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Journal Articles

Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization

Sontoria D. King, Swathi Veliginti, Martijn C.G.J. Brouwers, Zhewen Ren, Wei Zheng, Veronica W. Setiawan, Lynne R. Wilkens, Xiao-Ou Shu, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Federico Canzian, Mengmeng Du, Steven J. Gallinger, Graham G. Giles, Phyllis J. Goodman, Christopher A. Haiman, Manolis Kogevinas, Charles Kooperberg, Loic LeMarchand, Rachel E. Neale, Kala Visvanathan, Emily White, Demetrius Albanes, Gabriella Andreotti, Ana Babic, Sonja I. Berndt, Lauren K. Brais, Paul Brennan, Julie E. Buring, Kari G. Rabe, William R. Bamlet, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Edward L. Giovannucci, Thilo Hackert, Manal M. Hassan, Verena Katzke, Robert C. Kurtz, I.-Min Lee, Núria Malats, Neil Murphy, Ann L. Oberg, Irene Orlow, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jr, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Kai Yu, Brian M. Wolpin, Eric J. Duell, Donghui Li, Rayjean J. Hung, Sandra Perdomo, Marjorie L. McCullough, Neal D. Freedman, Alpa V. Patel, Ulrike Peters, Elio Riboli, Malin Sund, Anne Tjønneland, Jun Zhong, Stephen K. Van Den Eeden, Peter Kraft, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Rachael Z. Stolzenberg-Solomon, Samuel O. Antwi
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2023) 32 (9): 1265–1269.
https://doi.org/10.1158/1055-9965.EPI-23-0453
Published: 01 September 2023
View article titled, Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization
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Includes: Supplementary data
Journal Articles

Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response

Robert Carreras-Torres, Andre E. Kim, Yi Lin, Virginia Díez-Obrero, Stephanie A. Bien, Conghui Qu, Jun Wang, Niki Dimou, Elom K. Aglago, Demetrius Albanes, Volker Arndt, James W. Baurley, Sonja I. Berndt, Stéphane Bézieau, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Arif Budiarto, Peter T. Campbell, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Xuechen Chen, David V. Conti, Christopher H. Dampier, Matthew A.M. Devall, David A. Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Kristina M. Jordahl, Eric Kawaguchi, Temitope O. Keku, Anshul Kundaje, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, John L. Morrison, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A. Newcomb, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D.P. Pharoah, Elizabeth A. Platz, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoen, Anna Shcherbina, Martha L. Slattery, Mariana C. Stern, Yu-Ru Su, Catherine M. Tangen, Duncan C. Thomas, Yu Tian, Konstantinos K. Tsilidis, Cornelia M. Ulrich, Fränzel J.B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Tjeng Wawan Cenggoro, Stephanie J. Weinstein, Emily White, Alicja Wolk, Michael O. Woods, Li Hsu, Ulrike Peters, Victor Moreno, W. James Gauderman
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2023) 32 (3): 315–328.
https://doi.org/10.1158/1055-9965.EPI-22-0763
Published: 06 March 2023
View article titled, Genome-wide Interaction Study with Smoking for Colorectal Cancer Risk Identifies Novel Genetic Loci Related to Tumor Suppression, Inflammation, and Immune Response
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Includes: Supplementary data
Journal Articles

Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses

Niki Dimou, Wemimo Omiyale, Carine Biessy, Vivian Viallon, Rudolf Kaaks, Tracy A. O'Mara, Elom K. Aglago, Eva Ardanaz, Manuela M. Bergmann, Nicola P. Bondonno, Tonje Braaten, Sandra M. Colorado-Yohar, Marta Crous-Bou, Christina C. Dahm, Renée T. Fortner, Inger T. Gram, Sophia Harlid, Alicia K. Heath, Annika Idahl, Marina Kvaskoff, Therese H. Nøst, Kim Overvad, Domenico Palli, Aurora Perez-Cornago, Carlotta Sacerdote, Maria-Jose Sánchez, Matthias B. Schulze, Gianluca Severi, Vittorio Simeon, Giovanna Tagliabue, Anne Tjønneland, Thérèse Truong, Rosario Tumino, Mattias Johansson, Elisabete Weiderpass, Neil Murphy, Marc J. Gunter, Ben Lacey, Naomi E. Allen, Laure Dossus
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2022) 31 (9): 1839–1848.
https://doi.org/10.1158/1055-9965.EPI-21-1176
Published: 02 September 2022
View article titled, Cigarette Smoking and Endometrial Cancer Risk: Observational and Mendelian Randomization Analyses
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Includes: Supplementary data
Journal Articles

Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Nathalie Kliemann, Romain Ould Ammar, Carine Biessy, Audrey Gicquiau, Verena Katzke, Rudolf Kaaks, Anne Tjønneland, Anja Olsen, Maria-Jose Sánchez, Marta Crous-Bou, Fabrizio Pasanisi, Sandar Tin Tin, Aurora Perez-Cornago, Dagfinn Aune, Sofia Christakoudi, Alicia K. Heath, Sandra M. Colorado-Yohar, Sara Grioni, Guri Skeie, Hanna Sartor, Annika Idahl, Charlotta Rylander, Anne M. May, Elisabete Weiderpass, Heinz Freisling, Mary C. Playdon, Sabina Rinaldi, Neil Murphy, Inge Huybrechts, Laure Dossus, Marc J. Gunter
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2022) 31 (7): 1359–1367.
https://doi.org/10.1158/1055-9965.EPI-22-0160
Published: 01 July 2022
View article titled, Metabolically Defined Body Size Phenotypes and Risk of Endometrial Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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Includes: Supplementary data
Journal Articles

Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region

Kristina M. Jordahl, Anna Shcherbina, Andre E. Kim, Yu-Ru Su, Yi Lin, Jun Wang, Conghui Qu, Demetrius Albanes, Volker Arndt, James W. Baurley, Sonja I. Berndt, Stephanie A. Bien, D. Timothy Bishop, Emmanouil Bouras, Hermann Brenner, Daniel D. Buchanan, Arif Budiarto, Peter T. Campbell, Robert Carreras-Torres, Graham Casey, Tjeng Wawan Cenggoro, Andrew T. Chan, David V. Conti, Christopher H. Dampier, Matthew A. Devall, Virginia Díez-Obrero, Niki Dimou, David A. Drew, Jane C. Figueiredo, Steven Gallinger, Graham G. Giles, Stephen B. Gruber, Andrea Gsur, Marc J. Gunter, Heather Hampel, Sophia Harlid, Tabitha A. Harrison, Akihisa Hidaka, Michael Hoffmeister, Jeroen R. Huyghe, Mark A. Jenkins, Amit D. Joshi, Temitope O. Keku, Susanna C. Larsson, Loic Le Marchand, Juan Pablo Lewinger, Li Li, Bharuno Mahesworo, Victor Moreno, John L. Morrison, Neil Murphy, Hongmei Nan, Rami Nassir, Polly A. Newcomb, Mireia Obón-Santacana, Shuji Ogino, Jennifer Ose, Rish K. Pai, Julie R. Palmer, Nikos Papadimitriou, Bens Pardamean, Anita R. Peoples, Paul D.P. Pharoah, Elizabeth A. Platz, John D. Potter, Ross L. Prentice, Gad Rennert, Edward Ruiz-Narvaez, Lori C. Sakoda, Peter C. Scacheri, Stephanie L. Schmit, Robert E. Schoen, Martha L. Slattery, Mariana C. Stern, Catherine M. Tangen, Stephen N. Thibodeau, Duncan C. Thomas, Yu Tian, Konstantinos K. Tsilidis, Cornelia M. Ulrich, Franzel J.B. van Duijnhoven, Bethany Van Guelpen, Kala Visvanathan, Pavel Vodicka, Emily White, Alicja Wolk, Michael O. Woods, Anna H. Wu, Natalia Zemlianskaia, Jenny Chang-Claude, W. James Gauderman, Li Hsu, Anshul Kundaje, Ulrike Peters
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2022) 31 (5): 1077–1089.
https://doi.org/10.1158/1055-9965.EPI-21-1003
Published: 04 May 2022
View article titled, Beyond GWAS of Colorectal Cancer: Evidence of Interaction with Alcohol Consumption and Putative Causal Variant for the 10q24.2 Region
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Includes: Supplementary data
Journal Articles

Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case–Control Study and Meta-Analysis

Justin Harbs, Sabina Rinaldi, Audrey Gicquiau, Pekka Keski-Rahkonen, Nagisa Mori, Xijia Liu, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Claudia Agnoli, Rosario Tumino, Bas Bueno-de-Mesquita, Marta Crous-Bou, Maria-Jose Sánchez, Amaia Aizpurua, María-Dolores Chirlaque, Aurelio Barricarte Gurrea, Ruth C. Travis, Eleanor L. Watts, Sofia Christakoudi, Konstantinos K. Tsilidis, Elisabete Weiderpass, Marc J. Gunter, Bethany Van Guelpen, Neil Murphy, Sophia Harlid
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2022) 31 (4): 793–803.
https://doi.org/10.1158/1055-9965.EPI-21-0996
Published: 01 April 2022
View article titled, Circulating Sex Hormone Levels and Colon Cancer Risk in Men: A Nested Case–Control Study and Meta-Analysis
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Includes: Supplementary data
Journal Articles

Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study

Xinwei Hua, James Y. Dai, Sara Lindström, Tabitha A. Harrison, Yi Lin, Steven R. Alberts, Elizabeth Alwers, Sonja I. Berndt, Hermann Brenner, Daniel D. Buchanan, Peter T. Campbell, Graham Casey, Jenny Chang-Claude, Steven Gallinger, Graham G. Giles, Richard M. Goldberg, Marc J. Gunter, Michael Hoffmeister, Mark A. Jenkins, Amit D. Joshi, Wenjie Ma, Roger L. Milne, Neil Murphy, Rish K. Pai, Lori C. Sakoda, Robert E. Schoen, Qian Shi, Martha L. Slattery, Mingyang Song, Emily White, Loic Le Marchand, Andrew T. Chan, Ulrike Peters, Polly A. Newcomb
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2021) 30 (7): 1349–1358.
https://doi.org/10.1158/1055-9965.EPI-20-1848
Published: 01 July 2021
View article titled, Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study
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Includes: Supplementary data
Journal Articles

Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses

Niki Dimou, Nagisa Mori, Sophia Harlid, Justin Harbs, Richard M. Martin, Karl Smith-Byrne, Nikos Papadimitriou, D. Timothy Bishop, Graham Casey, Sandra M. Colorado-Yohar, Michelle Cotterchio, Amanda J. Cross, Loic Le Marchand, Yi Lin, Kenneth Offit, N. Charlotte Onland-Moret, Ulrike Peters, John D. Potter, Thomas E. Rohan, Elisabete Weiderpass, Marc J. Gunter, Neil Murphy
Journal: Cancer Epidemiology, Biomarkers & Prevention
Series: Author Choice
Cancer Epidemiol Biomarkers Prev (2021) 30 (7): 1336–1348.
https://doi.org/10.1158/1055-9965.EPI-20-1690
Published: 01 July 2021
View article titled, Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses
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Includes: Supplementary data
Journal Articles

Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study

Niki Dimou, James Yarmolinsky, Emmanouil Bouras, Konstantinos K. Tsilidis, Richard M. Martin, Sarah J. Lewis, Inger T. Gram, Marije F. Bakker, Hermann Brenner, Jane C. Figueiredo, Renée T. Fortner, Stephen B. Gruber, Bethany van Guelpen, Li Hsu, Rudolf Kaaks, Sun-Seog Kweon, Yi Lin, Noralane M. Lindor, Polly A. Newcomb, Maria-Jose Sánchez, Gianluca Severi, Hilary A. Tindle, Rosario Tumino, Elisabete Weiderpass, Marc J. Gunter, Neil Murphy
Journal: Cancer Epidemiology, Biomarkers & Prevention
Series: Author Choice
Cancer Epidemiol Biomarkers Prev (2021) 30 (5): 953–964.
https://doi.org/10.1158/1055-9965.EPI-20-1218
Published: 01 May 2021
View article titled, Causal Effects of Lifetime Smoking on Breast and Colorectal Cancer Risk: Mendelian Randomization Study
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Includes: Supplementary data
Journal Articles

Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk

Dalia H. Ghoneim, Jingjing Zhu, Wei Zheng, Jirong Long, Harvey J. Murff, Fei Ye, Veronica Wendy Setiawan, Lynne R. Wilkens, Nikhil K. Khankari, Philip Haycock, Samuel O. Antwi, Yaohua Yang, Alan A. Arslan, Laura E. Beane Freeman, Paige M. Bracci, Federico Canzian, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loïc Le Marchand, Rachel E. Neale, Ghislaine Scelo, Kala Visvanathan, Emily White, Demetrius Albanes, Pilar Amiano, Gabriella Andreotti, Ana Babic, William R. Bamlet, Sonja I. Berndt, Lauren K. Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie E. Buring, Peter T. Campbell, Kari G. Rabe, Stephen J. Chanock, Priya Duggal, Charles S. Fuchs, J. Michael Gaziano, Michael G. Goggins, Thilo Hackert, Manal M. Hassan, Kathy J. Helzlsouer, Elizabeth A. Holly, Robert N. Hoover, Verena Katske, Robert C. Kurtz, I-Min Lee, Núria Malats, Roger L. Milne, Neil Murphy, Ann L. Oberg, Miquel Porta, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jr, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Herbert Yu, Anne Zeleniuch-Jacquotte, Kai Yu, Brian M. Wolpin, Eric J. Jacobs, Eric J. Duell, Harvey A. Risch, Gloria M. Petersen, Laufey T. Amundadottir, Peter Kraft, Alison P. Klein, Rachel Z. Stolzenberg-Solomon, Xiao-Ou Shu, Lang Wu
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2020) 29 (12): 2735–2739.
https://doi.org/10.1158/1055-9965.EPI-20-0651
Published: 01 December 2020
View article titled, Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk
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Journal Articles

Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort

Leila Lujan-Barroso, Edoardo Botteri, Saverio Caini, Börje Ljungberg, Nina Roswall, Anne Tjønneland, Bas Bueno-de-Mesquita, Inger T. Gram, Rosario Tumino, Lambertus A. Kiemeney, Fredrik Liedberg, Tanja Stocks, Marc J. Gunter, Neil Murphy, Iris Cervenka, Agnès Fournier, Marina Kvaskoff, Christel Häggström, Kim Overvad, Eiliv Lund, Marit Waaseth, Renée Turzanski Fortner, Tilman Kühn, Virginia Menéndez, Maria-Jose Sánchez, Carmen Santiuste, Aurora Perez-Cornago, Raul Zamora-Ros, Amanda J. Cross, Antonia Trichopoulou, Anna Karakatsani, Eleni Peppa, Domenico Palli, Vittorio Krogh, Veronica Sciannameo, Amalia Mattiello, Salvatore Panico, Carla H. van Gils, N. Charlotte Onland-Moret, Aurelio Barricarte, Pilar Amiano, Kay-Tee Khaw, Heiner Boeing, Elisabete Weiderpass, Eric J. Duell
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2020) 29 (8): 1654–1664.
https://doi.org/10.1158/1055-9965.EPI-20-0184
Published: 03 August 2020
View article titled, Menstrual Factors, Reproductive History, Hormone Use, and Urothelial Carcinoma Risk: A Prospective Study in the EPIC Cohort
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Includes: Supplementary data
Journal Articles

Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer

Julia Butt, Mazda Jenab, Michael Pawlita, Kim Overvad, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Franck Carbonnel, Francesca Romana Mancini, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Antonia Trichopoulou, Anna Karakatsani, Domenico Palli, Valeria Maria Pala, Rosario Tumino, Carlotta Sacerdote, Salvatore Panico, Bas Bueno-de-Mesquita, Carla H. van Gils, Roel C.H. Vermeulen, Elisabete Weiderpass, José Ramón Quirós, Eric Jeffrey Duell, Maria-Jose Sánchez, Miren Dorronsoro, José María Huerta, Eva Ardanaz, Bethany Van Guelpen, Sophia Harlid, Aurora Perez-Cornago, Marc J. Gunter, Neil Murphy, Heinz Freisling, Dagfinn Aune, Tim Waterboer, David J. Hughes
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2019) 28 (9): 1552–1555.
https://doi.org/10.1158/1055-9965.EPI-19-0313
Published: 03 September 2019
View article titled, Antibody Responses to <em>Fusobacterium nucleatum</em> Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer
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Journal Articles

Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study

Lluís Cirera, José María Huerta, María Dolores Chirlaque, Kim Overvad, Martin Lindström, Sara Regnér, Anne Tjønneland, Marie-Christine Boutron-Ruault, Vinciane Rebours, Guy Fagherazzi, Verena A. Katzke, Heiner Boeing, Eleni Peppa, Antonia Trichopoulou, Elissavet Valanou, Domenico Palli, Sara Grioni, Salvatore Panico, Rosario Tumino, Fulvio Ricceri, Carla van Gils, Roel C.H. Vermeulen, Guri Skeie, Tonje Braaten, Elisabete Weiderpass, Susana Merino, María José Sánchez, Nerea Larrañaga, Eva Ardanaz, Malin Sund, Kay-Tee Khaw, Timothy J. Key, Mazda Jenab, Sabine Naudin, Neil Murphy, Dagfinn Aune, Heather Ward, Elio Riboli, Bas Bueno-de-Mesquita, Carmen Navarro, Eric J. Duell
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2019) 28 (6): 1089–1092.
https://doi.org/10.1158/1055-9965.EPI-18-1153
Published: 03 June 2019
View article titled, Socioeconomic Effect of Education on Pancreatic Cancer Risk in Western Europe: An Update on the EPIC Cohorts Study
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Journal Articles

Prediagnostic Intake of Dairy Products and Dietary Calcium and Colorectal Cancer Survival—Results from the EPIC Cohort Study

Vincent K. Dik, Neil Murphy, Peter D. Siersema, Veronika Fedirko, Mazda Jenab, So Y. Kong, Camilla P. Hansen, Kim Overvad, Anne Tjønneland, Anja Olsen, Laure Dossus, Antoine Racine, Nadia Bastide, Kuanrong Li, Tilman Kühn, Heiner Boeing, Krasimira Aleksandrova, Antonia Trichopoulou, Dimitrios Trichopoulos, Antonia Barbitsioti, Domenico Palli, Paolo Contiero, Paolo Vineis, Rosaria Tumino, Salvatore Panico, Petra H.M. Peeters, Elisabete Weiderpass, Guri Skeie, Anette Hjartåker, Pilar Amiano, María-José Sánchez, Ana Fonseca-Nunes, Aurelio Barricarte, María-Dolores Chirlaque, Maria-Luisa Redondo, Karin Jirström, Jonas Manjer, Lena M. Nilsson, Maria Wennberg, Kathryn E. Bradbury, Kay-Tee Khaw, Nicholas Wareham, Amanda J. Cross, Elio Riboli, H. Bas Bueno-de-Mesquita
Journal: Cancer Epidemiology, Biomarkers & Prevention
Cancer Epidemiol Biomarkers Prev (2014) 23 (9): 1813–1823.
https://doi.org/10.1158/1055-9965.EPI-14-0172
Published: 01 September 2014
View article titled, Prediagnostic Intake of Dairy Products and Dietary Calcium and Colorectal Cancer Survival—Results from the EPIC Cohort Study
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Includes: Supplementary data