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1 December 2021
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Cover Image
The cover image is adapted from Figure 1 in the article "Neighborhood Socioeconomic Deprivation and Mortality in Children with Central Nervous System Tumors," by Fahmideh and colleagues. The original figure shows distribution of area deprivation index (ADI) scores in Texas and selected metropolitan areas. Previous studies demonstrated the impact of neighborhood socioeconomic deprivation on survival among children with acute leukemia; however, little knowledge is available on the association between neighborhood socioeconomic deprivation and pediatric CNS tumor survival. Therefore, Fahmideh and colleagues aimed to examine the influence of neighborhood socioeconomic deprivation, using ADI, on the survival of pediatric CNS tumors and to investigate whether demographic characteristics such as sex, race/ethnicity, and metropolitan residency could potentially modify the identified associations. The results showed a significantly increased hazard ratio (HR) for death among children in the most (HR 1.29, 95% CI,1.09–1.51), second-most (HR 1.18, 95% CI,1.01–1.38) and third-most disadvantaged census tracts (HR 1.18, 95% CI,1.02–1.37) compared to children in the least disadvantaged tracts. Children living in the most disadvantaged neighborhoods experienced a significantly higher risk of mortality, indicating the important role of socioeconomic disparities in the survival of pediatric CNS tumors. The demographic and socioeconomic disparities identified by this study should be considered when planning treatment strategies for these susceptible groups and thus, lead to a better outcome in socioeconomically disadvantaged children diagnosed with CNS tumors. For more information, see the article beginning on page 2278. - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
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Research Articles
Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures
Verena A. Katzke; Charlotte Le Cornet; Rayaan Mahfouz; Bianca Brauer; Theron Johnson; Federico Canzian; Vinciane Rebours; Marie-Christine Boutron-Ruault; Gianluca Severi; Matthias B. Schulze; Anja Olsen; Anne Tjønneland; Kim Overvad; Marta Crous-Bou; Esther Molina-Montes; Pilar Amiano; José María Huerta; Eva Ardanaz; Aurora Perez-Cornago; Giovanna Masala; Valeria Pala; Rosario Tumino; Carlotta Sacerdote; Salvatore Panico; Bas Bueno-de-Mesquita; Roel Vermeulen; Malin Sund; Oskar Franklin; Sofia Christakoudi; Laure Dossus; Elisabete Weiderpass; Sven Olek; Rudolf Kaaks
Cancer in People with and without Hepatitis C Virus Infection: Comparison of Risk Before and After Introduction of Direct-Acting Antivirals
Jennifer O. Lam; Leo B. Hurley; Jennifer B. Lai; Varun Saxena; Suk Seo; Scott Chamberland; Charles P. Quesenberry, Jr; Jamila H. Champsi; Joanna Ready; Elizabeth Y. Chiao; Julia L. Marcus; Michael J. Silverberg
Smoking Methylation Marks for Prediction of Urothelial Cancer Risk
Chenglong Yu; Kristina M. Jordahl; Julie K. Bassett; Jihoon Eric Joo; Ee Ming Wong; Maree T. Brinkman; Daniel F. Schmidt; Damien M. Bolton; Enes Makalic; Theodore M. Brasky; Aladdin H. Shadyab; Lesley F. Tinker; Anthony Longano; John L. Hopper; Dallas R. English; Roger L. Milne; Parveen Bhatti; Melissa C. Southey; Graham G. Giles; Pierre-Antoine Dugué
Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study
Vanessa Y. Tan; Caroline J. Bull; Kalina M. Biernacka; Alexander Teumer; Tom G. Richardson; Eleanor Sanderson; Laura J. Corbin; Tom Dudding; Qibin Qi; Robert C. Kaplan; Jerome I. Rotter; Nele Friedrich; Uwe Völker; Julia Mayerle; Claire M. Perks; Jeff M.P. Holly; Nicholas J. Timpson
Dietary Advanced Glycation End-Products and Mortality after Breast Cancer in the Women's Health Initiative
Omonefe O. Omofuma; Lindsay L. Peterson; David P. Turner; Anwar T. Merchant; Jiajia Zhang; Cynthia A. Thomson; Marian L. Neuhouser; Linda G. Snetselaar; Bette J. Caan; Aladdin H. Shadyab; Nazmus Saquib; Hailey R. Banack; Jaime Uribarri; Susan E. Steck
Functional Outcomes and Social Attainment in Asian/Pacific Islander Childhood Cancer Survivors in the United States: A Report from the Childhood Cancer Survivor Study
Satomi Sato; Nan Li; Stephanie B. Dixon; Miho Kato; Hui Zhang; Chi Kong Li; Rebecca M. Howell; Wendy M. Leisenring; Smita Bhatia; Kevin C. Oeffinger; Gregory T. Armstrong; Yutaka Yasui; Kevin R. Krull; Yin Ting Cheung
Concordance between Self-reported Symptoms and Clinically Ascertained Peripheral Neuropathy among Childhood Cancer Survivors: the St. Jude Lifetime Cohort Study
Samah Hayek; Rikeenkumar Dhaduk; Yadav Sapkota; William E. Evans; Barthelemy Diouf; Kari Bjornard; Carmen L. Wilson; Melissa M. Hudson; Leslie L. Robison; Raja B. Khan; Deo Kumar Srivastava; Kevin R. Krull; Kirsten K. Ness
Age-Related Disease Risks in Younger versus Older B-Cell Non-Hodgkin's Lymphoma Survivors
Krista Ocier; Sarah Abdelaziz; Seungmin Kim; Kerry Rowe; John Snyder; Vikrant G. Deshmukh; Michael Newman; Alison Fraser; Ken R. Smith; Christina A. Porucznik; Kimberley Shoaf; Joseph B. Stanford; Catherine J. Lee; Mia Hashibe
Disease-Associated Risk Variants in ANRIL Are Associated with Tumor-Infiltrating Lymphocyte Presence in Primary Melanomas in the Population-Based GEM Study
Danielle R. Davari; Irene Orlow; Peter A. Kanetsky; Li Luo; Sharon N. Edmiston; Kathleen Conway; Eloise A. Parrish; Honglin Hao; Klaus J. Busam; Ajay Sharma; Anne Kricker; Anne E. Cust; Hoda Anton-Culver; Stephen B. Gruber; Richard P. Gallagher; Roberto Zanetti; Stefano Rosso; Lidia Sacchetto; Terence Dwyer; David W. Ollila; Colin B. Begg; Marianne Berwick; Nancy E. Thomas; on behalf of the GEM Study Group
Research Article
Null Results in Brief
Genetic Polymorphisms Involved in Mitochondrial Metabolism and Pancreatic Cancer Risk
Giulia Peduzzi; Manuel Gentiluomo; Francesca Tavano; Paolo Giorgio Arcidiacono; Stefano Ermini; Pavel Vodicka; Ugo Boggi; Giulia Martina Cavestro; Gabriele Capurso; Luca Morelli; Anna Caterina Milanetto; Raffaele Pezzilli; Rita T. Lawlor; Silvia Carrara; Martin Lovecek; Pavel Souček; Feng Guo; Thilo Hackert; Faik G. Uzunoğlu; Maria Gazouli; Andrea Párniczky; Juozas Kupcinskas; Maarten F. Bijlsma; Bas Bueno-de-Mesquita; Roel Vermeulen; Casper H.J. van Eijck; Krzysztof Jamroziak; Renata Talar-Wojnarowska; William Greenhalf; Domenica Gioffreda; Maria C. Petrone; Stefano Landi; Livia Archibugi; Marta Puzzono; Niccola Funel; Cosimo Sperti; Maria L. Piredda; Beatrice Mohelnikova-Duchonova; Ye Lu; Viktor Hlaváč; Xin Gao; Martin Schneider; Jakob R. Izbicki; George Theodoropoulos; Stefania Bunduc; Edita Kreivenaite; Olivier R. Busch; Ewa Małecka-Panas; Eithne Costello; Francesco Perri; Sabrina Gloria Giulia Testoni; Giuseppe Vanella; Claudio Pasquali; Martin Oliverius; Hermann Brenner; Martin Loos; Mara Götz; Konstantinos Georgiou; Bálint Erőss; Evaristo Maiello; Andrea Szentesi; Francesca Bazzocchi; Daniela Basso; John P. Neoptolemos; Péter Hegyi; Vytautas Kiudelis; Federico Canzian; Daniele Campa
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