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1 May 2023
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Cover Image
Cover Image
The cover image is adapted from Figure 1 in the article, “Genetic factors associated with absolute and relative plasma concentrations of calcitrio”l, by Wilson and colleagues. Figure 1 shows a Concordance Correlation Coefficient (CCC) Plot comparing the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR) to the crude 1,25(OH)2D3 to 24,25(OH)2D3 concentration ratio. The purpose of this study was to investigate genetic factors associated with plasma 1,25(OH)2D3 and a relative measure of plasma 1,25(OH)2D3—the calcitriol-24,25-dihydroxyvitamin D3-calcifediol proportion ratio (C24CPR) among healthy individuals. Because circulating vitamin D5 metabolite concentrations are known to differ to the greatest extent between individuals of African and European ancestry, the authors focused this study on healthy individuals from these racial/ethnic groups. Using a cross-sectional study design, healthy young adults of African and European descent, matched (1:1) on age (+/− 5 years) provided a blood sample in non-summer months. Both absolute and relative measures of calcitriol were significantly higher among African Americans. Otherwise, these biomarkers appear to be genetically distinct. C24CPR may be better suited to personalized medicine, due to a higher proportion of population variability explained by genetic variation and a less skewed distribution. For more information, see the article beginning on page 697.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
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Linking Physical Activity to Breast Cancer Risk via Inflammation, Part 1: The Effect of Physical Activity on Inflammation
Christopher T.V. Swain; Ann E. Drummond; Roger L. Milne; Dallas R. English; Kristy A. Brown; Makayla W.C. Lou; Leonessa Boing; Amy Bageley; Tina L. Skinner; Eline H. van Roekel; Melissa M. Moore; Tom R. Gaunt; Richard M. Martin; Sarah J. Lewis; Brigid M. Lynch
Linking Physical Activity to Breast Cancer via Inflammation, Part 2: The Effect of Inflammation on Breast Cancer Risk
Makayla W.C. Lou; Ann E. Drummond; Christopher T.V. Swain; Roger L. Milne; Dallas R. English; Kristy A. Brown; Eline H. van Roekel; Tina L. Skinner; Melissa M. Moore; Tom R. Gaunt; Richard M. Martin; Sarah J. Lewis; Brigid M. Lynch
Research Articles
Cancer Epidemiology in Hispanic Populations: An Analysis of Funded Observational Research at the National Cancer Institute
Joanne W. Elena; Lisa Gallicchio; Camille A. Pottinger; Kaitlin E. Akif; Rachel Hanisch; Amy E. Kennedy; Gabriel Y. Lai; Somdat Mahabir; Damali N. Martin; Shobha Srinivasan; Catherine T. Yu; Tram K. Lam
Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies
Ilona Argirion; Ruth M. Pfeiffer; Carla Proietti; Anna E. Coghill; Kelly J. Yu; Jaap M. Middeldorp; Yomani D. Sarathkumara; Wan-Lun Hsu; Yin-Chu Chien; Pei-Jen Lou; Cheng-Ping Wang; Nathaniel Rothman; Qing Lan; Chien-Jen Chen; Sam M. Mbulaiteye; Ruth F. Jarrett; Ingrid Glimelius; Karin E. Smedby; Henrik Hjalgrim; Allan Hildesheim; Denise L. Doolan; Zhiwei Liu
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