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1 November 2020
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Cover Image
Cover Image
The cover image is adapted from Figure 2 in the article, “Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study,” by Jeske and colleagues. The figure shows determination of on-chip expression by anti-tag staining. Green signals derive from anti-V5 (C-terminal) signal, while red signals derive from the anti-6xHis (N-terminal) antibody. Merged signals appear yellow. Detecting antibodies against specific Helicobacter pylori (H. pylori) proteins in peripheral blood can be applied to characterize infection and determine disease associations. Most studies analyzing the association between H. pylori infection and gastric cancer have focused on previously identified antigens, predominantly the virulence factor CagA. Selecting antigens in an unbiased approach may, however, allow the identification of novel biomarkers. Jeske and colleagues generated bacterial whole-proteome microarrays to develop an unbiased approach for the detection of seromarkers for the gastric bacterium H. pylori. In this study, the authors provide evidence that their H. pylori whole-proteome microarray offers a platform for unbiased de novo identification of serologic biomarkers. Given the microarray's versatile workflow, antibody responses against other H. pylori strains and possible associations with diverse H. pylori–related outcomes can be systematically analyzed. For more information, see the article beginning on page 2235. - PDF Icon PDF LinkTable of Contents
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ISSN 1055-9965
EISSN 1538-7755
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Research Articles
Risk of Persistent Opioid Use following Major Surgery in Matched Samples of Patients with and without Cancer
Mary Falcone; Chongliang Luo; Yong Chen; David Birtwell; Martin Cheatle; Rui Duan; Peter E. Gabriel; Lifang He; Emily M. Ko; Heinz-Josef Lenz; Nebojsa Mirkovic; Danielle L. Mowery; E. Andrew Ochroch; E. Carter Paulson; Emily Schriver; Robert A. Schnoll; Justin E. Bekelman; Caryn Lerman
Genetics of Smoking Behaviors in American Indians
Jeffrey A. Henderson; Dedra S. Buchwald; Barbara V. Howard; Patricia Nez Henderson; Yafang Li; Rachel F. Tyndale; Christopher I. Amos; Olga Y. Gorlova; for the Collaborative to Improve Native Cancer Outcomes (CINCO), a P50 Center for Population Health and Health Disparities program project sponsored by the National Cancer Institute
Association of Known Melanoma Risk Factors with Primary Melanoma of the Scalp and Neck
Renee P. Wood; Jane S. Heyworth; Nina S. McCarthy; Audrey Mauguen; Marianne Berwick; Nancy E. Thomas; Michael J. Millward; Hoda Anton-Culver; Anne E. Cust; Terence Dwyer; Richard P. Gallagher; Stephen B. Gruber; Peter A. Kanetsky; Irene Orlow; Stefano Rosso; Eric K. Moses; Colin B. Begg; Sarah V. Ward
Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study
Rima Jeske; Dennis Reininger; Busra Turgu; Amber Brauer; Christoph Harmel; Nerea Fernández de Larrea-Baz; Vicente Martín; Victor Moreno; Manolis Kogevinas; Marina Pollán; Jörg D. Hoheisel; Tim Waterboer; Julia Butt; Nuria Aragonés; Katrin Hufnagel
Author Choice
Reproducibility of a Rapid Human Papillomavirus Test at Different Levels of the Healthcare System in Tanzania: The AISHA Study
Armando Baena; Hugo De Vuyst; David Mesher; Mabula Kasubi; Safina Yuma; Julius Mwaiselage; Semi Zouiouich; Pendo Mlay; Crispin Kahesa; Sihem Landoulsi; Maria de la Luz Hernandez; Eric Lucas; Rolando Herrero; Maribel Almonte; Nathalie Broutet
Genetic Colorectal Cancer and Adenoma Risk Variants Are Associated with Increasing Cumulative Adenoma Counts
Brian A. Sullivan; Xuejun Qin; Thomas S. Redding, IV; Ziad F. Gellad; Anjanette Stone; David Weiss; Ashton N. Madison; Kellie J. Sims; Christina D. Williams; David Lieberman; Elizabeth R. Hauser; Dawn Provenzale
Association of Body Mass Index with Fecal Microbial Diversity and Metabolites in the Northern Finland Birth Cohort
Erikka Loftfield; Karl-Heinz Herzig; J. Gregory Caporaso; Andriy Derkach; Yunhu Wan; Doratha A. Byrd; Emily Vogtmann; Minna Männikkö; Ville Karhunen; Rob Knight; Marc J. Gunter; Marjo-Riitta Järvelin; Rashmi Sinha
Prediagnostic Circulating Concentrations of Vitamin D Binding Protein and Survival among Patients with Colorectal Cancer
Chen Yuan; Mingyang Song; Yin Zhang; Brian M. Wolpin; Jeffrey A. Meyerhardt; Shuji Ogino; Bruce W. Hollis; Andrew T. Chan; Charles S. Fuchs; Kana Wu; Molin Wang; Stephanie A. Smith-Warner; Edward L. Giovannucci; Kimmie Ng
Automated Quantitative Measures of Terminal Duct Lobular Unit Involution and Breast Cancer Risk
Kevin H. Kensler; Emily Z.F. Liu; Suzanne C. Wetstein; Allison M. Onken; Christina I. Luffman; Gabrielle M. Baker; Laura C. Collins; Stuart J. Schnitt; Vanessa C. Bret-Mounet; Mitko Veta; Josien P.W. Pluim; Ying Liu; Graham A. Colditz; A. Heather Eliassen; Susan E. Hankinson; Rulla M. Tamimi; Yujing J. Heng
Heritable Susceptibility to Breast Cancer among African-American Women in the Detroit Research on Cancer Survivors Study
Kristen S. Purrington; Sreejata Raychaudhuri; Michael S. Simon; Julie Clark; Valerie Ratliff; Gregory Dyson; Douglas B. Craig; Julie L. Boerner; Jennifer L. Beebe-Dimmer; Ann G. Schwartz
Null Results in Brief
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