The past decade has brought unprecedented progress in understanding the genetics of endometrial cancer, but cures remain elusive due to the lack of insights into mechanisms that can be leveraged to develop new therapies. Endometrial cancer is genetically heterogeneous and, therefore, it is imperative that therapeutic strategies become personalized by targeting distinct molecular subsets of endometrial cancer. Despite the importance of epigenetic regulators in endometrial cancer, the mechanism of action for these epigenetic regulators and the associated vulnerabilities exposed by their dysregulations have remained elusive for most of them. Here we will discuss our recent work on how to leverage epigenetic mechanisms to address unmet clinical needs in endometrial cancer through integrated approaches.

Citation Format: Rugang Zhang. Epigenetic approaches for endometrial cancer [abstract]. In: Proceedings of the AACR Special Conference on Endometrial Cancer: Transforming Care through Science; 2023 Nov 16-18; Boston, Massachusetts. Philadelphia (PA): AACR; Clin Cancer Res 2024;30(5_Suppl):Abstract nr IA015.