Time to Think about HLA-Based Diagnostics in Lung Cancer?

HLA evolutionary divergence reflects the ability to recognize diverse neoantigens as non-self, and as a biomarker is conceptually distinct from programmed cell death ligand 1 expression and tumor mutation burden. HLA-based assays to predict benefit from immunotherapy in lung cancer require prospective validation.

See related article by Jiang et al., p. 4830