PL01-03

Nanostructured materials have been designed for the controlled delivery of drugs, proteins and genes. These materials can be engineered for targeting specific cell types, and with responsiveness to selected stimuli. The intelligent delivery systems provide for greater efficiency and reduced side-effects for treatment of various diseases, including cancer.
 Fluorescent quantum dots have been subjected to thin glutathione or silane coating to render them water-soluble, buffer-stable and non-cytotoxic for biological applications. They are further bioconjugated to target specific cell types and compartments for biolabeling and bioimaging applications. We have also derived novel nanocomposites of quantum dots and magnetic nanoparticles to create multifunctional systems for imaging, bioseparation and targeted delivery applications. These materials are of particular interest for cancer and stem cell research.
 Miniaturized biological and medical devices have been fabricated with microfluidic control for drug screening and medical diagnostic applications. They allow for accurate and high-speed studies and detections involving small sample volumes. Such systems are being developed specifically cancer and infectious disease research.

First AACR Centennial Conference on Translational Cancer Medicine-- Nov 4-8, 2007; Singapore