CHIP’ing Signal from Noise in Liquid Biopsy

Bernard, Elsa; Micol, Jean-Baptiste

doi:10.1158/1078-0432.CCR-25-0569

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CCR Translations| May 13 2025

CHIP’ing Signal from Noise in Liquid Biopsy

Elsa Bernard

0000-0002-2057-7187

;

Elsa Bernard *

1INSERM U981, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

2IHU PRISM National PRecISion Medicine Center in Oncology, Gustave Roussy, Villejuif, France.

*Corresponding Authors: Jean-Baptiste Micol, Department of Hematology, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: [email protected]; and Elsa Bernard, INSERM U981, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: e[email protected]

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Jean-Baptiste Micol

0000-0003-0934-294X

Jean-Baptiste Micol *

3Department of Hematology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

4INSERM U1287, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

5Interception Program, Personalized Cancer Prevention Center, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

*Corresponding Authors: Jean-Baptiste Micol, Department of Hematology, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: [email protected]; and Elsa Bernard, INSERM U981, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: e[email protected]

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Author & Article Information

*Corresponding Authors: Jean-Baptiste Micol, Department of Hematology, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: [email protected]; and Elsa Bernard, INSERM U981, Gustave Roussy, 114 rue Edouard Vaillant, 94800 Villejuif, France. E-mail: e[email protected]

Clin Cancer Res 2025;XX:XX–XX

Received: March 06 2025

Revision Received: March 19 2025

Accepted: April 04 2025

Online ISSN: 1557-3265

Print ISSN: 1078-0432

2025

American Association for Cancer Research

Clin Cancer Res OF1–OF2.

https://doi.org/10.1158/1078-0432.CCR-25-0569

Summary

The presence of clonal hematopoiesis in cell-free DNA analysis can distort the interpretation of results and influence cancer treatment decisions. This CCR Translations discusses the importance of distinguishing the origin of cell-free DNA variants as tumoral or hematopoietic and its potential clinical implications.

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2025

American Association for Cancer Research

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CHIP’ing Signal from Noise in Liquid Biopsy

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