In this article (Clin Cancer Res 2014;20:6618–30), which was published in the December 15, 2014, issue of Clinical Cancer Research (1), the authors contacted the CCR editorial office regarding an error in Table 3. Specifically, the mutation in the borderline component of sample 65663 is incorrectly recorded as G12V. The correct mutation for this sample is G12D. This error does not change the interpretation of the data or the conclusions of the article. A corrected version of Table 3 is shown below. The authors regret this error.
Table 3.
. | . | . | Mutation . | . | |
---|---|---|---|---|---|
Case ID . | Grade . | Gene . | Borderline . | Invasive . | Method . |
65661 | 1 | No mutationa | Oncomap & HRM | ||
15043 | 1 | KRAS | G12D | G12D | Oncomap & HRM |
65662 | 1 | KRAS | G12V | G12V | Oncomap & HRM |
65663 | 1 | KRAS | G12D | No mutation | HRM |
9128 | 1 | NRAS | Q61R | Q61R | Oncomap & HRM |
2044 | 2 | NRAS | Q61K | Q61K | Oncomap & HRM |
5899 | 2 | NRAS | Q61R | Q61R | Oncomap & HRM |
3960 | 2 | TP53 | N239Pfs*6 | N239Pfs*6 | Oncomap & HRM |
65664 | 3 | TP53 | E326* | E326* | HRM |
15060 | 3 | TP53 | No mutation | N239T | HRM |
65665 | 3 | TP53 | M237V | M237V | HRM |
65666 | 3 | TP53 | P190Lfs*57 | P190Lfs*57 | HRM |
65667 | 3 | TP53 | V143G | V143G | HRM |
65668 | 3 | TP53 | R175H | R175H | HRM |
Additional NRAS mutations identified in extended mutation screenb | |||||
6582 | 1 | NRAS | pQ61R | HRM | |
7200 | 1 | NRAS | Q61R | HRM |
. | . | . | Mutation . | . | |
---|---|---|---|---|---|
Case ID . | Grade . | Gene . | Borderline . | Invasive . | Method . |
65661 | 1 | No mutationa | Oncomap & HRM | ||
15043 | 1 | KRAS | G12D | G12D | Oncomap & HRM |
65662 | 1 | KRAS | G12V | G12V | Oncomap & HRM |
65663 | 1 | KRAS | G12D | No mutation | HRM |
9128 | 1 | NRAS | Q61R | Q61R | Oncomap & HRM |
2044 | 2 | NRAS | Q61K | Q61K | Oncomap & HRM |
5899 | 2 | NRAS | Q61R | Q61R | Oncomap & HRM |
3960 | 2 | TP53 | N239Pfs*6 | N239Pfs*6 | Oncomap & HRM |
65664 | 3 | TP53 | E326* | E326* | HRM |
15060 | 3 | TP53 | No mutation | N239T | HRM |
65665 | 3 | TP53 | M237V | M237V | HRM |
65666 | 3 | TP53 | P190Lfs*57 | P190Lfs*57 | HRM |
65667 | 3 | TP53 | V143G | V143G | HRM |
65668 | 3 | TP53 | R175H | R175H | HRM |
Additional NRAS mutations identified in extended mutation screenb | |||||
6582 | 1 | NRAS | pQ61R | HRM | |
7200 | 1 | NRAS | Q61R | HRM |
aNo mutation = no mutation detected in “hot spot” regions tested.
bn = 44 SBT-EOC cases, n = 53 purely SBT cases, and n = 53 EOC cases without adjacent borderline.
References
1.
Emmanuel
C
, Chiew
Y
, George
J
, Etemadmoghadam
D
, Anglesio
MS
, Sharma
R
, et al Genomic classification of serous ovarian cancer with adjacent borderline differentiates RAS pathway and TP53-mutant tumors and identifies NRAS as an oncogenic driver
. Clin Cancer Res
2014
;20
:6618
–30
.©2016 American Association for Cancer Research.
2016
American Association for Cancer Research.