six patients demonstrated tumor imaging and received a single cycle of ⁹⁰Y-cT84.66 at 15 mCi/m² (three patients) and 22.5 mCi/m² (three patients). One patient did not demonstrate tumor imaging and was not treated. At these administered activities, ⁹⁰Y-cT84.66 was well tolerated. No dose-limiting toxicities have been observed. All patients demonstrated hematopoietic recovery after stem cell infusion. One patient demonstrated stable disease for 4 months; one patient had stable disease and reduction of bone pain for 3 months; and a third patient experienced >50% reduction of an ovarian metastasis, resolution of malignant pleural effusion, stable pleural metastases, and stable bone scan for 14 months. Preliminary results from this ongoing Phase I trial are promising and demonstrate the feasibility and potential for antitumor effects of stem cell supported ⁹⁰Y-cT84.66 therapy in patients with CEA-producing breast cancers.

¹

Presented at the “Seventh Conference on Radioimmunodetection and Radioimmunotherapy of Cancer,” October 15–17, 1998, Princeton, NJ. Supported by NIH Grant PO1 43904 and NIH Cancer Center Core Grant 33527.

This content is only available via PDF.

1999

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer^¹

Abstract

Citing articles via

Email alerts

AACR Journals

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer1

Abstract

Citing articles via

Email alerts

AACR Journals

This Feature Is Available To Subscribers Only

Initial Clinical Experience Evaluating Yttrium-90-Chimeric T84.66 Anticarcinoembryonic Antigen Antibody and Autologous Hematopoietic Stem Cell Support in Patients with Carcinoembryonic Antigen-producing Metastatic Breast Cancer^¹