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cpg-island-methylator-phenotype-cimp

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Journal Articles
Cancer Epidemiol Biomarkers Prev (2007) 16 (12_Supplement): CN12-04.
Published: 15 August 2014
...Martha Slattery CN12-04 The methylation of CpG islands near promoter regions of genes and subsequent transcriptional silencing of these genes, has lead to the definition of a new molecular pathway for colon carcinogenesis. Using data from a large population-based study of colon cancer...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (5): 1068–1076.
Published: 04 May 2022
... ) and is associated with survival time in colorectal cancer ( 7, 8 ). In addition, a well-studied subtype of colorectal cancer is the CpG Island Methylator Phenotype (CIMP), which is defined by the degree of methylation at specific CpG islands in the tumor genome ( 9–11 ). Other measures of DNAm and epigenetic...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (5): 1058–1067.
Published: 04 May 2022
... in the CpG island methylation phenotype (CIMP), leading to inactivation of certain tumor suppressor genes (e.g., MLH1, CDKN2A) via promoter hypermethylation. These changes can lead to either microsatellite unstable (MSI) or stable (MSS) colorectal cancer ( 3 ). Apart from differences...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (4): 783–792.
Published: 01 April 2022
... . Int J Cancer 2007 ; 121 : 810 – 8 . 22. Hughes LAE , Simons CCJM , van den Brandt PA , Goldbohm RA , de Goeij AF , de Bruïne AP , . Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype...
Includes: Supplementary data
Journal Articles
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (12): 2317–2326.
Published: 01 December 2021
... , . Body size, physical activity and risk of colorectal cancer with or without the CpG island methylator phenotype (CIMP) . PLoS One 2011 ; 6 : e18571 . 32. Jayasekara H , English DR , Haydon A , Hodge AM , Lynch BM , Rosty C , . Associations...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (3): 693.
Published: 04 March 2020
... Registry. We used multinomial logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association of ever versus never PMH use and each tumor subtype compared with controls. We defined subtypes according to microsatellite instability (MSI-high or -low/stable), CpG island...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (6_Supplement_1): IA26.
Published: 01 June 2020
... with previous cancer, lower overall mutation burden, and fewer copy number variants. We conducted an analysis of DNA methylation patterns and found an epigenetic signature that was distinct from the CpG island methylator phenotype characterized in microsatellite unstable disease, referred to as CIMP. Included...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (3): 693.
Published: 04 March 2020
.../ children. Response to comments about use on children did not correct stable), CpG island methylator phenotype (CIMP positive or negative), this misinformation. Comments indicated viewers had made or oncogenic mutations in BRAF and KRAS, and combinations of these planned to make the recipe in 63% of videos...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (5): 974–981.
Published: 01 May 2020
..., and microsatellite stable (MSS)/MSI-low if <30% of the markers showed instability. Classification was based on ≥5 interpretable markers (unless all four markers were unstable, in which case the tumor was classified as MSI-high). CpG island methylator phenotype (CIMP) status was determined for 498 tumors using...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (3): 693–694.
Published: 04 March 2020
.../ children. Response to comments about use on children did not correct stable), CpG island methylator phenotype (CIMP positive or negative), this misinformation. Comments indicated viewers had made or oncogenic mutations in BRAF and KRAS, and combinations of these planned to make the recipe in 63% of videos...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2017) 26 (2_Supplement): IA05.
Published: 05 February 2017
... elucidate some of the mechanisms leading to colorectal carcinogenesis. Non-familial, sporadic CRC is a result of three major molecular mechanisms: microsatellite instability (MSI), chromosomal instability (CIN), and the CpG island methylator phenotype (CIMP). AA have been reported to have a higher incidence...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2016) 25 (3_Supplement): B35.
Published: 01 March 2016
... in order to determine the prevalence of molecular markers. Methods: The molecular markers evaluated were microsatellite instability (MSI), CpG island methylation phenotype (CIMP), and mutations in KRAS and BRAF oncogenes. In addition, HPV infection status was assessed, as it has been...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2016) 25 (1): 68–75.
Published: 12 January 2016
...A. Joan Levine; Amanda I. Phipps; John A. Baron; Daniel D. Buchanan; Dennis J. Ahnen; Stacey A. Cohen; Noralane M. Lindor; Polly A. Newcomb; Christophe Rosty; Robert W. Haile; Peter W. Laird; Daniel J. Weisenberger Background: The CpG island methylator phenotype (CIMP) is a major molecular pathway...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2015) 24 (3): 512–519.
Published: 05 March 2015
.... Campbell; Graham Casey; Dennis J. Ahnen; John A. Baron; Robert W. Haile; John L. Hopper; Joanne P. Young; Peter W. Laird; Kimberly D. Siegmund Background: The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread aberrant DNA hypermethylation...
Includes: Supplementary data
Journal Articles
Series: Author Choice
Cancer Epidemiol Biomarkers Prev (2018) 27 (4): 418–428.
Published: 02 April 2018
... (isocitrate dehydrogenase 1). Mutation of IDH1 is a driver for gliomagenesis ( 43, 44 ) and is responsible for the CpG island methylator (G-CIMP) phenotype ( 45, 46 ). IDH mutation predominates in non-GBM glioma ( 47, 48 ); therefore, dysregulation of IDH1 is highly plausible as a basis...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2017) 26 (4): 622–631.
Published: 02 April 2017
... cancer patients ( 5, 6 ). Classification of colorectal cancer tumors by molecular characteristics [e.g., chromosome instability, microsatellite instability (MSI), CpG island methylator (CIMP) phenotype, and mutation in BRAF and/or KRAS genes] has emerged as an important prognostic tool...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2010) 19 (10_Supplement): B52.
Published: 16 October 2014
...Hassan Ashktorab; Mehdi Nouraie; DuaneT Smoot; Hassan Brim Purpose: Chromosomal instability (CIN), microsatellite instability (MIN), and CpG island methylation phenotype (CIMP) are known processes through which colorectal cancer (CRC) can occur. In a given tumor, one or more of these events might...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2017) 26 (6): 816–825.
Published: 31 May 2017
... hypomethylation of cancer genomes and the hypermethylation of the promoter sequence of mainly tumor suppressor genes, several “pan-cancer” DNA methylation patterns (patterns across multiple cancer types) have been identified (reviewed in ref. 3 ). The CpG island methylator phenotype (CIMP) was first described...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2015) 24 (3): 481.
Published: 05 March 2015
... ©2015 American Association for Cancer Research. 2015 The CpG island methylator phenotype (CIMP) represents a subset of colorectal cancers characterized by widespread DNA hypermethylation at select CpG islands, but risk factors for CIMP tumors are not known. Weisenberger...