A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma

Palanki, Rohan; Swingle, Kelsey L.; Mitchell, Michael J.

doi:10.1158/1078-0432.CCR-22-2626

Rohan Palanki

0000-0001-5168-5634

;

Rohan Palanki #

1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

2Center for Fetal Research, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

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Kelsey L. Swingle

0000-0001-8475-9206

;

Kelsey L. Swingle #

1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

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Michael J. Mitchell

0000-0002-3628-2244

Michael J. Mitchell *

1Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania.

3Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

4Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

5Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

6Institute for Regenerative Medicine, Perelman School of Medicine, Philadelphia, Pennsylvania.

*Corresponding Author: Michael J. Mitchell, Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104. E-mail: mjmitch@seas.upenn.edu

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R. Palanki and K.L. Swingle contributed equally to this article.

*Corresponding Author: Michael J. Mitchell, Department of Bioengineering, University of Pennsylvania, 210 South 33rd Street, Philadelphia, PA 19104. E-mail: mjmitch@seas.upenn.edu

Clin Cancer Res 2022;28:5010–2

Received: September 07 2022

Revision Received: September 22 2022

Accepted: September 27 2022

Online Issn: 1557-3265

Print Issn: 1078-0432

Funding

Funding Group:

Award Group:
- Funder(s):
  Burroughs Wellcome Fund (BWF)
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell
Award Group:
- Funder(s):
  National Heart, Lung, and Blood Institute (NHLBI)
- Award Id(s):
  1F30HL162465-01A1
- Principal Award Recipient(s):
  R.
  
  Palanki
Award Group:
- Funder(s):
  National Institutes of Health (NIH)
- Award Id(s):
  DP2 TR002776
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell
Award Group:
- Funder(s):
  National Institutes of Health (NIH)
- Award Id(s):
  NCI R01 CA241661
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell
Award Group:
- Funder(s):
  National Institutes of Health (NIH)
- Award Id(s):
  NCI R37 CA244911
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell
Award Group:
- Funder(s):
  National Institutes of Health (NIH)
- Award Id(s):
  NIDDK R01 DK123049
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell
Award Group:
- Funder(s):
  National Science Foundation (NSF)
- Award Id(s):
  1845298
- Principal Award Recipient(s):
  K.L.
  
  Swingle
Award Group:
- Funder(s):
  National Science Foundation (NSF)
- Award Id(s):
  CBET-2145491
- Principal Award Recipient(s):
  R.
  K.L.
  M.J.
  
  Palanki
  Swingle
  Mitchell

2022

American Association for Cancer Research

Clin Cancer Res (2022) 28 (23): 5010–5012.

https://doi.org/10.1158/1078-0432.CCR-22-2626

Summary

A microencapsulated, cell-based IL2 cytokine factory was recently developed, and the safety and efficacy of this platform in a mouse model of mesothelioma were demonstrated. This platform has the potential to overcome current challenges in the delivery of therapeutic cytokines for cancer immunotherapy.

2022

American Association for Cancer Research

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A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma

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