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Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (12): 2219–2227.
Published: 05 December 2022
... ) with ClinVar v2021.10.01, dbSNP v154.0.2, gnomAD v2.2.0 and Cancer Gene Census v85.0.12 databases. The driver genes considered were EGFR, ERBB2, KRAS, BRAF, NRAS, MAP2K1, MAP2K4, TP53, PIK3CA, MET, ALK...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (9): 1746–1751.
Published: 02 September 2022
... for patients with advanced colorectal cancer also extends beyond MMR/MSI: Among patients with metastatic colon cancer from 23 oncology practices across the U.S., overall, guideline-aligned biomarker (i.e., MMR/MSI, KRAS, NRAS, and BRAF) testing was used in only 40% of patients...
Includes: Supplementary data
Journal Articles
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (7): 1284–1297.
Published: 01 July 2022
... to those with somatic mutations related to the BRAF mutations in the MAPK pathway (BRAF-like) and those related to RAS mutations (RAS-like). BRAFV600E mutation has been associated with disease recurrence and mortality in patients with PTC, particularly when co...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (5): 1058–1067.
Published: 04 May 2022
... , Burgess AW , . Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation . Int J Cancer 2011 ; 128 : 2075 – 84 . 15. Gonsalves WI , Mahoney MR , Sargent DJ , Nelson GD , Alberts SR...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (2): 342–351.
Published: 01 February 2022
... by different embryologic origin, and different carcinogenetic pathways ( 3 ). RCC are more commonly associated with microsatellite instability (MSI), BRAF mutation, and the CpG island methylator phenotype whereas LCC are more frequently chromosomally instable ( 3 ). There is a continuum of genetic...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (1_Supplement): PO-052.
Published: 01 January 2022
... by BRAF V600E and later by MLH1 testing for loss of MLH1/PMS2 expression, from implementation (1/1012) until 1/1021. In 6/2015, a system was established where a designated Pathologist reviewed all results and a list of identified candidates for germline LS testing (abnormal MMR expression/wild...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2022) 31 (1_Supplement): PO-221.
Published: 01 January 2022
... on male and female (ages 34 to 90) colorectal cancer cases in Whites, African-Americans and Asians. The protein coding genes queried are APC, TP53, KRAS, PIK3CA, FAT4, KMT2D, RNF213, ARIDIA, BRAF, TET2, ATM, ZFHX3, FAT1, AMER1, NCOR2, FBXW7, SMAD4, TCFTL2, MYH9, CREBBP, KMT2C, CTNNB1, NRG1, ARAD1B, RNF 43...
Journal Articles
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (12): 2309–2316.
Published: 01 December 2021
... for presence of ulceration and tumor-infiltrating lymphocytes (TIL). We also assessed effect modification by tumor NRAS/BRAF mutational status. Results: Rs518394, rs10965215, and rs564398 passed false discovery and were each associated (P ≤ 0.005) with TILs, although only rs564398...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (12): 2317–2326.
Published: 01 December 2021
... status, alcohol intake, education level, systolic and diastolic blood pressure, CRP, and year of diagnosis. Although additional tumor data were available for some or all of the patients in this study (microsatellite instability status, BRAF, and KRAS mutations, and CpG island methylator...
Images
Population EVPI and EVPPI for (a selection of) the parameters in the PATTER...
Published: 01 September 2021
Figure 3. Population EVPI and EVPPI for (a selection of) the parameters in the PATTERN model. The population EVPI reflects the expected value of eliminating uncertainty from all model parameters over a range of willingness-to-pay thresholds of €0 to €100,000/QALY. The population EVPPI reflects the... More
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (10): 1977.
Published: 01 October 2021
... and differentiation ( 4 ). It has also been implicated in regulating the efficacy of BRAF inhibitors and checkpoint inhibitors in advanced melanoma ( 4 ). Finally, it remains unclear whether the inverse association between smoking and various estrogen- and nonestrogen-related cancers reported in epidemiologic...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (9): 1726–1734.
Published: 01 September 2021
... the expected value of eliminating uncertainty in the selected sets of prognostic parameters concerning the gene mutations (MMR, BRAF, and KRAS) and CMS, which are used to allocate adjuvant chemotherapy. The population EVPPI was depicted for the three following sets of parameters: (i) the MMR, BRAF, and KRAS...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (8): 1472–1479.
Published: 01 August 2021
... by lung cancer stage: analysis in BRAF mutated non-small cell lung cancer . Transl Lung Cancer Res   2020 ; 9 : 1441 – 51 . The most common type of tumor was adenocarcinoma (68.4%), followed by squamous cell carcinomas (19.0%). There was one case of large cell carcinoma (0.6%), one case...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (4): 808.
Published: 01 April 2021
.... Conclusions: Our findings indicate that NGS is not received uniformly by all patients with mCRC. Future analyses will incorporate receipt of individual molecular biomarker tests, as recommended by professional societies, as well as their results (e.g., KRAS, NRAS, BRAF, MMR/MSI), treatment information...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (4): 808.
Published: 01 April 2021
... as their results (e.g., KRAS, NRAS, BRAF, MMR/MSI), treatment information, and survival. Published online April 2. 2021. doi: 10.1158/1055-9965.EPI-21-0217 Ó2021 American Association for Cancer Research. Recommending Inequality? Patterns of US Healthcare Providers HPV Vaccine Recommendations Kong WY, Bustamante G...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (4): 808–809.
Published: 01 April 2021
... as their results (e.g., KRAS, NRAS, BRAF, MMR/MSI), treatment information, and survival. Published online April 2. 2021. doi: 10.1158/1055-9965.EPI-21-0217 Ó2021 American Association for Cancer Research. Recommending Inequality? Patterns of US Healthcare Providers HPV Vaccine Recommendations Kong WY, Bustamante G...
Journal Articles
Cancer Epidemiol Biomarkers Prev (2021) 30 (1): 166–174.
Published: 11 January 2021
...-semiconductor sequencing) was performed for somatic and germline DNA from 2,501 various cancer patients to detect TMB and g.MMR sequencing. MMR IHC was conducted when high TMB (≥10) was detected in LS-related cancers with an additional condition of wild-type BRAF in colorectal cancers. Target...
Includes: Supplementary data
Journal Articles
Cancer Epidemiol Biomarkers Prev (2020) 29 (12): 2599–2607.
Published: 01 December 2020
... I and II using the AJCC 7 staging system. We partitioned invasive cases according to their BRAF status; based on published studies ( 36–38 ), and assumed that approximately 45% of cases with advanced stage are BRAF-positive. While the potential for overdiagnosis in melanoma early detection...
Includes: Supplementary data