Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance

Zhou, Mi; Kim, William Y.

doi:10.1158/1078-0432.CCR-22-3574

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CCR Translations| April 03 2023

Viewing RCC with a DNA Methylation Lens ENHANCES Understanding of ICI Resistance

Mi Zhou

0000-0001-8144-3468

;

Mi Zhou

1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.

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William Y. Kim

0000-0001-7922-2156

William Y. Kim *

1Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina.

2Department of Medicine, Division of Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

3Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

4Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

*Corresponding Author: William Y. Kim, Lineberger Comprehensive Cancer Center, University of North Carolina, CB# 7295, 450 West Drive, Chapel Hill, NC 27599-7295. Phone: 919-966-4765; Fax: 919-966-8212; E-mail: [email protected]

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Author & Article Information

*Corresponding Author: William Y. Kim, Lineberger Comprehensive Cancer Center, University of North Carolina, CB# 7295, 450 West Drive, Chapel Hill, NC 27599-7295. Phone: 919-966-4765; Fax: 919-966-8212; E-mail: [email protected]

Clin Cancer Res 2023;29:1170–2

Received: December 06 2022

Revision Received: January 04 2023

Accepted: January 13 2023

Online ISSN: 1557-3265

Print ISSN: 1078-0432

Funding

Funding Group:

Award Group:
- Funder(s):
  Kidney Cancer Association (KCA)
- Principal Award Recipient(s):
  W.Y.
  
  Kim
Award Group:
- Funder(s):
  National Institutes of Health (NIH)
- Award Id(s):
  R01 CA202053
- Principal Award Recipient(s):
  W.Y.
  
  Kim

2023

American Association for Cancer Research

Clin Cancer Res (2023) 29 (7): 1170–1172.

https://doi.org/10.1158/1078-0432.CCR-22-3574

Summary

Clear-cell renal cell carcinoma tumors with an enhancer demethylator phenotype (TED) harbor a worse prognosis and derive less clinical benefit from immunotherapy. The TED phenotype may help predict immunotherapy resistance.

2023

American Association for Cancer Research

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