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1 December 2023
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Cover Image
The cover image is adapted from Fig. 1 in the article, “Birth Defects in Offspring of Adolescent and Young Adults with a History of Cancer: A Population-Based Study of 27,000 Women,” by Murphy and colleagues. Figure 1 is a forest plot illustrating risk of any birth defect among liveborn and stillborn offspring of adolescent and young adult (AYA) women by cancer type, receipt of chemotherapy, and time since cancer diagnosis compared to offspring of women without cancer. Cancer and its treatment may adversely affect the reproductive health of adolescent and young adult women with a history of cancer. Offspring of AYA women may also have higher risk of birth defects because women develop cancer and receive cancer treatment during childbearing years. However, reproductive decision-making for AYA women and counseling by their providers is limited by a lack of information on health-related consequences for offspring. To better inform the care of AYA women and their families, the authors examined birth defects among offspring of AYA women by linking population-based data from the Texas Cancer Registry to live birth and fetal death certificates and the Texas Birth Defects Registry. In this population-based study spanning 17 years in Texas, risk of birth defects was higher in liveborn and stillborn offspring of adolescent and young adult women with a history of cancer compared to offspring of age- and race/ethnicity-matched women without cancer, although birth defects were rare in both groups. Given the large, diverse population of AYA women and the statewide, active surveillance system used to ascertain birth defects in Texas, these findings represent some of the most robust evidence to date on birth defects among offspring of AYA women and fill a critical gap in clinical practice. For more information, see the article beginning on page 1699. - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
Issue Sections
Highlights
Research Articles
Gene–Environment Analyses Reveal Novel Genetic Candidates with Prenatal Tobacco Exposure in Relation to Risk for Childhood Acute Lymphoblastic Leukemia
Charlie Zhong; Shaobo Li; Katti Arroyo; Libby M. Morimoto; Adam J. de Smith; Catherine Metayer; Xiaomei Ma; Scott C. Kogan; W. James Gauderman; Joseph L. Wiemels
Hypothetical Interventions on Diet Quality and Lifestyle Factors to Improve Breast Cancer Survival: The Pathways Study
Isaac J. Ergas; Patrick T. Bradshaw; Elizabeth M. Cespedes Feliciano; Janise M. Roh; Marilyn L. Kwan; Barbara Laraia; Kristine A. Madsen; Song Yao; Catherine Thomsen; Lawrence H. Kushi
Associations between Longer Leukocyte Telomere Length and Increased Lung Cancer Risk among Never Smokers in Urban China
Jason Y.Y. Wong; Xiao-Ou Shu; Wei Hu; Batel Blechter; Jianxin Shi; Kevin Wang; Richard Cawthon; Qiuyin Cai; Gong Yang; Mohammad L. Rahman; Bu-tian Ji; Yutang Gao; Wei Zheng; Nathaniel Rothman; Qing Lan
ASPO Report
Community Outreach and Engagement at U.S. Cancer Centers: Notes from the Third Cancer Center Community Impact Forum
Amy E. Leader; Heather M. Brandt; Katherine J. Briant; Gina Curry; Kiara Ellis; Evelyn T. Gonzalez; Carmen E. Guerra; Garrett Harding; Pamela C. Hull; Aimee Israel; Rebecca Mellilo; Rachel J. Mesia; Jenna E. Schiffelbein; Yawei Song; Zul Surani; Jasmin A. Tiro; Susan T. Vadaparampil; Robin C. Vanderpool; Electra D. Paskett
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