Shedding Light on PARP Inhibitor Response through Functional Imaging

Liu, Ying L.; Zamarin, Dmitriy

doi:10.1158/1078-0432.CCR-22-3711

Shedding Light on PARP Inhibitor Response through Functional Imaging

Ying L. Liu

0000-0001-5790-851X

;

Ying L. Liu

1Division of Gynecological Medical Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

2Department of Medicine, Weill Cornell Medical College, New York, New York.

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Dmitriy Zamarin

0000-0002-0094-0161

Dmitriy Zamarin *

1Division of Gynecological Medical Oncology, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

2Department of Medicine, Weill Cornell Medical College, New York, New York.

*Corresponding Author: Dmitriy Zamarin, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, Room 13-13, New York, NY 10065. Phone: 646-888-4882; E-mail: zamarind@mskcc.org

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*Corresponding Author: Dmitriy Zamarin, Memorial Sloan Kettering Cancer Center, 300 East 66th Street, Room 13-13, New York, NY 10065. Phone: 646-888-4882; E-mail: zamarind@mskcc.org

Clin Cancer Res 2023;XX:XX–XX

Received: December 19 2022

Revision Received: January 06 2023

Accepted: January 19 2023

Online Issn: 1557-3265

Print Issn: 1078-0432

2023

American Association for Cancer Research

Clin Cancer Res OF1–OF3.

https://doi.org/10.1158/1078-0432.CCR-22-3711

Summary

Functional PET imaging using a PARP inhibitor (PARPi) analog may serve as an early, dynamic biomarker of response to PARPi therapy in high-grade serous ovarian cancer. Clinically, this could help to rapidly identify PARPi nonresponders, thereby maximizing efficacy and avoiding toxicities of futile treatments.

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2023

American Association for Cancer Research

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