In contrast with exon 19 deletions in the epidermal growth factor receptor (EGFR) gene, insertions in exon 19 are uncommon, and their association with EGFR tyrosine kinase inhibitor (TKI) sensitivity in lung adenocarcinoma is uncertain. He and colleagues report on a multifaceted analysis of this mutation, including clinical characteristics in the largest set of patients assembled to date, modeling of mutant protein structure, assessment of in vitro sensitivity, and review of EGFR TKI clinical response data. They show that exon 19 insertions lend TKI sensitivity, a finding that supports the clinical importance of identifying these insertions in exon 19 in addition to the more common deletions.

To explore aberrations related to progression in myxofibrosarcoma, Li and colleagues identified an amplified SKP2 gene on 5p by array comparative genomic hybridization. In myxofibrosarcoma tissues, SKP2 mRNA was upregulated, and gene amplification was detected in 38% of independent cases, which was...

You do not currently have access to this content.