Retraction: Suppression of N-Methyl-N-nitrosourea/Testosterone-Induced Rat Prostate Cancer Growth by Celecoxib: Effects on Cyclooxygenase-2, Cell Cycle Regulation, and Apoptosis Mechanism(s)

The article entitled “Suppression of N-Methyl-N-nitrosourea/Testosterone-Induced Rat Prostate Cancer Growth by Celecoxib: Effects on Cyclooxygenase-2, Cell Cycle Regulation, and Apoptosis Mechanism(s),” which was published in the August 15, 2003, issue of Clinical Cancer Research (CCR; ref. 1), is being retracted at the request of the corresponding author, based on a recommendation from the Investigation Committee for New York University School of Medicine, the corresponding author's current institution. A reader presented evidence of potential image manipulation in Fig. 5C (i.e., lanes 3 and 4 of the pRB panel and lanes 2 and 3 of the Rb panel appeared to be identical). During its investigation of this matter, the Investigation Committee requested that the authors produce the original film or the scanned image of the film for verification. The authors asserted that, because the experiments were performed at the American Health Foundation, which closed unexpectedly in 2004, they were unable to provide the requested materials and disprove the allegations. Thus, the Investigation Committee recommended retraction of the article. The corresponding author, Bhagavathi A. Narayanan, presented the recommendation of the Investigation Committee to the CCR editorial office and requested a retraction of the article. The matter was reviewed by members of the AACR Publications staff, who agree with the retraction recommendation. A copy of this notice was sent to the authors.