Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy

Yuan, Hao; Chen, Qun; Jiang, Kuirong; Houchen, Courtney W.; Zhang, Yuqing; Li, Min

doi:10.1158/1078-0432.CCR-24-4368

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CCR Translations| March 14 2025

Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy

Hao Yuan

0009-0007-4848-3354

;

Hao Yuan ^#

1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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Qun Chen

0000-0002-9034-9825

;

Qun Chen ^#

1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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Kuirong Jiang

0000-0002-2849-5450

;

Kuirong Jiang

2Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

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Courtney W. Houchen

0000-0003-2487-5242

;

Courtney W. Houchen

1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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Yuqing Zhang

0000-0001-8839-4849

;

Yuqing Zhang

1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

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Min Li

0000-0002-3971-9130

Min Li *

1Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

*Corresponding Author: Min Li, Department of Medicine and Department of Surgery, The University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1262A, Oklahoma City, OK 73104. E-mail: [email protected]

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Author & Article Information

*Corresponding Author: Min Li, Department of Medicine and Department of Surgery, The University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1262A, Oklahoma City, OK 73104. E-mail: [email protected]

Clin Cancer Res 2025;XX:XX–XX

#

H. Yuan and Q. Chen contributed equally to this article.

Received: January 15 2025

Revision Received: February 04 2025

Accepted: February 13 2025

Online ISSN: 1557-3265

Print ISSN: 1078-0432

Funding

Funding Group:

Award Group:
- Funder(s):
  National Cancer Institute (NCI)
- Award Id(s):
  R01 CA186338
  ,
  R01 CA203108
  ,
  R01 CA247234
- Principal Award Recipient(s):
  M.
  
  Li
Award Group:
- Funder(s):
  William and Ella Owens Medical Research Foundation (William & Ella Owens Medical Research Foundation)
- Principal Award Recipient(s):
  M.
  
  Li

2025

American Association for Cancer Research

Clin Cancer Res OF1–OF3.

https://doi.org/10.1158/1078-0432.CCR-24-4368

Summary

The shared HLA-bound neoepitopes in pancreatic ductal adenocarcinoma (PDAC) represent a novel class of noncanonical antigens with single amino acid substitutions resulting from translational errors. These peptides, shared across patients with PDAC, showed higher immunogenicity than wild-type counterparts, offering potential candidates for specific immunotherapy development in PDAC.

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2025

American Association for Cancer Research

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Shared HLA-Bound Neoepitopes Are New Targets for Pancreatic Cancer Immunotherapy

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