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1 July 2021
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Cover Image
Cover Image
The cover image is adapted from Figure 1 in the article “Tobacco smoking and the fecal microbiome in a large, multi-ethnic cohort,” by Prakash and colleagues. The figure shows beta diversity and ordination of microbiome by smoking status. Increasing evidence suggests that tobacco smoking, a well-known driver of carcinogenesis, influences the gut microbiome; however, these relationships remain understudied in diverse populations. The authors performed an analysis of smoking and the gut microbiome in a subset of 803 adults from the multi-ethnic NYU FAMiLI study. Results showed that the overall composition of the fecal microbiome in former and current smokers differs significantly from that of never smokers, while the taxa Lachnospira and Tenericutes were depleted, relative to never smokers. These shifts were consistent across racial and ethnic subgroups. The findings suggest common mechanisms of smoking associated microbial change across racial subgroups, regardless of initial microbiome composition. The correlation of these differentials with reactive oxygen species (ROS) exposure pathways may suggest a role for these taxa in the known association between smoking, ROS and carcinogenesis. For more information, see the article beginning on page 1328. - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
Highlights
Review
Commentaries
Research Articles
Epidemiologic Research of Rare Cancers: Trends, Resources, and Challenges
Lisa Gallicchio; Danielle L. Daee; Melissa Rotunno; Rolando Barajas; Sarah Fagan; Danielle M. Carrick; Rao L. Divi; Kelly K. Filipski; Andrew N. Freedman; Elizabeth M. Gillanders; Tram K. Lam; Damali N. Martin; Scott Rogers; Mukesh Verma; Stefanie A. Nelson
Author Choice
Circulating Levels of Testosterone, Sex Hormone Binding Globulin and Colorectal Cancer Risk: Observational and Mendelian Randomization Analyses
Niki Dimou; Nagisa Mori; Sophia Harlid; Justin Harbs; Richard M. Martin; Karl Smith-Byrne; Nikos Papadimitriou; D. Timothy Bishop; Graham Casey; Sandra M. Colorado-Yohar; Michelle Cotterchio; Amanda J. Cross; Loic Le Marchand; Yi Lin; Kenneth Offit; N. Charlotte Onland-Moret; Ulrike Peters; John D. Potter; Thomas E. Rohan; Elisabete Weiderpass; Marc J. Gunter; Neil Murphy
Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study
Xinwei Hua; James Y. Dai; Sara Lindström; Tabitha A. Harrison; Yi Lin; Steven R. Alberts; Elizabeth Alwers; Sonja I. Berndt; Hermann Brenner; Daniel D. Buchanan; Peter T. Campbell; Graham Casey; Jenny Chang-Claude; Steven Gallinger; Graham G. Giles; Richard M. Goldberg; Marc J. Gunter; Michael Hoffmeister; Mark A. Jenkins; Amit D. Joshi; Wenjie Ma; Roger L. Milne; Neil Murphy; Rish K. Pai; Lori C. Sakoda; Robert E. Schoen; Qian Shi; Martha L. Slattery; Mingyang Song; Emily White; Loic Le Marchand; Andrew T. Chan; Ulrike Peters; Polly A. Newcomb
Tumor-Associated Stromal Cellular Density as a Predictor of Recurrence and Mortality in Breast Cancer: Results from Ethnically Diverse Study Populations
Mustapha Abubakar; Jing Zhang; Thomas U. Ahearn; Hela Koka; Changyuan Guo; Scott M. Lawrence; Karun Mutreja; Jonine D. Figueroa; Jianming Ying; Jolanta Lissowska; Ning Lyu; Montserrat Garcia-Closas; Xiaohong Rose Yang
A Pooled Case-only Analysis of Reproductive Risk Factors and Breast Cancer Subtype Among Black Women in the Southeastern United States
Maureen Sanderson; Tuya Pal; Alicia Beeghly-Fadiel; Mary Kay Fadden; Steffie-Ann Dujon; Chrystina Clinton; Cecilia Jimenez; Jennifer Davis; Mieke Fortune; Jasmine Thompson; Kiera Benson; Nicholas Conley; Sonya Reid; Ann Tezak; Xiao-Ou Shu; Wei Zheng; William J. Blot; Loren Lipworth
Research Article
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Letters to the Editor
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