Issues

The cover image is adapted from Figure 2a and Figure 3 in the article, Prospective Cohort of Pre- and Post-diagnosis Diet with Survival Outcomes: An Alberta Endometrial Cancer Cohort Study, by Kokts-Porietis and colleagues. The prognostic relationship between diet and endometrial cancer survival remains largely unknown. The authors sought to determine pre- and post-diagnosis dietary composition, glycemic load (GL), inflammatory potential (Dietary Inflammatory Index (DII)) and quality (CanadianHealth Eating Index (C-HEI) 2005) associations with disease-free (DFS) and overall survival (OS) among endometrial cancer survivors. Additionally, they assessed associations between dietary changes with OS and explored obesity/physical activity effect modification. Figure 2a shows the Hazard Ratios (95% CI) for pre-diagnosis added sugar and disease-free survival. Figure 3 shows the Hazard Ratios (95% CI) for pre-diagnosis C-HEI 2005, glycemic load, total sugar and, added sugar by obesity and lifetime physical activity status with disease-free survival and overall survival in the Alberta Endometrial Cancer Cohort Study, 2002–2022. Results showed that adherence to higher quality dietary patterns were associated with better survival. The study provides novel evidence that both pre- and post-diagnosis diet are important prognostic factors for endometrial cancer survivors. Post-diagnosis survival associations with diet composition and quality highlight the potential for future interventions. For more information, see the article beginning on page 242.