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1 June 2021
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Cover Image
Cover Image
The cover image is adapted from Figure 2 in the article, "The Effects of Lifetime Estrogen Exposure on Breast Epigenetic Age," by Sehl and colleagues. The figure shows the relationship between age at menarche and age-adjusted measures of epigenetic age acceleration. Accelerated breast tissue aging is thought to contribute to an elevated incidence of breast cancer in younger women. Estrogen stimulation and cell cycling are thought to underlie this accelerated aging process. Sehl and colleagues investigated methylation-based estimates of biologic aging in normal breast tissue of healthy women donors, focusing analysis on Grim age, an epigenetic age measure whose acceleration in peripheral blood is associated with time to cancer. This is the one of the first and largest studies of normal breast tissue examining epigenetic age estimates. The study confirmed that epigenetic age acceleration in healthy breast is highest at earlier ages and identified factors associated with the degree of epigenetic age acceleration, including earlier age at menarche, and BMI. Epigenetic clock measures may help advance inquiry into the relationship between accelerated breast tissue aging and an elevated incidence of breast cancer in younger women. For more information, see the article beginning on page 1241.Close Modal - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
Issue Sections
Highlights
Reviews
Research Articles
Levels of Inflammation Markers Are Associated with the Risk of Recurrence and All-Cause Mortality in Patients with Colorectal Cancer
Evertine Wesselink; Michiel G.J. Balvers; Dieuwertje E. Kok; Renate M. Winkels; Moniek van Zutphen; Ruud W.M. Schrauwen; Eric T.P. Keulen; Ewout A. Kouwenhoven; Stephanie O. Breukink; Renger F. Witkamp; Johannes H.W. de Wilt; Martijn J.L. Bours; Matty P. Weijenberg; Ellen Kampman; Fränzel J.B. van Duijnhoven
Endogenous Progestogens and Colorectal Cancer Risk among Postmenopausal Women
Kara A. Michels; Ashley M. Geczik; Doug C. Bauer; Louise A. Brinton; Diana S.M. Buist; Jane A. Cauley; Cher M. Dallal; Roni T. Falk; Trisha F. Hue; James V. Lacey, Jr; Andrea Z. LaCroix; Jeffrey A. Tice; Xia Xu; Britton Trabert
Use of Medications for Treating Anxiety or Depression among Testicular Cancer Survivors: A Multi-Institutional Study
Shirin ArdeshirRouhaniFard; Paul C. Dinh; Patrick O. Monahan; Sophie D. Fossa; Robert Huddart; Chunkit Fung; Yiqing Song; Darren R. Feldman; Robert J. Hamilton; David J. Vaughn; Neil E. Martin; Christian Kollmannsberger; Lawrence Einhorn; Kurt Kroenke; Lois B. Travis
The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies
Jinyoung Byun; Younghun Han; Quinn T. Ostrom; Jacob Edelson; Kyle M. Walsh; Rowland W. Pettit; Melissa L. Bondy; Rayjean J. Hung; James D. McKay; Christopher I. Amos; for INTEGRAL-ILCCO
Urinary Cotinine and Cotinine + Trans-3′-Hydroxycotinine (TNE-2) Cut-points for Distinguishing Tobacco Use from Nonuse in the United States: PATH Study (2013–2014)
Kathryn C. Edwards; Tasmia Naz; Cassandra A. Stanton; Maciej L. Goniewicz; Dorothy K. Hatsukami; Danielle M. Smith; Lanqing Wang; Andrea Villanti; Jennifer Pearson; Benjamin C. Blount; Maansi Bansal-Travers; June Feng; Raymond Niaura; Michelle T. Bover Manderski; Connie S. Sosnoff; Cristine D. Delnevo; Kara Duffy; Arseima Y. Del Valle-Pinero; Brian L. Rostron; Colm Everard; Heather L. Kimmel; Dana M. van Bemmel; Andrew Hyland
Role of DNA Repair Variants and Diagnostic Radiology Exams in Differentiated Thyroid Cancer Risk: A Pooled Analysis of Two Case–Control Studies
Monia Zidane; Thérèse Truong; Fabienne Lesueur; Constance Xhaard; Emilie Cordina-Duverger; Anne Boland; Hélène Blanché; Catherine Ory; Sylvie Chevillard; Jean-François Deleuze; Vincent Souchard; Yan Ren; Mohammed Zakarya Zemmache; Sandra Canale; Françoise Borson-Chazot; Claire Schvartz; Eugènia Mariné Barjoan; Anne-Valérie Guizard; Pierre Laurent-Puig; Claire Mulot; Julie Guibon; Mojgan Karimi; Martin Schlumberger; Elizabeth Adjadj; Carole Rubino; Pascal Guenel; Jean-Baptiste Cazier; Florent de Vathaire
Type 2 Diabetes and Cancer: An Umbrella Review of Observational and Mendelian Randomization Studies
Jonathan Pearson-Stuttard; Nikos Papadimitriou; Georgios Markozannes; Sofia Cividini; Artemisia Kakourou; Dipender Gill; Evangelos C. Rizos; Grace Monori; Heather A. Ward; Maria Kyrgiou; Marc J. Gunter; Konstantinos K. Tsilidis
Dietary Patterns of Insulinemia, Inflammation and Glycemia, and Pancreatic Cancer Risk: Findings from the Women's Health Initiative
Qi Jin; Phil A. Hart; Ni Shi; Joshua J. Joseph; Macarius Donneyong; Darwin L. Conwell; Steven K. Clinton; Zobeida Cruz-Monserrate; Theodore M. Brasky; Lesley F. Tinker; Simin Liu; Aladdin H. Shadyab; Cynthia A. Thomson; Lihong Qi; Thomas Rohan; Fred K. Tabung
Risk Factors for Breast Cancer, Overall and by Tumor Subtype, among Women from Mozambique, Sub-Saharan Africa
Mariana Brandão; Assucena Guisseve; Albertino Damasceno; Genoveva Bata; Carla Silva-Matos; Matos Alberto; Josefo Ferro; Carlos Garcia; Clésio Zaqueu; Cesaltina Lorenzoni; Dina Leitão; Otília Soares; Alberto Gudo-Morais; Fernando Schmitt; Samantha Morais; Satish Tulsidás; Carla Carrilho; Nuno Lunet
Null Results in Brief
Soft Drink and Juice Consumption and Renal Cell Carcinoma Incidence and Mortality in the European Prospective Investigation into Cancer and Nutrition
Alicia K. Heath; Joanna L. Clasen; Nick P. Jayanth; Mazda Jenab; Anne Tjønneland; Kristina Elin Nielsen Petersen; Kim Overvad; Bernard Srour; Verena Katzke; Manuela M. Bergmann; Matthias B. Schulze; Giovanna Masala; Vittorio Krogh; Rosario Tumino; Alberto Catalano; Fabrizio Pasanisi; Magritt Brustad; Karina Standahl Olsen; Guri Skeie; Leila Luján-Barroso; Miguel Rodríguez-Barranco; Pilar Amiano; Carmen Santiuste; Aurelio Barricarte Gurrea; Håkan Axelson; Stina Ramne; Börje Ljungberg; Eleanor L. Watts; Inge Huybrechts; Elisabete Weiderpass; Elio Riboli; David C. Muller
Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk
Derek W. Brown; Qing Lan; Nathaniel Rothman; John Pluta; Kristian Almstrup; Marlene D. Dalgaard; Mark H. Greene; Tom Grotmol; Chey Loveday; Stephen M. Schwartz; Clare Turnbull; Fredrik Wiklund; Peter A. Kanetsky; Katherine L. Nathanson; Katherine A. McGlynn; Mitchell J. Machiela; for the Testicular Cancer Consortium
Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large U.S. Consortium
Chun-Han Lo; William J. Blot; Lauren R. Teras; Kala Visvanathan; Loïc Le Marchand; Christopher A. Haiman; Yu Chen; Howard D. Sesso; Sylvia Wassertheil-Smoller; Lesley F. Tinker; Richard M. Peek; John D. Potter; Timothy L. Cover; Anne Zeleniuch-Jacquotte; Sonja I. Berndt; Tim Waterboer; Meira Epplein; Julia Butt; Mingyang Song
Retraction
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