The relevance of the findings reported in the article on vandetanib inhibition of growth of adenoid cystic carcinoma in an orthotopic nude mouse model in the August 15, 2008, issue of Clinical Cancer Research is now in question. The research reported was conducted on three cell lines that the authors believed to be adenoid cystic salivary carcinoma cell lines. Because of reports of cell line contamination after publication, they have since genotyped the three cell lines used in the article-ACC--2, ACC-3, and ACC-M-- by short tandem repeat (STR) analysis, and this analysis revealed that all three lines had identical genotypes. On comparison to the genotypes of the ATCC cancer cell line collection, they found that their genotype was identical to that of HeLa cells.
Sungweon C, Sano D, Cheung M, et al. Vandetanib inhibits growth of adenoid cystic carcinoma in an orthotopic nude mouse model. Clin Cancer Res 2008;14:5081–9.
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