Clinical Cancer Research is committed to publishing innovative clinical translational research to accelerate the movement of new discoveries in the practice of medicine. CCR is especially interested in publishing clinical trials evaluating new treatments, research on molecular abnormalities that predict incidence, response to therapy, and outcome, and laboratory studies of new drugs and biological agents that will lead to clinical trials. CCR's audience includes scientists in academia, industry, and government research organizations, as well as highly trained practitioners, providing new insights into cancer biology and therapeutics as they emerge.

CCR is pleased to announce a new feature that is designed to provide a scholarly, in-depth review of a particular area of translational research. This feature, CCR Focus, will be published periodically and cover various facets of a chosen topic. CCR Focus is meant to provide a review for individuals who are interested but not necessarily expert in a field, and to also stimulate new insights for those who are already working in this area. A guest editor will guide content and ensure timeliness and accuracy and will be selected for each installment of CCR Focus. These review articles, which may contain new data, will be analytical rather than a catalogue of published information. CCR Focus will also attempt to analyze the limitations in current methods or knowledge and thereby identify important areas needing further discovery or interpretation. The subject matter will have sufficient application to clinical oncology to appeal to the journal's readership.

The first CCR Focus, “Predictive Preclinical Models of Human Cancer: Mouse Models Get Another Chance,” Dr. Cory Abate-Shen, Guest Editor, appears in this issue. “Inhibiting the Epidermal Growth Factor Receptor: Mutations, Misregulation, and More,” Dr. Rafael Rosell, Guest Editor, will appear in December. We look forward to bringing exciting topics to our readers in the months to come. We are happy to receive proposals for new features. Ideas for topics will be generated through the AACR meetings, as well as from interest expressed by the readership. Ideas can be submitted to http://www.aacr.org/.