ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?

Pellini, Bruna; Chaudhuri, Aadel A.

doi:10.1158/1078-0432.CCR-23-0420

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CCR Translations| June 13 2023

ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?

Bruna Pellini

0000-0003-0898-0202

;

Bruna Pellini

1Department of Thoracic Oncology, Moffitt Cancer Center and Research Institute, Tampa, Florida.

2Department of Oncologic Sciences, Morsani College of Medicine, University of South Florida, Tampa, Florida.

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Aadel A. Chaudhuri

0000-0003-3115-3061

Aadel A. Chaudhuri *

3Division of Cancer Biology, Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri.

4Division of Biology and Biomedical Sciences, Washington University School of Medicine, St. Louis, Missouri.

5Department of Genetics, Washington University School of Medicine, St. Louis, Missouri.

6Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri.

7Department of Computer Science and Engineering, Washington University in St. Louis, St. Louis, Missouri.

8Siteman Cancer Center, Barnes Jewish Hospital and Washington University School of Medicine, St. Louis, Missouri.

*Corresponding Author: Aadel A. Chaudhuri, Washington University in St. Louis School of Medicine, 4511 Forest Park Avenue, St. Louis, MO 63108. E-mail: [email protected]

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Author & Article Information

*Corresponding Author: Aadel A. Chaudhuri, Washington University in St. Louis School of Medicine, 4511 Forest Park Avenue, St. Louis, MO 63108. E-mail: [email protected]

Clin Cancer Res 2023;29:2176–8

Received: March 05 2023

Revision Received: March 17 2023

Accepted: March 31 2023

Online ISSN: 1557-3265

Print ISSN: 1078-0432

Funding

Funding Group:

Award Group:
- Funder(s):
  V Foundation for Cancer Research (VFCR)
- Award Id(s):
  V Scholar
- Principal Award Recipient(s):
  A.A.
  
  Chaudhuri
Award Group:
- Funder(s):
  National Cancer Institute (NCI)
- Award Id(s):
  U2C CA252981
- Principal Award Recipient(s):
  A.A.
  
  Chaudhuri

2023

American Association for Cancer Research

Clin Cancer Res (2023) 29 (12): 2176–2178.

https://doi.org/10.1158/1078-0432.CCR-23-0420

Summary

Small cell lung cancer (SCLC) is the deadliest form of lung cancer and has few precision medicine approaches available. A recent study analyzed circulating tumor DNA (ctDNA) in 33 patients with extensive-stage SCLC and showed that ctDNA levels and response patterns correlate strongly with clinical response and survival outcomes.

2023

American Association for Cancer Research

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ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?

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ctDNA Monitoring for Small Cell Lung Cancer: Ready for Prime Time?