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1 June 2023
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Cover Image
The cover image is adapted from Figure 1 in the article, “Exploring the complex relationship between gut microbiota and risk of colorectal neoplasia using bidirectional Mendelian randomization analysis”, by Li, Zhou, and colleagues. Figure 1 shows a schematic representation of the two-sample bidirectional Mendelian randomization (MR) analysis. Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis. In this study, summary-level data for gut microbiota and metabolites were obtained from MiBioGen, FINRISK and human metabolome consortia. In forward MR, the authors employed genetic instrumental variables (IVs) for 24 gut microbiota taxa and six bacterial metabolites to examine their causal relationship with CRC. They also utilized a lenient threshold for nine apriori gut microbiota taxa as secondary analyses. In reverse MR, they explored association between genetic liability to colorectal neoplasia and abundance of microbiota studied above using 95, 19, and 7 IVs for CRC, adenoma, and polyps, respectively. The study found genetic liability to colorectal neoplasia may be associated with abundance of certain microbiota taxa. It is more likely that subset of CRC genetic liability variants changes gut biology by influencing both gut microbiota and CRC risk. This study highlights the need of future complementary studies to explore causal mechanisms linking both host genetic variation with gut microbiome and CRC susceptibility. For more information, see the article beginning on page 809. - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
Highlights
Commentary
Cancer Surveillance Research
Research Articles
Efficacy of the Outsmart HPV Intervention: A Randomized Controlled Trial to Increase HPV Vaccination among Young Gay, Bisexual, and Other Men Who Have Sex with Men
Paul L. Reiter; Amy L. Gower; Dale E. Kiss; Abigail B. Shoben; Mira L. Katz; José A. Bauermeister; Electra D. Paskett; Annie-Laurie McRee
Recruiting African American Prostate Cancer Survivors for a Population-based Biobank Study
Xiaoyin Li; Siddhartha Roy; Jennifer Damonte; Hyun Y. Park; Aasha I. Hoogland; Kala Jamison; Khaled R. Komrokji; Chang Dong Yeo; Youngchul Kim; Jasreman Dhillon; Lisa M. Gudenkauf; Laura B. Oswald; Heather S.L. Jim; Kosj Yamoah; Julio M. Pow-Sang; Peter A. Kanetsky; Clement K. Gwede; Jong Y. Park; Brian D. Gonzalez
Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC)
Shuo Wang; Guillaume C. Onyeaghala; Nathan Pankratz; Heather H. Nelson; Bharat Thyagarajan; Weihong Tang; Faye L. Norby; Chinenye Ugoji; Corinne E. Joshu; Christian R. Gomez; David J. Couper; Josef Coresh; Elizabeth A. Platz; Anna E. Prizment
Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Wanxin Li; Xuan Zhou; Shuai Yuan; Lijuan Wang; Lili Yu; Jing Sun; Jie Chen; Qian Xiao; Zhongxiao Wan; Ju-Sheng Zheng; Cai-Xia Zhang; Susanna C. Larsson; Susan M. Farrington; Philip Law; Richard S. Houlston; Ian Tomlinson; Ke-Feng Ding; Malcolm G. Dunlop; Evropi Theodoratou; Xue Li
Nitrated Polycyclic Aromatic Hydrocarbon (Nitro-PAH) Signatures and Somatic Mutations in Diesel Exhaust-Exposed Bladder Tumors
Nicole Gonzalez; Nina Rao; Michael Dean; Donghyuk Lee; Amber N. Hurson; Dalsu Baris; Molly Schwenn; Alison Johnson; Ludmila Prokunina-Olsson; Melissa C. Friesen; Bin Zhu; Nathaniel Rothman; Debra T. Silverman; Stella Koutros
Measurement of Ovarian Tumor Immune Profiles by Multiplex Immunohistochemistry: Implications for Epidemiologic Studies
Cassandra A. Hathaway; Jose R. Conejo-Garcia; Brooke L. Fridley; Bernard Rosner; Daryoush Saeed-Vafa; Carlos Moran Segura; Jonathan V. Nguyen; Jonathan L. Hecht; Naoko Sasamoto; Kathryn L. Terry; Shelley S. Tworoger; Mary K. Townsend
Null Results in Brief
ASPO 47th Annual Meeting Abstracts
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