An unbiased approach to map the sentinel lymph node landscape reveals progressive immune dysfunction associated with micrometastasis in patients with stage I–III cutaneous melanoma. Evidence of tumor-induced lymph node dysfunction may motivate new hypotheses for neoadjuvant therapy with potential to reinvigorate endogenous antitumor immunity.

See related article by Yaddanapudi et al., p. 2069

©2022 American Association for Cancer Research
2022
American Association for Cancer Research
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