A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

Lechner, Melissa G.; Brent, Gregory A.

doi:10.1158/1078-0432.CCR-23-3503

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CCR Translations| April 01 2024

A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

Melissa G. Lechner

0000-0002-4744-6566

;

Melissa G. Lechner

1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California.

2VA Greater Los Angeles Healthcare System, Los Angeles, California.

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Gregory A. Brent

0000-0002-4638-6645

Gregory A. Brent *

1Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California.

2VA Greater Los Angeles Healthcare System, Los Angeles, California.

*Corresponding Author: Gregory A. Brent, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California Los Angeles David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 57-145, Los Angeles, CA 90095. E-mail: [email protected]

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Author & Article Information

*Corresponding Author: Gregory A. Brent, Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of California Los Angeles David Geffen School of Medicine, 10833 Le Conte Avenue, CHS 57-145, Los Angeles, CA 90095. E-mail: [email protected]

Clin Cancer Res 2024;30:1220–2

Received: November 29 2023

Revision Received: December 15 2023

Accepted: December 29 2023

Online ISSN: 1557-3265

Print ISSN: 1078-0432

Funding

Funding Group:

Award Group:
- Funder(s):
  Doris Duke Charitable Foundation (DDCF)
- Principal Award Recipient(s):
  M.G.
  
  Lechner
Award Group:
- Funder(s):
  Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM)
- Award Id(s):
  NIH KO8 DK129829
- Principal Award Recipient(s):
  M.G.
  
  Lechner
Award Group:
- Funder(s):
  U.S. Department of Veterans Affairs (VA)
- Award Id(s):
  01BX001966
- Principal Award Recipient(s):
  G.A.
  
  Brent

2024

American Association for Cancer Research

Clin Cancer Res (2024) 30 (7): 1220–1222.

https://doi.org/10.1158/1078-0432.CCR-23-3503

Summary

Advanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane–bound iodine transporter, NIS, and restore iodine uptake.

2024

American Association for Cancer Research

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A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer

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